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Questions and Answers

Fruithurst and Muscadine Cancer Concerns

January 30, 2018

Table of Contents
Extent of Cancer ......................................................................................................................... 3
How much cancer is in the community? .................................................................................. 3
What about other kinds of cancers in the area? ....................................................................... 3
Problend ..................................................................................................................................... 4
How long was the Problend Rubber facility in operation and what was it doing during that
time? ....................................................................................................................................... 4
What chemicals were used at the Problend facility? ................................................................ 4
Did the Alabama Department of Environmental Management (ADEM) regulate Problend? ..... 5
How much contaminated water was feasibly discharged from the ProBlend facility? ............... 8
Could contaminated water from Problend have feasibly traveled to wells miles away?............ 8
Water and Soil Test Results........................................................................................................ 9
What contaminants were tested for in water? .......................................................................... 9
What contaminants were tested for in soil? ........................................................................... 10
How do I make sense of the health impacts of these contaminants? ..................................... 10
Arsenic...................................................................................................................................... 13
How does arsenic impact health? .......................................................................................... 13
Bis(2-ethylhexylphthlate)........................................................................................................... 15
How does bis(2-ethylhexylphthlate) impact health? ............................................................... 15
Caprolactam ............................................................................................................................. 17
Barium ...................................................................................................................................... 18
How does barium impact health? .......................................................................................... 18
Cadmium .................................................................................................................................. 20
How does cadmium impact health? ....................................................................................... 20

1
Chloroform ................................................................................................................................ 21
Chlorodibromomethane ............................................................................................................ 22
Chromium ................................................................................................................................. 23
How does chromium impact health? ...................................................................................... 23
Dichlorobromomethane ............................................................................................................. 25
Lead ......................................................................................................................................... 26
How does lead impact health?............................................................................................... 26
Naphthalene ............................................................................................................................. 28
How does naphthalene impact health? .................................................................................. 28
Nickel ........................................................................................................................................ 29
How does nickel impact health? ............................................................................................ 29
Selenium................................................................................................................................... 31
How does selenium impact health? ....................................................................................... 31
Silver ........................................................................................................................................ 32
Zinc........................................................................................................................................... 33
How does zinc impact health? ............................................................................................... 33
Radium ..................................................................................................................................... 35
Radon ....................................................................................................................................... 36
How does radon impact health? ............................................................................................ 36
Mercury..................................................................................................................................... 38
References ............................................................................................................................... 39

2
Extent of Cancer

How much cancer is in the community?

Initially, Cleburne Cancer Concerns worked with Auburn University rural sociologist Dr.
Ashwood to identify patients with only
leukemia and lymphoma, which are closely
related cancers. Interviews revealed that Census Block Map CLL
! Haralson County
between 2013 and 2017, three children and one CLL &AML
"
adolescent were diagnosed with leukemia,
about 39 times the prevalence expected in the Non-Hodgkin LympohmaALL
!!
census block where they reside, compared to Leukcoytosis & Hyperlipidemia
county-wide averages over a five year period.1 ! Lymphoma
!
Cleburne County, which houses Fruithurst and
Muscadine, typically averages only about one APL !
APL

childhood leukemia diagnosis in a 5-year "


CML
period. Further, between 2016 and 2017, four !
adults in the same census block have been
diagnosed with leukemia, and two adults with

AL/GA
Cleburne County Osteosarcoma
lymphoma. !

Stateli
Fruithurst Elementary School
"

ne
"
Interviews revealed occupational exposure to ALL
Problend Rubber Facility

rubber and well-water drinking as potential !


common routes for exposure. Especially for
pregnant mothers and infants on formula,
exposure to contaminated well water was of
concern. Based on information collected in
interviews, Cleburne Cancer Concerns, Auburn " Former Patient Homes
University researchers, and University of
.
! Current Patient Homes
Alabama researchers collected well water and 0 0.75 1.5 3 Miles Cleburne County roads
soil samples. The findings are presented in this Map Made By:
document. Kenzley Defler !
Auburn University
Undergraduate Student

What about other kinds of cancers in the area?

Cleburne Cancer Concerns would like the next step to include a survey of all residents who live
in the above census block to understand what other kinds of cancers may be related to
environmental, occupation, or household exposures. Initial accounts suggest a potential
prevalence of breast, colon, prostate, stomach, and other cancers.

3
Problend

How long was the Problend Rubber facility in operation and what was it doing during that
time?

The Problend location in Fruithurst Alabama opened in 1987 and in 2006 was taken over by
Preferred Compounding. This acquisition included the Associated Rubber Company locations in
Fruithurst and Tallapoosa, GA. Problend’s purpose was to, “supply proprietary and custom
mixed rubber compounds, chemical blends and calendered sheet to molders, extruders, mixers
and others in the non-tire rubber goods market. Primary industries served include automotive,
construction, power generation and roll goods.”2 Because Problend was a sister company with
Associated Rubber in Tallapoosa, an interviewee stated that all waste and chemical cleanups
materials from the Fruithurst location were picked up and handled by Associated Rubber.

What chemicals were used at the Problend facility?


From statements given by former employees of Problend, ADEM documents, and interviews,
several chemicals have been identified. Former employees state there were many chemicals used,
some they could not identify. A former employee of Problend described that many of the
products used on site were sulfur-based powders which were mixed with oil for dispersion. This
mixture was then used for further stages of rubber production. Some of the chemicals that have
been identified include:

o Zinc dimethyldithiocarbamate, commonly known as methyl zimate or ZDMC. 3


§ A creamy white powder used as an accelerator in low temperature rubber
processes
§ Is an industrial fungicide
§ Looks like an odorless white powder
§ When heated to decomposition it emits toxic fumes of carbon monoxide,
carbon dioxide, sulfur oxides and nitrogen oxides

o N-Cyclohexy(thio)phthalmide or PVI. 4
§ Used to protect the rubber material from scorching during processing,
especially during high temperature and high speed processes
§ Also used for better storage capacities

o Talc or magnesium silicate

o N-diethlethanolamine (ADEM Permit 1994)5


§ Used to neutralize acids and make salts
§ Known to be highly caustic
§ Corrosive to metals and tissues
§ Used to manufacture petroleum products

4
o Sodium Hydroxide (ADEM Permit 1994)6
§ Used to neutralize acids and make salts
§ Known to be highly caustic
§ Corrosive to metals and tissues
§ Used to manufacture petroleum products

Did the Alabama Department of Environmental Management (ADEM) regulate Problend?

Problend was required to submit twice yearly stormwater reports to ADEM. That means that
ADEM permitted the facility, and required water reports, but had no enforceable standard. In the
event Problend discharged too much of something into the environment, ADEM had no
regulatory authority to act.

They did, though, have authority to act if Problend did not submit water reports. For the first
seven years of Problend’s operation, they did not submit any reports, as ADEM did not require
it. From the time of which they were required to submit reports, they failed to report water
quality data eighteen times bi-annually. In other words, nine years of water quality reports are
missing as required by law, according to what ADEM has available.

From the 24 water reports we have access to, we know that Problend was outside of acceptable
EPA benchmarks for stormwater monitoring for the following measurements: Biochemical
Oxygen demand (twice); pH, which measures acidity or alkalinity of water (12 times); total
suspended solids (4); zinc (22 times); lead (3 times); chromium (9 times); oil/grease (twice). In
total, Problend’s stormwater runoff was over EPA benchmarks for water quality 54 times for 7
different criteria. Please not that these criteria encompass only regulatory ones, and do not
include other chemicals that could have been used in production, and ones that we tested for.

In 2012, ADEM implemented a new permitting standard for rubber and plastics facilities. That
included monitoring for benzene, ethylbenzene, toluene, xylene, napthalene, and Methyl Tertiary
Butyl Ether. From 2012 until Problend’s closing in 2015, it submitted no water quality reports to
ADEM, as the law requires.

Please see the next page for a comprehensive table that summarizes of all of the ADEM
stormwater discharge reports relating to ProBlend. Note the “times above EPA Benchmark”
columns: standout numbers include zinc levels in 2008, which were 42,222 times the benchmark,
and lead levels in 2008, which were 804 times above the benchmark.

5
Problend Stormwater Discharge (runoff) Water Quality Reports (ADEM Reports)

Highlighted numbers are above the EPA threshold; Abbreviations: ND = no discharge occurred during the monitoring period; 6
NR = not required; BRL = below reporting limit; BDL = below detection limit; NODI=B or NODI-B = no discharge/no data indicator
7
How much contaminated water was feasibly discharged from the ProBlend facility?

Problend had one household


septic tank with a 1,000 gallon
capacity. A regulatory
document from the Alabama
Public Health Department
estimated daily use at the
facility to be 330 gallons of
water (see image). This means
that there was no formal
treatment system for
contaminated water. Water
usage documents from the City
of Fruithurst show that
ProBlend used an average of
1,315 gallons of city water
daily, more than the septic
system could process.
Interviews suggest that
ProBlend employees switched
from the city water supply to a
well-water supply during the
second shift, making the 1,315
gallons a conservative estimate.
Problend feasibly could have
used between 1,972 to 2,630
gallons of water a day,
adjusting for one or two shifts
of well-water use plus recorded
municipal amounts. In any
event, more water was used
than the septic tank could hold
on a daily basis.

Could contaminated water from Problend have feasibly traveled to wells miles away?
Auburn University Geoscientist Dr. Lee and his team calculated that the artesian well located
250 feet from Problend is at a higher elevation than wells where some cancer patients once drank
from. The artesian well likely is a groundwater recharging site for the area. This is especially
possible in the event that fractures exists, and there are hydrologically connected aquifer
bedrocks between Problend and wells that patients drank from.

8
Water and Soil Test Results

This map shows

Co
the locations of Co

Rd
R
Well Water d 40

Co Rd 91
Pilgrims R

247
wells, one stream
Point 3
Test Results

31
(Point 11), and one

Co Rd
Point 7

est Rd
municipal

Co Rd 80
household water

6
Co Rd 24
sample (Point 2) Point 5
Co Rd 296
that were tested for

7
d 21
heavy metals,

Co R
volatile organic
compounds, semi- 4

Co Rd 255
R d1
volatile organic Co Point 2
compounds, and/or
9

radon.
22

Co Rd 232
Rd
Co

949
Co Rd

Co Rd 250
What Point 4

262
d 4
oR
contaminants C

Rd
Point 9
Co
were tested for in Co R
d 20
Co Rd 50
y Rd Co
Rd
5 C offe 49
water? Point 8 Co Rd 7
6
Co
Co

Rd
24
Auburn University,
Rd

3
Co
435

7
Co Rd 65

University of
Rd

Co Rd 5
26

Alabama, and two 6


Co R
d 69
21
Back 40 Rd

labs – TestAmerica Co Rd 426


Co
R d
Co Rd 208
and RA data –
Co Rd 35

tested for heavy Co Rd 82


Co

4
Rte
metals, volatile d State
Rd

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ia
r g Co Rd 449
organic
23

eo Point 10 y 78
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compounds, and
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h

semi-volatile Rd 228
St

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46 0
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6
46

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organic
7

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compounds. The
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only chemicals Co R
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listed are those Co Rd 2 8
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.
2 9 5 Co R
33

which showed up o R d
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in levels at or tested well 0 0.5 1 2 Miles
Co

above the reporting Map Made By:


limit set by Test Kenzley Defler
Auburn University
America in their Undergraduate Student
procedure or those
utilized by researchers at the University of Alabama (for radon), or RA data (for radon). A
reporting limit means the detectable amount of a specific contaminant. More simply, it is when

9
the laboratory equipment finds there is something in the water. Detecting something does not
mean there is too much according to federal or international standards, but it does mean there is
something in your well that could potentially cause health problems.

What contaminants were tested for in soil?


Co

Co Rd 91
Rd
40
We examined the same Soil Sample

31
contaminants in soil as
Test Results

Co Rd
we did water,

0
Co Rd 8
excluding radon and

6
Co Rd 24
Point 1 Co Rd 266
radium, which were 7
Co Rd 296 !
only tested for in water.
d 21

65
Co R

Rd
Co
How do I make sense
4

Co Rd 255
of the health impacts R d1 Co Rd 1 8
0
Co
of these Co Rd 380

contaminants?
9
22

Co
Rd

Rd
22
Co

2
949
Co Rd
WATER:

d 232
The charts below list Co Rd 250
Point 2
262

d 4
every time a oR

Co R
C !
Rd

contaminant was found,


Co

Co Rd 50 Co
Rd Rd
ffey Co
and contextualize its Co 49 Rd
76
level by using Co

57
Co

Rd
24

Rd
standards for water
Rd

3
Co

Co
435

Rd

established by the
Co Rd 65

26

Environmental 6
Co H
wy 6
9C
1 oR
Protection Agency Co Rd 426 d2 d6
C oR Co Rd 208 9
(EPA) or World Health
Co Rd 35

76
Organization (WHO). Co Rd 82 R
d
Co

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The first organization is
Rd

Co Rd 449
23

domestic and the te R


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second is international.
4t

Co
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The WHO Rd
Co Rd 267
St

Rd

46 Co Rd 2
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4th St

6 90
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School St
recommendations are
7

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guidelines for US Hwy
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!!
! Points 3 & 6
chemicals that are of Co R
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significance to human Co Rd 2 8
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33

health. They are set at a


Rd

.
level over which
Co

Co
29

remedial action is ! tested soil site Rd 0 0.5 1 2 Miles


Rd

48
9
Co

encouraged. Co Rd 59
Map Made By:
Kenzley Defler
Auburn University
Undergraduate Student

10
In terms of the EPA, the chemical levels found in your water were compared to maximum
contaminant levels (MCL) and maximum contaminant level goals (MCLG). The first level,
MCL, reflects a negotiated level of pollution allowed based on discussion between researchers,
industry, and the EPA. This is the most pollution that can legally be in the water. MCLG,
conversely, is a level that the EPA sets to be reflective of health concerns. The MCLG for some
contaminants is often lower than the MCL.

Maximum contaminant levels are not always straightforward. Take radon, for example. The EPA
does not federally enforce safe levels of radon that can be found in drinking water. They do
propose communities to monitor and regulate radon levels at a state-level to provide water with
no more than 4,000 pCi/L. The radon test results shown below are from water samples.

Any row highlighted in red shows the chemical level in the water sample was higher than the
MCL level set by the EPA. Any row highlighted in yellow is above the MCLG set by the EPA.
Any row highlighted in green is above the WHO guideline.

The following legend applies to water test results:

B = compound was found in the blank and sample


^ is for Di(2-ethylhexyl)phtalate
* = The relative percent difference between the laboratory control samples and the laboaratory
control sample duplicates exceeds the control limits
** = denotes the action level set by EPA meaning if more than 10% of water samples exceed this
level then additional steps should be taken
*** = denotes the secondary MCL meaning this is a non-enforceable guideline for a contaminant
that may cause cosmetic or aesthetic effects; some are enforced at a state level
**** = denotes the ambient water criterion set by the National Service Center for Environmental
Publications (NSCEP) of the EPA

SOIL: Unfortunately there is not one overarching soil contaminant standard accepted by all,
therefore, the sample results were compared to standards set by different organizations. The
California Human Health Screening Levels (CHHSLs) from the Office of Environmental Health
Hazard Assessment (OEHHA) are used as a guideline, but have no regulatory effect or authority
to require remediation for affected sites. Numbers are advisory and simply a reference for
citizens, government, and communities. For individual homes, the CHHLs residential scenario
standards were used.

For locations other than homes, for example the Problend test sites, the commercial industrial
scenario standards were used. OEHHA notes that the arsenic numbers are for contamination
from human activities only and natural arsenic concentrations may be above the screening value.

The Environmental Protection Agency (EPA) also developed standards, called soil screening
levels (SSL), which are limits above which site-specific studies of risks are warranted. These
take into account data from the regulatory and human health benchmarks used for SSL
development, but again, have no regulatory power and are not enforced federally. While there

11
are many different categories of SSLs, the two used are the ingestion limits and the limits for one
dilution-attenuation factor (DAF). A category of 1 DAF refers to chemicals released into the
environment through groundwater pathways with one natural process present to reduce
contaminant concentrations. According to EPA, DAF is defined as the ratio of contaminant
concentration in soil leachate to the concentration in ground water at the receptor point. For
example, if the acceptable ground water concentration is 1 mg/L and the DAF is 10, the target
soil leachate concentration would be 10 mg/L.

Any row highlighted in red shows the soil sample level was above the CHHLs set limit. Any row
highlighted in yellow shows the sample was above the EPA SSL set limits for ingestion. Any
row highlighted in green shows the sample was above the EPA SSL set limits for 1 DAF.

The follow legend applies to soil test results:

F1 = MS and/or MSD Recovery is outside acceptance limits


F2 = MS/MSD RDP exceeds control limit
B = compound was found in the blank and sample
ca = screening number is based on carcinogenic potency factor
nc = screening number is based on reference level for chronic toxic effects other than cancer
max = screening number is based on maximum concentration allowed (100,000 mg/kg) and not
toxicity
b
Calculated values correspond to a noncancer hazard quotient of 1
e
Calculated values correlated with a cancer risk level of 1 in 1,000,000
i
SSL for pH of 6.8
k
A screening level of 400 mg/kg has been set for lead based on Revised Interim Soil Lead
Guidance for CERCLA Sites and RCRA Corrective Action Facilities (US EPA, 1994)
L
SSL is based on RfD for mercuric chloride
m
SSL is based on dietary RfD
Note: Lead acetate and nickel subsulfide, both forms of metal salt, are significantly more toxic
that their corresponding metal in general. If these forms were used on site, the specific screening
level should be used.

12
Arsenic

How does arsenic impact health?


All metals, not just arsenic, bioaccumulate in soft tissues over time, interfering with normal
reactions. They can, “exert their toxic effects by forming complexes with organic compounds.”
Arsenic is the first of a series of metals found in water and soil samples in the Fruithurst-
Muscadine area.8

Arsenic can be found in many sources in which people come in contact with everyday including
food, soil, and drinking water. In many studies, arsenic from drinking water was found to be a
leading cause of cancer risk9, most typically linked with cancer of the bladder, kidney, lung, and
liver10. In addition to cancer, arsenic has been reported to cause DNA disruptions including
strand breaks, synthesis inhibition, repair inhibition, and retardation of replication11. It also is
connected to chronic respiratory problems, circulatory disease, hypertension, diabetes,
myocardial infarction, cerebrovascular disease, reproductive issues, immune system effects,
endocrine effects, development issues, skin cancer, coronary heart disease, and neurological
impacts.12 Evidence suggests that high levels of arsenic exposure can cause leukemia,
particularly childhood leukemia.13

Water Test Results: Arsenic


Address Chemical Amount EPA WHO
Detected

MCL MCLG

Point 11: Arsenic 0.003 mg/L 0.01 0 mg/L 0.01 mg/L


Northside mg/L
Railroad

Point 7: Arsenic 0.0043 mg/L 0.01 0 mg/L 0.01 mg/L


531 County Road mg/L
91 Muscadine,
AL 36269

13
Soil Test Results: Arsenic

Chemical Amount CHHLs SSLs


Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/kg)

Point 1: Arsenic 3.2 mg/Kg 0.07 ca 0.4 e 1i


422 Co Rd 88,
Fruithurst, AL 36262

Point 2: Arsenic 3.1 mg/Kg 0.07 ca 0.4 e 1i


456 County Road 80,
Muscadine AL, 36269

Point 3: Dirt Pile Arsenic 9.5 mg/Kg 0.24 ca 0.4 e 1i

Point 4: North Side Arsenic 3.2 mg/Kg 0.24 ca 0.4 e 1i


Railroad

Point 5: East Field Arsenic 3.1 mg/Kg 0.24 ca 0.4 e 1i

Point 6: Dirt Pile Arsenic 6.2 mg/Kg 0.24 ca 0.4 e 1i

14
Bis(2-ethylhexylphthlate)

How does bis(2-ethylhexylphthlate) impact health?

Bis(2-ethyhexyl) phthalate, also called DEHP or phthalates, is an endocrine disrupting chemical


(EDC), causes DNA methylation, has epigenetic effects on DNA, and is an immune disruptor.
Bis(2-ethylhexyl)phthalate is linked to multiple medical complications. It is used predominately
in the production of plastic, but also other industries. DNA methylation and the epigenetic effects
from environmental exposures to bis(2-ethyhexylphthalate) and during fetal development is
linked multiple medical problems, and acts similarly to BPA. Potential health impacts include
leukemia, pancreatic cancer, neuroblastoma, osteosarcoma, reproductive issues, infertility in
men, ovarian disease, prostate cancer, testicular cancer, pancreatic cancer, pulmonary issues,
respiratory issues, non-Hodgkin lymphoma, testicular disease, obesity, neurodevelopment
(decreased IQ, poorer memory, ASD, ADHD, and other behavioral problems), cardiac muscle
problems, pubertal abnormalities, diabetes and insulin resistance, fibroids, uterine cancer
(because of endocrine disrupting chemicals), Wilm's Tumor (indirectly by DNA methylation),
ewing sarcoma (indirectly by DNA methylation), rhabdomyosarcoma (indirectly by DNA
methylation), high blood pressure, hyperglycemia and hypertriglyceridemia, low HDL
concentrations and too much fat in the waist area, and oxidative stress. 14

Water Test Results: Bis(2-ethylhexylphthlate)

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 7: Bis(2- 0.013 mg/L B* .006 0 0.008 mg/L ^


531 County ethylhexyl) mg/L
Road 91 phthalate
Muscadine, AL
36269

Point 8: Bis(2- 0.024 mg/L B* .006 0 0.008 mg/L ^


24420 County ethylhexyl) mg/L
Road 49 phthalate
Muscadine, AL
36269

15
Soil Test Results: Bis(2-ethylhexylphthalate)

Chemical Amount CHHLs SSLs


Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/kg)

Point 3: Dirt Pile Bis(2- 2.1 mg/kg None given. 46 e 180


ethylhexyl)
phthalate

16
Caprolactam

Water Test Results: Caprolactam

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 8: Caprolactam* 0.053 None None None given


24420 County mg/L given given
Road 49
Muscadine, AL
36269

17
Barium

How does barium impact health?


Large amounts of barium consumption can change heart rhythm or cause paralysis in human.
Small amounts of consumption (drinking or eating) can cause vomiting and diarrhea, muscle
weakness, or numbness around the face.15

Water Test Results: Barium

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 1: Fruithurst Well Barium 0.034 mg/L 2 mg/L 2 mg/L 0.7 mg/L

Point 11: Barium 0.029 mg/L 2 mg/L 2 mg/L 0.7 mg/L


Northside Railroad

Point 2: Barium 0.021 mg/L 2 mg/L 2 mg/L 0.7 mg/L


1807 County Road 80
Muscadine AL, 36269

Point 3: Barium 0.026 mg/L 2 mg/L 2 mg/L 0.7 mg/L


747 County Road 91
Muscadine, AL 36269

Point 4: Barium 0.011 mg/L 2 mg/L 2 mg/L 0.7 mg/L


456 County Road 80,
Muscadine, AL 36269

Point 5: Barium 0.027 mg/L 2 mg/L 2 mg/L 0.7 mg/L


425 County Rd 88,
Fruithurst, AL 36262

Point 7: Barium 0.031 mg/L 2 mg/L 2 mg/L 0.7 mg/L


531 County Road 91
Muscadine, AL 36269

Point 8: Barium 0.17 mg/L 2 mg/L 2 mg/L 0.7 mg/L


24420 County Road 49
Muscadine, AL 36269

18
Soil Test Results: Barium
Chemical Amount CHHLs SSLs
Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/kg
)

Point 1: Barium 110 mg/Kg 5200 nc 5,500 b 82 i


422 Co Rd 88,
Fruithurst, AL
36262

Point 2: Barium 55 mg/Kg 5200 nc 5,500 b 82 i


456 County Road
80, Muscadine
AL, 36269

Point 3: Dirt Pile Barium 240 mg/Kg 63,000 nc 5,500 b 82 i

Point 4: North Barium 35 mg/Kg 63,000 nc 5,500 b 82 i


Side Railroad

Point 5: East Barium 67 mg/Kg F2 63,000 nc 5,500 b 82 i


Field

Point 6: Dirt Pile Barium 220 mg/Kg 63,000 nc 5,500 b 82 i

19
Cadmium

How does cadmium impact health?


Cadmium is used in industrial processes, including the manufacture of plastics and rubbers.16
Cadmium can cause kidney, lung, bone damage, DNA strand breaks and chromosomal damage.
Cadmium chloride, oxide, sulfate, and sulfide can case increased rates of testicular, prostate and
lung cancer.17 Further, cadmium and nickel function as endoctrine disruptors by mimicking the
action of estrogen, which contributes to the development of breast cancer.18 The development of
mammalian cells can be negatively impacted by exposure to nickel compounds, which increases
breast cancer development.19 Cadmium is also associated with prostate cancer,20 pancreatic
cancer,21 and cancers of the pulmonary system, liver, hemapoetic system, urinary, bladder and
stomach cancers.22

Soil Test Results: Cadmium

Chemical Amount CHHLs SSLs


Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/k
g)

Point 1: Cadmium 1.3 mg/Kg 1.7 ca 78 b,m 0.4 i


422 Co Rd 88,
Fruithurst, AL
36262

20
Chloroform

Water Test Results: Chloroform

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 1: Chloroform 0.0049 None 0.07 0.3 mg/L


Fruithurst Well mg/L given mg/L

Point 2: Chloroform 0.012 mg/L None 0.07 0.3 mg/L


1807 County given mg/L
Road 80
Muscadine AL,
36269

21
Chlorodibromomethane

Water Test Results: Chlorodibromomethane

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 2: Chlorodibrom 0.0045 None None 0.06 mg/L


1807 County omethane mg/L given given
Road 80
Muscadine AL,
36269

22
Chromium

How does chromium impact health?


Chromium most commonly impacts the respiratory track, causes asthma, cough, shortness of
breath and wheezing. It also causes ulcers in the stomach, and anemia. Known impacts include
sperm damage to the male reproductive system, as well as cancer, including stomach, intestinal
and lung.23 Some studies show a relationship between chromium exposure and lip, oral cavity
and pharynx cancer, female breast cancer, prostate cancer, and leukemia.24 Chromium also can
damage DNA and cause mutations.25

Water Test Results: Chromium

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 7: Chromium 0.0094 0.1 mg/L 0.1 mg/L 0.05 mg/L


531 County mg/L
Road 91
Muscadine,
AL 36269

Soil Test Results: Chromium

Chemical Amount CHHLs SSLs


Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/kg)

Point 1: Chromiu 12 F1 F2 III: 100,000 Total: 390 b Total: 2 i


422 Co Rd 88, m mg/Kg nc, max III: 78,000 b III: ---
Fruithurst, AL IV: 17 ca IV: 390 b IV: 2 i
36262

Point 2: Chromiu 11 mg/Kg III: 100,000 Total: 390 b Total: 2 i


456 County m nc, max III: 78,000 b III: ---
Road 80, IV: 17 ca IV: 390 b IV: 2 i
Muscadine AL,
36269

23
Point 3: Dirt Chromiu 17 mg/Kg III: 100,000 Total: 390 b Total: 2 i
Pile m nc, max III: 78,000 b III: ---
IV: 37 ca IV: 390 b IV: 2 i

Point 4: North Chromiu 7.6 mg/Kg III: 100,000 Total: 390 b Total: 2 i
Side Railroad m nc, max III: 78,000 b III: ---
IV: 37 ca IV: 390 b IV: 2 i

Point 5: East Chromiu 13 mg/Kg F1 III: 100,000 Total: 390 b Total: 2 i


Field m nc, max III: 78,000 b III:
IV: 37 ca IV: 390 b IV: 2 i

Point 6: Dirt Chromiu 18 mg/Kg III: 100,000 Total: 390 b Total: 2 i


Pile m nc, max III: 78,000 b III:
IV: 37 ca IV: 390 b IV: 2 i

24
Dichlorobromomethane

Water Test Results: Dichlorobromomethane

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 2: Dichlorobrom 0.0040 None .006 0.1 mg/L


1807 County omethane mg/L given mg/L
Road 80
Muscadine AL,
36269

25
Lead

How does lead impact health?

Children exposed to lead have cognitive impairment and behavioral problems. Health effects
later in life include ADHD, hypertension, renal effects, and reproductive problems. In pregnant
women, maternal exposure to lead reduces fetal growth and results in lower birth weight,
including decreased postnatal growth of head, height, and delayed puberty. Pregnant women can
also experience neurological symptoms similar to children. Childhood lead exposure can have
renal effects, cause anemia, and effect endocrine levels. Amongst all people, exposure can cause
cardiovascular effects, reproductive effects (like fertility), lower bone mineral density – which
slows childhood growth. Classified elemental lead and inorganic lead can be carcinogenic,26 and
is connected to pancreatic cancer,27 cancers of the stomach, lunch, kidney, brain, and meninges.28

Water Test Results: Lead

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 7: Lead 0.015 mg/L 0.015 0 0.01 mg/L


531 County Road 91 mg/L**
Muscadine, AL
36269

Point 8: Lead 0.0017 0.015 0 0.01 mg/L


24420 County Road mg/L mg/L**
49
Muscadine, AL
36269

26
Soil Test Results: Lead

Chemical Amount CHHLs SSLs


Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/k
g)

Point 1: Lead 130 B F2 Lead & lead 400 k None


422 Co Rd 88, mg/Kg compounds: 80 nc given
Fruithurst, AL Lead acetate: 2.3 ca
36262

Point 2: Lead 20 mg/Kg Lead & lead 400 k None


456 County Road compounds: 80 nc given
80, Muscadine Lead acetate: 2.3 ca
AL, 36269

Point 3: Dirt Pile Lead 20 mg/Kg Lead & lead 400 k None
compounds: 320 nc given
Lead acetate: 10 ca

Point 4: North Lead 15 mg/Kg Lead & lead 400 k None


Side Railroad compounds: 320 nc given
Lead acetate: 10 ca

Point 5: East Lead 19 mg/Kg Lead & lead 400 k None


Field F1 F2 compounds: 320 nc given
Lead acetate: 10 ca

Point 6: Dirt Pile Lead 19 mg/Kg Lead & lead 400 k None
compounds: 320 nc given
Lead acetate: 10 ca

*Note: test results did not differentiate type of lead.

27
Naphthalene

How does naphthalene impact health?


Naphtalene, as well as 1-Methylnaphthalen and 2-Methylnaphthalene, in large amounts can destroy
red blood cells, called hemolytic anemia. Other symptoms include pale skin, lack of appetite, fatigue,
restlessness, blood in urine, or yellow skin color. For children, naphthalene can cause lung injury and
possibly lung disease later in life.29

Water Test Results: Naphthalene

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 5: Naphthalene 0.00039 0.143 mg/L**** None


425 County mg/L given.
Rd 88,
Fruithurst,
AL 36262

28
Nickel

How does nickel impact health?


The most common reaction is a skin rash – like dermatitis or hand eczema – on contact. The
most serious harmful health effects are chronic bronchitis, reduced lung function, or lung cancer.
This most commonly happens for workers who have high levels of exposure, especially the most
soluble compounds of nickel. Nickel refiner dust and nickel subsulfide are human carcinogens.30
Nickel is connected to lung and nasal cancer, along with testicular DNA damage,31 and
endometriosis.32

Water Test Results: Nickel

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 7: Nickel 0.0067 0.1 0.1 0.07


531 County mg/L mg/L**** mg/L*** mg/L
Road 91 * **
Muscadine, AL
36269

29
Soil Test Results: Nickel

Chemical Amount CHHLs SSLs


Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/kg)

Point 1: Nickel 6.5 Nickel & compounds: 1,600 b 7i


422 Co Rd 88, mg/Kg 1600 nc
Fruithurst, AL Nickel subsulfide:
36262 0.38 ca

Point 2: Nickel 3.6 Nickel & compounds: 1,600 b 7i


456 County Road mg/Kg 1600 nc
80, Muscadine AL, Nickel subsulfide:
36269 0.38 ca

Point 3: Dirt Pile Nickel 4.6 Nickel & compounds: 1,600 b 7i


mg/Kg 16,000 nc
Nickel subsulfide:
11,000

Point 4: North Side Nickel 9.4 Nickel & compounds: 1,600 b 7i


Railroad mg/Kg 16,000 nc
Nickel subsulfide:
11,000

Point 5: East Field Nickel 4.3 Nickel & compounds: 1,600 b 7i


mg/Kg 16,000 nc
Nickel subsulfide:
11,000

Point 6: Dirt Pile Nickel 4.5 Nickel & compounds: 1,600 b 7i


mg/Kg 16,000 nc
Nickel subsulfide:
11,000

30
Selenium

How does selenium impact health?


Human skin contact with industrial selenium compounds can cause rashes, redness, heat,
swelling, and pain. Burning to the eyes and tearing can result. One particular form of selenium,
selenium sulfide, is probably a human carcinogen. Very high amounts of selenium can reduce
sperm counts and change reproductive cycles.33

Soil Test Results: Selenium

Chemical Amount CHHLs SSLs


Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/kg
)

Point 2: Selenium 0.69 mg/Kg 380 nc 390 b 0.3 i


456 County Road
80, Muscadine
AL, 36269

Point 6: Dirt Pile Selenium 0.70 mg/Kg 4800 nc 390 b 0.3 i

31
Silver

Water Test Results: Silver

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 7: Silver 0.0017 0.1 None None given


531 County Road mg/L mg/L*** given
91 Muscadine,
AL 36269

32
Zinc

How does zinc impact health?


Some zinc is good for health, but too much is not. Inhaling large amounts of zinc can cause a
short-term disease called metal fume fever, which is reversible. Little is known about long-term
impacts. Drinking or eating too much zinc can cause vomiting, nausea, and stomach cramps
short-term; long-term, it causes anemia, damages the pancreas, and decreases level of high-
density lipoprotein (HDL) cholesterol.34

Water Test Results: Zinc

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 4: Zinc 0.029 mg/L 5 None None given


456 County Road mg/L*** given
80, Muscadine, AL
36269

Point 5: Zinc 0.021 mg/L 5 None None given


425 County Rd 88, mg/L*** given
Fruithurst, AL
36262

Point 6: Zinc 0.023 mg/L 5 None None given


139 County Road mg/L*** given
417 Fruithurst, AL
36262

Point 7: Zinc 0.093 mg/L 5 None None given


531 County Road mg/L*** given
91 Muscadine, AL
36269

33
Soil Test Results: Zinc

Chemical Amount CHHLs SSLs


Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/k
g)

Point 1: Zinc 1500 mg/Kg 23000 nc 23,000 b 620 b,i


422 Co Rd 88,
Fruithurst, AL
36262

Point 2: Zinc 33 mg/Kg 23000 nc 23,000 b 620 b,i


456 County Road
80, Muscadine AL,
36269

Point 3: Dirt Pile Zinc 3000 mg/Kg 23000 nc 23,000 b 620 b,i

Point 4: North Side Zinc 22 mg/Kg 23000 nc 23,000 b 620 b,i


Railroad

Point 5: East Field Zinc 30 mg/Kg 23000 nc 23,000 b 620 b,i

Point 6: Dirt Pile Zinc 2600 mg/Kg 23000 nc 23,000 b 620 b,i

34
Radium

Water Test Results: Ra-226

Address Chemical Amount EPA WHO


Detected

MCL MCLG

Point 2: Ra-226 0.162 pCi/L 5 pCi/L 0 1 Bq/L


1807 County or 0.006
Road 80 Bq/L
Muscadine AL,
36269

Point 4: Ra-226 0.297 pCi/L 5 pCi/L 0 1 Bq/L


456 County or 0.011
Road 80, Bq/L
Muscadine, AL
36269

Point 5: Ra-226 0.135 pCi/L 5 pCi/L 0 1 Bq/L


425 County Rd or 0.005
88, Fruithurst, Bq/L
AL 36262

Point 6: Ra-226 0.027 pCi/L 5 pCi/L 0 1 Bq/L


139 County or 0.001
Road 417 Bq/L
Fruithurst, AL
36262

35
Radon

How does radon impact health?


The EPA recommends anyone exposed to 4pCi/L or more to fix their home and address the
radon level.35 There are many studies correlating radon exposure with increased risk of lung
cancer. Other studies have looked at radon specifically with childhood cancer and/or leukemia.
Domestic radon exposure was linked specifically to Acute Lymphoblastic Leukemia (ALL)36.
Children who were born and grew up in areas with normal or high levels of exposure were more
likely to develop ALL than children in areas of low exposure. 37 Relative risk for various forms of
cancer was increased slightly due to medium or high radon exposure while childhood leukemia
risk was significantly increased in medium and high exposure counties. 38 High radon sections
have been shown to have an increased incidence of AML.39 Areas with higher average radon
levels saw higher disease incidence and increased mortality rates from childhood leukemia.40

Water Test Results: Radon

Address Chemical Amount EPA WHO


Detected

MCL MCL
G

Point 1: Fruithurst Well Radon 4077 pCi/L <4000 pCi/L 2702.7


11/27/2017 pCi/L

Point 10: 844 County Radon 2165 pCi/L <4000 pCi/L 2702.7
Road 35 Fruithurst, AL 11/27/2017 pCi/L
36262

Point 9: 3500 County Radon 6586.0 pCi/L <4000 pCi/L 2702.7


Road 35 Muscadine, AL 7/10/2017 pCi/L
36269

Point 2: 1807 County Radon 1.3 pCi/L <4000 pCi/L 2702.7


Road 80 Muscadine AL, 11/27/2017 pCi/L
36269

Point 3: 747 County Radon 842 pCi/L <4000 pCi/L 2702.7


Road 91 Muscadine, AL 11/27/2017 pCi/L
36269

36
Point 4: 456 County Radon 3206.5 pCi/L <4000 pCi/L 2702.7
Road 80, Muscadine, AL 7/10/2017 pCi/L
36269

Point 4: 456 County Radon 1004 pCi/L <4000 pCi/L 2702.7


Road 80, Muscadine, AL 11/27/2017 pCi/L
36269

Point 5: 425 County Rd Radon 368 pCi/L <4000 pCi/L 2702.7


88, Fruithurst, AL 36262 11/27/2017 pCi/L

Point 6: 139 County Radon 8449.4 pCi/L <4000 pCi/L 2702.7


Road 417 Fruithurst, AL 7/10/2017 pCi/L
36262

Point 6: 139 County Radon 5391 pCi/L <4000 pCi/L 2702.7


Road 417 Fruithurst, AL 11/27/2017 pCi/L
36262

Point 7: 531 County Radon 348.1 pCi/L <4000 pCi/L 2702.7


Road 91 Muscadine, AL 7/10/2017 pCi/L
36269

Point 7: 531 County Radon 1449 pCi/L <4000 pCi/L 2702.7


Road 91 Muscadine, AL 11/27/2017 pCi/L
36269

Point 8: 24420 County Radon 66 pCi/L <4000 pCi/L 2702.7


Road 49, Muscadine, AL 11/27/2017 pCi/L
36269

37
Mercury

Soil Test Results: Mercury


Chemical Amount CHHLs SSLs
Detected (mg/kg) mg/L

Ingestion 1 DAF
(mg/kg) (mg/kg)

Point 1: Mercury 0.050 mg/Kg 18 nc 23 b,L 0.1 i


422 Co Rd 88,
Fruithurst, AL
36262

Point 2: Mercury 0.047 mg/Kg 18 nc 23 b,l 0.1 i


456 County Road
80, Muscadine AL,
36269

Point 3: Dirt Pile Mercury 0.020 mg/Kg 18 nc 23 b,l 0.1 i

Point 5: East Field Mercury 0.020 mg/Kg 18 nc 23 b,l 0.1 i

38
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Preferred Compounding. 2006. “Preferred Compounding Acquires Associated Rubber
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National Center for Biotechnology Information. “PubChem Compound Database- CID=8722.”
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Note, that zinc and lead level benchmarks are dependent upon the hardness of the water; which
we are uncertain of. This is a middle-line standard: see
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provided at https://www3.epa.gov/npdes/pubs/msgp2008_part8.pdf.
8
Aquino, Natalie B., Mary B. Sevigny, Jackielyn Sabangan, and Maggie C. Louie. 2012. “Role
of Cadmium and Nickel in Estrogen Receptor Signaling and Breast Cancer: Metalloestrogens or
Not?” Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis &
Ecotoxicology Reviews 30(3): 189-224. Accessed January 28, 2018
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476837/.

39
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For more details about arsenic impacts, see these peer-reviewed articles:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546776/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781005/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575137/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621177/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143819/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621177/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522704/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314243/
13
Infate Rivard, C. Olson E., Jacques L., Ayotte P. 2001. “Drinking water contaminants and
childhood leukemia.” Epidemiology 12(1): 13-9. Accessed January 29, 2018
https://www.ncbi.nlm.nih.gov/pubmed/11138808/.
14
For more details, see the following peer-reviewed articles:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492068/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702494/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174260/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521879/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171169/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565614/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554682/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527472/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928498/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678847/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306137/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554682/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313599/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129340/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273518/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443608/

40
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348351/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632802/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443608/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572204/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554682/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170195/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962211/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572204/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286269/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429819/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003946/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554682/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702494/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201388/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801991/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636966/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554682/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443608/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384040/
15
Department of Health and Human Services. Agency for Toxic substances and Disease
Registry. 2007. “Public Health Statement Barium.” CAS#7440-39-3.
16
Celia Byrne, Shailaja D. Divekar, Geoffrey B. Storchan, Daniela A. Parodi, and Mary Beth
Martin. 2009. “Cadmium – a metallohormone?” Toxicology and Applied Pharmacology 238(3):
266-271. Accessed January 29, 2018 from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709711/

17
Department of Health and Human Services. Agency for Toxic substances and Disease
Registry. “Case Studies in Environmental Medicine (CSEM) Cadmium Toxicity.” Accessed
January 29, 2018 from https://www.atsdr.cdc.gov/csem/cadmium/docs/cadmium.pdf.
18
Aquino, Natalie B., Mary B. Sevigny, Jackielyn Sabangan, and Maggie C. Louie. 2012. “Role
of Cadmium and Nickel in Estrogen Receptor Signaling and Breast Cancer: Metalloestrogens or
Not?” Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis &
Ecotoxicology Reviews 30(3): 189-224.

Natalie B. Aquino, Mary B. Sevigny, Jackielyn Sabangan, and Maggie C. Louie. “Role of
19

Cadmium and Nickel in Estrogen Receptor Signaling and Breast Cancer: Metalloestrogens or
Not?” Accessed January 29, 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476837/

41
B Julin, A Wolk, J-E Johansson, S-O Andersson, O Andrén, and A Åkesson. “Dietary
20

Cadmium exposure and prostate cancer incidence: a population-based prospective cohort study.”
Accessed January 29, 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425979/
21
Brian G. Luckett, L. Joseph Su, Jennifer C. Rood, and Elizabeth T. H. Fontham. “Cadmium
Exposure and Pancreatic Cancer in South Louisiana.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540786/

Natalie B. Aquino, Mary B. Sevigny, Jackielyn Sabangan, and Maggie C. Louie. “Role of
22

Cadmium and Nickel in Estrogen Receptor Signaling and Breast Cancer: Metalloestrogens or
Not?” Accessed January 29, 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476837/
23
Department of Health and Human Services. Agency for Toxic substances and Disease
Registry. 2012. “Public Health Statement Chromium.” CAS#7440-47-3. Accessed January 29,
2018 from https://www.atsdr.cdc.gov/ToxProfiles/tp7-c1-b.pdf.
24
Athena Linos, Athanassios Petralias, Costas A Christophi, Eleni Christoforidou, Paraskevi
Kouroutou, Melina Stoltidis, Afroditi Veloudaki, Evangelia Tzala, Konstantinos C. Makris, and
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cancer mortality in an industrial area of Greece – An ecological study.” Environmental Health
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25
Zhitkovich, Anatoly. 2011. “Chromium in Drinking Water: Sources, Metabolism, and Cancer
Risks.” Chemical Research in Toxicology 24(10): 1617-1629; and Sun, Hong, Jason Brocato,
and Max Costa. 2015. “Oral Chromium Exposure and Toxicity.” Current Environmental Health
Reproduction 2(3): 295-303.
26
Department of Health and Human Services. Agency for Toxic substances and Disease
Registry. “Case Studies in Environmental Medicine (CSEM) Lead Toxicity.” Accessed January
29, 2018 https://www.atsdr.cdc.gov/csem/lead/docs/CSEM-Lead_toxicity_508.pdf
27
André F. S. Amaral, Miquel Porta, Debra T. Silverman, Roger L. Milne, Manolis
Kogevinas, Nathaniel Rothman, Kenneth P. Cantor, Brian P. Jackson, José A. Pumarega,2 Tomàs
López, Alfredo Carrato, Luisa Guarner, Francisco X. Real, and Núria Malats. “Pancreatic cancer
risk and levels of trave elementas.” Accessed January 29, 2018.
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28
Linda M. Liao, Melissa C. Friesen, Yong-Bing Xiang, Hui Cai, Dong-Hee Koh, Bu-Tian
Ji, Gong Yang, Hong-Lan Li, Sarah J. Locke, Nathaniel Rothman, Wei Zheng, Yu-Tang
Gao, Xiao-Ou Shu, and Mark P. Purdue. “Occupational Lead Exposure and Associations with
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42
29
Department of Health and Human Services. Agency for Toxic substances and Disease
Registry. 2005. “Public Health Statement Naphthalene, 1-Methylnaphthalene, and 2-Methyl-
naphthalene..” CAS# 91-20-3, 90-12-0, 91-57-6.
30
Department of Health and Human Services. Agency for Toxic substances and Disease
Registry. 2005. “Public Health Statement Nickel.” CAS#7440-02-0. Accessed January 29, 2018
from https://www.atsdr.cdc.gov/ToxProfiles/tp15-c1-b.pdf.

Keyuna S. Cameron,1 Virginia Buchner,2 and Paul B. Tchounwou1,* “Exploring the Molecular
31

Mechanisms of Nickel-Inducted Genotoxicity and Carcinogenicity: A Literature Review.”


Accesed January 29, 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172618/
32
Jin-Sung Yuk, Jong Seung Shin, Ji-Yeon Shin, Eunsuk Oh, Hyunmee Kim, and Won I. Park.
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33
Department of Health and Human Services. Agency for Toxic substances and Disease
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from https://www.atsdr.cdc.gov/ToxProfiles/tp92-c1-b.pdf.
34
Department of Health and Human Services. Agency for Toxic substances and Disease
Registry. 2005. “Public Health Statement Zinc.” CAS#7440-66-6. Accessed January 29, 2018
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