i oat alt a YNATCTBO BO TTAKYBAIBETO/HH®OPMALIJA 3A, KOPHCHHKOT HA JEKOT METHYLERGOMETRIN / METHJIEPTOMETPHH pactnop 3a unjexruparwe methylergometrine Tpeq ynorpe6ara na nexor numMaresino mposmrajre ro ynaterBoTo © Uypajre ro ynarernoro. Moxe6u ke TpeGa fa ro pounrate noBTopHO. © Ako mate jononHirre tH mpamarsa, oOpatete ce Kaj Bano ,oKTOp iu cbapmanenr. © Osoj nex Bue npenmumay Bam sno u He TpeGa na ro Aapare Ha ApyrHt sua, 3aT0a ITO MOXe fla HM HaLITETH NypIt H AKO HHBHUTE CHMITTOMIE ce ner kako Bauntre. Ynarernoro coapan: Ilia iipeiticitaayea METHYLERGOMETRIN u 3a witto ce yiiotpe6yaa Mlitio opa da auacite, ped da yioiipebuitie METHYLERGOMETRIN Kaxo ce yioiupe6yea METHYLERGOMETRIN Monenu necaxanu dejeitea Yyaarve u pox na yulolupeba na METHYLERGOMETRIN Apyzu unopmayuuu ITO MPETCTABYBA JIEKOT METHYLERGOMETRIN 3A ITO CE YNOTPEBYBA Jlexor = METHYLERGOMETRIN kako akTHBHa —cyncTantrja compan. MeTHIeproHOBHH-MazieaT. MeTHeproHOBHH-MaTeaT € MOTCHHTETCKH NepuBaT Ha eproMeTpii, NpHponeH atKaston Ha ‘pxanaTa rnawumMma Secale commutum. Jlekor METHYLERGOMETRIN yeaysa p3 Ma3HItTe MyckysIHH BNakHa Ha MatkaTa (yTepycor) m jOReAyBA JO Ops mM MOBTOpysaHM KOHTpaxnimt Ha MyckymitTe Ha YTepycor, Co ITO To HaMaayBa rYOHTOKOT Ha KPB Mo Hoponypaise. METHYLERGOMETRIN ce yrorpeGyna 3a cripeuyBarbe Mt sleverbe Ha KpBaperbe On Markara 10 HOpoRYBalbe, UapCKM Pes WI aGOpryc, $4 aKTHBHO BOIeHe Ha TpeTOTO pomHIHO BpeMe M 3aGpsysare Ha MHBOAyUNjaTa ( 60s. 3a BpeMe Ha alLAUKauujaTa apTepucKHOT KPBeH MPHTHCOK TpeGa BHUMATENHO ja ce cen. Crporo qa BHMMaBaTe fa He TO MujeKTHMpare seKOT uHTpaaprepucKH (Bo aprepHickit KpReH ca) 1.1 nepaprepcKut (11oKpaj apreptja). Tpu ynorpeGa Wa ter noceGHa BHHMaTeMHOCT € HOTPeGHA BO BTOpoTo PoAILIHO Bpeme. TorpeGwa ¢ noceGxa npernasmBoct mpi ynotpeGa Ha xeKoT Kaj naxuteHTH co Gaara no yMepexa xunepTeusuja (1loKayBaike Ha KPBHHOT MpHTHCOK); TemKaTa xumeprenauja € KoHTpannnuKanuja 3a ynorpeGa Ha METHYLERGOMETRIN, Kaj nauueHTH co avesuja (caaGoKpsHocr) HAM TelKa (popMa Ha xilKleprupeosisam (sronemena cyHxuuja Ha urrurHara 2k1e3qa) HopaqH MoxHaTA ojaBa Ha cpyeBt kommamkanit, Ynorpeda co xpana u myjacrou Xpauara i GesanKoXomHHTe nujanouN He BaMjaaT Bps ecbeKToT Ha neKoTMped da touneitie da yiioipeOyaaite nekoj sex, o6pailieme ce 3a coved Kaj Bawuoid doxiaop uau dapayesia. Jlekor METHYLERGOMETRIN xe cme ja ce ynorpe6yga Bo Gpemewocr sapanit Yreporoununnor ecekt (rH stoneMyBa pHTMMYKHTe KOHTPAKUMH Ha 3HAOT Ha Matkara). Tipit npuMena Ha TepariickH HO3H, eKOT ce H3:A4YBA BO MEKOTO BO KOMHIHHA Koja Moe Ja Ma TOKCHYEH ecbexT BPS HoeHYeTO. KeHM KOH Lojar He TpeGa Na TpuMaar Tepanuja nogorro on TpH neKa. HoKomky Alone METHYLERGOMETRIN Move fla ja Hamann nponyKtjata Ha MITeKO. Tipu ynorpeGa Ha -1eKoT 3a BpeMe Ha ete MOTpeGHa € MOceGHa NpeTHasauBocT. Howoany usaitie nexaxau fpawarsa 60 apcka co aeKoil oGpaitieltie ce Kaj Bauuoit doxiiop. Boseme 1 ynpasysame co Maui Jlexor METHYLERGOMETRIN ue saujae eps ncuxodpusnaxara cnocoGHocr 3a Boseibe Mt ympanyBatse co Mam, Ilro TpeGa ja saeTe 3a MOMOMINNTe KOMMONeHTH KOM FH co_pAM seKOT METHYLERGOMETRIN Hema sHauajiu nogatouit sa HoMOUIHitTe cycHcraHiyiH Bo MpenapaTor. ‘Ynorpe6a na pyri eKonu Huajitie ipedaud dea oaue unpopmayuu moxe da ce odnecyeaaill 2a aekoau KOU sexe ne Zu tpunailte, KAKO Ua aeKooU KOU HaaHupaitie da 2u yilotpebysailie 6o udnura. Hudopaupajiae %0 Bauuoia doxitop uau bapmanesii axo yilotipedysaiie, uau 00 Keodanna cille yilotipebysane nexoj Opye .a€K, ekayuyeajku u aeKoau Koj ce fpodusaaia Ges peyeititi 00 DoKitiop. Hssectete ro maumot xteKap Kosky ynorpeGysate KIM BO MUHATHTe jBe Hele cTe ynoTpeGyBasie HCKOH ON cHeAHHBe eKOBH: - MaXpOnIIHH aNTHGHOTHUM (Ha np. epitTpoMMUMH, TponeHnaMmuutE, Kaapurpomuuun). OBve teKoBH ce ynOTpeGyBaat BO TpeTMaH Ha GakTepHcKH undpexiuit. - HUXHOWTOpH Ha peBep3Ha Tpaxexpunrasa u XVIB mporeasa (np. prronanp, MAUHABUP, HespUaBMp, eNABMpANK) -TeKOBH KOH ce KOPHCTAT BO Teparija Ha XMB w cma + aNTHebyHraHH neKoBH (Ip. KeTOKOHason, WTpaKoHasom, BopuKOHasom)- AeKoBH KON ce ynloTpeGyBaar 3a TpeT Maw Ha raGHYEE MAcpeK IAI - HHXHGHTOpH Ha eHsuMoT CYP3A4 (caHtrennaaMp, Hecpasonon, dbaykoHas0a, cok on rpejneppyr, cbayoKceTan, cpayBoKcamus, sHs1eyTOH H K:IOTpHMA3021) + APYrW_ BasOKOHCTPHKTOpH (TpuTTaHH), CHMMATOMMMeETHIM HIM amkastouqH xa Secale comutum. He ce mpenopaysa ncospemena ynorpeGa Ha neKor METHYLERGOMETRIN Spomoxpmrit,a npenenuuja m TperMax Ha KpBaneHe Of MaTKATA MOHeKOrAI MOKE ja Gre ToTpeOwa M HCTOBpeMeHa ynorpeGa Ha ABA YTepOTOHHKa, KaKO UNTO ce MeTILIeproMeTpHH M OKcHTOUMH. OKCHTOKMH HMA 6p30 AejcTBO, HONeKa MAK MeTILIeproMeTpHH HMa Noyosro BpeMe Ha jejcrByBare. Tpujasenn ce caysan Ha BeHTPHKynapHH TaxHKapsUM H q>HGpHnaumlja (Hapyiysara Ha cpyeBHOT pias) KaKo H MiapKT Ha MHOKApAOT H 3acTOj Ha cptle NOHeKOTall! CO sleTAMIeH HCXOR pH McTOBpeMeHa mpuMea Ha cysmpocron wWanH OKcHTOMNH W/E MerieproMeTPHH KaKO Tepamlija Ha KPBABEHe NO MOpORYBare s4pann aTOHIMEH yrepycor. AvecTeTHuiTe Kako XaoTaH HM MeToKendpypaH Moxe jla To HaManaT nejcrsoTo Ha METHYLERGOMETRIN.. 3.KAKO CE YIIOTPEBYBA METHYLERGOMETRIN Cexoramt 3emajre ro eKot METHYLERGOMETRIN TowHo onaKa KaKo u1To Bu e npentopayano on Bauior noxrop.He ro npexnuysajre TpetManor joKonKy Toa xe Bue kaxano og Baumor soxtop. [lokouky Mucautre eka {e|CTBOTO Ha eKOT METHYLERGOMETRIN ¢ npemory cnaGo 11m mpemuory jako 3a Bac, o6patere ce kaj Bammor noxtop nan cbapwanenr. Tosata Koja Bu e norpeOwa ox sleKoT ce ompemyBa BO SaBCHOcT on npHYUHATa ‘apa Koj aro npumenysarte METHYLERGOMETRIN: Tlopaéaroe Tpenopasiana gosa e 0.2 mg im (Bo myckn) mam 0.1-0.2 mg iv (Bo Bewa), METHYLERGOMETRIN ce animmupa zypu orkako Ke ce nojasu rmapaTa wa JeTeTO H NpeAHOTO paMo HHH HajkacHO Mo patarbe Ha YeTeTO. JloKonKy nopofajot ce ciponesyBa toy atectesuja, ce faBaat 0.2 mg iv., Gufejku BO OBHe yerOBH, oceTamBocta Ha MaTKaTa € HaMastena. Kaj Kapamio HoposyBatbe MijeKWNijaTa ce jaBa BejHall HO Maptycor, a MIpH MysTuMIa Gpemenocr, 10 pafameto Ha nocaeqHoro nere. Laperu pea Tlo ecrpaxuuja ua netero, ce antmuspaar 0.2 mg i.m. a 0.05-0.1 mg (esentyanHo 0.2 mg) iv. Atlionuja na maitixaitia fo Hopodysarve u aGopiaye 0.2 mg ism nan 0.1 mg iv AGopinye Tipenopauiana 03a ¢ 0.1-0.2 mg iv Kon ce anauuupaar npea mATepBeHttnjara. Citonitian aGopiaiye 0.05-0.1 mg iv, Tipeaynpenysarse: [pen ynorpeGa amnyaure TpeGa BHHMATENHO ja ce MpoBepat 3a MpHCYCTBO Ha NpeuMMHTaTH WIM MpoMeHa Ha Gojata Ha pactBopoT HTH. AKo cre 3emaite noroteMa 1038 07 eKOT OTKO: -e.noTpeduo:_—a AKo cre seMarte norosiea 4034 Of 1eKOT OTKOAKY UNTO ‘TpeOa WIM HeKOj pyr ro sex Baumor sex, TpeGa BeAHaI ja ce NOcoBeTyBaTe co Baumor JOKTOp HIN Aa ce oOparirre Bo HajGaneKaTa sapancrenna HHCTHTY HUH, Cumnromm Ha mpemosnpawe ce: Ma4uHHHa, MoBpakate, GomKa Bo croMaKor, ‘TpHeHe Ha EKCTPEMMTETHTE, STONIEMEH KPBEH MPHTHCOK, @ BO MOTELIKU CAysaIL Jempecija Ha julereTo, nay Ha TesecHaTa TeMmepatypa, rpuere H BKOUAKeTOCT Ha Myekyslute H KOMA. Tpermawor Ha mpeqosupaie © cHMMTOMATCKH CO BHNMATeAHO cmeqeHe Ha nirrananre byHKuum (quuere H paGora Ha cpyeTo).. Bo caysaj Ha mpegosupame TpeGa qa ce mpeBseMat cneqHUTe MepKH: © onpxkypame Ha cooyBeTHa BeHTHMTaMUja (qmIeRe), MOCeGHO ako HO cny'taj a KoNBya3nja (rp4eBH) WI KONA Koperipaibe Ha HaMasleHHoT KpBeH MPHTHCOK co coomBeTHA Tepaniija ‘TpeTMall Ha KOHBY.ISHMTE Co AHTHKOHBY3HBHM TeKOBH ‘TpetMan Ha nepncbepHHor Ba3ocasaM co 3arpeBare Ha eKcTpemuTeTHTe Ako cre 3aGopaniuie ta ro 3emere s1eKoT: Bauunor joxrop ke we conetyza Kora fa mpectanete co Tepanujara. 4, HECAKAHH JIEJCTBA Kako cute aekosu, METHYLERGOMETRIN Moxe ja npegu3BmkKa HecakaHH nejerba Kaj HeKOM On NanuenTHTe Hoxoaxy ce Bu ce janu nexoe ox creamure necaxann jejcraa, Tpeda nequaut 3a ce oGparure 3a nomou kaj Baumor zoxrop Hajuecto necakaHo sejcrB0 © sromeMeRHOT KPBEH MPITHCOK, BO OTeUIKH caysant Npwipy:KeH co emMenTHIHH HanapH H rmaBoGoAKa KaKO M Mag Ha KpBHHOT IpHTHCOK. Yecto ce jasypa koxkew ersaneM (cin) Tlospemerio: mania 1 noppakame, 601 no rpagitre 1H xumepxitpo3a (sroseMeHo niotewe) Perko: aKyreH miapkT Ha MHOKApHoT, cHasaM Ha apTepiickHTe KPBHHL cazoDIl (koponapun H nepucpepam), 3aGanena Ham 3aGp3ana paGora Ha cpyeTo, OTeKHATO JMere, KPB BO ypHHaTa, BOCTIATeHMe Ha NOBPUIMHCKHTe ReHH, XAnYIUMHALH, Tp¥eoH Bo HoraTa, wecBecTHMa, ayere BO yuMTe, aaTHAT Hoc, Mpo-mB, npenorysare, nanmuranun (cyGjextHBHO uyBCTBO Ha ayNare wa cpueTo), UpBeHuo, Hapyuien BKYC. Muory perko: anacuaxrisna peaxuuja (remka cbopma wa peaxuuja Ha mpeoceranpoct).. Aoxoary iipumeiiuiie fojasa na Guao Kaxou cusitiiomu Kou 6u momene da Gudait necaxanu dejcitiea Ha 2exoit METHYLERGOMETRIN, a ne ce ciiomenaitiu 0 ova yiaiticitieo, Be Moaume Oa 20 unopsupaiie Bawuoti doxiio uau hapmanesiti.5. HAUHMH HA YYBAIbBE HA METHJIEPTOMETPHH AA CE YYBA HA MECTA HEJOCTATIHH 3A EWA ! Pox na ynorpesa 3 roqunn. Jlexoiti we caee Oa ce yioitipebyea tio uctieKoit Ha Oaitlymomti Ha yitottipeba witio € Haseden Ha taxyearwerio. Hctiexoil Ha daitiynoii na yiloilipeba € do tocaedHuoit den 00 meceyott wilio ¢ naseden na taxyearertio. Ma ce uysa Ha Temmepatypa go 25°C Bo opurnHanHoTo nakyBawse, saurrHTeH of Hsnop Ha cBeTAMHA. Hawi na waanane na neKor Jlekor METHYLERGOMETRIN, pacrsop 3a nujekruparse ce ynoTpe6ysa Bo supancreena MHCTHTY Ij, ToceGun mepku 3a yuMurryname Ha oTnayoT u HeynorpeGenaTa KoauMHA O7 sleKor HeynorpeGewara KommunHa of meKOT TpeGa fa ce YHHMITH BO cormacHocT co Baxeukute mporictt 6. TOMOTHATEIHH HH®OPMALIHH Miro coapau METHYLERGOMETRIN, pacraop 3a nujextupame Axitiueua cyitciianyuja Equa annysta (1 ml) conpsku Meruepronopun-Manear__0,1 mg Equa amnysa (1 ml) conp:ku Metuepronopmit-maneaT 0.2 mg Tlomounu cyiiciticitianyun © Manemicka xitcemuia © Damn © Hatpym-xaopin + Tuoypea © Boga sa majexnu Onme # coxpanua na naxysarero METHYLERGOMETRIN, pactsop 4a uujextupaise e Guctap, Ge3GoeH pacrsop. Kaproncka kytija co 50 craknenn amy: co BonyMer on | ml Kon conpxaT 0.1 mg MeTHMeproHoBHH Maztear. Kaproucka kyruja co 50 crakneHst aMnystH co BoxyMeHt of 1 ml KOH coapsKaT 0.2 mg MeTHNeproHoBHH ManeaT.im =m Hpowswoawres HEMOFARM A.D., ya. Beorpancxn nyt 6.6., Bpmia, Peny6mka Cp6uja Hocures na ogo6pennerosa npomer no PenySamxka Maxexouuja XEMO®APM AJ, ®APMAUEBTCKO - XEMMCKA MHJIYCTPHJA MPETCTABHULITBO CKOTIE ; ya.Higo ona PuGap 39/1-1, Ckonje, PenyGnuxa Maxenonnja = =m ary na nocxequara penusuja ua pHarpeumoro ynarerso Bnaitipewnoito yitaiticttiao e o006peno... a a — ae