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a r t i c l e i n f o abstract
Article history: The deformation dynamics of metal foils (o 0.25 mm thick) subjected to micro-blast wave are
Received 25 March 2011 presented in this paper. The energy of micro-blast wave emanating from the open end of a polymer
Received in revised form tube is used to deliver micro-particles for bio-medical applications. In these experiments metal foils are
8 December 2011
used to transfer the energy of the micro-blast wave to the micro-particles. Using cubic root scaling law
Accepted 17 April 2012
the over pressure of the blast wave at the open end of the polymer tube is estimated and using this peak
Available online 24 May 2012
plate over pressure is estimated. The finite element analysis is used to estimate the velocity profile of
Keywords: the deforming metal foils. The finite element analysis results are compared with experimental results
Metal forming for the maximum deformation and deformed shape. Based on the deformation velocity, metal foil to be
Micro-blast waves
used for experiments is selected. Among the materials investigated 0.1 mm thick brass foil has the
Explicit dynamic analysis
maximum velocity of 205 m/s and is used in the experiments. It is found from finite element analysis
FEM
Biomedical applications that the particles deposited within a radius of 0.5 mm will leave the foil with nearly equal velocity
(error o 5%). The spray cone angle which is the angle of deviation of the path of particles from the axis
of the polymer tube is also estimated and found to be less than 71 up to a radius of 0.75 mm. Illustrative
experiments are carried out to deliver micro particles (0.7 mm diameter tungsten) into plant tissues.
Particle penetration depth up to 460 mm was achieved in ground tissue of potato tuber.
& 2012 Elsevier Ltd. All rights reserved.
0020-7403/$ - see front matter & 2012 Elsevier Ltd. All rights reserved.
http://dx.doi.org/10.1016/j.ijmecsci.2012.04.004
2 S.R Nagaraja et al. / International Journal of Mechanical Sciences 61 (2012) 1–7
eccentricity of the charge and die assembly from the axis of the These results have indicated that the penetration depth of the gold
water tank in which the experiments are performed. They con- particles into the skin is a strong function of the particle density,
cluded that spherical charges produce larger midpoint deflections. velocity and radius. Lee et al. [20] have used a shock tube for
Symonds and Weirzbicki [11], Perrone and Bhadra [12] have transdermal delivery in fuzzy rats. Rhodamine-B dextran, 10 kDa
developed empirical/theoretical relations to predict the deflection molecular weight, was used as the probe molecule. Shock waves
of plates subjected to impulsive loads. Most of these relations are were generated by a two-stage shock tube. Matsumi Nakada et al.
a function of the imparted impulse, the plate thickness and radius, [21] have used this device for invivo DNA transfer by delivering
the density and the static yield stress of the material in combina- plasmid DNA coated, 1-mm size gold particles into onion scale,
tion with an empirical factor. tobacco leaf and soybean seed cells.
Jiang et al. [13] have developed a device to generate micro- From the above discussion, it is very clear that in recent time,
shock waves in ambient air by focusing the energy from a pulsed many innovative inter disciplinary applications of shock waves
laser beam into small spherical volumes. Once the deposited have emerged. Shock wave assisted techniques are increasingly
energy of the focused laser beam exceeds the threshold value for being used for many industrial and biomedical applications. In
optical breakdown, ambient air breaks down with subsequent many of these devices metal foils (diaphragms) are used for
formation of laser plasma. The energy deposition immediately transferring the shock wave energy to the micro particles. The
creates a primary spherical micro-shock wave travelling outwards deformation and velocity vector of the metal foil governs the
from the focal point. Jagadeesh and Takayama [14] have used direction of motion of particles and energy they carry till they
Nd:YAG glass laser beam to generate spherical shock waves with reach the target. Therefore, understanding the deformation and
typical radius of few millimetres both in ambient air as well as in velocity distribution is important for efficient design and optimi-
water and typically the energy expended in this process is 1.38 J, sation of the diaphragm in terms of its diameter and thickness in
which is equivalent to 0.3 mg of conventional TNT explosive. these systems. This has necessitated the study of behaviour of
Miller [15] has used shockwave technology for the destruction of thin metal foils when subjected to blast waves. Numerical solu-
renal calculi through an endoscope. Shock waves are also used for tions using finite element method provide a cost effective and
subcutaneous drug delivery into human skin. Possibility of reliable procedure to carry out parametric sensitivity study and
destruction of E-Coli bacteria subjecting them to shock waves help in selection of appropriate diaphragm. In this paper the
has been explored by Jagadeesh [16] and the preliminary results method of generation of micro blast waves, finite element
have shown that there is a substantial reduction in the number of modelling of the foils subjected to blast wave loading, analysis
E-Coli cells after subjecting them to repeated shock wave loading. of deformation velocities, particle spray cone angle and selection
Klein et al. [17] have reported delivery of nucleic acids into plant of metal foil are explained.
cells using high velocity micro projectiles. Small tungsten particles
of 4 mm diameter are coated with RNA or DNA and are accelerated
using the device, called ‘particle gun’, so that the particles (micro 2. Generation of micro blast waves
projectiles) pierce cell walls and membranes and enter into plant
cells without killing them. This method is used to study the A polymer tube coated with explosives acts like a shock tube to
transient expression of foreign genes in an intact tissue. Yoko generate micro blast wave. Small amounts ( 18 mg/m length) of
Yoshida et al. [18] have used Helios Gene Gun system to accelerate micro explosive (High Melt Explosive (HMX) and traces of Alumi-
DNA coated gold particles to deliver genes into cell. For introduc- nium) is uniformly coated on the inner wall of this polymer tube
tion of genes into the liver of living rats, the best results were (1 mm inner diameter; wall thickness 1 mm). When the micro
obtained with this hand-held gene delivery system. The b-galac- explosive is electrically triggered from one end of the polymer
tosidase gene introduced into rat liver with gold particles by tube, a detonation wave is generated inside the tube. When this
helium at 17.5 bar was expressed in a limited area of the liver detonation front is allowed to escape from the open end of the
surface (8 8 mm, depth 0.5 mm). Distribution and also the actual polymer tube, a micro-blast wave is generated. The schematic
amount DNA delivered into the cells have been examined in this representation of formation of micro blast wave at the open end of
study. M.A.F. Kendall et al. [19] have used Dermal Powder Ject the polymer tube is shown in Fig. 1. Since the amount of energy
device to deliver gold particles into excised human skin. Penetra- expended in the generation of the blast wave from the open end of
tion depth of 75 mm has been achieved with gold particles of the polymer tube is very small ( 8.7 J; TNT equivalent 1.63 mg)
2.24 mm diameter entering the skin with a velocity of 640 m/s. they are referred here as micro-blast waves. The ignition of the
S.R Nagaraja et al. / International Journal of Mechanical Sciences 61 (2012) 1–7 3
Thin metal foils placed at the open end of this polymer tube
along with appropriate mechanical fixtures is used to transfer the
impulse-momentum generated by micro-blast wave to appropri- 100
ate medium.
50
3. Peak plate over pressure
The peak pressure at any distance for any size of any explosive
can be quite accurately estimated based upon scaling experiments 0
using TNT. It is customary to plot the blast property of interest 0 100 10 10-6 20 10-6 30 10-6 40 10-6
(in the present case overpressure) against the scaled distance Z. Time (s)
R
Z¼ ð1Þ Fig. 3. Pressure profile showing the plate peak over pressure.
W ð1=3Þ
where R is the distance from the centre of charge and W is the TNT
equivalent weight of the explosive under consideration. It is estimated by extrapolation from graph of peak over pressure
Experiments were conducted using polymer tubes to measure versus scaling distance for TNT blast as depicted in Fig. 2 and it is
the pressure behind the micro-blast wave in open domain. Side found to be 24 bar. The actual pressure (peak plate over
on overpressure behind the micro-blast wave is measured at pressure or reflected pressure) felt by the metal foil which is
different distances from the blast source by sensors placed side on placed normal to the polymer tube near the open end can be
to the flow. PCB Piezotronics pressure transducers are used for calculated using Rankine–Hugoniot relations as ([22])
measuring the overpressure levels in open domain. Assuming that
the micro-blast wave emanating from the open end of the ð7P0 þ 4P s Þ
Pr ¼ 2P s ð2Þ
polymer tube follows the cubic root scaling law, the scaled ð7P o þP s Þ
distance for an experimentally observed value of overpressure
was calculated from the scaling curve. From this scaled distance where
and actual distance the weight of explosive in TNT equivalent
weight was estimated to be 1.63 mg. Based on this energy level Pr-Peak plate over pressure (reflected pressure)
subsequent peak overpressures were estimated from the scaling Ps-Peak over pressure of the blast wave
law and was found to be matching very well with the experi- Po-Atmospheric pressure
mental values of overpressures obtained at different lengths from
the micro blast. Fig. 2 shows the plot of peak overpressure versus
scaling distance for TNT blasts along with the values obtained For peak over pressure of Ps ¼24 bar and Po ¼1 bar, the peak
from the micro blast studies (marked in black spots). The values plate over pressure Pr ffi 160 bar. After calculating the peak plate
used are average of 12 firings. over pressure, pressure profile with exponential decay as shown
The over pressure value near the open end of the blast tube in Fig. 3 is assumed. This pressure profile is used as an input to the
cannot be measured due to high temperature of the debris gas. finite element analysis.
4 S.R Nagaraja et al. / International Journal of Mechanical Sciences 61 (2012) 1–7
After expressing the above Eq. (3) in the weak form and using an
interpolation function they can be expressed in the matrix form as
½Mü þ½Cu_ þ ½Ku ¼ ½F ð4Þ
Fig. 5. A photograph of the device used micro particle delivery into soft targets.
where [M], [C] and [K] are mass, damping and stiffness matrices, {u}
displacement vector and [F] externally applied force vector. Eq. (4)
can be solved using finite element analysis solvers, which incorpo-
rate both geometric non-linearities and material non-linearities. The The computational domain used in the finite element analysis
explicit dynamic analysis is carried out using ANSYS with LS-DYNA is shown in Fig. 4. The shock wave is treated as a slug force acting
solver. The boundary condition used is—all degrees of freedom are instantaneously on the thin metallic plate constrained at the
fixed at the outer periphery of the plate (fixed plate). It is assumed outer periphery. In order to validate the finite element model
to have biaxial stress system, which is valid since thickness of the developed, experiments were carried out using a specially
plate is very small. Hence the SHELL 163 element with five designed holder shown in Fig. 5. The maximum (midpoint)
integration points is used. It is a 4 node element with both bending deflection of the plate/foil obtained from the experiments is
and membrane capabilities. Both in-plane and normal loads are compared with those values from the finite element simulations.
permitted. The element has 12 degrees of freedom at each node, i.e., The results are tabulated as shown in Table 1. The table also lists
translations, accelerations and velocities in the nodal x, y, and z the velocity values for aluminium, brass and copper foils of
directions and rotations about the nodal x, y, and z axes. Fully- 0.1 mm, 0.15 mm and 0.18 mm thickness obtained using finite
integrated Belytschko-Tsay shell element formulation (KEYOPT element analysis. It can be observed that the experimental values
(1)¼12) which is generally used for metal forming applications for the midpoint deflection closely agree with simulated values.
has been used (ANSYS reference manual). It uses a 2 2 quadrature Fig. 6 shows the variation of velocity and midpoint deflection
in the shell plane. Non linear strain rate dependent plasticity of 0.1 mm brass foil. It is observed that peak velocity is reached
material model generally used in metal forming applications is before the maximum deflection is reached and hence the particles
selected. This material model follows constitutive relationship of the would have been ejected from the free surface of the foil before
form the completion of the deformation process. Fig. 7 shows the
variation of pressure and velocity with time for 0.1 mm thick
s ¼ kA m A_ n ð5Þ
brass foil. It is observed that the velocity vector lags behind
where e is the strain, A
_ is the strain rate, k is the material constant, the rate of application of pressure. The deformation of the foil
m is the hardening coefficient, and n is the strain rate sensitivity and velocity are very slow compared to the rate of applied
coefficient. pressure.
S.R Nagaraja et al. / International Journal of Mechanical Sciences 61 (2012) 1–7 5
Table 1
Values of midpoint deflection and midpoint velocity for various foils obtained
from finite element analysis and midpoint deflection from experiments.
Velocity (m/s)
3 150
80
2 100 60
40
1 50
20
0 0
0
0 100 10 10-6 20 10-6 30 10-6 40 10-6 0 0.5 1 1.5 2 2.5 3
Time (s) Radius of foil (mm)
Fig. 6. Variation of midpoint deflection and velocity with time for a 0.1 mm brass Fig. 9. Variation of the resultant velocity along the radius of the foil at different
foil loaded with the blast wave. time intervals for brass foil of thickness 0.18 mm.
Pressure (bar) (boundary conditions) are also axisymmetric, all the variables
250 250
(deformation, velocity, stress, strain) are functions of radius and
Velocity (m/s)
time only. The deformation velocity vector determines the angle
200 200 of spray (d) i.e., angle of deviation from axis of the shock tube
(polymer tube). Larger the value of d, greater is the distance a
Pressure (bar)
150 150 the target and smaller is the velocity at target surface. This
smaller velocity of the particle results in smaller depth of
penetration in the target material. Assuming the velocity of
100 100
particles leaving the metal foil surface to be same as that of the
foil (Menezes et al.[1]), the magnitude and angle of deviation of
50 50 the particles can be calculated.
qffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
V r ¼ V 2x þ V 2z ð6Þ
0 0
0 100 10 10-6 20 10-6 30 10-6 40 10-6 Vx
Time (s) d ¼ tan1 ð7Þ
Vz
Fig. 7. Variation of plate peak over pressure and velocity with time for a 0.1 mm where Vr Resultant velocity of the particle
thick brass foil loaded with the blast wave.
Vz Velocity of particle parallel to the shock tube axis.
5. Spray cone angle Vx Velocity of particle perpendicular to the shock tube axis.
d Angle of deviation (spray).
Fig. 8 shows the components of deformation velocity vector at
any point on the deforming metal foil. Vz is velocity component Fig. 9 shows the resultant velocity of various points along the
parallel to axis of the shock tube (polymer tube) and d the spray radius of the foil at different time intervals. It is observed that all
cone angle or angle of deviation. As the applied pressure load is the points along the radius initially have almost same velocity.
rotationally symmetric (or axisymmetric) and edge conditions The central portion accelerates and rapidly reaches the peak
6 S.R Nagaraja et al. / International Journal of Mechanical Sciences 61 (2012) 1–7
20
Spray Cone Angle (degrees)
16
12
0
0 0.5 1 1.5 2
Radius (mm)
Fig.12. A photograph showing penetrated tungsten micro particles in ground
Fig. 10. Variation of the spray cone angle d along the radius of the foil for brass foil tissue of potato tuber.
of thickness 0.1 mm.
150
7. Bio-medical applications
100
Illustrative experiments were carried out to demonstrate the use
of metal foil deformation (by blast wave loading) for bio-medical
50 applications. For this a device has been built to deliver micro
particles in to soft targets using the energy of the micro blast wave.
This device uses the metal foils as energy transferring mechanism
0 between the micro blast wave and micro particles. Using finite
0 100 5 10-6 10 10-6 15 10-6 20 10-6 25 10-6 element analysis, it was concluded that brass foils of 0.1 mm thick
Time (s) are best suited to conduct these experiments. Fig. 6 shows a
photograph of the device used to deliver micro-particles. Experi-
Fig. 11. Variation of velocity for aluminium, brass and copper foils of different
ments were carried out to deliver micro particles into the plant
thickness loaded with the blast wave.
tissue. Fig. 12 shows penetration of micro particle in the ground
tissue of potato tuber. The depth of penetration up to 460 mm is
velocity. In this case the maximum difference in the magnitude of achieved. In these experiments the micro particle (0.7 mm diameter
velocity between the central point and a point at a distance of tungsten) are deposited on the posterior side of the brass foil.
0.5 mm along the radius is o5%. Therefore, if the particles are
deposited over an area of radius 0.5 mm then all of them will have
same velocity when they leave the metal foil. Fig. 10 shows the 8. Concluding remarks
variation of the spray cone angle (angle of deviation-d) along the
radius of the metal foil. The values plotted are over a radius of The maximum midpoint deflection and the deformation velo-
1.5 mm and at the time corresponding to maximum midpoint cities obtained from finite element analysis closely agree with
velocity. It is observed that spray cone angle increases with the measured values (error o13%).
radius. The particles deposited nearer to centre of the metal foil Among the materials investigated (brass, aluminium, copper)
deviate less from the axis of the shock tube (polymer tube) than for a particular thickness aluminium foils have maximum
those deposited far away from the centre. The spray cone angle in deformation velocity.
this case is about 71 at a radius of 0.75 mm. Brass foil of thickness 0.1 mm has maximum deformation
velocity (204 m/s) among those foils which did not fail.
The angle of deviation from axis of penetration varies from
6. Selection of metal foil zero at the midpoint to about 71 at a radius of 0.75 mm for
brass foil of 0.1 mm thickness.
The thickness and material of the metal foil selected is based The particles deposited over a radius of 0.5 mm will leave the
on the maximum velocity to be imparted to the particles. The metal foil with same velocity (maximum difference is o5%).
velocity of the particles is assumed to be equal to the velocity Tungsten particles of 0.7 mm diameter were successfully delivered
of the foil. It was observed that for a given thickness aluminium in to plant tissue (potato tuber) with a depth of penetration
foil has the maximum velocity compared to brass and copper. up to 460 mm.
S.R Nagaraja et al. / International Journal of Mechanical Sciences 61 (2012) 1–7 7