12/5/2017 DNA-Binding of Semirigid Binuclear Ruthenium Complex Δ,Δ-[μ-(11,11‘-bidppz)(phen)4Ru2]4+:  Extremely Slow Intercalation Kinetics - Jou…

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DNA-Binding of Semirigid Binuclear Ruthenium Complex Δ,Δ-[μ-(11,11‘-

bidppz)(phen)4Ru2]4+:  Extremely Slow Intercalation Kinetics
L. Marcus Wilhelmsson,Fredrik Westerlund,Per Lincoln, andBengt Nordén*
Department of Physical Chemistry, Chalmers University of Technology, S-41296 Gothenburg, Sweden Article Options
J. Am. Chem. Soc., 2002, 124 (41), pp 12092–12093
DOI: 10.1021/ja027252f
Publication Date (Web): September 19, 2002 PDF (54 KB) Abstract
Copyright © 2002 American Chemical Society
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We here report a remarkably slow rearrangement of binding modes for a binuclear ruthenium(II) Sign in
complex upon interaction with DNA. It has been previously shown that Δ,Δ-[μ-(11,11‘-bidppz)
(phen)4Ru2]4+ binds to DNA in one of the grooves. However, we find that this is only an initial,
metastable, binding mode, which is extremely slowly reorganized into an intercalative binding Retrieve Detailed Record of this Article

geometry. The slow rearrangement and dissociation, revealed by flow linear dichroism and Retrieve Substances Indexed for this Article
fluorescence spectroscopy, are concluded to be a result from the complex being threaded through
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the DNA, with one of the bridging aromatic dppz ligands intercalated between the base pairs of the
DNA, placing one metal center in the minor groove and one in the major groove. A negative LD, a Retrieve All References Citing this Article
high luminescence quantum yield, and long luminescence lifetimes, similar to the intercalating Explore by:
complex Δ-[Ru(phen)2dppz]2+, indicate intercalation of the bidppz moiety. The unique slow
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dissociation of the complex in its final DNA-binding mode suggests that this class of threading, Any Author
partially intercalated binuclear complexes may be interesting in the context of cancer therapy. Research Topic
Also, their unique optical and photophysical properties could make such complexes, either alone
or scaffolded by DNA structures, of interest for the development of nanometer-sized molecular Wilhelmsson, L. Marcus Search
optoelectronic devices.
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Received 11 June 2002

Citing Articles Related Content Published online 19 September 2002
Published in print 1 October 2002
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