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Sirosis

 Sirosis hati: penyakit hati menahun,difus,fibrosis ,nodul-nodul(mikro,makro, mixed), kerusakan

parenchim

 Merupakan stadium akhir: Hipertensi Portal,HCC

 Insidensi tinggi: negara barat

 Insidensi: usia 50-60, pria >>>wanita ,2-4:1

 Etiologi multifaktorial: Alkohol,Hepatitis virus(B&C)

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