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Cancer doctors tend to get to their profession in one of three ways. Some are drawn in
through their love of cancer science. Cancer has always been something like a cobra to
those who study it: dangerous and beautiful and endlessly fascinating. Cancer is a
universe. One can spend an entire life exploring it without ever getting bored, for the
biology of cancer is the biology of life.
Some doctors are inspired by a great teacher. Medicine is still a profession dominated
by old-world apprenticeships, where a mentor’s passion can be transmitted to a new
generation. I have known several oncologists whose careers turned on chance
encounters with inspiring professors.
Others get there by way of their patients. I’m one of these. When I was a resident,
cancer patients were the ones who touched my heart. In fact, I can remember the very
moment I started my path to becoming an oncologist.
I was an intern at St. Louis University, a brand-new doctor, with my white coat still fresh
and creased, when I first met Carmelita Steele. Carmelita was in her early twenties,
married, with (as I recall) two young children. She came to our hospital as a transfer in
the middle of the night. She had undergone a routine dental procedure, and after her
surgery had first oozed, and then gushed blood. By the time she got to us she was
severely anemic, and had a low platelet count. There was a very real concern in those Commented [OD2]: Relating to anemia: condition of
first few hours that she would bleed to death. having less than normal count of red blood cells and
hemoglobin in blood.
We worked through the night stabilizing her. Her veins were hard to access–they had all
been used up during her time at the other hospital. In those days (the late 1970's) we Commented [OD3]: An irregular blood component that
assists in blood clotting.
lacked modern venous access devices, and I remember it taking a frighteningly long
time establishing an intravenous line. Through it all I spoke to Carmie, who was a Commented [OD4]: (IV): tube attached to body to
cheerful if appropriately anxious African-American woman, somewhat overweight, proud transport medications, fluids, and nutrients.
of her children and her loving family. We poured several units of blood into her that
night, bringing her back from the brink.
We spent the next couple of days establishing a diagnosis. She had Acute
Myelogenous Leukemia, then as now a dangerous disease requiring toxic Commented [OD5]: (AML): rapid spreading cancer of bone
chemotherapy to clear the blood and bone marrow of treacherous cells. I learned the marrow and influences many other body parts including
lymph nodes, liver, spleen, and the brain.
diagnosis shortly after morning rounds. Her staff doctor, an elderly hematologist (or so
he seemed then, though I am now about his age) would, I discovered, be off campus
until the following morning. I knew that Carmie and her family were desperate for news,
so I phoned the staff physician and asked if it was OK for me to speak to her. He
agreed.
I had never told a patient that he or she had cancer before. I sat on the edge of her bed
and told her that she had a type of leukemia, that it was very dangerous but that it was
potentially curable with chemotherapy. I told her that we would be starting treatment the
following morning, as soon as her staff physician had a chance to go over the drug
regimen with her.
Carmelita had sat quietly while I spoke, a sad look on her face. When I was through she
said, almost in a whisper, "Doctor Sledge, who will take care of my children?"
It was the last thing I was expecting, and it was thoroughly devastating. I did not know
how to answer. Today I hope I would do better, but at the time I was in my mid-twenties,
just a few years older than Carmie, and I did not know how to answer that question. I
stammered something, barely maintaining my composure, and then left her room and
hid in a stairwell for a half an hour sobbing.
The next day we started her chemotherapy regimen, full of hope. I spoke to her
regularly, and to her family. Her husband, a quiet decent man, stood by looking worried.
Her mother, a medical technician who understood leukemia, rarely left her daughter's
bedside. They were the sort of family we all should have.
For several days things went well. Then, as her blood counts plummeted in response to
the chemotherapy, she developed an infection in the area of her intravenous line,
followed by sepsis. Her blood pressure dropped, and her breathing became rapid and Commented [OD6]: Infection that develops when the
labored. She was transferred to the intensive care unit, intubated, and treated with chemicals the immune system releases into the
bloodstream to fight an infection cause inflammation
broad-spectrum antibiotics. Sometime in the middle of the night, disoriented and alone, throughout the entire body instead.
she pulled the breathing tube out of her mouth. Though she was quickly re-intubated,
things rapidly went from bad to worse, and she died the following day.
I went home that night in a furiously angry mood. I was supposed to be going out with
my girlfriend, but in my grief and guilt I simply could not think straight or act civil, so I
begged off. I relived every moment of her care: what had I missed, what could I have
done differently, what foul-up had I committed that kept a 22 year-old from taking care
of her young children? It is the arrogance of interns that they believe that acute
leukemia would turn out differently if only they had gotten a little more sleep. Commented [OD7]: Highlights important idea that some
A few weeks later I got a call from Carmelita's mother. She wanted to meet with me. I cases are out of the hands of the doctor.
agreed, with real trepidation. The wound was still too raw, and there was part of me that
feared she might hold me responsible for her daughter's passing.
But she was as gracious as I could ever have imagined. I have three sons, all in their
twenties, and if one of them died of leukemia I do not know how I would handle it.
Poorly, I suspect. But she was dignified, pleasant and grateful. She told me that Carmie,
before she had died, had told her that, come what may, she wanted to give me a gift to
thank me for my care, and for the hours I had spent with her. She then handed me $40
and told me I was to spend it on something fun. Carmie had wanted it that way.
My patients, starting with Carmelita Steele, have taught me so much about what it
means to be a good doctor and, I hope, a good person. I am an oncologist because of
her, and it is a job I have loved for three decades. But Carmelita's question still haunts
me: "who will take care of my children?"
There are some debts you can never repay.