Documente Academic
Documente Profesional
Documente Cultură
by
Allyson Pinson
Marley Robison
April 2018
Thesis Committee:
ACKNOWLEDGMENTS
First, we would like to thank our incredible mentor, Dr. McKnight, for helping us
throughout the entire thesis process, from choosing our topic to the finishing touches. We would
especially like to thank him for his assistance in formatting and distributing our surveys; without
him, our thesis would not have been possible. In addition, we would like to thank St. Thomas
environment to distribute our surveys. We would like to thank the head of nurses in labor and
delivery, Dr. Angelique Dooley, RNC, and her staff for agreeing to aid in our thesis.
We would also like to thank all of our teachers- Mrs. Harrison, Dr. Thomas, and Mrs.
Roland- for helping to format and revise our thesis over the past year. Mrs. Harrison, our STEM
IV teacher, has been with us since our junior year of high school. Now in our senior year, she has
been a tremendous help with our surveys, formatting, and content. We would also like to thank
Dr. Thomas for her constant help and advice. Without her expertise, our layout would not be
nearly as organized. Thankfully, she was always available to read and revise. Next, we want to
thank Mrs. Roland for revising our paper throughout the year. She has helped us to fix countless
careless errors and aided in making our thesis the best it can be.
Additionally, we would like to thank our advisors: Mr. Brooks and Mrs. Cook. They have
been with us for the past four years, helping to guide us through high school and prepare us for
our future. They helped us to stay on track with deadlines and made sure we had every resource
Finally, we would like to thank every woman who was generous enough to take the time
to fill out our survey, as well as everyone who helped throughout the entire process.
THE IMPACT OF FACTORS ON EPIDURAL iii
TABLE OF CONTENTS
Acknowledgements………………………………………………………………………………ii
Abstract…………………………………………………………………………….……………iv
Introduction…………………………………………..…………………………………..……1-7
Research Question……………………………………………………………...…………………1
Research Purpose………………………………………………………………………………..1-2
Background Information………….……………………………………………………….….…2-6
General factors……………………………………………..……………………………3-4
BMI……………………………………………………………………………………..4-5
Hypothesis…………………………………………………………..………………..…6-7
Methodology………………………………..…………………………………………..………8-9
Participants……………….…………………………………………………..……………8
indenttProcedure………………………………………………………………………………..8-9
Results…………………………………………………………..……………………………10-11
Discussion……………………………………………..………..……………………………12-14
indenttLimitations………….……………………………………………………………………14
Conclusion………………………..…………………………………………………….…….…15
Appendix A……………………………………………………………..……………………16-18
Appendix B…………………………………………………………………………..………19-21
THE IMPACT OF FACTORS ON EPIDURAL iv
Appendix C………………….……………………………………………………………….22-25
References………………………………………………………………..…………….……26-27
THE IMPACT OF FACTORS ON EPIDURAL v
ABSTRACT
The purpose of this research is to observe the effects of specific habits, preconceptions,
demographics, and conditions on the outcome of epidurals during labor and delivery. Based on
prior research, it is known that certain lifestyle factors and techniques have an impact on the
effectiveness of epidurals, so this research seeks to make new connections. With the
administration of three surveys, it was expected that results would show trends that negative
connotations and unhealthy habits would lead to ineffective epidurals and more side effects. The
survey to the public shows that although 54% of participants had a positive connotation of
epidurals, 51% had complications. A few main factors had a high correlation with side effects
and failures, such as anxiety and depression. In a variety of cases, failures occurred as the result
of human error. By taking more precautionary measures and ensuring accuracy during
administration, the percentage of failed epidurals- along with epidural complications- can be
reduced.
THE IMPACT OF FACTORS ON EPIDURAL !1
INTRODUCTION
Research Question
Research Purpose
This study sought to explore the impact of lifestyle choices and demographics on the
effectiveness of epidural anesthesia during labor and delivery through the administration of three
surveys: pre-delivery, post-delivery, and open to the public. Some of the key factors we planned
to consider before delivery included body mass index, unhealthy living habits, history of disease,
age, and ethnicity. Likewise, we also considered and observed the impact of current medications
in use, complications during pregnancy, and the number of previous births prior to the epidural
Unbeknown to the participants, the experiment also focused on patients’ expectations concerning
pain control during labor and delivery, and how these expectations affect patients’ pain
management choices, and in turn, the epidural’s outcome. Epidurals can fail in a multitude of
ways and have multiple side effects. These failures include the following: only working for
certain areas, complete failure, and the necessity to be re-administered (Hermanides, Hollmann,
Stevens, & Lirk, 2012). The most common side effects we planned to discern were hypertension,
hypotension, spinal headache, maternal fever, spinal pain, facial flushing, anxiety, sleeplessness,
neck stiffness, dural puncture, bleeding, bruising, nausea, itching skin, loss of bladder control,
and difficulty breathing (Staehler, 2017). If demographics and lifestyle choices impact the
THE IMPACT OF FACTORS ON EPIDURAL !2
effectiveness of epidural anesthesia during child labor, expectant moms should be warned prior
to labor and coached through the necessary habits for a more seamless delivery.
Background Information
There are a multitude of pain management techniques utilized during labor; these
techniques include narcotics, spinal block, and epidural. Typically administered in child birth,
epidural anesthetic is an injection of a local anesthetic into the space outside the dura mater- the
tough outermost membrane of the brain and spinal cord in the lower back region- to produce loss
of sensation, especially in the abdomen or pelvic region. While an epidural is the most common
type, it can easily fail. Arendt and Segal (2017) qualify a failure as when the “catheter is not sited
within the epidural space correctly, the patient’s neuraxial anatomy is problematic, or a patient’s
labor progresses more quickly than expected by the anesthesiologist, and the epidural block does
not set up on time.” More plainly, these failures include the following: insufficient analgesia,
temporary paralysis, and dislodgment (Hermanides et al., 2012). In this case, insufficient
analgesia qualifies as both complete failure and failure only in certain areas. Additionally,
dislodgment requires the necessity to be re-administered. Arendt and Segal (2017) cited the study
that claimed, “the most comprehensive review of obstetric neuraxial failures is a retrospective
In addition to failures, there are many possible side effects. The most common side
effects of an epidural are hypertension, hypotension, spinal headache, maternal fever, spinal pain,
facial flushing, anxiety, sleeplessness, neck stiffness, dural puncture, bleeding, bruising, nausea,
itching skin, loss of bladder control, and difficulty breathing (Staehler, 2017). A common theme
THE IMPACT OF FACTORS ON EPIDURAL !3
evident throughout our research was that epidural failure and epidural side effects can be traced
Epidural analgesia is known to be the most effective method of pain management during
child labor. While it is so commonly used, it has many drawbacks that mothers have to consider
before committing to the procedure. To reiterate, these downsides include things such as
hypotension, headaches, and dural puncture. Additionally— although only in very rare
occurrences— permanent morbidity and mortality have also been observed as negative results of
an epidural.
Researchers concluded that the overall downfalls that warrant consideration regarding the
topic of epidural versus no epidural include the following: more operative intervention, longer
labor process, and an increase in cost (Avard & Nimrod, 1985). One study was performed to
observe risk factors for failed epidural analgesia and to study postpartum effects after failure. Of
the 414 women who participated, 8.5% experienced a failed epidural analgesia (Bucstain et al.,
2017). Knowledge of the risk of failure rate, risk factors, and the post-delivery effects of failed
epidural analgesia could potentially improve mothers’ awareness and labor management choices.
General factors
administration and maternal fever during labor. Additionally, after observing oxytocin use,
seniority of the anesthesiologist, and fetal head station, researchers concluded that both higher
fetal head station and oxytocin- a drug used to stimulate labor- use may correlate with high
failure rates. On the other hand, outcomes after delivery did not correlate with second-stage
THE IMPACT OF FACTORS ON EPIDURAL !4
duration and operative vaginal delivery rate and success or failure rate of the epidural (Bucstain,
2017).
depth from skin to epidural space before the epidural technique could decrease the rate of failed
epidural analgesia before labor. According to the results, the ultrasound group had fewer failed
epidural replacements and placement attempts than the control group (Vallejo, Phelps, Singh,
Orebaugh, & Sah, 2010). Upon conclusion, researchers determined the ultrasound measurement
of the epidural space depth before epidural placement technique before delivery does, in fact,
decrease the need for epidural catheter replacement after a failed labor analgesia in labor. At the
same time, the measurement also reduces the number of attempts of epidural administration by
BMI
One recurring lifestyle factor that has a tendency to increase the epidural failure rate is
body mass index (BMI), and thus, obesity. In a study that took place at an inner-city teaching
hospital, 2,048 women who were set to receive an epidural for labor were observed. This study
was conducted in the hopes of finding a link between the increasing of body mass index as
related to epidural failure and difficulty. It was discovered that, in most cases, patients with a
higher body mass index were more likely to experience epidural failure and difficulty (Kula,
Riess, & Ellinas, 2017). There were also apparent correlations with higher body mass index and
prolonged discovery of epidural failure. This experiment demonstrated the relationship between
obesity and issues related to epidurals, as well as served as an advisory for practitioners to plan
THE IMPACT OF FACTORS ON EPIDURAL !5
to spend extra time whilst dealing with a patient who has a high body mass index that is
receiving an epidural.
high failure rate. Epidurals are performed in a multitude of surgeries, not solely labor and
delivery. In addition to studies focused on labor, research has been performed regarding epidurals
in other procedures. One study was directed at the debate regarding how often the procedure
should be performed for credibility to be maintained. Prior to the study, researchers hypothesized
that an increase in procedure frequency would have a positive correlation with the success of the
procedure. While not focused on labor, this study was conducted on patients undergoing intra-
After a total of 881 epidurals preformed over the course of the study, it was concluded that there
were no obvious correlations between procedure frequency and success rate; however, parallels
could be drawn between the success of epidurals and institutional factors such as the experience
Factors such as permanency of physicians, body mass index, fetal head station,
ultrasounds, and oxytocin use have already been scientifically proven to have an impact on the
effectiveness, or lack thereof, of an epidural during both fetal delivery and miscellaneous
surgeries. Although studies have not yet been done regarding life style factors such as drinking,
smoking, and medication usage, studies and their effect on epidurals, the effects of these factors
Approximately 10% of women reported smoking during the last 3 months of pregnancy.
Of women who smoked 3 months before pregnancy, 55% quit during pregnancy. Among
women who quit smoking during pregnancy, 40% started smoking again within 6 months
Smoking during pregnancy can inflict: a higher chance for miscarriage, placenta
problems, low birth weight, prematurity, Sudden Infant Death Syndrome, and birth defects
(Centers for Disease Control, 2017). In addition, drinking during pregnancy has proven to have
Drinking alcohol during pregnancy can cause miscarriage, stillbirth, and a range of
lifelong physical, behavioral, and intellectual disabilities. These disabilities are known as
The effects of drug usage during pregnancy have also been observed and were proven to be
counter) drugs or use social drugs (such as tobacco and alcohol) or illicit drugs at some
time during pregnancy, and use of drugs during pregnancy is increasing. About 2 to 3%
of all birth defects result from drugs that are taken to treat a disorder or symptom (Merek
Hypothesis
Based on the research above, many factors contribute to failed epidural analgesia. The
impact on epidural success in relation to factors we studied, such as history of disease, age, race,
ethnicity, and patients’ expectations concerning pain control during labor and delivery and how it
THE IMPACT OF FACTORS ON EPIDURAL !7
affects their pain management choices had not previously been determined. Lifestyle factors,
epidural administered during child labor. We hoped to prove unhealthy habits and negative
METHODOLOGY
Participants
Our study was partially conducted at St. Thomas Rutherford Hospital in Murfreesboro,
Tennessee and consisted of women in labor. Each expectant woman who entered the hospital
during the duration of our study was asked by their nurse to participate, and if they agreed, they
were given a pre-delivery survey to fill out. Every woman entering labor and delivery was
requested to participate, and surveys regarding all methods of pain management were collected;
however, data was only used from those who received an epidural as their method of pain
management. Data was collected in order to observe the correlation between both age and
ethnicity factors. Any given woman could come across the survey, as each nurse of Dr.
McKnight offered it to every patient. Since being a woman who had received an epidural in the
past was the only criteria, women from all age groups, ethnicities, and socioeconomic levels
were involved.
To expand upon this, our second group of participants consisted of any woman who had
received an epidural in the past and was willing to participate in our study. These women were
randomly selected, as anyone who came across the survey- via social media, word of mouth, or
Procedure
effectiveness of epidurals during childbirth, we administered three surveys. The first survey was
administered to pregnant women immediately prior to labor. The second was filled out by the
same women prior to discharge. In order to distribute the surveys, each nurse handed the patient
THE IMPACT OF FACTORS ON EPIDURAL !9
participate, the pre-delivery survey was handed out by paper copy, each containing a unique
number. The pre-delivery survey contained demographic questions including: age range, BMI,
medical history, complications during surgery, knowledge about epidurals, and details regarding
previous births. This survey can be found in Appendix A. The post-delivery survey, in Appendix
B, was administered online and linked to the first by filling out the corresponding number. The
delivery, method of pain management, the length of delivery, and if applicable, how far along the
patient was when she received the epidural and post-epidural side effects. During the first and
second surveys, a nurse who was aware of the research process was present to help and answer
any questions regarding the survey. The nurse also filled out the BMI for each patient on the pre-
The third survey was administered through word of mouth, social media, and email. We
asked parents, teachers, and friends to distribute the survey in any way they could. It was
distributed to as many people as possible, yet only answered by women who had an epidural in
the past. It was intended to gain more results, as well as to observe patterns. Questions included
age when the participant gave birth, methods of delivery, complications with pregnancy,
complications with the epidural, number of births, the length of the delivery process, et cetera.
RESULTS
35%
54%
11%
No Complications Complications
49% 51%
THE IMPACT OF FACTORS ON EPIDURAL !11
ineffective epidural. An ineffective epidural was categorized as not “taking” completely, not
“taking” at all, or not working in time. Additionally, nearly 17% of the participants who
experienced complications experienced slowed labor. The additional 21% with complications
DISCUSSION
Some of the most prominent complications we found from our study were epidurals
resulting in the slowed progression of labor and epidurals being ineffective as a pain treatment
intervention. While the majority of participants indicated that they had either a positive
connotation of epidurals or didn’t have any connotation at all, we did notice nearly all of the
participants who selected that they had a “negative connotation” of epidurals pre-delivery
experienced some form of epidural failure. This being said, we suspect that people who chose to
respond to our survey may have done so because of their suboptimal experience. People who are
happy with their results don’t have an ax to grind, and thus, may be less likely to respond to a
survey such as this. For example, one woman pushed for three hours and still has urinary
incontinence twelve years later. She blames the epidural for this issue; however, her urinary
incontinence is probably “stress urinary incontinence,” which virtually every woman who has
had a vaginal birth experiences to some degree. This complication is not related to her epidural,
but it does go along with our suspicion that women who are less satisfied with their epidural
We found that patients with a past or present history of anxiety and/or depression were
more apt to experience slowed progression. In addition, we found that women who reportedly
had a history of smoking and/or drinking experienced a multitude of epidural failures including,
but not limited to, slowed labor and/or ineffectiveness of epidural. In one case of smoking and
drinking abuse, a woman experienced temporary paralysis for a day and half and extreme
Nearly half of our participants selected one or more side effect(s) that they experienced
within twenty-four hours of receiving their epidural. Some of the most present side effects we
saw were the following: nausea (27%), itching skin (24.2%), spinal headache (20.7%), and fetal
distress (16.4%).
Multiple women experienced epidurals that did not “take,” requiring repetitions of
administration or feeling the entire delivery, as well as epidurals only taking on one side. Often
times, the epidural caused the inability to push, which in turn, resulted in the necessity for
delivery by forceps or vacuum. Further, we noticed a few unusual failures of epidurals. One
woman explained that she experienced a bad epidural, wherein the epidural went to her brain
instead of legs. This participant had a multitude of factors that we looked into including:
diabetes, older age, history of hypertension, and preeclampsia. Another woman shook
uncontrollably after the epidural wore off. On the other hand, one participant’s epidural wore off
before the baby was delivered, but it was too late to administer again.
Human error also played a role in some of the epidural failures in the instances of incorrect
numbness from the neck down. Another woman’s epidural was done upside down, wherein she
could not feel anything above her legs, but felt everything in her lower body. Additionally, many
of our participants reported misplacement during the administration of their epidurals, resulting
We did not find any significant correlations between ethnicity and effectiveness of
epidural, as 95.7% of our 529 participants were of European descent. Likewise, we also did not
Limitations
One major limitation we faced was the lack of surveys received back from the hospital, so
we did not gather results from either survey A or B. We were able to compensate for this loss
with the numerous responses we received back from our survey open to the public; however, had
we gotten back more responses from our survey administered from the hospital, we would have
CONCLUSION
Of the many pain management techniques used during labor, epidurals are the most
commonly used. While many women experienced epidural side effects and failures, the vast
majority of participants were very pleased with the success and pain relief of their epidurals. Any
method of pain management is bound to have complications, but an improved success rate could
improve connotations. A larger percentage of positive connotations could, in turn, lessen anxiety
If this study were to be redone, it would require more time, as to increase participants. A
larger participation in the hospital surveys would allow for more significant results and more
obvious patterns. More participants in the hospital surveys would have allowed for enough
results to be used; these results are desirable, as they would be more current and exact.
There was, if fact, an impact of lifestyle factors and preconceptions on the effectiveness of
epidurals during labor. Women with negative connotations and unhealthy habits had a lower
success rate with more side effects and complications. Moms who are expecting should be
warned of the side effects and complications prior to labor and delivery and informed of the best
APPENDIX A
1. 18 and under
2. 19-22
3. 23-26
4. 27-30
5. 31-34
6. 35-40
7. 41-45
8. 46+
3. Is there any past or present history of: (Circle all that apply)
1. Anxiety
2. Asthma
3. Cancer
4. Depression
THE IMPACT OF FACTORS ON EPIDURAL !17
5. Diabetes
6. Drinking
7. Drug Use
8. Epilepsy
9. Headaches
11. Hypertension
12. Hypotension
13. Migraines
14. Smoking
1. European descent
2. African descent
3. Hispanic descent
6. Asian descent
7. Other
8. Has a family member or close friend used epidural anesthesia for childbirth?
1. If Yes, was their experience positive or negative? If No, continue on to number 9.
1. If one or more, what were your previous methods of delivery? If none, the
survey is complete.
3. Previous complications:
THE IMPACT OF FACTORS ON EPIDURAL !19
APPENDIX B
Post-Delivery Survey
* Required
Survey Number *
Your answer:
Method of Delivery *
Vaginal Birth
Cesarian Section
Your answer
Please select any of the following that you experienced within 24 hours of receiving your method
of pain management. *
Spinal Headache
Maternal Fever
Spinal Pain
Facial Flushing
Anxiety
THE IMPACT OF FACTORS ON EPIDURAL !20
Bleeding
Bruising
Nausea
Itching Skin
Difficulty Breathing
Fetal Distress
Sleeplessness
Positive
Negative
Neither
THE IMPACT OF FACTORS ON EPIDURAL !21
Your answer:
Natural Birth
Epidural
Narcotics
Spinal Block
Other
How far along were you when the epidural was administered? (Answer in centimeters of
dilation.)
Your answer:
Your answer:
Your answer:
THE IMPACT OF FACTORS ON EPIDURAL !22
APPENDIX C
Our names are Ally Pinson and Marley Robison, and we are seniors at Central Magnet School.
As a partial fulfillment of the requirements for graduation, we are completing a senior thesis. If
you are a woman who has had an epidural in the past, we would really appreciate it if you could
fill out our anonymous survey. Thank you!
* Required
Ethnicity *
African descent
Asian descent
European descent
Hispanic descent
Other:
Number of births *
Your answer:
Method of deliveries: *
Vaginal birth
Cesarian Section
Both
THE IMPACT OF FACTORS ON EPIDURAL !23
Your answer:
Your answer:
At the time of your epidural, was there any past or present history of: *
Anxiety
Asthma
Cancer
Depression
Diabetes
Drinking
Drug Use
Epilepsy
Headaches
Heart Disease
Hypertension
Hypotension
Migraines
Smoking
THE IMPACT OF FACTORS ON EPIDURAL !24
Please select any of the following that you experienced within 24 hours of receiving your
epidural.*
Spinal headache
Maternal fever
Spinal Pain
Facial flushing
Anxiety
Sleeplessness
Bleeding
Bruising
Nausea
Itching Skin
Difficulty breathing
Fetal distress
THE IMPACT OF FACTORS ON EPIDURAL !25
Were you taking any medications at the time of epidural? (List if possible) *
Your answer:
Did you have a positive or negative connotation of epidurals before you had your first? *
Positive
Negative
Neither
Your answer:
Your answer:
THE IMPACT OF FACTORS ON EPIDURAL !26
REFERENCES
Arendt, K., MD, & Segal, S., MD. (2008). Why Epidurals Do Not Always Work. Retrieved
Avard, D. M., & Nimrod, C. M. (1985). Risks and benefits of obstetric epidural analgesia: a
Bucstain, C., Garmi, G., Zafran, N., Zuarez-Easton, S., Carmeli, J., & Salim, R. (2017). Risk
factors and peripartum outcomes of failed epidural: a prospective cohort study. Archives
Drug Use During Pregnancy - Women's Health Issues. (2017). Retrieved September 28, 2017,
from http://www.merckmanuals.com/home/women-s-health-issues/drug-use-during-
pregnancy/drug-use-during-pregnancy
Fetal Alcohol Spectrum Disorders (FASDs). (2016, July 21). Retrieved September 28, 2017,
from https://www.cdc.gov/ncbddd/fasd/alcohol-use.html
Heinink, T. P., Baker, B. G., Yates, V. F., Addison, D. C., & Williams, J. P. (2015). The effect of
10.1186/1471-2253-15-5
Hermanides, J., Hollmann, M. W., Stevens, M. F., & Lirk, P. (2012). Failed epidural: causes and
epidural-causes-and-management
THE IMPACT OF FACTORS ON EPIDURAL !27
Kula, A. O., Riess, M. L., & Ellinas, E. H. (2017). Increasing body mass index predicts
increasing difficulty, failure rate, and time to discovery of failure of epidural anesthesia in
Staehler, R. A., MD. (2017). Epidural Steroid Injections: Risks and Side Effects. Retrieved
steroid-injections-risks-and-side-effects
Tobacco Use and Pregnancy. (2016, July 20). Retrieved September 28, 2017, from https://
www.cdc.gov/reproductivehealth/maternalinfanthealth/tobaccousepregnancy/index.htm
Vallejo, M., Phelps, A., Singh, S., Orebaugh, S., & Sah, N. (2010). Original Article: Ultrasound
decreases the failed labor epidural rate in resident trainees. International Journal Of