RSV – Recommended Literature

Down Syndrome/Trisomy 21

• Aboussouan LS, O’Donova PB, Moodie DS, Gragg LA, Stoller JK Hypoplastic
trachea in Down’s Syndrome. Am Rev Resp Dis, 1993; 147: 72-5.

• Bloemers BL, Bont L, de Weger RA, Otto SA, Borghans JA, and Tesselaar K.
Decreased Thymic Output Accounts for Decreased Naïve T Cell numbers in
Children with Down Syndrome. J Immunol 2011; 186:4500-4507

http://www.jimmunol.org/content/186/7/4500.full.pdf+html

• Bloemers BL, van Bleek, GM, Kimpen, JL, Bont L. Distinct abnormalities in the
innate immune system of children with Down syndrome. J Pediatr. 2010; 156 (5):
804-9.

http://www.sciencedirect.com/science/article/pii/S0022347609012293

• Bloemers BL, Broers CJM, Bont L, Weijerman ME, Gemke R, van Furth A.
Increased risk of respiratory tract infections in children with Down syndrome: the
consequence of an altered immune system. Microbes Infect 2010; 12 (11): 799-
808.

http://www.sciencedirect.com/science/article/pii/S1286457910001449

• Bloemers BL, van Furth AM, Weijerman ME, et al. Down syndrome: a
novel risk factor for respiratory syncytial virus bronchiolitis–a prospective birth-
cohort study. Pediatrics. 2007; 120: e1076–e1081.

http://pediatrics.aappublications.org/content/120/4/e1076.full.html

• Chaney RH, Eyman RK, Miller CR. The relationship of congenital heart disease
and respiratory infection mortality in patients with Down syndrome. J Ment Def
Res. 1985; 29: 23-27.
• Clapp S, Perry BL, Farooki ZQ, et al. Down syndrome, complete atrioventricular
canal, and pulmonary vascular obstructive disease. J Thorac Cardiovasc Surg.
1990; 100:115-121.

• Cooney TP, Thurlbeck WM. Pulmonary hypoplasia in Down’s syndrome. N Engl

J Med. 1982 307:1170-1173.

http://www.nejm.org/doi/full/10.1056/NEJM198211043071902

• Doull I. Respiratory disorders in Down’s syndrome: overview with diagnostic and

treatment options. DSMIG (UK) 2001:1-19.

• Garrison MM, Jeffries H, Christakis DA. Risk of death for children with Down
syndrome. J Pediatr 2005; 147:748-52.

http://www.sciencedirect.com/science/article/pii/S0022347605005871

• Greenwood RD, Nadas AS. The clinical course of cardiac disease in Down’s
syndrome. Pediatrics 1976; 58: 893-7.

http://pediatrics.aappublications.org/content/58/6/893.full.pdf+html

• Gonzalez OR, Gomez IG, Recalde AL, Landing BH. Postnatal development of
the cystic lung lesion of Down syndrome: suggestion that the cause is reduced
formation of peripheral air spaces. Pediatr Pathol 1991; 11:623-33.

• Gyves-Ray K, Kirchner S, Stein S, Heller R, Hernanz-Schulman M. Cystic lung

disease in Down syndrome. Pediatr Radiol 1994; 24: 137-8.

• Kristensen K, Stensballe LG, Bjerre J, Roth D, Fisker N, Kongstad T, Svendsen

AL, Nielsen BW. Risk factors for respiratory syncytial virus hospitalisation in
children with heart disease. Arch Dis Child 2009: 94 (10): 785-789.

http://adc.bmj.com/content/94/10/785.full.pdf+html

• Leonard S. Bower C, Petterson B, Leonard H. Survival of infants born with

Down’s syndrome: 1980-96. Paediatr Pernia Epidemiol. 2000; 14 (2): 163- 171
 http://onlinelibrary.wiley.com/doi/10.1046/j.1365-3016.2000.00252.x/pdf

• Marcus, CL, Keens TG, Bautista DB, von Pechmann WS, Davidson Ward, SL.
Obstructive sleep apnea in children with Down syndrome. Pediatr 1991; 88 (1):
132-139.

http://pediatrics.aappublications.org/content/88/1/132.full.pdf+html

• Piatti G, Allegra L, Ambrosetti U, Margherita De Santi, M. Nasal ciliary function

and ultrastructure in Down syndrome. Laryngoscope 2001; 111 (7): 1227-1230.

http://onlinelibrary.wiley.com/doi/10.1097/00005537-200107000-00016/pdf

• Ram G, Chinen J. Infections and immunodeficiency in Down’s syndrome. Clin

Exp Immunology 2011; 164 (1) :9-16

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2011.04335.x/pdf

• Scholl T, Stein Z, Hansen H. Leukemia and other cancers, anomalies and

infections as causes of death in Down’s syndrome in the United States during
1976. Dev Med Child Neurolol 1982; 24: 817-29.

• Shah PS, Hellmann J, Adatia I. Clinical characteristics and follow up of Down

syndrome infants without congenital heart disease who presented with persistent
pulmonary hypertension of newborn. J Perinatol Med. 2004: 32: 168-170.

• Thase ME. Longevity and mortality in Down’s syndrome. J Ment Defic Res 1982;
26:177-192.

• Uong EC, McDonough JM, Tayag-Kier CE, et al. Magnetic resonance imaging of
the upper airway in children with Down syndrome. Am J Respir Crit Care Med
2001; 163:731-736.

http://ajrccm.atsjournals.org/content/163/3/731.full.pdf+html
• Weijerman ME, Furth AM, Vonk Noordegraaf A, et al. Prevalence, neonatal
characteristics and first-year mortality of Down syndrome: a national study. J
Pediatr 2008; 152 (1) :15-19.

http://www.sciencedirect.com/science/article/pii/S0022347607008955

• Yang Q, Rasmussen SA, Friedman JM. Morality associated with Down’s

syndrome in the United States from 1983-1997: a population-based study.
Lancet 2002; 359 (9311): 1019-25.

http://www.sciencedirect.com/science/article/pii/S0140673602080923

• Zachariah P, Ruttenber M, Simoes EA. Down syndrome and hospitalizations due

to respiratory syncytial virus: a population-based study. J Pediatr 2012: 160 (5):
827-31.e1.

http://www.sciencedirect.com/science/article/pii/S0022347611011279