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Mecanisme de transport

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30.000 piesede2 transport
Mijloace t, vs megauzine
durata de viata 10-15 ani

11.000 piese 54 t, 4.000.000 piese, 178 t,


durata de viata 40-50 ani durata de viata 35-40 ani

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la nivelul membranelor
celulare 1-100 piese;
volum 40 nm 3;

masa 6 pg (10-15);
durata de viata:
minute sau ore;
parte a unei suprafețe
de 100-200 um2

40.000-100.000
mld
4 10 ani
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Cale/drum/
mijloc
De ce e nevoie ?
Ce aduce?
Ce presupune?
Gestiune a traficului
Lucrări de întreținere
Accidente (patologie)
Deturnări (farma)
(intenționate/neintenționate)
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(Altfel de) Spațiu

(Altfel de) Timp

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Timp
“Timp procedural”
“Timp relativ”
“Timp manipulat” -accelerare
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-înghețare
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Spațiu

Volum

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Distanța

Condiții de trafic

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http://ami.org/medical-illustration/view-art-and-
animations/2015-salon-winners

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Control și manipulare
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I. Transportul moleculelor mici
Principii generale
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Imagini ‘Cellular landscapes”:
Cell signaling.com

Linda S.
Nye

Medical
Illustration/
Animation

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ANUAL 57 mld animale
1 trilion viețuitoare marine
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Selectivitatea
membranei

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Proteinele
facilitează
transportul
transmembranar

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Gradient

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Ce transportă celulele?

Molecule mici

MACROMOLECULE

DETRITUSURI
CELULARE

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Câtă energie se
consumă în transport?

până la 2/3 din cele


40 kg ATP care se
produc Într-o zi!!!!
într-un organism
uman!!!

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Hidrofob și
hidrofil în
același timp

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Osmoza

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Direcția
mișcării

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Presiunea
hidrostatică

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Izoton,
hipoton,
hiperton

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Viteza de
transport

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Canale
ionice

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Modele
fizice
de
control
pentru
canale
ionice
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Canale de Ca, Na, K, Cl

• Subfamilii
• 100 M ioni/s
• Țintă moleculară pt. medicamente
• Electrofiziologie; mutageneză dirijată 41

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Trecerea
prin trei
stări

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Canale pentru apă, aquaporine

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13 Aqp

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Transportori

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Caracteristici

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II. Transportul activ
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Pompele sau ATP-azele
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Pompa de Na /K
+ +

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Un tip de
transportor

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Sistemele de co-transport 54

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Cotransport

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Simport

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Antiport

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B. Transportul macromoleculelor
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Spre interior = endocitoza
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Endocitoza

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fagocitoza

Endocitoza

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fuziune cu
fagocitoza lizozomii pentru
digestie

Endocitoza

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fuziune cu
fagocitoza lizozomii pentru
digestie

Endocitoza
pinocitoza

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fuziune cu
fagocitoza lizozomii pentru
digestie

Endocitoza
proces
pinocitoza nespecific

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fuziune cu
fagocitoza lizozomii pentru
digestie

Endocitoza
proces
pinocitoza nespecific

endocitoza mediata

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fuziune cu
fagocitoza lizozomii pentru
digestie

Endocitoza
proces
pinocitoza nespecific

endocitoza mediata
de receptor

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fuziune cu
fagocitoza lizozomii pentru
digestie

Endocitoza
proces
pinocitoza nespecific

endocitoza mediata declanșat de un


de receptor semnal
molecular

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Spre exterior - exocitoza
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Copyright © 2016  The Association of Medical
Monday, October 24, 16
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MVE= multivesicular
endosome

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http://ami.org/medical-illustration/view-art-and-
animations/2015-salon-winners

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Anexa 1

III. Un exercițiu:
Transportul glucozei
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Distribuția
transportorilor

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Difuziunea
facilitată a
glucozei

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DZ tip 1
și tip 2

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Transportul
de glucoză
este diferit
în țesuturi
diferite

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Efectul insulinei asupra transportorilor

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Absorbția glucozei

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Anexa 2

IV. Transportul medicamentelor


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Medicamente
administrate
per os

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Mecanisme
de transport
pentru
medicamente
administrate
oral

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Manipularea
mecanismelor
de transport

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