Subject: PEDIATRICS I Second Semester A.Y.

2015-2016
Topic: HEMA-ONCO REVIEWER
Lecturer: Dra. Taquiqui

PRAYER BEFORE STUDYING c. Normal infant dietary requirement is 25-35 μg/day

Holy Spirit, Giver of all good gifts, enter into my mind and heart. d. Phenobarbital can impair absorption of folic acid
Give me the gift of knowledge and the grace to use it wisely. e. None of the above
Help me in all my endeavors.
Give me perseverance and fortitude. 6. Warning signs in pediatric cancers include the following
Help my memory, that I may remember what I learn EXCEPT
and recall it when necessary. a. Unexplained pallor
Guide me in the classroom. b. Changes in urine or bowel habits
You who are the Way, the Truth, and the Life, c. Unusual masses or swelling
Let me not be deceived by false teaching. d. Headache with vomiting
Our Lady of Good Studies, pray for me. e. None of the above
Amen.
7. The following conditions present with anemia and
TEST I reticulocytopenia with defect hemoglobin synthesis EXCEPT
1. The following statements are true of anemia EXCEPT a. Iron deficiency anemia
a. Usually a consequence of bleeding b. Thalassemia
b. Shunting of blood flow toward vital organs and c. Hemoglobin E disorder
tissues d. None of the above
c. Reflects impairment of normal erythropoiesis
d. Decreased oxygen extraction 8. What is the daily dose of elemental iron needed by the body
e. None of the above a. 1-2 mg/kg
b. 2-3 mg/kg
2. The following statements are true of congenital hypoplastic c. 3-5 mg/kg
anemia EXCEPT d. 4-6 mg/kg
a. Most cases are sporadic
b. Average age of diagnosis 5 months 9. Vaccine are given against the following organisms prior to
c. RBCs are macrocytic for age splenectomy EXCEPT
d. Treatment is corticosteroid a. Hemophilus influenza B
e. None of the above b. Pneumococcus
c. Streptococcus
3. The following statements are true of transient d. Meningococcus
erythroblastopenia of childhood EXCEPT
a. Markedly decreased reticulocytes 10. The following drugs and chemicals are agents precipitating
b. Majority recover within 1-2 months hemolysis in G6PD deficiency EXCEPT
c. Most common hematologic disease in children a. Phenobarbital
d. Due to transient immunologic suppression of b. Primaquine
erythropoiesis c. Nitrofurantoin
e. None of the above d. Naphthalene

4. These statements are true of physiologic anemia of infancy 11. Typical facies in homozygous B thalassemia includes the
EXCEPT following EXCEPT
a. No therapy required a. Frontal bossing
b. In premature infants, there is short survival of RBC b. Epicanthal fold
c. Decrease in blood oxygen content after birth down c. Maxillary hyperplasia
regulates EPO production d. Flat nasal bridge
d. RBC volume of 5-10 ml/kg is recommended when
transfusion is necessary 12. Which of the following is the most common hereditary
e. None of the above disorder of the primary hemostasis?
a. Hemophilia A
5. These statements are true of folic acid deficiency EXCEPT b. Christmas disease
a. Polyglutamates are converted to monoglutamates by c. Von Willebrand disease
folic conjugase to facilitate absorption d. Wiskott-Aldrich Syndrome
b. Normal serum folic acid level is 3 ng/ml

Trans By: Page 1 of 4

Edited By:
13. Which of the following is the most common thrombocytopenic c. Hydrops fetalis
purpura in childhood?
a. Glanzmann thrombastenia 21. This is the most common inherited abnormality of RBC
b. Immune thrombocytopenic purpura membrane
c. Bernard-Soulier syndrome a. G6PD deficiency
d. Kassabach-Meritt syndrome b. Thalassemia major
c. Hereditary spherocytosis
14. The following are characteristics of Kassabach-Meritt d. Alpha thalassemia
syndrome EXCEPT
a. Intravascular coagulation 22. The following statement are true of iron deficiency anemia
b. Severe thrombocytopenia EXCEPT
c. Menorrhagia a. 1 mg of iron must be absorbed each day to maintain
d. Cavernous hemangiomas positive iron balance
b. Iron is absorbed 2-3x more efficiently from human
15. The following are differential diagnosis of a patient with milk than cow’s milk
prolonged PT, PTT and low platelet count EXCEPT c. Pallor is the most important sign
a. Kassabach-Meritt syndrome d. Daily dose of 2-3 mg/kg elemental iron in 3 divided
b. DIC doses provides optimal amount
c. Liver syndrome e. NOTA
d. ITP
23. Which of the following factors is not commonly associated
16. The following statements are true of classic hemophilia with childhood leukemia?
EXCEPT a. Atomic radiation
a. Hallmark is hemarthrosis b. Benzene
b. X-linked trait c. Leaded petrol
c. A female carrier has 50% chance having one affected d. Pesticides
male child
d. Also known as Christmas disease 24. What percentage of blasts in bone marrow are diagnostic of
leukemia?
17. Three of the most important predictive factor in ALL are the a. >30%
following EXCEPT b. 5-15%
a. Age of patient at time of diagnosis c. 15-20%
b. Initial platelet count
c. Initial leukocyte count 25. Besides induction, conduction, maintenance therapy, which is
d. Speed of response to treatment the most common component of ALL chemotherapy?
a. Adjuvant therapy
18. Small round blue cell tumors are seen in the following EXCEPT b. CNS prophylaxis
a. Rhabdomyosarcoma c. Immunotherapy
b. Neuroblastoma
c. Lymphoma 26. Which lymph node will you biopsy in a child with multiple
d. NOTA lymph nodes?
a. Inguinal
19. Initial bone marrow response is erythroid hyperplasia after b. Cervical
iron therapy in IDA is seen at: c. Axillary
a. 48 – 72 hrs
b. 36 – 48 hrs 27. Which childhood malignancy does not present with proptosis?
c. 12 – 24 hrs a. Neuroblastoma
d. 4 – 30 days b. Wilm’s tumor
c. Burkitt’s lymphoma
20. In this condition, there is excess of alpha chain of globin
relative to beta globin and gamma globin 28. Which of the following is the biochemical marker of
a. Alpha thalassemia neuroblastoma?
b. Beta thalassemia a. Urinary catecholamines

Page 2 of 4
 b. Beta HCG a. Progressive decline in hgb level beginning 1st week of
c. Serum AFP life until 12 week
b. When transfusion is necessary, an RBC volume of 5-
29. Which pediatric malignancy is not commonly associated with 10 ml/kg is recommended
mediastinal mass? c. In healthy premature infants, RBC transfusion is
a. T-cell lymphoma rarely needed
b. Lymphoma d. AOTA
c. Neuroblastoma
d. Osteosarcoma 7. Which of the following is the most common hematologic
disease of the infancy and childhood?
30. What is the principle behind combination chemotherapy? a. Iron deficiency anemia
a. Increased chances of complete remission b. Folic acid deficiency
b. Increased duration of remission c. Vitamin B12 deficiency
c. Decreased chances of drug resistance d. Hereditary spherocytosis
d. AOTA
8. This is the most common inherited abnormality of RBC
TEST II membrane
1. The following conditions present with anemia and a. G6PD deficiency
reticulocytopenia with defect hemoglobin synthesis EXCEPT b. Thalassemia
a. Iron deficiency anemia c. Hereditary spherocytosis
b. Thalassemia d. Alpha thalassemia
c. Hemoglobin E disorder
d. None of the above 9. The following statement are true of iron deficiency anemia
EXCEPT
2. The recommended folate supplement from the start of a. 1 mg of iron must be absorbed each day to maintain
pregnancy to prevent neural tube defect is: positive iron balance
a. 200 μg/day b. Iron is absorbed 2-3x more efficiently from human
b. 400 μg/day milk than cow’s milk
c. 200 mg/day c. Pallor is the most important sign
d. 400 mg/day d. Daily dose of 2-3 mg/kg elemental iron in 3 divided
doses provides optimal amount
3. What is the daily dose of elemental iron needed by the body
a. 1-2 mg/kg 10. Initial bone marrow response is erythroid hyperplasia after
b. 2-3 mg/kg iron therapy in IDA is seen at:
c. 3-5 mg/kg a. 48 – 72 hrs
d. 4-6 mg/kg b. 36 – 48 hrs
c. 12 – 24 hrs
4. Vaccine are given against the following organisms prior to d. 4 – 30 days
splenectomy EXCEPT
a. Hemophilus influenza B 11. What percentage of childhood malignancy is constituted by
b. Pneumococcus ALL?
c. Streptococcus a. 30-35%
d. Meningococcus b. 12-25%
c. 40-50%
5. The following drugs and chemicals are agents precipitating
hemolysis in G6PD deficiency EXCEPT 12. Which of the following factors is not commonly associated
a. Phenobarbital with childhood leukemia?
b. Primaquine a. Atomic radiation
c. Nitrofurantoin b. Benzene
d. Naphthalene c. Leaded petrol
d. Pesticides
6. The following statements regarding physiologic anemia of
infancy is/are TRUE 13. What percentage of blasts in bone marrow are diagnostic of

Page 3 of 4
 leukemia? 4. Give 5 warning signs in pediatric cancers
a. >30% 5. Name 2 bone cancers in pediatric age group
b. 5-15%
c. 15-20%

14. A child has come with inguinal lymph nodes, when will you
consider them as NOT significant?
a. Single node of 1 cm
b. Multiple nodes of 3 cm or more
c. Matted lymph nodes

15. Which lymph node will you biopsy in a child with multiple
lymph nodes?
a. Inguinal
b. Cervical
c. Axillary

16. Which of the following is the biochemical marker of

neuroblastoma?
a. Urinary catecholamines
b. Beta HCG
c. Serum AFP

17. Which of the following is the most common hereditary

disorder of the primary hemostasis?
a. Hemophilia A
b. Christmas disease
c. Von Willebrand disease

18. Which of the following is the most common pediatric soft

tissue sarcoma?
a. Rhabdomyosarcoma
b. Fibrosarcoma
c. Leiomyosarcoma

19. The following statements are true of classic hemophilia

EXCEPT
a. Hallmark is hemarthrosis
b. X-linked trait
c. A female carrier has 50% chance having one affected
male child PRAYER BEFORE EXAMINATION
d. Also known as Christmas disease Lord, thank you that you are with me right now
Your love surpasses all fear
20. Which of the following is considered the hallmark of Hodgkin’s I give you the anxiety I feel
disease? I surrender all my worries to you
a. Philadelphia chromosome
b. Reed-Sternberg cells Clear my mind
c. Rosenthal fibers Calm my heart
Still my Spirit
QUIZ Relax my being
1. 2 examples of microcytic anemia That I may always glorify you
2. 2 examples of macrocytic anemia In everything I write, speak and do
3. Give 5 unfavorable factors in Acute Lymphocytic Leukemia Amen.

Page 4 of 4