No Course Information

1. Course Name: ESSENTIAL PATHOLOGY

2. Course Code:UDDD2124
3. Classification: Core Major
4. Credit Hour: 4
5. Trimester / Year Offered: 1/2, 2/2 & 3/2
Pre-requisite (if any):
UDDD1204 Metabolic Biochemistry
6.
UDDD1124 Anatomy and Physiology I
UDDD1214 Anatomy and Physiology II
7. Mode of Delivery: Lecture, Tutorial and Practical
8. Assessment Methods:
Continuous Assessment
• Tests/Quizzes/Assignments – 25% 50%
• Practical report/laboratory test – 25%
Final Examination 50%
9. Name(s) of Academic Staff:
• Dr. Michelle Ng Yeen Tan
• Ms. Kokila Thiagarajah
• Dr. Tan Gim Cheong
10. Course Objective:
This course aims to introduce the students to the fundamental concepts of pathology
for a better understanding of the changes in cellular, tissue and organs structure and
functions associated with diseases.
11. Course Learning Outcomes:
After completing this course, students should be able to:
1. Define the term and the subject of pathology and discuss the types of injures and
the mechanisms of their repair and healing.
2. Analyse the cellular changes that mark benign and malignant tumors and explain
the tissue changes that lead to common medical emergency.
3. Discuss the outcome of exposure to air, water and soil pollution, and
smoking, alcohol and drug abuse.
4. Relate the common diseases of the respiratory system, gastrointestinal
system, genito-urinary system, musculoskeletal system, hepatobiliary system
and heart diseases to the basic pathological changes.
5. Describe the basic steps in histopathology.
6. Identify the abnormalities in cells and tissues affected by inflammation,
malignancy and other disorders.
12. Course Synopsis:
This course provides general introduction to the two divisions of pathology, basic
and systemic pathology. Basic pathology includes cellular, tissue and organs
reactions to acute and persistent stresses; acute and chronic inflammation; neoplasia,
characteristics of malignant and benign tumors; and systemic pathology.
13. Topics and Notional Hours:
Learning
Topic L T P SL TLT
Outcomes
Topic 1: Introduction to Pathology and Cell 1 3 1 - 6 10
Response to Stress and Injury
• Pathology.
• Cellular reactions.
• Reversible and irreversible cellular changes.
• Cell death, apoptosis and necrosis.
Topic 2: Inflammation 1 3 - - 4 7
• Acute inflammation.
• Chronic inflammation.
• Chemical mediators and regulators of
inflammation.
Topic 3: Tissue Repair 1 3 - - 4 7
• Wound healing by primary intension or secondary
intension.
• Scar formation
• Factors that influence tissue repair
Topic 4: Neoplasia 2 3 1 - 6 10
• Benign tumors.
• Malignant tumors.
• Invasion and metastasis of tumors.
• Cancer grading and staging.
• Systemic effect of cancer on host.
Topic 5: Haemodynamics Disorders 2 4 1 - 6 11
• Oedema.
• Embolism.
• Infarction.
• Shock.
Topic 6: The Liver and biliary system 3 4 - - 5 9
• Alcoholic liver and non-alcoholic liver disease
• Acute and chronic hepatitis
• Iron overload syndrome
• Drug or toxin induced liver disease
• Gallbladder disease
• Tumour and hepatic nodules
Topic 7: Respiratory System 4 4 - - 5 9
• Atelectasis
• Obstructive lung diseases
• Restructive lung disease
• Pulmonary infections
• Lung tumours
• Pleural lesions
Topic 8: Gastrointestinal Tract 4 4 - - 5 9
• Oesophagitis
• Inflammatory disease of the stomach
• Diarrheal disease
• Inflammatory intestinal disease
• Benign and malignant tumours
Topic 9: Genito-urinary System 4 4 - - 5 9
• Adenomyosis and endometriosis
• Disease of ovary
• Neoplasia of cervix and breast
• Disease of prostate, penis and testis
• Disease of urinary tract
• Renal failure
Topic 10: Musculoskeletal System 4 4 - - 5 9
• Acquired disease of bone
• Osteonecrosis
• Bone tumours
• Arthritis
• Disorder of skeletal muscles
Topic 11: The Heart&Blood Vessels 4 4 - - 5 9
• Atherosclerosis
• Hypertensive vascular disease
• Aneurysms
• Ischemic heart disease
• Hypertensive heart disease
• Valvular heart disease
• Congenital heart disease
• Percardial disease
Practical:
Practical 1: Introduction to Histopathology Lab, - - 2 2 4
Safety Equipments, Tissue Processing, Fixation, 5
Staining
• Steps in tissue preparing
Practical 2: Demonstration for Tissue Cutting - - 2 2 4
• Steps of tissue cutting. 5
Practical 3: Tissue Staining - - 2 2 4
• HE staining 5
Practical 4: Respiratory system - - 2 2 4
• Identify the characteristic features ofhistopathology 6
slides
Practical 5: Gastrointestinal system - - 2 2 4
• Identify the characteristic features of 6
histopathology slides
Practical 6: Genitourinary system - - 2 2 4
• Identify the characteristic features of 6
histopathology slides
Practical 7: Musculoskeletal system - - 2 2 4
• Identify the characteristic features of 6
histopathology slides
Practical 8: The heart and blood vessel - - 2 2 4
• Identify the characteristic features of 6
histopathology slides
Practical 9: The hepatobiliary system - - 2 2 4
• Identify the characteristic features of 6
histopathology slides
Assessment - - - 25 25
• Assignments/ Quizzes/ Tests
• Lab reports/Lab test
• Final Examination
Total Notional Hours 40 3 14 103 160
Credit Hours 4
Main References:
1. Kumar, Abbas, Fausto, & Mitchell. (2012). Robbins basic pathology. (9th ed.).
Philadelphia:Saunders.
2. Rubin, R., & Strayer, D.S. (2012).Rubin’s Pathology: Clinicopathologic Foundations of
Medicine. Philadelphia: Lippincott William & Wilkins.
3. Klat, E.C. (2015). Robbins and Cotran Atlas of Pathology. (3rded). Philadelphia: Elsevier
Sounders.
Additional References:

Date of Senate’s Approval:

02nd February 2016

L = Lecture SL = Self- Learning

T = Tutorial TLT = Total Learning Time
P = Practical