OSPE -2008

1. Four test tubes given with 4 different levels of fat. How would a specimen of a person’s serum
look after a fatty meal?

ANS: One with the highest level

2. Slide of MI. What risk factors are associated with this condition? What will be the histological
change after 3 days?

3. Jar: Mitral Stenosis. What is the clinical feature most likely to be associated with this condition?

4. Specimen of Ascaris Lumbricoides. What is the treatment?

5. What drug would u give to a pregnant woman who has tachycardia, HTN and fever?
(Tetracycline, Ceftriaxone)

6. Diagram of a gastric cell. What is an example of a Proton Pump Inhibitor and what is the
mechanism of action of H2 antagonist?

7. Type 1 Hypersensitivity – flow chart. What are the mediators?

8. What disease is associated with hyper segmented neutrophils and ecchinocytes?

9. X – Ray: Pneumothorax

10. X – Ray: Breast. What is the lump: fibroadenoma, lymphoma, carcinoma?

11. Identify: Ink stain of Cryptococcus neoformans.

12. Treatment for the above

13 Bee sting diagram showing allergic rxn with IgE etc. Patient given a small dose of sting venom
several times. What change are they trying to achieve?

(a) Mast Cell -> Basophil

(b) TH2 -> TH1

(c) TH1 -> TH2

14. Urine Dipstick test for a 16 yr old male:

+ve Ketones, +ve Glucose, +ve Protein

(Diabetic Ketoacidosis, NIDDM, Nephrotic Syndrome)

15. Diagram of a macrophage binding to a foreign cell and shows MHC class 2 on cell. What binds?
CD4 (T Helper), CD8 (T cytotoxic)
16. Patient is blood group O. Diagram showing a Coomb’s test.

17. Blood film showing hyper segmented neutrophils. What is the next test u would perform? Serum
B12

OSPE 2011

1.Microscope:

a. Prostate Cancer
b. Which grading system would you use to grade? Ans: Gleason Score

2.. Microscope: TB

a. Ans. Caseating granulomas present

b. Ans: Zhiel Neelson stain

3. Jar Specimen: I. Colon Cancer:

a. Infiltrating Adenocarcinoma

b. Examination for Dx: Ans: Colonoscopic biopsy

4. Adenocarcinoma of stomach (Jar Specimen)

5. Picture showing a nucleate blood cell in a blood smear. a. Ans: the cell(monocyte) is from a similar
lineage as a Kupper Cell (the other options described features of a neutrophil)

6. Blood Typing: Forward reaction

Drawing showing:

Anti A (shows agglutination)

Anti B ( no agglutination)

Anti AB ( agglutination)

The previous drawing showed the forward rxn of a woman who gave birth to her second child who
has been jaundiced. She is Rh –ve and her husband is Blood grp A +ve

Ans: the woman has antiB antibodies and Rh antibodies. ( because she is grp A and Rh –ve, she will
have anti B antibodies naturally and anti D antibodies from her previous pregnancy)

7. Picture of Rheumatoid Arthritis (hands)

Ans: CRP- used to monitor progress of Tx in chronic inflammatory diseases.

8. Flow cytometry graph.

Identify NK cells and neutrophils

9. (Dengue)

A red tube used to collect specimen from a pt with dengue. What type of specimen will be collected

a. Ans: Acute alone OR acute and convalescent blood samples to diagnose dengue
b. Measure Ig M, isolate virus from mosquito BUT NOT on blood agar ( because it’s a virus)

10. Which of the following is an antithrombin drug?

Ans: Lepirudin

11. Identify the blood sample of a patient who had a fatty meal. 4 test tubes shown:

Ans: a. Tube with white-yellow stuff on top

12. Serum protein electrophoresis. Monoclonal band in the gamma region. The patient had bone
pain

What other test would you do to make a diagnosis?

Ans: Serum Ca

13. Drug used to treat AIDS

13. A kidney stone on an abdominal X ray. What is it most likely to be made of?

a. Ca oxalate

b. Ca phosphate

c. Struvite stone

d. Xanthine stone

14. Bacteria is LAP and PYR +ve and colourless on blood agar jar given

a. Ans: Enterococcus

15. Picture of child with ugly lesions on skin and coke colour urine.

Ans: post streptococcal Glomerulo nephritis

2013 OSPE TOPICS:

1. Prostate cancer- which lobe, grading

2. Rabies- histology
3. Identify strep pneumonia- quelling reaction, bile salts
4. Malaria- microscopic features, diff species
5. GIT jar
6. Purpose of barcode on custody form
7. Picture of brain with blood- what is it- charchot-bouchard aneurysm, berry aneurysm,
tearing of bridging veins
8. Down’s syndrome child- what test should mother have done to detect it
9. Picture of pleural effusion- alcoholic man, cough with rusty sputum. What are features of
pleural effusion eg. Serum LDH, protein, glucose
10. Pharm: what drug to treat unconscious boy with diabetic ketoacidosis either regular ins or
ins glargine etc
11. Coomb’s test
12. SLE: immunofluorescence, antibodies detected
13. What does radioimmunodiffusion detect
14. Mast cell- which hypersensitive reaction involved in
15. Flow cytometry
16. Immunoelectrophoresis

2014 OSPE topics

MicroB

1. Rabies-Negri Bodies
2. Picture of clue cells-Bacterial vaginosis
3. Picture of plasmodium falciparum
4. Treatment for ascaris lumbricoides is all except metronidazole
5. Green tinge odxidase positive motility-psuedomonas aeruginosa
6. Picture of aspergillus fumigatum
7. Indole and MR positive-E coli

Anat Path

1. Picture of micronodular cirrhosis

2. Cause-alcohol
3. Test-GGT
4. Presentation-constipation
5. Picture of malignant melanoma-NEST CELLS
6. Fibroadenoma? Breast cancer? Slide
7. Bone-pathological fracture
Pharm

1. Gynecosmastia-spironolactone
2. Edema-stop atenolol
3. Cardiodopa/levodopa-melanoma
4. Amlodipine
5. Metoprolol
6. Pathway 1
7. Asthma question incorrect answer-salmeterol is used as monotherapy
8. Candesartan-no effect on bradykinin

chem Path

1. Denature anneal extension know specific temperatures for PCR

2. HPV question
3. Picture of RBS cast-glomerulonephritis
4. STAT electrolytes done in green top tube
5. True of drug testing cup is split urine containers
6. Know DM graphs from Ezenwaka’s lecture-identify DM patient and flat response
7. Know graph for systematic error

Haem

1. DAT-haemolyic disease of newborn

2. CML picture
3. Calmitta criteria which is NOT lymphocytes 80%
4. Treatment for TTP-FFP
5. Treatment for man with megaloblastic anemia-vitamin B12
6. Hodgkin’s lymphoma with owl eye

Immuno

1. Picture of butterfly rash-SLE

2. ELISA visualized using peroxidase
3. MM SPE graph
4. Trough for Immunoelectrophoresis has antiserum human IgG
5. Label IgM to detect classical pathway
6. Gel rxn you can conclude that patient A is incompatible