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Parentheses
PEMDAS
Exponents
• Pharmcalc: Multiplication • Order of operations or
http://www.proprofs.com/training/course/?ti precedence rule is a rule
tle=inpharmatics-module-31-review-of- Division used to unambiguously
pharmaceutical-calculation Addition clarify which procedures
should be performed first
Subtraction in a given mathematical
REVIEW OF expression
MATHEMATICS
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1 scruple 20 gr f
1 fluidounce 8 480
1 dram 3 60 gr f
1 pint 16
(pt or O)
1 ounce 8 24 480 gr
1 quart (qt) 2 32
1 gallon 4 qt 8
1 pound (lb) 12 96 288 5760 gr
(gal or C)
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Avoirdupois System
INTERSYSTEM
grain (gr)
AVORDUPOIS CONVERSION
1 ounce (oz) 437.5 gr
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Frequency Frequency
Abbreviation Meaning Abbreviation Meaning
alt Alternating q.i.d 4 times a day
b.i.d
b.i.w.
Twice a day
Twice a week
q.o.d.
t.i.d.
Every other day
3 times a day
QUIZ!
HS Bedtime t.i.w. 3 times a week
od Once daily h hour
q Every
q12h Every 12 hours
q24h Every 24 hours
q4-6h Every 4-6 hours
q4h Every 4 hours
q6h Every 6 hours
q8h Every 8 hours
Question 1 Question 2
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Quantity of ingredient in each specified Quantity of ingredient in each specified IV Fluids & Rate of Flow
dose, given quantity in total amount dose, given quantity in total amount Sample Problem #1
A medication order for a patient weighing 154 lb calls
Example: for 0.25 mg of amphotericin B per kg of body weight to
Example: be added to 500 mL of 5% dextrose injection. If the
If 0.05 g of a substance is used in amphotericin B is to be obtained from a constituted
1.8 g of fluconazole was used in
preparing 200 tablets, how many injection that contains 50 mg/10mL, how many mL
compounding a 60mL suspension. If one
micrograms does one tablet contain? should be added to the dextrose injection?
dose is one teaspoonful, how many mg
are contained in one dose?
Calculation of doses 2
Units of potency 2
Isotonic solution 1
Electrolyte solutions 1
Based on Age
Dilution and concentrations 2 Based on Body Weight
Reducing and enlarging of formula 1 Based on Surface Area
BMI and nutrition label 1
thermometry 1
Proof strength 1
Drug pricing 3
• Toddlers: 1-3
years
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Drug Dosage based on Body Drug Dosage based on Body Dosage Calculation in Children
Surface Area (BSA) Surface Area (BSA) based on BSA
Commonly used methods to calculate BSA: Mosteller formula Using the adult dose and a child’s
• If weight is expressed in pounds (lbs) BSA:
1. DuBois formula – most widely used
and height in inches (in):
Child' s BSA (m 2 )
BSA W 0.425 H 0.725 0 .007184 Child dose adult dose
2. Mosteller formula 1.73 m2
W H
Where… W = weight (expressed in kg) BSA
H = height (expressed in cm) W H 3131
• 1.73 m – average adult BSA
BSA units: m2 BSA
3600 • BSA is still in m2
If
Am I at my HEALTHY
WEIGHT?
Sample problem
BMI = kg (weight) • The 5yo patient weighs 35kg the height is
m2(height) 1.2 m. the normal adult dose is 350mg.
A. youngs
Expressions and Calculation
B. frieds of Drug Amounts
C. cowling
D. clarks IP 121
E. BMI
University of the
F. BSA
Philippines Manila
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Expression of Concentration
Percentage Percent Weight-in-Volume (%w/v)
Part 1
• Percentage • For solutions or liquid preparations,
Strength expressed as:
• Ratio Strength
– Percent weight-in-volume (% w/v)
• Parts
– Percent volume-in-volume (% v/v)
• Proof Strength
– Percent weight-in-weight (% w/w) in 100 mL of
• Units of potency solution or
liquid
FS AY 2010-2011 Dept of Industrial Pharmacy 55 FS AY 2010-2011 Dept of Industrial Pharmacy 56 FS AY 2010-2011 Dept of Industrial Pharmacy 57
How many g of dextrose are required to What is the percentage strength (w/v) of a
prepare 4000mL of a 5% solution? solution of urea, if 80 mL contain 12 g?
in 100 mL of
solution or
liquid
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Sample Problem
Sample Problem
Parts Per Million (PPM)
Express 1:4000 as a percentage strength • Parts per one million parts
Express 0.02% as a ratio strength • Used to express concentrations of dilute
solutions
• Used to designate test limits
– Limit of arsenic in zinc oxide is 6 ppm or
0.0006%
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Sample Problem
Parts Per Million (PPB) Sample Problem
• Parts per one billion parts Express 5 ppm of iron in water in % strength The concentration of a drug additive in an
and ratio strength? animal feed is 12.5 ppm. How many mg of
• Used to express concentrations of dilute the drug should be used in preparing 5.2
solutions kg of feed?
FS AY 2010-2011 Dept of Industrial Pharmacy 73 FS AY 2010-2011 Dept of Industrial Pharmacy 74 FS AY 2010-2011 Dept of Industrial Pharmacy 75
FS AY 2010-2011 Dept of Industrial Pharmacy 79 FS AY 2010-2011 Dept of Industrial Pharmacy 80 FS AY 2010-2011 Dept of Industrial Pharmacy 81
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90
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96
98
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Osmolarity Osmolarity
• Osmotic pressure is proportional to the mOsmol/L
• How many mOsmols are
total number of particles in solution
= wt of substance (mg/L) represented in a L of 0.9%
------------------------------------- x no. of species
• The unit used to measure osmotic MW
NaCl solution? MW 58.5
concentration is the milliosmol (mOsmol)
• B.) %w/w F.) Molality Percentage ratio strength and other expressions of concentrations 1
Calculation of doses 2
• C.) Ratio strength G.) Normality Units of potency 2
DENSITY = grams/ mL • 1. what is the weight in g of 500mL • 2. if the weight of the oil sample is 52.78
glycerin having a density of 1.25g/mL and the weight of an equal volume of
Specific gravity= wt of substance* standard used water is 54.96 what is the
wt of water specific gravity?
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• These formulas list the amount of each - Official formulas and most other formulas are based on
the preparation of 1000 ml or 1000 g of product.
Reducing and enlarging of ingredient needed to make a certain
formula amount of the preparation. = Quantity of each ingredient
X in formula
Total amount desired Total amount specified in
• At times, it is necessary to reduce or formula
enlarge a formula to satisfy the needs of
your pharmacy
X = Quantity of each ingredient in amount desired
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Sample
Formula Sample problem
problem
• Formula: W C = W1 C1 How many milliliters of a
How many grams of 14% zinc oxide
2% stock solution of ointment can be made from one pound
W = Weight of stock preparation potassium of 20% zinc oxide ointment?
permanganate
C = Concentration of stock preparation (KMn04) would be
W1 = Weight of desired preparation needed to compound
C1 = Concentration of desired preparation the following
prescription?
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METHODS TO MAKE
SOLUTIONS ISOTONIC
Methods of Adjusting
Isotonicity ISOTONICITY ADJUSTMENTS
• Class I: Addition of a tonicity adjusting BY NaCl EQUIVALENT
agent
– Sodium Chloride Equivalent Method / E Value • most frequently used method in the
Method calculation of the amount of sodium
– Freezing Point Depression Method / chloride needed to prepare isotonic drug
Cryoscopic Method solutions.
• Class II. Addition of water and dilution
with buffered isotonic solution
– White Vincent Method
– Sprowl’s Method
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Sprowls Method
• E value of procaine HCl = 0.21
V = 0.3g x E x 111.1
Discounts Example
PHARMACOECONOMIC • Provided by supplier may be based on the The list of price of an
COMPUTATION quantity on buying and/or payment of
invoice within a specific period. antihistamine elixir is P65, less
40%. What is the net cost per
• Maybe a means of increasing gross profit. pint of the elixir?
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Reconstitution
Powders or crystals occupy a greater volume
than after reconstitution
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• A perfume oil has a specific gravity of • How many milliliter of U-100 insulin How many milliliters of two liquids with
0.960 and costs P776.25 per kg. How should be used to obtain 50 units of specific gravities of 0.950 and 0.875 should
much would 5 fluidounces cost? insulin? be used to prepare 1500 mL of a liquid
• a. P110.15 having a specific gravity of 0.925?
a. 1000 mL (sp gr 0.950) c. 500 mL (sp gr 0.950)
• b. P111.15 a. 5 mL b. 50 mL c. 0.5 mL d. 500 mL 500 mL (sp gr 0.875) 1000 mL (sp gr 0.875)
• c. P109.15
• d. P 180.15 b. 2250 mL (sp gr 0.950) d. 1125 mL (sp gr 0.950)
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• Convert 5%(w/v) to mg/mL: • The pediatric dose of cefadroxil is 30mg/Kg/day. • A manufacturing pharmacist received a
If a child was given a daily dose of 2 drawback of P1500 on the alcohol that was used
a. 50 mg/mL teaspoonfuls of pediatric suspension containing during a certain period. If the drawback on
125 mg of cefadroxil per 5 mL, what was the alcohol is P12.50 per proof gallon, how many
b. 500 mg/mL weight, in pounds, of the child? wine gallons of 95% alcohol were used during
c. 5000 mg/mL the period?
d. 5 mg/mL a. 19 lbs a. 63.2
b. 17.3 lbs b. 60
c. 18.3 lbs
c. 58
d. 18.5 lbs
d. 65
• If 800 g of a 5% coal tar ointment is mixed Concentrated HCl (MW = 36.5 g/mol, s.g. =
with 1200 g of a 10% coal tar ointment,
what is the concentration of coal tar in the
1.18) contains approximately 36.5% (w/w)
HCl. How many mL of concentrated HCl is KEEP
finished product? needed to prepare 500 ml of 0.1 N HCl?
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