DRUG STUDY

GENERIC NAME: Piperacillin / Tazobactam

Brand name: Zosyn
Drug Classification: Antiinfective; Beta-lactam antibiotic; Anti-pseudomonal penicillin

DOSAGE, ROUTE, SIDE EFFECTS and

FREQUENCY (prescribed and INDICATION MECHANISM OF ADVERSE REACTIONS
recommended) ACTION (by system)

It is similar to that of
Treatment of moderate to CNS: headache, insomnia,
other penicillins.
severe appendicitis, fever
Interfere with bacterial
uncomplicated and
cell wall synthesis
complicated skin and skin GI: diarrhea, nausea,
promotes loss of constipation, vomiting,
structure infections,
membrane integrity and nosocomial or community- pseudomembranous colitis
leads to death of the acquired pneumonia caused
organism. piperacillin-resistant, SKIN: hypersensitivity
reactions ,rash, pruritus
piperacillin/tazobactam
susceptible, beta-lactamase-
producing bacteria.

NURSING RESPONSIBILITIES
CONTRAINDICATION/S (at least 10)
 Before:
Hypersensitivity to penicillins, > check the doctor’s order
cephalosphorins, or other > assess for history: hepatic and renal impairment, lactation, pregnancy
> assess for physical cues: skin status, LFTs, renal function tests, culture
drugs. Safety in children < 12
of affected area
years old, pregnancy, lactation. - > Obtain specimen for culture and sensitivity prior to first dose of the
drug; start drug pending results. Periodic CBC with differential, platelet
count, Hgb & Hgt, and serum electrolytes.

During:
> administer the right drug
> explain to the patient about the importance and purpose of the drug
> administer at the right time and right dosage
> avoid alcohol while taking this drug and for 3 days after because severe
reactions often occur
> discontinue if hypersensitivity reaction occurs

After:
> document and record.
- >Monitor for hypersensitivity response; discontinue drug and notify physician if
allergic response noted.
- Monitor for hemorrhagic manifestations because high dose may induce
coagulation abnormalities.
- Instruct family/significant others to report significant, unexplained diarrhea.

Patient’s Name / Room No.