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Fat Soluble Absorption depends on gut Water Soluble vitamins all wash out easily
(ileum) and pancreas. Toxicity is more from the body EXCEPT B12 and folate
common than for water-soluble, because (stored in the liver). B-complex deficiencies
these accumulate in fat. Malabsorption often result in dermatitis, glossitis, and
syndromes (steatorrhea), such as cystic diarrhea.
fibrosis and sprue, or mineral oil intake can B1 (thiamine: TPP);
cause fat-soluble vitamin deficiencies. B2 (riboflavin: FAD, FMN);
B3 (niacin: NAD+);
A; B5 (pantothenic acid: CoA);
D; B6 (pyridoxine: PLP);
E; B7 (biotin);
K; B9 (folate);
B12 (cobalamin);
C (ascorbic acid);
Deficiency
Cheliosis (inflammation of the
lips, scaling, and fissures at the
corners of the mouth);
Corneal vascularization;
Vitamin B3 Constituent of NAD+ and NADP+ (used DEFICIENCY: EXCESS:
(niacin) in redox reactions). Glossitis; Facial Flushing (due
Pellagra = diarrhea, to pharmacologic doses
It is derived from tryptophan and its dermatitis, dementia; for treatment of
synthesis requires vitamin B6. hyperlipidemia);
Vitamin B5 DEFICIENCY:
(pantothenate) Essential component of CoA (a cofactor Dermatitis;
for acyl transfers) and fatty acid Enteritis;
synthase. Alopecia;
Adrenal insufficiency;