Triamcinolone

Triamcinolone

Clinical data

Trade names Kenalog Nasacort

Synonyms [show]
Click show to see

AHFS/Drugs. Monograph
com

Pregnancy AU: A

category  US: C (Risk not ruled out)

Routes of Oral, topical, IM, intra-articular, intrasynovial

administratio
n

ATC code A01AC01 (WHO) C05AA12 (WHO), D07AB09 (WHO), H02AB08 (WHO), R01AD11 (WHO), R03BA0

6 (WHO), S01BA05 (WHO)

Legal status


Legal status UK: POM (Prescription only)
 US: ℞-only OTC (Nasacort, Intranasal)
 Pharmacokinetic data

Protein 68%
binding

Metabolism Hepatic

Biological 88 minutes
half-life

Excretion Fecal and renal

Identifiers

IUPAC name[show]

 124-94-7
CAS Number

PubChemCI 31307
D

 2870
IUPHAR/BP
S

DrugBank DB00620

 29046
ChemSpider

UNII  1ZK20VI6TY

KEGG  D00385

ChEBI  CHEBI:9667

ChEMBL CHEMBL1451

ECHA 100.004.290
InfoCard

Chemical and physical data

Formula C21H27FO6

Molar mass 394.434 g/mol

3D model  Interactive image

(JSmol)

SMILES[show]

InChI[show]

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Triamcinolone is an intermediate-acting synthetic glucocorticoid given orally, by injection, by

inhalation, or as a topical ointment or cream.[1]

Contents
[hide]
 1Uses
 2Forms
 3Side effects
 4Chemistry
 5Society and culture
o 5.1Brand names
 6See also
 7References
 8External links

Uses[edit]
Triamcinolone is used to treat a number of different medical conditions, such as eczema, lichen
sclerosus, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal
arteritis, uveitis, ocular inflammation, keloids, urushiol-induced contact dermatitis, aphthous
ulcers (usually as triamcinolone acetonide), visualization during vitrectomy and the prevention
of asthma attacks. It will not treat an asthma attack once it has already begun.[2][3][4] It has also
been used off-label for macular degeneration.[5]
Prior to 2007 it was sold under the name Azmacort as a corticosteroid inhaler for asthma long-
term care.
In 2010, TEVA and Perrigo launched the first generic inhalable triamcinolone.[6]
Triamcinolone is used to alleviate infection-induced eczema in fungal skin infections in
the combination drug of econazole/triamcinolone.
The derivative triamcinolone acetonide is one of the ingredients of Ledermix,
an endodontic (tooth's root canal) lotion used between sessions, and Sanofi sold it under the
brand name Nasacort. Triamcinolone acetonide is also used as intra lesional steroid injection to
treat keloids and hypertrophic scars.
According to Chang et al (2014), "Triamcinolone acetonide (TA) is classified as an
S9 glucocorticoid in the 2014 Prohibited List published by the World Anti-Doping Agency, which
caused it to be prohibited in-competition when administered orally, intravenously, intramuscularly
or rectally".[7]

Forms[edit]
Different triamcinolone derivatives are available, including acetonide, benetonide, furetonide,
hexacetonide and diacetate.
Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as
effective as prednisone.

Side effects[edit]
Side effects of triamcinolone include sore throat, nosebleeds, increased coughing, headache,
and runny nose.[citation needed] White patches in the throat or nose indicate a serious side effect.[clarification
needed]
Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble
breathing.[8] An additional side effect for women is a prolonged menstrual cycle.

Chemistry[edit]
Triamcinolone is a synthetic pregnane corticosteroid and derivative of cortisol (hydrocortisone)
and is also known as 1-dehydro-9α-fluoro-16α-hydroxyhydrocortisone or 9α-fluoro-16α-
hydroxyprednisolone as well as 9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-
3,20-dione.[9][10]
Society and culture[edit]
Brand names[edit]
Trade names for triamcinolone include Aristocort (Sandoz, now Novartis), Kenacort (Bristol-
Myers Squibb), Kenalog (Bristol-Myers Squibb), Tricort (Cadila), Triaderm (Schering-Plough),
Azmacort (KOS), Trilone, Volon A, Tristoject, Tricortone, Ratio-Triacomb, and Trianex.

See also[edit]
 Glucocorticoid (a chart comparing various glucocorticoids)
 Triamcinolone acetonide

References[edit]

Aristocort (triamcinolone) topical cream

Kenalog (triamcinolone) IM injection

1. Jump up^ Chrousos G, Pavlaki AN, Magiakou MA (2011). "Glucocorticoid Therapy and Adrenal
Suppression". PMID 25905379.
2. Jump up^ Triamcinolone - Drugs.com
3. Jump up^ Triamcinolone Inhalation - Drugs.com
4. Jump up^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for
Use in Eye Surgery - Drugs.com
5. Jump up^ Age-Related Macular Degeneration (AMD) Treatment
6. Jump up^ Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit
7. Jump up^ Chang, Chih-Wei; Huang, Tai-Yuan; Tseng, Yi-Chun; Chang-Chien, Guo-Ping; Lin, Su-
Fan; Hsu, Mei-Chich (2014). "Positive doping results caused by the single-dose local injection of
triamcinolone acetonide". Forensic Science International. 244: 1–
6. doi:10.1016/j.forsciint.2014.07.024. PMID 25126738.
8. Jump up^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD.
Retrieved 2008-03-24.
9. Jump up^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data,
Structures and Bibliographies. Springer. pp. 1228–. ISBN 978-1-4757-2085-3.
10. Jump up^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000.
pp. 1054–. ISBN 978-3-88763-075-1.
External links[edit]
 Triamcinolone Topical | MedlinePlus
 Triamcinolone (Topical Application Route) | MayoClinic