Aloe Vera (1) More Than Skin Care, Discover 9/ 28 Hidden Health Benefits That You Always Want To Know, According To Medical Literature

Aloe Vera(1)More Than Skin Care, Discover 9/ 28 Hidden Health Benefits
That You Always Want to Know, According to Medical Literature
By Kyle J. Norton
Aloe Vera is species of succulent plant in the genus Aloe, belongings to the
Family Xanthorrhoeaceae, native to Sudan.
The herb has become very popular for commercial cultivation due to its health
benefits.
Aloe vera has been used in herbal medicine in treating many kinds of disease,
including wound, burn healing, minor skin infections, sebaceous cysts,
diabetes, and elevated of cholesterol,...
It is also one of many popular herb studied in scientific ways with some
conflicted results.
The Ingredients
The ten main areas of chemical constituents of Aloe vera include: amino acids,
anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide,
polysaccharides, salicylic acid, saponins, and sterols.
1.
Diabetes is defined as a condition caused by insufficient insulin entering the
bloodstream to regulate the glucose. It is either caused by cells in pancreas
dying off or receptor sites clogged up by fat and cholesterol. In some cases,
diabetes is also caused by allergic reactions of cells in the immune system.
Many herbs have been proven in studies to be effective in treating type II

diabetes, including Aloe vera.
As a popular herbal remedy in the United Kingdom, oral administration of aloe

vera might be a useful adjunct for lowering blood glucose in diabetic patients
as well as for reducing blood lipid levels in patients with hyperlipidaemia.
In other study of Aloe vera gel in a mouse model of non-insulin-dependent

diabetes mellitus, Oral administration of PAG for 8 weeks was found to reduce
circulating blood glucose concentrations to a normal level in these DIO mice.
Its leaf is also found to be useful in treating diabetes, as study said A. vera leaf
pulp extract showed hypoglycaemic activity on type I (IDDM) and type II
(NIDDM) diabetic rats, the effectiveness being enhanced for type II diabetes in
comparison with glibenclamide. On the contrary, A. vera leaf gel extract
showed hyperglycaemic activity on NIDDM rats.
2. Ance vulgaris
Ance vulgaris, one of skin diseases with areas of scaly red skin with seborrhea,
blackheads and whiteheads. Aloe vera one of many herbs has been studied and
researched in pharmaceutical world, because of its common problem to the
young ages and commercial profits.
The study to compare the efficacy and safety of the combination of tretinoin
(TR) cream (0.05%) and Aloe vera topical gel (50%) with TR and vehicle, has
been well tolerated and significantly more effective than TR and vehicle for the
treatment of mild to moderate acne vulgaris and with less side effects.
Other researchers in the observation of traditional medicines of many cultures

used to treat skin diseases, indicated that certain ingredients, including aloe
vera, have been identified in the treatment of psoriasis and atopic dermatitis.
3. Gastric Ulcers
Gastric ulcers is defined as a condition of a localized tissue erosion in the lining
the stomach. as a result of bacteria Helicobacter pylori (H pylori) in most cases.
Some people with gastric ulcers may be not experience any symptoms at all,
while others may have burning pain, severe nausea, and vomiting.
In the comparison of the effects of Aloe vera and sucralfate on gastric

microcirculatory changes, cytokine levels and gastric ulcer healing, treatment
of Aloe vera found to reduce leukocyte adherence and TNF-alpha level, elevate
IL-10 level and promote gastric ulcer healing.
Because of its Anti-inflammatory effects, treatment of A. vera process the

enhancement in leukocyte-endothelium interaction are associated with
reduction in TNF-alpha level.
Other in the study of acute gastric mucosal lesions induced by 0.6 M HCl and
acid outpu, indicated that Aloe vera is endowed with gastric acid anti-secretory
activity and could protect the gastric mucosa at low concentrations against
injurious agents.
Another component of Aloe vera, the Polymer fraction (Avpf; molecular weight
cut-off ≥50 kDa; 150 mg/kg body weight, p.o.), reduce 50% of the mRNA
expressions of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide
synthase (nNOS), according to the study.
4. Cancers
Cancer is a class of diseases in which a group of cells growing and multiplying
disordered and uncontrollable way in our body, have become progressively
worse and damaged other healthy tissues, sometimes spreads to other organs in
the body via lymph or blood and results may be in death.
Aloe-Emodi, a chemical compound found in Aloe vera, specifically suppress

breast cancer cell proliferation by targeting ER α protein stability through
distinct mechanisms and may be used as a possible application of
anthraquinones in preventing or treating breast cancer in the future.
Also in other study, Aloe-Emodi is considered as a potential value for the

treatment of gastric cancer and cervical cancer because of its mechanisms are
by means of cell cycle interruption and induce differentiation and suppressed
the expression of PKCalpha and c-myc.
Radiotherapy are most often used to treat head and neck cancer patients. Ina
study ofAloe Vera, Dr. Ahmadi A. found that oral Aloe vera mouthwash may
not only prevent radiation-induced mucositis, but also may reduce oral
candidiasis of patients undergoing head and neck radiotherapy due to its
antifungal and immunomodulatory properties.
5. Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by
undeveloped follicles clumping on the ovaries that interferes with the function
of the normal ovaries as resulting of enlarged ovaries, leading to hormone
imbalance( excessive androgen), resulting in male pattern hair development,
acne,irregular period or absence of period, weight gain and effecting fertility. It
effects over 5% of women population or 1 in 20 women. According to the study
by Desai BN, Maharjan RH, Nampoothiri LP. almost 70% PCOS women have
abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese.
Several classes of pharmacological agents have been used to manage
dyslipidemia. However, studies have shown adverse effects associated with
these drugs.
Aloe Vera may be a potential herb in treating Polycystic Ovarian Syndrome by
enhancing the reductions of plasma triglyceride and LDL cholesterol levels,
with an increase in HDL cholesterol or by restoring the ovarian steroid status.
According to the study of PCOS was induced in Charles Foster female rats by
oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg
body weight, 21 days), AVG treated PCOS rats exhibited significant reduction
in plasma triglyceride and LDL cholesterol levels, with an increase in HDL
cholesterol.
The gel treatment also caused reversion of abnormal estrous cyclicity, glucose
intolerance, and lipid metabolizing enzyme activities, bringing them to normal.
Other study also indicated that Aloe vera gel formulation exerts a protective
effect in against the PCOS phenotype by restoring the ovarian steroid status,
and altering key steroidogenic activity.
This can be attributed to phyto-components present in the extract.
Dr.Pérez YY and the research team in the study of Effect of a polyphenol-rich

extract from Aloe vera gel on experimentally induced insulin resistance in mice
also indicated that decreasing significantly both body weight (p < 0.008) and
blood glucose levels of Aloe, calculated using the homeostasis model
assessment for insulin resistance (HOMA-IR) formula by the polyphenol-rich
extract from Aloe vera.
Also in the confirmation of above result, study of Aloe vera leaves on blood
glucose level in type I and type II diabetic rat models, vera leaf pulp extract
showed hypoglycaemic activity on IDDM and NIDDM rats, the effectiveness
being enhanced for type II diabetes in comparison with glibenclamide. On the
contrary,
A. vera leaf gel extract showed hyperglycaemic activity on NIDDM rats. It may
therefore be concluded that the pulps of Aloe vera leaves devoid of the gel
could be useful in the treatment of non-insulin dependent diabetes mellitus.
Where non-diabetic (ND), type I (IDDM) and type II (NIDDM) diabetic rats.
6. Gingivitis
Gingivitis is defined as a condition of Inflammation of Gum Diseases.
Aloe Vera anti-inflammatory property may be the result of the plant used in
treatment of gum diseases. In the sudy of 45 patients who were diagnosed with
plaque-induced gingivitis were included, aloe mouth wash is proven to be the
most potential in reduction in gingival inflammation caused by plagues.
Other in the the randomized, controlled, and double-blind study, a total of 148
systemically healthy subjects, showed statistically significant decrease in PI,
MGI, and BI scores after the rinse regimen began in comparison with the use of
chlorhexidine.
But Dr. de Oliveira SM, and the research team in comparison of Aloe vera and
fluoridated dentifrice, found that here was a significant reduction on plaque and
gingivitis in both groups, but no statistically significant difference was
observed among them (p>0.01), Aloe vera did not show any additional effect
on plaque and gingivitis control compared to the fluoridated dentifrice.
7. Psoriasis
Psoriasis is defined as chronic condition of inflammatory skin disease, affecting
the joins and mostly happens to people who are obese are predisposed to
diabetes and heart disease.
Many herbal extracts have been used as topical management of plaque

psoriasis, including Aloe vera based on multiple studies.
Aloe vera gel is used in alternative medicine over the century for the treatment
of skin diseases, including psoriasis, and recent study showed that ethanolic
extract of Aloe vera leaf gel also produced a significant increase in relative
epidermal thickness and an overall antipsoriatic activity of high effective rate.
Other in the comparison of comparion to evaluate the efficacy of Topical aloe

vera (AV) and 0.1% triamcinolone acetonide (TA) in mild to moderate plaque
psoriasis, AV cream may be more effective than 0.1% TA cream found to be
more effective in reducing the clinical symptoms of psoriasis.
Unfortunately, in diverse dermatologic conditions, even though there are some

promising results with the use of aloe vera, but clinical effectiveness of oral and
topical aloe vera may require further studies, according to the study of Dr. Feily
A, and Dr. Namazi MR.
8. Irritable bowel syndrome

Irritable bowel syndrome is defined as a condition, if a patient is diagnosed
with abdominal pain or discomfort, bloating, and alteration of bowel habits at
least three times a month for the last 3 months without preexistence of other
disease.
Aloe vera (AV) has long been suggested by herbal medicine in treating irritable
bowel syndrome (IBS) symptoms. In the comparison of the effectiveness of a
mixture of Aloe vera (AV) and Matricaria recutita (German chamomile, GC) in
treating Irritable bowel syndrome, GC inhibited only small bowel transit while
the AV/GC mixture delayed gastric emptying at the doses of 150 and 300
mg/kg.
The AV/GC mixture also reduced colonic transit and small bowel transit at the
dose of 150 mg/kg. In other randomised double-blind placebo-controlled trial
of to test the effects of aloe vera for irritable bowel syndrome, there was no
evidence that AV benefits patients with IBS and superior to placebo in
improving quality of life proven Irritable Bowel Syndrome patients, but in 49
completed the protocol to 1 month and 41 to 3 months.
Eleven of thirty-one (35%) AV patients, and 6 of 27 (22%) placebo patients

responded at 1 month (p = 0.763). Diarrhoea predominant patients showed a
trend towards a response to treatment at 1 month (10/23 V 2/14, p = 0.07).
9. Skin diseases
Skin diseases is defined as a condition of skin damage and classified according
to each pathogenic causes of diseases.
In the a systematic review of Aloe vera's clinical effectiveness, topical

application of aloe vera is not an effective preventative for radiation-induced
skin injuries, but might be effective for genital herpes and psoriasis.
In support to above, study by Feily A, Namazi MR. indicated that Topical

application of aloe vera is not an effective in sunburn or suntan protection, but
might be effective in treating genital herpes, psoriasis, human papilloma virus,
seborrheic dermatitis, aphthous stomatitis, xerosis, lichen planus, frostbite,
burn, wound healing and inflammation.
Reference can be found at
References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a
letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude
Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(3) Aloe vera: a systematic review of its clinical effectiveness. by Vogler BK,
Ernst E.(PubMed)
(4) Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a
mouse model of non-insulin-dependent diabetes mellitus. by Kim K, Kim H,
Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee
CK, Kim K.(PubMed)
(5) Effect of Aloe vera leaves on blood glucose level in type I and type II
diabetic rat models.
Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N.(PubMed)(7) Oral aloe vera-
induced hepatitis(PubMed)
(8) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month
double blind placebo-controlled study(PubMed)(1) Aloe barbadensis Mill.
formulation restores lipid profile to normal in a letrozole-induced polycystic
ovarian syndrome rat Model (PubMed)
(3) Effect of Aloe vera topical gel combined with tretinoin in treatment of mild
and moderate acne vulgaris: a randomized, double-blind, prospective trial. by
Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A.(PubMed)
(10) Innovations in natural ingredients and their use in skin care. by Fowler JF
Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)
(11) Oral aloe vera-induced hepatitis(PubMed)
double blind placebo-controlled study(PubMed)
(15) Effects of Aloe vera and sucralfate on gastric microcirculatory changes,
cytokine levels and gastric ulcer healing in rats, by Eamlamnam K, Patumraj S,
Visedopas N, Thong-Ngam D.(PubMed)
(16) Anti-inflammatory effects of Aloe vera on leukocyte-endothelium
interaction in the gastric microcirculation of Helicobacter pylori-infected rats
by Prabjone R, Thong-Ngam D, Wisedopas N, Chatsuwan T, Patumraj S.
(PubMed)
(17) The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and
acute gastric mucosal injury in rats by Yusuf S, Agunu A, Diana M.(PubMed)
(18) Polymer fraction of Aloe vera exhibits a protective activity on ethanol-
induced gastric lesions.
Park CH, Nam DY, Son HU, Lee SR, Lee HJ, Heo JC, Cha TY, Baek JH, Lee
SH.(PubMed)
(21) Potential prevention: Aloe vera mouthwash may reduce radiation-induced
oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(22) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation
through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(23) Growth inhibitory effects of gastric cancer cells with an increase in S
phase and alkaline phosphatase activity repression by aloe-emodin. by Guo J,
Xiao B, Zhang S, Liu D, Liao Y, Sun Q.(PubMed)
(24) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M
arrest and induction of differentiation. by Guo JM, Xiao BX, Liu Q, Zhang S,
Liu DH, Gong ZH.(PubMed)
(29) Effect of Aloe barbadensis Mill. formulation on Letrozole induced
polycystic ovarian syndrome rat model (PubMed)
(30) Effect of a polyphenol-rich extract from Aloe vera gel on experimentally
induced insulin resistance in mice (PubMed)
(35) Aloe vera: It's effect on gingivitis by Ajmera N, Chatterjee A, Goyal V.
(PubMed)
(36) A randomized, double-blind clinical study to assess the antiplaque and
antigingivitis efficacy of Aloe vera mouth rinse by Chandrahas B, Jayakumar
A, Naveen A, Butchibabu K, Reddy PK, Muralikrishna T.(PubMed)
(37) Effect of a dentifrice containing Aloe vera on plaque and gingivitis control.
A double-blind clinical study in humans by de Oliveira SM, Torres TC, Pereira
SL, Mota OM, Carlos MX.(PubMed)(38) Aloe barbadensis Mill. formulation
restores lipid profile to normal in a letrozole-induced polycystic ovarian
syndrome rat Model (PubMed)
(40) Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a
mouse tail model of psoriasis.
Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R.
(PubMed)
(41)A prospective, randomized clinical trial comparing topical aloe vera with
0.1% triamcinolone acetonide in mild to moderate plaque psoriasis by
Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P.(PubMed)
(42) Aloe vera in dermatology: a brief review by Feily A, Namazi MR.
(PubMed)
(47) Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel
syndrome: Combination of antioxidant and spasmolytic effects by Asadi-
Shahmirzadi A, Mozaffari S, Sanei Y, Baeeri M, Hajiaghaee R, Monsef-
Esfahani HR, Abdollahi M.(PubMed)
(48) Randomised double-blind placebo-controlled trial of aloe vera for irritable
bowel syndrome.
Davis K, Philpott S, Kumar D, Mendall M.(PubMed)
(49) A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in
Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life by
Hutchings HA, Wareham K, Baxter JN, Atherton P, Kingham JG, Duane P,
Thomas L, Thomas M, Ch'ng CL, Williams JG.(PubMed)(7) Oral aloe vera-
induced hepatitis(PubMed)
(54) Aloe vera: a systematic review of its clinical effectiveness by Vogler BK,
Ernst E. (PubMed)
(55) Aloe vera in dermatology: a brief review. by Feily A, Namazi MR
(PubMed).

Aloe Vera (1) More Than Skin Care, Discover 9/ 28 Hidden Health Benefits That You Always Want To Know, According To Medical Literature

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Aloe Vera (1) More Than Skin Care, Discover 9/ 28 Hidden Health Benefits That You Always Want To Know, According To Medical Literature

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Drepturi de autor:

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Aloe Vera(1)More Than Skin Care, Discover 9/ 28 Hidden Health Benefits

That You Always Want to Know, According to Medical Literature

Many herbs have been proven in studies to be effective in treating type II

As a popular herbal remedy in the United Kingdom, oral administration of aloe

In other study of Aloe vera gel in a mouse model of non-insulin-dependent

Other researchers in the observation of traditional medicines of many cultures

In the comparison of the effects of Aloe vera and sucralfate on gastric

Because of its Anti-inflammatory effects, treatment of A. vera process the

Aloe-Emodi, a chemical compound found in Aloe vera, specifically suppress

Also in other study, Aloe-Emodi is considered as a potential value for the

5. Polycystic Ovarian Syndrome

This can be attributed to phyto-components present in the extract.

Dr.Pérez YY and the research team in the study of Effect of a polyphenol-rich

Many herbal extracts have been used as topical management of plaque

Other in the comparison of comparion to evaluate the efficacy of Topical aloe

Unfortunately, in diverse dermatologic conditions, even though there are some

8. Irritable bowel syndrome

Eleven of thirty-one (35%) AV patients, and 6 of 27 (22%) placebo patients

In the a systematic review of Aloe vera's clinical effectiveness, topical

In support to above, study by Feily A, Namazi MR. indicated that Topical

Reference can be found at

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