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DOI 10.1007/s10803-007-0380-6
ORIGINAL PAPER
Abstract An empirically based 78 question self-rating Diagnosis of autism and Asperger’s Disorder in adults can
scale based on DSM-IV-TR and ICD-10 criteria was be a daunting task. First, they share many symptoms with
developed to assist clinicians’ diagnosis of adults with aut- other DSM-IV-TR disorders, such as social anxiety disor-
ism and Asperger’s Disorder-the Ritvo Autism and Asper- der, obsessive–compulsive disorder, and schizoaffective
ger’s Diagnostic Scale (RAADS). It was standardized on 17 disorder (Baron-Cohen and Wheelwright 2004; Fitzgerald
autistic and 20 Asperger’s Disorder and 57 comparison and Corvin 2001; Klin et al. 2005; Ritvo 2006; Volkmar
subjects. Both autistic and Asperger’s groups scored signif- and Lord 1998). Second, the differentiation of autism from
icantly higher than comparison groups with no overlap; Asperger’s Disorder according to DSM-IV-TR and ICD-10
sensitivity, specificity, and content validity equaled one. criteria depends on the time of onset of language and
Cronbach’s alpha coefficients of internal consistency of three cognitive functions, and this information is often lacking,
subscales were satisfactory. Gender, age, and diagnostic especially in adults. Finally, there is no consensus among
categories were not significantly associated factors. The clinicians and researchers as to the relationship of the two
RAADS can be administered and scored in less than an hour disorders. Some consider them to be separate, and some as
and may be useful as a clinical scale to assist identification of being on a continuum and differing only in their degree of
autism and Asperger’s Disorder in adults. The RAADS does severity (Baron-Cohen 1995; Frith 1991).
not distinguish between autism and Asperger’s Disorder. In 1944, Hans Asperger first described a group of indi-
viduals he labeled as having ‘‘autistic psychopathy.’’ He
Keywords Diagnosis Autism Asperger’s Disorder characterized these individuals as having problems in social
RAADS integration and nonverbal communication. He also noted
that they had idiosyncratic verbal communication, preoc-
cupations with unusual interests, deficits with empathy and
R. A. Ritvo (&)
Yale Child Study Center, Yale University School of Medicine, intuition, and were clumsy. He did not, however, provide
New Haven, CT, USA specific diagnostic criteria (Frith 1991). Wing (1981), a
e-mail: Ariritvo@aol.com British psychiatrist, translated Asperger’s work from the
original German into English and renamed the condition
E. R. Ritvo D. Guthrie
Neuropsychiatric Institute, Los Angeles Medical School, Asperger’s Syndrome. She noted these subjects displayed a
University of California, Los Angeles, CA, USA lack of normal interest in people, a lack of shared interests,
delayed speech acquisition, impoverished speech content,
A. Yuwiler
and absence of imaginary play. Gillberg (1992) proposed
Los Angeles Medical School, University of California, Los
Angeles, CA, USA diagnostic criteria closer to Asperger’s original description.
They included social impairments, narrowed interests,
M. J. Ritvo repetitive routines, speech and language peculiarities,
Harvard Westlake School, Los Angeles, CA, USA
nonverbal communication problems, and motor clumsiness.
L. Weisbender Inclusion of Asperger’s Syndrome in the ICD-10 (World
California Graduate Institute, Los Angeles, CA, USA Health Organization 1992) and DSM-IV (American
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Psychiatric Association 1994) resulted in broad clinical who were familiar with the project, and (d) advertisement in
recognition of the syndrome, which was renamed Asper- websites for adults with Asperger’s Disorder. The subjects
ger’s Disorder. The DSM-IV-TR, however, excluded were enrolled in the order they volunteered. They were
speech and language difficulties from the criteria, thus judged clinically (via mental status exam) to be functioning
providing a broader definition than that previously used by in the non-retarded range of intelligence, had been educated
Asperger, Wing, and Gillberg (Fitzgerald and Corvin in regular schools, were reported to have an average IQ, had
2001). DSM-IV diagnostic criteria distinguish Asperger’s a driver’s license, and obtained a high school diploma,
Disorder from autism by the time of language onset and college, or graduate school education. All subjects were in
cognitive development (i.e., for Asperger’s Disorder there good general health between the ages of 18–65.
must be no delay). Also, for autism but not for Asperger’s A first group of comparison subjects, called the ‘‘other
Disorder, qualitative impairment in communication must diagnoses’’ group (Group 3), consisted of 16 adults with
be evident. Currently, there is a growing consensus that DSM-IV-TR Axis I diagnoses other than autism or Asper-
Asperger’s Disorder is a sub-group on the autistic spectrum ger’s Disorder. They were recruited from psychiatric out-
(Baron-Cohen 1995; Frith 1991; Ritvo 2006; Wing 1981). patient clinics in Los Angeles. Two clinicians also confirmed
Several diagnostic scales have been developed for chil- their diagnoses with clinical interviews and mental status
dren and adolescents with autism and Asperger’s Disorder examinations. They had the following Axis I disorders:
(Attwood 1998; Ehlers et al. 1999; Williams et al. 2005) and schizophrenia (n = 3), psychosis NOS (n = 1), schizoaf-
their various strengths and weaknesses have been evaluated fective (n = 2), bipolar (n = 1), ADHD (n = 1), generalized
(Campbell 2005; Goldstein 2002). Only one scale, ‘‘The anxiety (n = 2), obsessive compulsive (n = 2), social phobia
Autism-Spectrum Quotient’’ (AQ), was designed specifi- (n = 2), dysthymic (n = 1), and post traumatic stress
cally for adults (Baron-Cohen et al. 2001). These authors (n = 1). Initially, the authors sought a comparison group
emphasized that the AQ is not diagnostic, but serves as a large enough with social phobia and schizoid personality
useful instrument identifying the extent of autistic traits disorder—as they are often confused with Asperger’s Dis-
shown by an adult of normal intelligence. They recom- order—in order to allow separate statistical analyses. How-
mended exploring its potential as a screening tool for aut- ever, because the sample size was small and the diagnoses
ism-spectrum conditions in adults of normal intelligence. were diverse, this group was combined with Group 4 for
These investigators also proposed a diagnostic system, ‘‘The statistical analyses to increase the statistical power.
Adult Asperger’s Assessment (AAA): A Diagnostic Meth- A second group of comparison subjects (Group 4), called
od’’ (Baron-Cohen et al. 2005). It consists of a questionnaire the ‘‘no diagnosis’’ group, consisted of 41 volunteers who did
that encompasses the DSM-IV-TR criteria and the admin- not have, and never reported having had, a DSM-IV-TR Axis
istration of two scales, the AQ and the Empathy Quotient I diagnosis. They were recruited from associates of the
Scale (EQ) (Baron-Cohen and Wheelwright 2004). investigators, two colleges, and two graduate schools in the
Los Angeles area. Similar to the autistic and Asperger’s
Methods Disorder subjects, Groups 3 and 4 were combined to form
one group of 57 comparison subjects. These comparison
Subjects subjects were all in good general health, were clinically
judged to be in the average range of intelligence, had a dri-
Four groups of subjects were recruited and compressed into two ver’s license, were literate, and educated in regular schools
groups for the purpose of evaluation and analysis as follows: with no special education. They were between the ages of 18–
Group 1 consisted of 20 volunteers with Asperger’s 65 years and all were desirous of cooperating (see Table 1).
Disorder and Group 2 of 17 volunteers with autistic disor-
der. They were grouped together because of difficulties Informed Consent
ascertaining age of language onset in three cases. Two
independent psychiatrists diagnosed these subjects using The California Institutional Review Board, Inc., located in
DSM-IV-TR criteria for Asperger’s Disorder or autism Pasadena, California, approved the consent form and scale
(American Psychiatric Association 2000). Evaluations (IRB #06-001, January 27, 2006). After complete
consisted of reviewing prior medical records when avail- description of the study to the subjects, written informed
able, obtaining a developmental history, conducting an consent was obtained.
interview, and a mental status examination. They were re-
cruited from (a) diagnosed patients of clinicians known to Development of the Scale
the authors throughout the country, (b) national autism and
Asperger’s Disorder support groups known to the authors, One hundred questions were initially formulated on an
(c) referrals from Asperger’s and autism diagnostic clinics empirical basis to detect symptoms (behaviors and thought
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patterns) in the three main areas of disturbances noted in the 1. Social relatedness, total of 31 questions: 1, 3, 5, 6, 9,
ICD-10 and DSM-IV-TR criteria for autism and Asperger’s 11, 12, 13, 14, 18, 19, 21, 22, 31, 34, 40, 41, 42, 46, 50,
Disorder. These three areas are (a) qualitative impairments 51, 56, 57, 58, 59, 63, 66, 70, 71, 74, 78.
in social interaction; (b) qualitative impairments in com- 2. Language and communication, total of 23 questions: 2,
munication; and (c) restricted repetitive and stereotyped 7, 8, 15, 23, 24, 25, 26, 27, 32, 37, 39, 43, 44, 45, 47,
patterns of behavior, interests, and activities (American 48, 53, 55, 64, 68, 72, 77.
Psychiatric Association 2000; World Health Organization 3. Sensorimotor and stereotypies, total of 24 questions: 4,
1992). The authors utilized the above criteria and relabeled 10, 16, 17, 20, 28, 29, 30, 33, 35, 36, 38, 49, 52, 54, 60,
them into three simplified representational categories of (a) 61, 62, 65, 67, 69, 73, 75, 76.
social relatedness, (b) language and communication, and (c)
These assignments were made by consensus among the
sensorimotor and stereotypies. Each question was worded
investigators. Three expert judges then reviewed the ques-
from the patient’s point of view (i.e., in the first person as
tions again. If there was consensus, the question remained in
the scale is of the self-rating type). Each question was then
its assigned domain; if not, it was revaluated and reassigned.
assigned to one of the three domains above.
A 4-point Likert scale for answers to each question was
Two types of questions were developed: (a) 60 ‘‘posi-
designed to allow for subsequent statistical comparisons of
tively worded questions,’’ identifying specific symptoms as
factors such as time of onset, duration, and frequency of
listed in DSM-IV-TR and ICD-10; and (b) 18 ‘‘negatively
specific symptoms and subsets of symptoms. The two types
worded questions,’’ which identify ‘‘normally expected
of questions were scored in reverse order:
answers.’’ Though these questions also address areas rele-
vant to the diagnosis of autism and Asperger’s Disorder, 1. ‘‘Positively worded questions’’ were scored: Present now
they are negatively worded to avoid a response bias. These and when young (before 16 years) = 3, Only now = 2,
were also included to ascertain whether certain skills (such Only when young (before 16 years) = 1, Never true = 0.
as social skills) were acquired over the developmental 2. ‘‘Negatively worded questions’’ (identified on the scale
span. These questions are scored in reverse order from the by an asterisk next to their numbers) were scored:
positively worded questions. Three expert judges, clini- Present now and when young = 0, Only now = 1, Only
cians who specialize in autism spectrum disorders, re- when young = 2, Never true = 3.
viewed all questions. Questions were revised based on their
Instructions for scoring each question and a sample score
recommendations.
sheet are presented in the appendix. They can be down-
An initial field trial was undertaken by administering the
loaded from the online version of the Journal. Translations
scale to 8 Asperger’s Disorder, 8 autistic, and 16 volunteers
into languages other than English are available on request.
with no DSM-IV-TR diagnosis. After administration of the
The categories showed a developmental profile indi-
questionnaire, each question was reviewed with these 32
cating which symptoms the subjects outgrew naturally or
individuals. Evaluating and reviewing their comments led
with treatment and which symptoms persisted. The cate-
to the elimination of 17 questions due to redundancy,
gory of ‘‘Only now’’ evaluated skills learned over time
ambiguity, or lack of clarity. A second field trial was then
either naturally or with treatment. This answer category is
undertaken by administering the scale to another set of 5
designed for the 18 ‘‘negatively worded questions.’’
autistic, 5 Asperger’s Disorder, and 10 comparison sub-
jects, and again reviewing each question with them. After Procedure
evaluating their comments, five additional questions were
eliminated due to redundancy or lack of clarity, leaving 78 An investigator accompanied each subject during admin-
questions for the final version of the scale. istration of the scale. This was to assure that they attended
Each of the final 78 questions was assigned to one of the to the questions and to provide a short answer if a subject
three domains previously described: asked for clarification.
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Subjects’ identifying information was coded to preserve improved without them. Removing questions 2 and 8
anonymity and entered together with their responses into increased alpha to 0.65 for the language and communica-
Excel spreadsheets and then transferred to SAS for statis- tion subscale, and removing question 10 increased the al-
tical analyses. The internal consistency of the items in each pha for the sensorimotor and stereotypies subscale to 0.73.
of the three subscales was calculated and Cronbach’s alpha Although sample sizes were small, we conducted factor
coefficients were determined. A factor analysis was then analyses to attempt to identify meaningful subscales within
carried out to determine the most discriminatory questions. our data. This was intended to suggest patterns within the
Lastly, ANCOVAs for age and sex and for comparisons of present data rather than to imply a specific factor structure.
group means were conducted. The procedure involved four steps:
1. Identification of three groups of questions with similar
Results semantic content.
2. Computing principal component factor analyses with
Subjects’ demographics are shown in Table 1. An age- varimax rotation.
adjusted ANCOVA of total scores (over all 78 questions) 3. Examining factor loadings in order to select variables
across diagnostic and gender groups showed group differ- to represent the factors.
ences, but age was not statistically significant as a covariate 4. Computing subscale scores by adding the reported
(p = 0.141). Gender was statistically significant as a main values of the selected variables after computing
effect (p = 0.0177), but the gender-diagnosis effect was not internal consistency reliability (Cronbach’s alpha) and
significant (p = 0.5532). We therefore concluded that eliminating variable found to be inconsistent.
gender and diagnosis were additive effects.
Post-hoc unequal variance t-tests were performed for These subscale scores, together with the overall total across
pair-wise comparisons of each of the 78 questions. The all 78 questions, were then compared between the autistic and
autistic and Asperger’s Disorder subjects significantly Asperger’s Disorder group and the comparison group.
differed from the comparison groups on 77 questions (i.e., The first group of questions, named ‘‘Social Related-
for these questions, df = 39.1 vs. 92, t = 3.64 vs. 13.83, all ness,’’ produced two factors accounting for 33.8% of the
p values < 0.002). Only one question, 28 (‘‘I am more multidimensional variance; subscales derived from these
sensitive to smells than anyone I know’’), was not signifi- factors had reliability of 0.909 and 0.820 respectively. Two
cant between groups (t = 1.65, df = 92, p = 0.1031). factors from the second group, ‘‘Language,’’ accounted for
Comparison of the mean RAADS scores of the combined 25.3% of the variance and had reliability of 0.819 and 0.817.
autistic and Asperger’s group to the combined comparison Two factors from the third group, ‘‘Sensorimotor,’’ ac-
subject group revealed they were significantly different counted for 35.6% of the variance and had reliability of 0.785
(F = 256.49, p < 0.0001). Inspection of the ranges of the and 0.761. While these results suggest adequate structure, it
combined groups revealed that there were no overlapping should be recognized that our samples were small.
scores. This indicates that the sensitivity, specificity, and ANOVAs of the subscales reveal statistically significant
content validity of the RAADS each equal one (Table 2). differences (p < 0.0001) on each of the three subscales (see
Cronbach’s alpha coefficients were computed for each Table 3).
of the three subscales described previously: (a) social
relatedness, a = 0.86; (b) language and communication, Table 3 Statistical analysis of subscales
a = 0.60; and (c) sensorimotor and stereotypies, a = 0.70.
Groupa Subscale M SD F
Analysis of the frequency of responses for questions 2, 8,
and 10 revealed that internal consistency could be Autistic & Asperger’s Social 150.466 45.415 66.56
Disorder Relatedness
Table 2 One-way ANOVA comparisons and statistical characteris-
Comparison Controls Social 34.894 50.425
tics of subject groups
Relatedness
Group Mean Scores SD Range of Autistic & Asperger’s Language 135.270 44.976 83.54
for 78 Questions RAADS Scores Disorder
Comparison Controls Language 25.315 38.565
Autistic & 138.243 29.585 77–204
Asperger’s Autistic & Asperger’s Sensorimotor 148.094 52.898 57.14
Disordera Disorder
Comparison 27.701 19.282 1–64 Comparison Controls Sensorimotor 31.851 51.146
Controlsb a
n = 37 for Autistic & Asperger’s Disorder; n = 57 for Comparison
a b
n = 37; n = 57 Controls
F = 256.49; df = 2; *p < 0.0001 *p < 0.0001
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Clinical Utility of the RAADS indicate that more women were included than is usual in
studies of autism and Asperger’s Disorder. However, sta-
The means, standard deviations, and ranges of scores of tistical analysis revealed gender was not a significant factor.
each diagnostic group are shown in Table 2. Based on this Two unavoidable methodological issues were encoun-
information: tered while developing the scale. First was the dilemma
facing the clinicians and researchers dealing with the dif-
1. A score of 64 or less indicates that it is highly unlikely
ferential diagnosis of autism versus Asperger’s Disorder
that a patient has autism or Asperger’s Disorder.
when a subject’s early developmental history was
2. A score of 77 or higher indicates that it is highly likely
unavailable. DSM-IV-TR diagnostic criteria for Asperger’s
that the patient has either autism or Asperger’s Dis-
Disorder states: ‘‘There is no clinically significant general
order. To differentiate Asperger’s Disorder from high-
delay in language (e.g., single words used by age 2 years,
functioning autism, the clinician must examine pa-
communicative phrases by age 3 years)’’ (criterion D). It
tient’s early developmental history (i.e., diagnostic
also states, ‘‘There is no clinically significant delay in
criteria of DSM-IV-TR regarding time of onset of
cognitive development or in the development of age
language cognitive development).
appropriate self help skills, adaptive behavior other than in
3. None of the 94 subjects in the study scored in the 65–
social interaction, and curiosity about the environment in
76 range. An increased sample size of all of the groups
childhood’’ (Criterion E) (American Psychiatric Associa-
will ultimately reveal a statistically significant cut-off
tion 2000). Fortunately, only 3 subjects were unable to
point between autistic and Asperger’s Disorder pa-
confirm their early developmental histories. One recalled
tients and comparison subjects. At this time, due to the
having had difficulties ‘‘for as long as I can remember,
limited sample size, it appears best to consider that a
from my earliest memories on,’’ and his family dated his
score between 65 and 76 could be due to misreading or
symptoms to his infancy. He was assigned to the autism
misunderstanding questions, errors when marking an-
group. The other two recalled never having been told of
swers on the scale, language processing difficulties, or
early developmental problems, and did not recall having
other confounding factors which rendered the scale
symptoms until grammar school. These two were assigned
non discriminatory at that point in time.
to the Asperger’s Disorder group. When dealing with adult
subjects, it is often difficult to obtain an accurate devel-
Discussion opmental history and this problem is encountered fre-
quently. We combined the Asperger’s Disorder and autistic
A self-rating diagnostic scale for adults that can assist subjects into one group to correct for this; thus, our sta-
clinicians is presented. It can be administered and scored in tistical analyses were not affected by this limitation.
less than one hour and it is highly sensitive and specific. A second methodological issue was that the two clini-
All subjects completed the scale without difficulty. Many cians were not blind to subjects’ prior diagnoses. However,
of the autistic and Asperger’s Disorder subjects used it as a each of the autistic and Asperger’s Disorder subjects and
springboard to discuss their life experiences and specific those with other DSM-IV-TR diagnoses had medical his-
symptoms. For many it also fostered a discussion of tories, psychological and/or educational testing, and cur-
treatment options. For example, one subject with Asper- rent mental status examinations that made diagnosis easily
ger’s Disorder stated, ‘‘Taking the scale gave me an apparent to an experienced clinician.
opportunity to look at my feelings. I hardly ever get to As noted in the introduction, a literature review revealed
do that. I also had a chance to talk about things I love.’’ only one similar self-rating scale designed for adults, the
Another subject with autism said, ‘‘Many questions applied AQ (Baron-Cohen et al. 2001). Unlike the RAADS, it is not
to me. Every time I encountered a question I’d go, ‘Yeah, based on DSM-IV-TR and ICD-10 criteria. Rather, it has 50
that’s me alright!’ or ‘Nope, not at all.’’’ Although the questions that assess four different areas: social skills,
questions are specific and empirically based, most of the attention switching, attention to detail, and imagination.
subjects in the autistic and Asperger’s Disorder group made Each item is answered on a 4-point Likert scale, ranging
spontaneous comments while they marked the answers. from definitely agree to definitely disagree. In contrast, the
The qualitative data as described above may also be useful Likert scale used in the RAADS is developmentally based
to the clinician in understanding the patient and designing and the domains assess symptoms in the three DSM-IV-TR
the appropriate treatment plan. and ICD-10 areas. The two are also different in their method
As noted in Table 1, the male to female ratios were 11:6 in of administration. The AQ was standardized on scales that
the autistic group and 11:9 in the Asperger’s Disorder group. were completed at home and mailed back to the researchers,
Although subjects were enrolled in the order they volun- whereas the RAADS was standardized only on scales with
teered with no prescreening gender criteria, these ratios the researcher sitting with each subject during its adminis-
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Based on preliminary data presented, the Ritvo Autism Determining a patient’s score: In order to identify the
Asperger’s Diagnostic Scale (RAADS) appears to be a 60 positively worded questions and the 18 that are nega-
useful clinical scale that can assist clinicians in identifying tively worded, we have devised a simple code:
autistic disorder and Asperger’s Disorder in adults. How-
ever, this is a cautionary statement. Though initial results 1. Each of the 60 positively worded questions has a
demonstrated it is highly sensitive and specific and can be regular period after its number on the scale (e.g., 70. I
administered and scored in less than one hour, further cannot tell if someone is interested or bored with what
studies to determine reliability and validity are indicated. I am saying).
The RAADS is neither intended nor able to distinguish 2. Each of the 18 negatively worded questions has an asterisk
between Asperger’s Disorder and autistic disorder because (*) after its number (e.g., 1* I am a sympathetic person).
the DSM-IV-TR and ICD-10 criteria require that diagnosis To score the scale, first write a number from 0 to 3 by
depends on the time of onset of language and cognitive the side of each question, depending on which box the
functions. Further multi-center studies are underway to patient checked. Second, enter the total for that page on the
expand the sample and test several hypotheses concerning bottom of the page. Third, add the totals of each page to
the nature of autism and Asperger’s Disorder. determine the total score for all 78 questions.
Clinical implications of a patient’s total score: Based
Acknowledgments We wish to express our gratitude to David Al- on the statistical parameters described in the results sec-
len, PhD; Anne Panofsky, PhD; Victoria Ritvo; Stephen Shore;
Temple Grandin, PhD; Roger N. Meyer; Colleen Clegg and Alan tion, the following conclusions can be drawn as shown in
Slifka for their invaluable contributions and support. the following table.
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______________________________________________________________________________
Please answer the questions according to what is true
*3. Your phone number (________) _______________________ *4. Today’s date __________
for you and only what you feel is true and correct, not what
*5. Your age in years _____________________
you think others expect you to say or taught you to say.
Your gender: *6. male *7. female
Check only one column.
Marital status: *8. single *9. married *10. divorced
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continued continued
Some life experiences and True now True True only Never Some life experiences and True now True True only Never
personality characteristics and when I only when I was true personality characteristics and when I only when I was true
that may apply to you was young now young that may apply to you was young now young
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J Autism Dev Disord
continued continued
Some life experiences and True now True True only Never Some life experiences and True now True True only Never
personality characteristics and when I only when I was true personality characteristics and when I only when I was true
that may apply to you was young now young that may apply to you was young now young
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J Autism Dev Disord
continued continued
Some life experiences and True now True True only Never Some life experiences and True now True True only Never
personality characteristics and when I only when I was true personality characteristics and when I only when I was true
that may apply to you was young now young that may apply to you was young now young
123
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