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1. INTRODUCTION
*
Chris D. Nugent, University of Ulster, Jordanstown, Northern Ireland, BT37 0QB. Email:
cd.nugent@ulster.ac.uk.
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solutions which have significant potential in the prevention of serious cardiac disorder.
This chapter examines the developments in telecardiology and looks forward to how they
might appear in the future.
1.1. Cardiology
Heart disease still remains one of the major causes of premature deaths. With careful
clinical evaluation, some of the causes of heart disease can be foreseen and prevented.
Many factors contribute to the likelihood of developing a heart disease; cholesterol levels,
blood pressure levels, family history etc. and hence, in certain conditions, these must be
carefully monitored. Various clinical tests may be performed to evaluate the status of the
heart. One of the most commonly employed non-invasive tests is that of the
Electrocardiogram (ECG) which records the electrical activity of the heart. Careful
consideration of this electrical information provides sufficient detail to identify and
diagnose a number of cardiac abnormalities which may induce untimely deaths.
The ECG has established itself as a standard tool in modern clinical medicine. It is a
non-invasive technique, painless to the patient, inexpensive, simple to use and the most
popular practical means of recording the cardiac activity, in electrical terms (Wellens,
1990). The major advantage of the ECG is its relationship to physiology. It is possible to
correlate the recorded electrical activity of the ECG with the fundamental behaviour of
the heart. Hence, through careful analysis, it is possible to establish relationships
between electrophysiological events and measured signals.
From a diagnostic point of view, the ECG offers two perspectives. Firstly, by
analysis of wave shapes it is possible to describe the condition of the heart’s working
muscle masses. Secondly, consideration of the rate of the cardiac cycle provides rhythm
statements which give additional diagnostic information. In normal subjects, the ECG
remains reasonably constant, whereas, under pathological conditions, several pertinent
differences appear. Not all cardiac abnormalities, however, are identifiable by the ECG.
Nevertheless, when used in conjunction with other clinical techniques e.g. angiography
and echocardiography, an accurate ‘picture’ of the heart may be obtained for diagnostic
purposes.
The ECG can be taken in several ways. Single lead recordings employ two
electrodes on the patient’s body and produce a single ECG trace. These are useful for
continuous or ambulatory methods (Holter recordings) of rhythm monitoring. The 12-
lead ECG records differences in voltages between 10 electrodes placed on the patient’s
body (see Figure 1). The 12 leads are subdivided into 2 groups: the limb leads
measuring the cardiac activity in the frontal plane of the body and the chest leads or
precordial leads measuring the cardiac activity in the horizontal plane of the body. As the
number of leads are increased so too is the information attained. Hence, the 12-lead ECG
provides a fuller consistent diagnosis in comparison with single (or configurations of
single) lead recordings. A Body Surface Mapping approach may also be utilised whereby
many recording sites on the patient’s body are used (for example >80). With this
increase in the number of sensors, in comparison to the 12-lead approach, a more
complete picture of the electrical activity of the heart may be obtained. The potentials
recorded from the Body Surface Map are reconstructed as contour maps for each
instantaneous time period. The Body Surface Mapping approach has been widely
accepted as mainly a research tool, however, from an electrical point of view, the 12-lead
TELECARDIOLOGY: PAST, PRESENT AND FUTURE 377
ECG is the most commonly performed procedure in the standard routine daily
examination of cardiac function (Cox et al., 1972).
Figure 1. 12-Lead ECG Recording indicating electrical activity in both frontal and horizontal planes of the
body.
1.2. Telecardiology
Figure 2. Telecardiology system overview providing communication between patients, medical personnel and
cardiologists.
TELECARDIOLOGY: PAST, PRESENT AND FUTURE 379
monitoring tasks where the added noise and distortion of the PSTN do not have a
significant impact on the observation of rhythm changes. However, for more precise
clinical diagnosis, the integrity is not acceptable.
A natural progression has been made to support telecardiology recordings via digital
communications. In comparison with analogue approaches McKee et al. (1996) indicate
the following advantages:
x Low cost – digital technology, for example in VLSI form, is much cheaper than
complex analogue circuitry.
x Data integrity – channel noise and interference can be addressed.
x Utilization – Time Division Multiplexing (TDM) can provide better bandwidth
than FDM.
x Integration – diverse signals can be carried in a common format.
Through the use of modems, it is possible to convey digital information over
analogue PSTN lines. Many attempts have been made to adopt a digital approach to the
transmission of ECGs over the PSTN. Berson in 1963 (Coopers and Caceres, 1965)
reported one of the first attempts which involved the use of an acoustically coupled
modem. Unfortunately, the bit rate of any such transmissions are constrained by PSTN
limits. For example, a single lead digitised ECG at a rate of 250 samples per second with
16 bit resolution generates 4000 bits per second. With modern modems, supporting 56
kilo bits per second or higher, real-time transmission of multi-lead ECGs becomes
difficult, especially if other data is also required. Hence to decrease transmission times,
and move towards the reality of real-time telecardiology systems various attempts have
been made and put in place to compress the ECG prior to transmission (McKee et al.,
1994; Berbari, 1995). This has now become a necessity in digital approaches.
It has been recognised that to assist further in the process of telecardiology there is a
requirement to transfer additional information in the form of speech. This can be useful
to assist with call-setup, transfer of patient details, interrogation of the person making the
recording and a means to provide patient diagnosis or feedback. Systems have been
developed that provide a means of switchable ECG-Voice transmission (Hagan, 1965)
and also simultaneous ECG and voice transmission (McKee, 1996).
Although the approach of transmitting the ECG via the PSTN (via both analogue and
digital means) is well established, it was recognised that restrictions of these systems
were present due to the logistical presence of PSTN lines. Nevertheless, many
manufacturers have integrated digital PSTN ECG transmission facilities into their
products. To overcome these limitations it is necessary to introduce a mobile aspect into
the telecardiology telecommunications framework. The facilitation of this mobile aspect
supports the recording and transmitting of ECGs from, for example, ambulances, accident
or emergency scenes and general rural areas not readily supported by the PSTN.
The first instances of mobile telecardiology were reported in the 1970’s. These
provided remote means of the acquisition and transmission of ECGs using conventional
radio equipment. From the 1980’s onwards, the popularity of commercial cellular
networks were exploited to provide ECG transfer facilities.
One of the first studies carried out employed the transceivers of ambulances and used
FM (Uhley, 1970). In this system, when ECGs were not being transmitted, the normal
TELECARDIOLOGY: PAST, PRESENT AND FUTURE 381
voice channel of the transceivers were available. Lambrew (1973) used a self-contained
radio based system to transmit from either ambulances or helicopters either the ECG
information or voice. Pozen (1977) and Cayten (1985) also employed mobile
telecardiology systems from ambulances. Both systems permitted either voice or ECG
information to be transmitted.
Grim et al. (1987) investigated the possibility of using cellular networks for the
transmission of the 12-lead ECG. A portable recording machine was used and connected
to a cellphone. Prior to transmission, the recorded ECG signal was digitised and
compressed. Although, in principle, it was possible to demonstrate a mobile
telecardiology approach in this manner, a problem at that time was found with the cellular
network’s capacity i.e. at certain times, due to network peaks, a transmission was not
possible, however, when compared with approaches using ambulance transceivers this
was not the case as proprietary radio communications could reserve emergency channels.
To further extend on the aspect of mobile telecardiology, systems have been made
available which provide mobile transmission of both ECG and voice simultaneously.
This has advantages of no instances of breaks in communications between the two users
of the system. Shimizu (1999) provided a system whereby ECG and voice could be
transmitted via a single vocal communication channel of a mobile phone. The approach
offered real time transmissions and the facility of duplex communications. McKee et al.
(1996) presented a system employing GSM mobile and conventional telephone
technologies. The system facilitated a 5 second 12-lead ECG recording and supported
simultaneous communication of digitised, full duplex speech and ECG signals.
With digital cellular mobile communications and compact acquisition machines
employing efficient compression algorithms, mobile telecardiology is at present a reality.
The challenges now lie in the standardisation of the approach and tailoring of the solution
to all stakeholders involved.
As advances have taken place in the communications arena these have been equally
matched with the advances in the development of medical devices. Modern ECG
machines are no longer required to be devices in their own right, but now are miniature
machines, smaller and lighter than standard ECG machines used in conventional hospital
settings (Daja et al., 2001). It is no longer necessary to connect cumbersome ECG cables
and apply electrodes to the patient, as new acquisition devices can have, for example,
inbuilt sealed metal contacts in place of the use of conventional electrodes. These may be
simply placed against the chest of the patient and the ECG signal recorded. Such an
approach permits the use of the device by the patient and hence reduces the need of
clinical input/assistance during ECG acquisition. This can be seen as a significant
advantage in the progression towards improved patient empowerment. With ECG
devices now being considered as miniature and the reality of mobile telecommunications
supporting telecardiology, patients can carry on their person integrated medical and
mobile devices and when an irregularity of the heart rhythm is experienced a recording
can be made and relayed to a control centre for analysis. This provides the users with a
degree of geographic freedom, eliminating the necessity to be in the home environment to
facilitate telecare. Many patients who currently exploit home care monitoring systems in
the cardiology domain feel uneasy to leave their home environment incase the need to
contact, or transmit cardiac information to the control centre arises. With mobility and
provision of geographic independence for the patient, telecardiology overcomes these
constraints and has now become appealing to the patient.
Examples of systems combining the development of new miniature ECG acquisition
devices and digital mobile communications have been presented in the form of
wallets/purses and hybrid mobile phone devices. With these systems, the inclusion of
miniature electronics permits the production of inconspicuous devices which users may
carry on their person without any possible discomfort or embarrassment. It is possible to
inconspicuously embed an ECG device into a wallet which at the appropriate time can be
placed on the chest to acquire a recording. With this product, the recorded ECG signal
can be acoustically coupled to a phone handset (mobile or fixed) and the subsequent
recording relayed to a control centre. Figure 3 shows a device developed by Meridian
Medical Technologies, which is currently being supported by the Sahal monitoring centre
in Israel.
Another possibility is to include the ECG device within the housing of a standard
mobile phone. Metal contacts can be incorporated on the back of the phone which can be
connected to the acquisition circuitry. By placing the contacts onto the chest of the
patient, the ECG can be recorded, subsequently compressed, digitised and transmitted via
mobile communications modules all within the handset. These devices also offer the
TELECARDIOLOGY: PAST, PRESENT AND FUTURE 383
potential to incorporate GPS (Global Positioning System) in the handset to permit the
exact location of the patient to be located in instances of emergency. Istepanian et al.
(2001) have developed an approach involving a mobile telephone and a miniature ECG
acquisition device. For modularity purposes, the mobile telephone and the ECG
acquisition device were not integrated. Instead, the digitised and compressed ECG
signals could be transferred from the acquisition device to the mobile telephone via an
infra-red link. The protocol used was compliant with IrDa standards and hence provides
the opportunity to use a number of different handsets to make the remote transmission.
The device itself was designed as a waist mounted holster with a cradle for the mobile
phone. When not acquiring ECGs, the mobile phone could be operated as normal. As
can be seen from these new approaches, trends are moving towards personalised and
tailored solutions for the patient, to produce inconspicuous and mobile solutions which
strive to place healthcare more in the hands of the patients themselves and alleviate the
impositions posed by non portable monitoring equipment.
Not only is it necessary to provide a means of remote transfer of the acquired ECG
data from the patient to the control centre, but it is a necessity to provide Cardiologists
with the ability to remotely access patient information from the control centre. This may
be necessary in instances were cardiologists are not available at the control centre and
when second opinions are required (Shanit et al., 1996), or the general case of access to
patient information/history during remote patient examinations.
Vassanyi et al. (2001) addressed this by providing a WAP (Wireless Application
Protocol) interface to a cardiology repository via the Internet. Via the WAP interface on
a mobile phone limited information could be retrieved and displayed providing the ability
to remotely access the information. This provides a platform to address the issues
mentioned above where cardiologists’ input is not available at the control centre,
however, it may be accessed remotely. Black et al. (1999) used a fax routine
incorporated into the control centre’s software to transmit a 12-lead ECG recording to a
384 C.D. NUGENT ET AL.
fax compatible mobile phone (see Figure 4 (a)). A potentially more interactive approach
to this is the use of PDAs and mobile phones (or smartphones). The ability to send a fax
to a mobile device is useful, but it only provides a simplex communications channel.
WAP systems are also useful, but provide limited functionality in terms of interactivity
with the user interface and have limited display content. Through the inclusion of
appropriate web browsing software it is possible to access the Internet via a PDA with the
communications channel being provided by a mobile phone (or conventional PSTN).
PDAs and mobile phones can now be easily connected via infra red or Bluetooth links.
Figure 4 (b) shows an example of a PDA displaying cardiac information. With such an
approach, the user of the PDA can dictate, in a similar manner when using a standard web
interface, the information content to be displayed/accessed. Barro et al. (1999) have
developed an approach whereby an expert can retrieve cardiac information from a central
location via the use of a PDA and modem. The information details can be selected by the
user of the PDA and ECG information can be visually displayed through customised
software hosted on the PDA. In a similar manner to providing tailored and personalised
solutions to the patient, the aforementioned have provided the same potential benefits to
cardiologists and medical personnel.
(a) (b)
Figure 4. (a) 12-lead ECG transmission to a fax compatible mobile phone (b) PDA screen shot.
To date, the majority of efforts relating to telecardiology have been focused on the
developments of the telecommunications infrastructure. These have focused on providing
a reliable means to transmit the ECG recordings from a patient in a remote location to a
central facility by both fixed and mobile telecommunication channels. As described in
section 1.2 this forms a key aspect of a telecardiology system, but to provide a holistic
approach to patient analysis and actively involve all stakeholders in the process and
support their roles, trends have moved towards assisting the cardiologist in making the
final patient diagnosis through assistive computerised means. Future trends in mobile
telecardiology are currently addressing 2 issues:
Decision tasks, such as ECG classification—to determine whether the patient under
examination is ‘normal’ or exhibits any cardiac abnormalities requiring treatment, are key
components to the successful introduction of reliable and practical telecare systems. Over
the past decades, research techniques based on AI, ranging from decision trees and fuzzy
logic to advanced neural networks, have produced decision support systems which are
becoming more attractive in the field (Nugent et al., 1999). What is important to note,
however, is that the role of such systems is not to replace the human cardiologist in their
decision making process, but to assist them in the overall patient diagnosis. Decision
support systems have the ability to rapidly consider vast amounts of information and
produce consistent results, with lower levels of intra-observer variability in comparison
with humans. Recent investigations have shown that the computerised approach has the
ability to produce comparable diagnostic results with cardiologists (MacFarlane, 1992).
It is likely that the role of such systems will be used to analyse certain aspects of the
recorded electrocardiographic data and where appropriate take into account other non-
ECG data, hence providing indications to operators during potential situations of concern.
386 C.D. NUGENT ET AL.
Clinical acceptance of medical decision support systems are now gaining popularity as
formalisation of evaluation of their potential are being established (Smith et al., 2002).
This has the potential for a larger scale uptake of their use.
5. CONCLUSIONS
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