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Oculoplastic Surgery

Aesthetic Surgery Journal


2015, Vol 35(7) 774–781
The Effect of Hering’s Law on Different Ptosis © 2015 The American Society for
Aesthetic Plastic Surgery, Inc.
Repair Methods Reprints and permission:
journals.permissions@oup.com
DOI: 10.1093/asj/sjv052
www.aestheticsurgeryjournal.com

Arie Y. Nemet, MD

Abstract
Background: The Hering’s law effect has significant importance in surgical planning and outcomes of eyelid surgery.
Objectives: The current study examined the preoperative and intraoperative effect of Hering’s law in Mullerectomy and levator aponeurosis
advancement.
Methods: A retrospective analysis was conducted of 52 patients with unilateral ptosis who underwent surgical repair from January 2011 through June
2013. Patients underwent levator aponeurosis advancement or Mullerectomy with or without tarsectomy. Preoperative and postoperative clinical documen-
tation and photographs were evaluated. Preoperative Hering’s dependency and postoperative changes in positioning of the non-operated eyelid were mea-
sured. The decision to operate on the ptotic eye alone or on both eyelids was based on preoperative Hering’s dependence and intraoperative changes in
the contralateral eyelid.
Results: Fifty-two patients with unilateral ptosis were included. Average age was 63.3 ± 20.1 years (range, 22–88 years; median, 61 years); 34 (65.4%)
were female. The 14 cases that were not aponeurotic (either congenital, secondary to trauma, or due to postoperative ptosis) did not need contralateral
repair ( p = .000). In 4 (19%) cases of Mullerectomy and in 9 (52.9%) cases of levator advancement, both eyelids required surgery ( p = .029). Hering’s
law effect was significantly more apparent in the levator advancement approach than in Mullerectomy.
Conclusions: Levator surgery resulted in a higher incidence of combined intraoperative and postoperative Hering’s law effect than did Mullerectomy.
Cases with poor levator function or congenital ptosis can be repaired unilaterally with no need for contralateral surgery. The fibrotic levator palpebrae
muscle and its special innervations probably explain this phenomenon. This should be considered in surgical planning.

Level of Evidence: 3

Accepted for publication March 5, 2015; online publish-ahead-of-print April 24, 2015. Therapeutic

Outcomes of ptosis surgery are less predictable than those apply to the superior rectus. The motor neuronal pool for
of blepharoplasty and other types of eyelid surgery. In most the levators lies in a single, unpaired central caudal nucleus
cases of asymmetric eyelid ptosis, the level of the contralat- of the oculomotor complex. Single motor neurons innervate
eral eyelid is at least partially dependent on both the preop- the LP bilaterally.5,6 Clinically, according to Hering’s law, a
erative and postoperative positions of the ptotic eyelid.1 patient’s attempt to overcome ptosis in one eye will induce
Hering originally described the phenomenon of equal in-
nervations for dependent extraocular eye muscles.2 Walsh3
Dr Nemet is the Director of Oculoplastic Service in the Department of
was the first to describe Hering’s law for eyelids, which is Ophthalmology at the Meir Medical Center, Kfar Sava, Israel, a Senior
the compensatory retraction of the contralateral upper Lecturer in the Sackler Medical School Tel Aviv University, Tel Aviv,
eyelid in cases of unilateral ptosis. The Hering’s law phe- Israel, and Chair of the Israeli Society of Ophthalmic Plastic and
nomenon is explained by the special innervations of the Reconstructive Surgery.
levator palpebralis (LP). Phylogenetically, it evolves by sep-
Corresponding Author:
arating from the superior rectus muscle and differentiates Dr Arie Y. Nemet, Department of Ophthalmology, Meir Medical
from it only late in embryogenesis.4 Therefore, the LP Center, Tchernichovsky 59, Kfar Sava 44281, Israel.
would be expected to obey neurophysiologic rules that E-mail: nemet.arik@gmail.com

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an increase in innervation in both levators, resulting in general histories were taken. Patients were photographed
contralateral lid retraction.7,8 The development of ptosis preoperatively and 1 and 6 months postoperatively.
in the contralateral upper eyelid after successful repair of The ptosis workup includes measurements of the mar-
unilateral ptosis was demonstrated in 9.6% to 17% of ginal reflex distance (MRD), levator function (LF), the pal-
patients.7,9 The postoperative effect might be suppressed at pebral fissure, and the presence of Bells’ phenomena. We
different levels by mechanisms including, but not limited traditionally classify ptosis as mild (2 mm), moderate (3
to, frontalis muscle action.7 mm), or severe (4 mm). Here, only cases with a MRD dif-
Hence, it is important to consider Hering’s law when ference of more than 1 mm between eyes were operated.
planning blepharoptosis repair, bearing in mind every spe- Hering’s dependence was tested by manually elevating the
cific condition. In cases of bilateral ptosis, even with differ- ptotic eyelid with a single finger to the desired position
ent levels in each eye, both eyelids are repaired. However, during the patient’s initial assessment, and the contralateral
in unilateral cases, the repair of one eyelid may result MRD was remeasured.12 The 2.5% phenylephrine test was
in contralateral eyelid drooping due to Hering’s law phe- also performed for patients on whom a Mueller muscle re-
nomena. Likewise, Hering’s law effect may be influenced section procedure was considered, which also helps deter-
either by the etiology of the ptosis or by the method of mine the effect of Hering’s law. The test is performed by
surgical repair. It does not manifest in some circumstances, instilling 2 drops of 2.5% phenylephrine into the eye. The
for example with congenital ptosis.1,10,11 Thus, the Hering’s phenylephrine test is more physiologic than the manual
law effect for different ptosis etiologies has not yet been lift; however, it influences the lower eyelid position and
investigated. dilates the pupil diameter, so both tests were performed.
Another unanswered question is whether Hering’s law After 5 minutes, the MRD1 was reassessed. An increase of
presents similarly when different surgical approaches are 2 mm or more in the MRD1 is considered a positive test.
used. Anterior repair by levator advancement and posterior Based on these results, Mullerectomy was performed when
repair by Mullerectomy are two entirely different tech- the test was positive and when no significant dermato-
niques. In Mullerectomy, Muller’s muscle still regulates chalasis was present. In the presence of significant der-
the position of the upper eyelid. However, when the matochalasis, the anterior approach was chosen (although
levator aponeurosis is sutured directly to the tarsal plate, it some surgeons use a posterior approach with skin ex-
bypasses this mechanism. Muller’s muscle no longer cision). When it was negative, levator advancement
affects the eyelid level; rather, the levator aponeurosis per- was performed. Intraoperatively, if the contralateral eyelid
forms this function.1 drooped, it was also corrected using the same surgical tech-
The current study examined the effect of Hering’s law nique performed on the first side.
on Mullerectomy and levator aponeurosis advancement
repair methods for cases of unilateral ptosis. Based on our
Surgical Procedures
clinical impression, each surgical repair creates a different
Hering’s dependence. All surgeries were performed under local anesthesia with
2% lidocaine and 1/100,000 epinephrine, administered by
local infiltration. No sedation was used, in order to prevent
METHODS eyelid drooping from the sedation effect.
For Mullerectomy, the surgical procedure was based on
Study Population the Hering’s dependence (if positive, the contralateral
This study reports a retrospective analysis of patients who eyelid was operated simultaneously). The amount of resec-
had surgical repair for unilateral ptosis performed by a tion was adjusted slightly as needed to achieve small differ-
single surgeon (A.Y.N.), from January 2011 through June ences in the degree of elevation. Usually, a 2 mm ptosis
2013. In this study, patients with bilateral ptosis were requires an 8 mm resection of Muller’s muscle and con-
excluded. When performing the surgery, the decision to junctiva. In cases needing more than 2 mm of elevation,
operate only on the ptotic eye or also on the contralateral additional tarsectomy of 1 to 2 mm was performed, de-
eyelid was based on the preoperative Hering’s dependence pending on the amount of ptosis (Figure 1).13
and on the intraoperative result of the contralateral eyelid, The anterior levator aponeurosis advancement approach
in all cases. was performed in cases with a negative phenylephrine test
or when significant dermatochalasis was present. The lid
crease was cut and the levator aponeurosis and the anterior
margin of the tarsal plate was exposed. The levator was ad-
Patient Evaluation
vanced to the tarsus using 3 Vicryl 5-0 stitches. The eyelid
The preoperative evaluation included a full-slit lamp exami- contours and heights were compared and evaluated with
nation, visual acuity test, and ptosis workup. Medical and the patient in a sitting position (Figure 2). Excess muscle

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Figure 1. Mullerectomy (the posterior approach). (A) The eyelid of a 42-year-old woman is elevated and two forceps are used to
catch the edge of the Muller’s muscle and the palpebral conjunctiva 4.5 mm below the tarsus. (B) The eyelid is elevated and the
Putterman’s clamp catches the Muller’s muscle and the palpebral conjunctiva. Additional tarsectomy can be included, based on
the amount of ptosis.

contralateral repair was performed on a second occasion.


The medical documentation was evaluated 6 months postop-
eratively, along with clinical examination of the preoperative
and postoperative photographs. The study was approved by
the Meir Medical Center Institutional Review Board.

Statistical Analysis
Categorical variables were analyzed using Fisher’s exact
test. Results were considered statistically significant when
p < .05. Data were analyzed using SPSS-12 Statistical
Software SPSS (SPSS Inc. Chicago, IL).

Figure 2. Levator aponeurosis advancement (the anterior ap- RESULTS


proach). The lid crease of a 65-year-old man is cut and the
levator aponeurosis (upper arrow) and the anterior margin of A total of 52 adult patients (range, 22–88 years; median, 61
the tarsal plate (middle arrow) are exposed. The levator is ad- years) with unilateral ptosis were included in the study.
vanced to the tarsus using 3 Vicryl 5-0 stitches. The lower
There were 34 females (65.4%). Mullerectomy was per-
arrow points to the edge of the orbicularis oculi muscle.
formed on 27 patients (52%), with an average follow-up of
15 months (range, 9–22 months), and levator advancement
was performaed on 25 (48%), with an average follow-up of
and skin were excised and the skin sutured with single, 16 months (range, 11–24 months). Patient demographics
deep Vicryl 6-0 stitches. Supratarsal fixation to aponeurosis and preoperative measurements are presented in Table 1. A
was used to recreate the lid crease. Following repair of one summary of the surgical procedures is presented in Table 2.
eyelid, the patient was again examined in a sitting position The results of cases with aponeurosis ptosis were evaluated
and the lid height of both eyes measured. If the contralater- separately.
al eye was ptotic, it was also repaired surgically. Unilateral ptosis in those with Hering’s is actually bilat-
Postoperatively, an eyelid position of less than 1 mm dif- eral ptosis (latent) that is masked by the Hering’s in the re-
ference from the contralateral eyelid position, with a sym- tracted eyelid. Hering’s law effect was encountered less
metrical contour was considered a good result. Otherwise, a frequently with the posterior surgical approach. Both

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Table 1. The Result of Ptosis Repair of the Contralateral Eye in Patients Table 2. Summary of Cases With Unilateral and Bilateral Ptosis Repair
With Unilateral Ptosis
Variable Mullerectomy Levator advancement
Variable Mullerectomy Levator Advancement (n = 27) (n = 25)
(n = 27) (n = 25)
Etiology
Gender, female 20 (74.5%) 14 (56.0%)
Aponeurotic 21 17
Mean age (years) 63.5 ± 18.9 62.9 ± 21.2
Other 6 8
Side (right) 10 (37.0%) 10 (40%)
Primary surgery
Bilateral 8 15
Unilateral 19 10
Secondary contralateral 2 2
surgery Bilateral 8 15

Average follow-up, 15 (9-22) 16 (11-24) Secondary contralateral surgery 2 2


months (range)
Total contralateral surgeries 10 (37%) 17 (68%)
Ptotic eye MRD
Aponeurosis ptosis contralateral 4/21 (19%) 9/17 (52.9%)
Preoperative 0.64 ± 0.59 0.813 ± 1.05 repaira

a
Postoperative 3.18 ± 0.76 3.33 ± 0.76 Excluding cases with congenital, poor levator function, or post-traumatic/surgical ptosis.

Difference 2.54 2.52


We further evaluated the ptosis repair for aponeurotic
Contralateral eye MRD ptosis only. In 19% of Mullerectomy cases and in 53%
Preoperative 3.03 ± 0.92 3.18 ± 1.13 cases of levator advancement, both eyelids needed surgery
(Pearson chi-square = 4.795, DF = 1, p = .029). Hering’s
Postoperative 3.24 ± 0.77 3.28 ± 0.2
law was significantly more common with the levator ad-
Difference −0.21 −0.1 vancement approach than with posterior surgical approach
(Mullerectomy).
Preoperative to postoperative −0.15 ± 0.8 −0.12 ± 0.65
MRD change

MRD, marginal reflex distance. DISCUSSION


This series shows that levator surgery results in a higher in-
eyelids required surgery in 10 (37%) cases of Mullerectomy cidence of combined intraoperative and postoperative
and in 17 (68.0%) cases of levator advancement. For both Hering’s law than the Mullerectomy procedure. Hering’s
surgical methods, the 14 cases that were not aponeurotic law effect was not present in patients with post-traumatic,
(congenital, post-trauma, or post-ocular operative ptosis) post-intraocular surgery, or in congenital ptosis (even with
did not need contralateral ptosis repair ( p = .000, Pearson good LF). Retraction of the contralateral eyelid depends on
Chi-Square = 26.580). multiple factors that affect eyelid height, including the fron-
Among the cases of Mullerectomy, eight (29.6%) had a talis muscle, the orbicularis oculi, sympathetic reaction by
Hering’s effect on the contralateral eyelid that was lifted Muller’s muscle, and coexisting mild ptosis in the opposite
during the first operation, while two cases (7.4%) with re- eye. In addition, a compensatory retraction may not be
sidual ptosis of more than 1 mm had ptosis repair on a visible if the patient uses the fellow eye for fixation.14
second occasion. The same surgical procedure was per- Ocular dominance probably has a strong influence on the
formed with good results. The etiology of ptosis was apo- surgical results, as well.7
neurotic in 21 cases (77.8%). The etiologies of the In order to predict contralateral ptosis, preoperative eval-
remaining six cases were congenital ptosis in four (16.7%) uation of Hering’s dependency is based on various studies,
and post-intraocular surgery in two (8.3%). including digital lift, closure, and pharmacologic stimula-
Among patients who underwent levator advancement, tion tests.12,15,16 Corrective surgery for Hering’s depend-
15 (60%) needed lifting of the contralateral eyelid during ency is reported to give predictable results and excellent
the first operation (Figure 3) and two (8%) needed ptosis symmetry.17
repair on a second occasion (Figure 4). The etiology of Cetinkaya et al7 recently showed that bilateral ptosis
ptosis was aponeurotic in 17 cases (68%), congenital in cases with documented Hering’s dependency yield better
three (12%), mechanical ( post-trauma or postoperative) in results when both eyes are operated in the same session,
four (16%), and neurological (third cranial nerve paresis) rather than delaying surgery for the second eyelid.
in one (4%). However, Hering’s dependency is not documented in all

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Figure 3. (A) A 34-year-old man with left ptosis (marginal reflex distance 1.5 mm in his right eye and 0.5 mm in the left). He had
levator advancement on his left eye in April 2011. Intraoperatively, there was right eyelid drooping and the right eyelid was correct-
ed. (B) Twelve months postoperatively, there is a symmetric result of 3.5 mm, bilaterally.

Figure 4. A 71-year-old man with left Horner’s syndrome (marginal reflex distance 2 mm in right and 0 in left eye). He had levator
advancement on his left eye in June 2011. (A) Postoperatively, he had symmetric results. (B) Two years later he presented with
right ptosis with 0 mm marginal reflex distance. He underwent Mullerectomy with tarsectomy. (C) Twelve months after the right
ptosis repair.

cases of unilateral ptosis. Lepore et al18 initially suggested (Figure 4). Erb et al23 noted that 17% of patients undergo-
that Hering’s law applies only to patients with ptosis result- ing unilateral ptosis repair developed a decrease in contra-
ing from neuromuscular junction or more distal dysfunc- lateral eyelid height of at least 1 mm over the course of a
tion. However, Averbuch-Heller et al10 showed that some year, resulting in a 5% rate of contralateral surgery.
cases were due to third nerve palsy proximal to the neuro- Interestingly, this effect was not correlated with preopera-
muscular junction, so the effect was not restricted to neuro- tive Hering’s law interdependence. In one study, a week
muscular junction dysfunction.1 Mehta19 reported that after unilateral blepharoptosis repair, 64% of patients had
Hering’s law also occurs in mechanical ptosis. decreased MRD on the contralateral eyelid, whereas it was
While McCulley et al9 reported that reoperation was present in only 36% after 6 months.24
more than twice as likely in patients undergoing bilateral It has recently been shown that Hering’s law does not
versus unilateral procedures (13% and 5.2%, respectively), occur in congenital ptosis when addressed with either
the success rates for unilateral ptosis repair reported by levator resection or frontalis sling procedures.11 In the
other studies have varied from 27% to 72%.20-22 current study, Hering’s law did not manifest in cases of
The postoperative effect on the contralateral eyelid ap- poor levator function, post-trauma, or in congenital ptosis
parently continues to evolve a long time after surgery (even with good LF). A possible explanation for these

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findings is that the LP muscle is fibrotic and not elastic in activity, as the length is decreased, but not the muscle
cases of traumatic or congenital ptosis.25,26 Thus, in con- tension. Hence, Hering’s law effect is less significant than
trast to the normal elastic eyelid (also in aponeurotic ptosis in levator advancement, where the muscle tension is more
cases), if one pulls up the ptotic eyelid in cases of fibrotic significant. Another possible difference of Hering’s law on
muscle, sensory input is diminished and the unpaired various ptosis approaches is that the eyelid lift in
motor central caudal nucleus of the oculomotor complex Mullerectomy stems from the conjunctival shortening and
does not respond.5,26 The contralateral eyelid will not plication or scarring of the posterior lamella and not the
retract preoperatively. amount of resected Muller muscle.31 As such, there is no
This study compared the results of two surgical methods influence on the LP nucleous (which innervates the LP bi-
for unilateral ptosis repair (Figures 1–7). The preferred laterally) and the LP of other eye does not stretch.
method for ptosis repair is controversial. Some physicians More Hering’s effect was found in levator repair of com-
prefer Mullerectomy with or without tarsectomy over bined intraoperative and postoperative cases, but not with
levator advancement, even when performed in conjunction pure postoperative cases. A staged, second surgery on the
with blepharoplasty. Many consider this method more pre- contralateral lid was required in only 20% and 12% of
dictable, shorter, and easier for the patient.27,28 In addition, Mullerectomy and levator surgery patients, respectively. So
it eliminates the need for patient cooperation. The orbicula- while Hering’s effect was seen more often with levator
ris plane can be preserved29 and it reduces the chance of surgery, most manifested on the table with less need for
postoperative lagophthalmos, as well.29 Others advocate a second surgery. Intraoperative Hering’s testing is not accu-
aponeurotic approaches as more predictable, simple to rate and might lead to an inaccurate MRD1 assessment.
reverse, and more logical and anatomical.30 Injection and surgery usually cause swelling and bruising,
The anterior and posterior approaches involve signifi- making such intraoperative evaluations inaccurate for assess-
cantly different mechanisms. Hence, it is reasonable that ing Hering’s law on the un-operated side. The author uses
the Hering’s law effects vary between these approaches. about 1 cc of local anesthesia for the posterior approach and
The actual eyelid level is regulated from moment to about 2 cc for the anterior approach for each eyelid, so the
moment by Muller’s muscle, which attaches directly from swelling and bruising is different between these methods.
the levator muscle to the upper edge of the tarsal plate. A The findings presented here are limited by possible con-
delicate mechanism and power balance are present in founding factors. It is possible that a second surgery was re-
every normal eyelid and account for some of the unusual quired less often with Mullerectomy because these patients
manifestations of various presentations of ptosis. For responded to a physiologic phenylephrine test to lift the lid
example, the aponeurosis acts as a “check” ligament only, with a similar physiologic lowering of the other lid (an ac-
preventing too much eyelid descent.1 If a ptotic eyelid is curate evaluation of Hering’s). In patients who had levator
corrected with the usual technique of aponeurosis to tarsus advancement, the lid was lifted manually, which may be a
reinsertion, the contralateral lid is still dependent on less accurate assessment of Hering’s effect. In addition, for
Muller’s muscle and the elastic aponeurosis. There will, in these cases a posterior approach was chosen when the
fact, be a difference between the lifting mechanisms of the phenylephrine test was positive. It is possible that it is not
previously ptotic (operated) eyelid and the contralateral necessarily the surgical approach that causes the difference
(unoperated) eyelid, which might drop.1 However, after detected, but rather the physiology of the eyelid as to
Mullerectomy, the length of the muscle does not affect LP whether or not it respond to pheynylephrine.

Figure 5. (A) A 61-year-old woman with left aponeurotic ptosis (marginal reflex distance 4 mm in right and 1 mm in the left eye).
She had Mullerectomy with tarsectomy on the left eye, in December 2011. (B) 12 months postoperatively, she had symmetric
results of 4 mm, bilaterally.

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Figure 6. (A) A 21-year-old woman with left congenital ptosis (marginal reflex distance 4 mm in right and 1 mm in the left eye).
She had good levator function (12 mm). She underwent left levator advancement on April 2009. (B) Two years postoperatively,
she had symmetric results of 4 mm, bilaterally.

Figure 7. (A) A 50-year-old woman with right congenital Horner’s syndrome. Note the characteristic iris heterochromia (the iris of
the affected eye is lighter in color than that of the unaffected eye). Since there was a positive Hering’s dependency, she had under-
gone bilateral levator advancement on July 2010. (B) Three years postoperatively, she had symmetric results of 3 mm, bilaterally.

Despite the fact that there was no significant difference unilaterally, with no need to repair the contralateral side. We
preoperatively in MRD1 between both methods in the also found that the Hering’s law effect was more common
current study, it is possible that the likelihood of a Hering’s with the levator advancement approach than Mullerectomy.
dependence and contralateral ptosis following surgery This information has broad clinical applicability. In
would be higher with levator surgery since it is often per- some cases of unilateral ptosis, as in congenital ptosis,
formed in cases with more severe initial ptosis. In addition, there is no need to examine for Hering’s law phenomena
the results may be related to the parameters dictated (ie, at preoperatively or to operate on the contralateral eyelid. A
least 2 mm ptosis). For patients with smaller degree of thorough patient history and preoperative assessment, in-
ptosis, as is often the case with aesthetic patients, the situa- cluding specific inquiry regarding poor levator function
tion may differ. and trauma, are needed, as well as early childhood photo-
The study includes a relatively small number of patients. graphs and a clinical examination. If indeed Hering’s law
Moreover, they have a heterogeneous ptosis etiology, which effects occur less often with a posterior surgical approach,
we attempted to differentiate. Hence, each parameter might this should be considered in the surgical plan for cases
change the statistical interpretation. Likewise, many factors where a second surgery is less desired (such as with elderly
can influence ptosis repair, including etiology, preoperative patients). Despite the mentioned limitations, we believe
values (LF, MRD, etc.), and measurement errors by the ex- that the current results can assist surgical planning and
aminer, among others.32 Palpebral fissure height and intraoperative management of ptosis repair. To investigate
diurnal variation can also change the surgical outcome.33 this phenomenon more thoroughly, a prospective study
should be conducted with preoperative videos, additional
photographs, and long-term follow-ups.
CONCLUSION
In the current study, the Hering’s law effect was not found in Acknowledgments
cases with poor levator function, post-trauma, or congenital The author would like to thank Faye Schreiber, MS, for editing
ptosis (even with good LF). These cases can be performed the manuscript.

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Disclosures 17. Wladis EJ, Gausas RE. Transient descent of the contralat-
The author declares no potential conflicts of interest with respect eral eyelid in unilateral ptosis surgery. Ophthal Plast
to the research, authorship, and publication of this article. Reconstr Surg. 2008;24(5):348-351.
18. Lepore FE. Unilateral ptosis and Hering’s law. Neurology.
1988;38(2):319-322.
Funding 19. Mehta HK. The contralateral upper eyelid in ptosis: some
observations pertinent to ptosis corrective surgery. Br J
The author received no financial support for the research,
Ophthalmol. 1979;63(2):120-124.
authorship, and publication of this article.
20. Bartley GB, Lowry JC, Hodge DO. Results of levator-
advancement blepharoptosis repair using a standard
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on 04 February 2018

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