Documente Academic
Documente Profesional
Documente Cultură
To cite this article: Anna Augustyniak & Helena Rotsztejn (2016): Intense pulsed light (IPL)
treatment for the skin in the eye area – clinical and cutometric analysis, Journal of
Cosmetic and Laser Therapy, DOI: 10.1080/14764172.2016.1247963
Article views: 3
Download by: [Flinders University of South Australia] Date: 31 October 2016, At: 10:57
Just Accepted by Journal of Cosmetic and Laser Therapy
© 2016 Taylor and Francis. This provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF
and full text (HTML) versions will be made available soon.
DISCLAIMER: The ideas and opinions expressed in the journal’s Just Accepted articles do not necessarily reflect those of Taylor and Francis (the Publisher), the Editors or
the journal. The Publisher does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of the material contained
in these articles. The reader is advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be
administered to verify the dosages, the method and duration of administration, and contraindications. It is the responsibility of the treating physician or other health care
professional, relying on his or her independent experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Just Accepted
articles have undergone full scientific review but none of the additional editorial preparation, such as copyediting, typesetting, and proofreading, as have articles published
in the traditional manner. There may, therefore, be errors in Just Accepted articles that will be corrected in the final print and final online version of the article. Any use of the
Just Accepted articles is subject to the express understanding that the papers have not yet gone through the full quality control process prior to publication.
Intense pulsed light (IPL) treatment for the skin in the eye
area – clinical and cutometric analysis
Abstract
Objective: The aim of the research was to establish the influence of IPL
treatment on skin aging in the eye area. Material and methods: This study
included 24 women, aged 38 – 63 years (mean age was 48.04) with Fitzpatrick
skin type II and III who underwent 5 successive treatment sessions with an IPL
in two-week intervals. The Cutometer (Courage + Khazaka electronic) reference
test was an objective method for the assessment of the biomechanical
properties of the skin. The measurements were made in three places around the
eye. The photo documentation was used to compare state of skin before and
after three months of treatments. Additionally, patients filled in a questionnaire
which contained questions concerning self-assessment of the procedure effects.
Results: Cutometric analysis showed significant improvement of skin elasticity
(statistical significance level is mostly < 0.0001). The comparison of clinical
changes in the therapy, based on photo documentation, showed a 25%
improvement. Conclusions: This treatment was used in order to improve skin
elasticity and decrease the amount and depth of wrinkles. It is a non-invasive
treatment, with low risk of complications.
Key words: Intense Pulsed Light, Cutometer, eye area, skin rejuvenation
1
Introduction
Intense pulsed light (IPL) is a procedure used both in aesthetic dermatology and
cosmetology. IPL can be used for the treatment of skin aging, vascular lesions,
pigmented lesions, acne and unwanted hair. IPL devices emit a polychromatic (420–
1300 nm range), non-coherent and non-collimated light via a filtered, xenon flash
lamp light source [1, 2, 3]. This light allows for selective photothermolysis of
various cutaneous targets with polychromatic absorption spectra, including those of
oxyhemoglobin (540 and 575–580 nm), deoxyhaemoglobin (550–560 nm) and
melanin (400–755 nm) [2]. Various wavelengths can be obtained by the use of
selective filters that narrow the spectrum of wavelengths emitted from the device.
High cut-off filters allow for the emission of longer wavelengths, which reduce
relative absorption by melanin and water [3]. Individual light pulses are of a specific
intensity, duration and spectral distribution allowing for a controlled and confined
energy delivery into tissue [4]. IPL treatment uses short pulses of light to rejuvenate
skin. Skin is stimulated to increase its reproduction. During the treatment, the IPL
raises the temperature of the skin. The heat of skin stimulates renewal of the
epidermis and increases the production of collagen [5].
A clear cool gel should be applied to help to cool the skin and additionally
to facilitate the movement of the handpiece. A slight or more pronounced
discomfort may appear. Side effects are rare, but they are possible and include:
erythema, oedema, hyperpigmentation and hypopigmentation, crusts, blisters and
atrophic scars [6].
Material and Methods
This study included 24 women, aged 38 – 63 years (the mean age was
48.04) with Fitzpatrick skin type II - III. Patients with mild to moderate periorbital
wrinkles were enrolled in this study. Clinical evaluation of eye skin area was made
on the basis of Fitzpatrick Wrinkle Classification System (FWCS). Additionally,
some of patients presented typical hallmarks of periorbital aging (Table 1). There
were no contraindications for IPL treatment. None of the patients had been included
in any other cosmetology or aesthetic dermatology study before. Each patient was
provided with detailed information regarding post-treatment behaviour, for example
UV protection.
2
60 ms. Time of the impulse: 2 -15 ms. Repeatability: 0.3-1Hz. Targeted area:
15×35mm. Treatment parameters varied due to different treatment response of each
patient (Table 2).
A cool colourless gel was applied to the eyes area. Patients wore external overlay
eye shields for eye protection during the treatment. Patients underwent five IPL
sessions in the eye area, separated by two-week intervals. The treated area was
purified using micellar water.
This research project and its procedures were approved by the Bioethics Committee
of the Medical University of Lodz (Protocol No. RNN/97/15/KE).
Cutometer
Results
3
The results of R2 demonstrated significant differences between individual
measurements. First beneficial changes could be observed as early as after third
treatment (measurement 1) (Figure 1a).
Changes within the first analysed site occurred gradually after each
treatment, i.e. in 20 patients the improvement appeared after three sessions of
treatment (measurement 1 – measurement 2). In 16 patients, improvement was seen
after fifth treatment (comparison between measurement 2 and measurement 3).
Measurements were also performed after three months from the last treatment
session (measurement 4), however, only in 6 patients further improvement was
observed. However, the comparison of measurement 1 (before the series of
treatment) with measurement 4 (3 months after the last treatment) demonstrated
sustained improvement in the tension of the skin in 17 persons.
4
The comparison between measurement 1 (before the series of
treatment) and measurement 4 (3 months after the last treatment)
demonstrated a sustained improvement in the tension of the skin in 17
patients.
5
observed slightly darker colour of pigmented lesions which persisted up to 7
days after treatment.
6
increases fibroblasts activity (1BR3G human skin fibroblasts). It seems to be
produced more specifically in determined wavelengths (a biochemical mechanism
light depending) [10]. Luo D. et al. demonstrated mRNA expression levels of MMP-
1 and MMP-2 (matrix metalloproteinase) decreased progressively after IPL
irradiation. IPL can not only enhance new collagen production, but also decrease
collagen degradation [11].
IPL apart from remodeling of the dermis also influences the reduction of
discoloration and vascular lesions, which are often closely associated with
photoaging. There have been many studies demonstrating improvement of
photoaging after IPL treatment. The use of IPL allows to enhance these effects,
especially in skin pigmentation disorders and telangiectasia [2, 12, 13, 14, 15, 16,
17]. In our study, the reduction of discoloration and small vascular lesions was also
observed in several cases. According to Hedelund L. et al. IPL improved skin
texture, telangiectasia and pigmentation but had no efficacy on rhytids. They
performed 3 series of IPL treatment at 1-month intervals [18].
IPL is also associated with physiological effects related to the organism’s
thermoregulatory reaction. The increased temperature in tissues results in dilatation
of blood vessels, increased metabolism and oxygen transport. In our study, patients
frequently reported general improvement of skin appearance defined as healthy
appearance. It can be associated with the stimulation of skin microcirculation, and
further with ameliorated metabolism (improvement of skin nutrition and
oxygenation).
7
photoaging after IPL treatments with the use of non-invasive, objective skin
measuring devices (Cutometer, Mexameter etc.). They assessed overall elasticity of
skin using Cutometer (R2) and net elasticity of skin using Cutometer (R5). R2
values showed a gradual but significant increase, whereas R5 exhibited considerable
and significant improvement, indicating that skin elasticity improved significantly
after IPL treatments. Moreover, colorimetric measurement demonstrated significant
improvement that was most remarkable after one session of IPL [12]. In our study,
there were significant differences in R2 values between individual measurements.
First beneficial changes were observed as early as after three series of treatment. It
was demonstrated that in majority of patients changes occurred gradually after each
treatment. In the Cutometeric study, viscoelasticity of skin on the basis of R6
parameter was also assessed. The results of R6 measurement were not as significant
as in the case of R2. Many authors [19, 20, 21] revealed that R6 parameter depends
on skin moisture. Water content in the dermis is frequently associated with the
hydration of epidermis. IPL can only indirectly influence the improvement of skin
hydration via affecting the stimulation of the production of water-binding
glycosaminoglycans. This is not the main objective of this method, therefore, the
treatment may improve skin moisturization only to a small extent.
8
keloids, hypertrophic scars and also in the reduction of the redness, height and
hardness of scars. The mechanism of IPL is not fully understood. It probably targets
vascular proliferation essential to collagen overgrowth and its effect on the
pigmentation [26].
Potential side effects after IPL treatments, such as hypopigmentation,
hyperpigmentation, wounds, and erythema are very rare [18]. In our research,
patients observed only redness, burning and skin tenderness.
Conclusion
Effects after series of IPL treatments appeared to be more remarkable in
terms of the improvement of skin elasticity rather than the reduction of wrinkles
depth and length. Objective measurement (cutometric) and subjective
(questionnaire) as well as clinical (photo documentation) assessment allowed for a
full analysis of anti-ageing effectiveness of IPL therapy. Results obtained after IPL
are often subtle and there is a need for multiple treatment sessions (min 5
treatments) to reach a goal. There were no complications during three months after
treatment.
Acknowledgements: This study was supported by statutory research activity Department of
Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Lodz
no.: 503/3-066-01/503-31-001 and 502-03/3-066-01/502-34-059.
Declaration of interest: The authors report no declarations of interest. The authors
themselves are responsible for the content and writing of the paper.
9
References
1. Augustyniak A, Erkiert-Polguj A, Rotsztejn H. Variable pulsed light
treatment of melasma and post-inflammatory hyperpigmentation - a pilot
study. J Cosmet Laser Ther 2015; 17:15-9.
2. Friedmann DP, Fabi SG, Goldman MP. Combination of intense pulsed light,
Sculptra, and Ultherapy for treatment of the aging face. J Cosmet Dermatol
2014; 13:109-18.
3. Stewart N, Lim AC, Lowe PM, et al. Lasers and laser-like devices: part one.
Australas J Dermatol 2013; 54:173-83.
4. Goldberg DJ. Current trends in intense pulsed light. J Clin Aesthet Dermatol
5:45-53.
5. Schroeter CA Photorejuvenation using intense pulsed light: my technique. J
Cosmet Laser Ther. 2003; 5:206-7.
6. Bahmer F, Drosner M, Hohenleutner U, et al. Recommendation for laser
and intense pulsed light (IPL) therapy in dermatology. J Dtsch Dermatol
Ges 2007; 5:1036-42.
7. Hernandez-Perez E, Ibiett EV. Gross and microscopic findings in patients
submitted to nonablative full-face resurfacing using intense pulsed light: a
preliminary study. Dermatol Surg 2002; 28:651–655.
8. Zhong H, Ma W, Cai D, et al. A comparison of Q-switched 1064 nm
Nd:YAG laser and intense pulsed light in the nonablative rejuvenation on
rat model. J Cosmet Laser Ther 2013; 15:126-32.
9. Bedewi AE, Khalafawy GE. The use of synchrotron infrared
microspectroscopy to demonstrate the effect of intense pulsed light on
dermal fibroblasts. J Cosmet Laser Ther 2013; 1:305-9.
10. Cuerda-Galindo E, Díaz-Gil G, Palomar-Gallego MA, et al.. Intense pulsed
light induces synthesis of dermal extracellular proteins in vitro. Lasers Med
Sci 2015; 30:1931-9.
11. Luo D, Cao Y, Wu D, et al. Impact of intense pulse light irradiation on
BALB/c mouse skin-in vivo study on collagens, matrix metalloproteinases
and vascular endothelial growth factor. Lasers Med Sci 2009; 24:101-8.
12. Shin JW., D-H Lee, S-Y Choi et al. Objective and non-invasive evaluation
of photorejuvenation effect with intense pulsed light treatment in Asian
skin. J Eur Acad Dermatol Venereol 2011; 25:516-22.
13. Kim JE, Kim BJ, Kang H. A retrospective study of the efficacy of a new
intense pulsed light for the treatment of photoaging: report of 70 cases. J
Dermatolog Treat 2012; 23:472-6.
10
14. Bitter PH.. Noninvasive rejuvenation of photodamaged skin using serial,
full-face intense pulsed light treatments. Dermatol Surg 2000; 26:835-42.
15. Mezzana P, Valeriani M. Rejuvenation of the aging face using fractional
photothermolysis and intense pulsed light: a new technique. Acta Chir Plast
2007; 49:47-50.
16. Papageorgiou P, Clayton W, Norwood S, et al. Treatment of rosacea with
intense pulsed light: significant improvement and long-lasting results. Br J
Dermatol 2008; 159:628-32.
17. Dierickx CC, Anderson RR. Visible light treatment of photoaging.
Dermatologic Therapy 2005; 18:191– 208.
18. Hedelund L, Due E, Bjerring P, et al. Skin rejuvenation using intense pulsed
light: a randomized controlled split-face trial with blinded response
evaluation. Arch Dermatol 2006; 142:985-90.
19. Pierard GE, Nikkels-Tassoudji N, Pierard-Franchimont C. Influence of the
test area on the mechanical properties of the skin. Dermatology 1995;
191:9–15.
20. Dobrev H. Use of Cutometer to assess epidermal hydration. Skin Res
Technol 2000; 6:239–244.
21. Choi JW, Kwon SH, Huh CH, et al. The influences of skin visco-elasticity,
hydration level and aging on the formation of wrinkles: a comprehensive
and objective approach. Skin Res Technol 2013; 19:349-55.
22. Brazil J, Owens P. Long-term clinical results of IPL photorejuvenation. J
Cosmet Laser Ther 2003; 5:168-74.
23. Chan CS, Saedi N, Mickle C, et al. Combined treatment for facial
rejuvenation using an optimized pulsed light source followed by a fractional
non-ablative laser. Lasers Surg Med 2013; 45:405-9.
24. Tao L, Wu J, Qian H, et al. Intense pulsed light, near infrared pulsed light,
and fractional laser combination therapy for skin rejuvenation in Asian
subjects: a prospective multi-center study in China. Lasers Med Sci 2015;
30:1977-83.
25. El-Domyati M, El-Ammawi TS, Moawad O,et al. Intense pulsed light
photorejuvenation: a histological and immunohistochemical evaluation. J
Drugs Dermatol. 2011; 10:1246-52.
26. Erol OO, Gurlek A, Agaoglu G, et al. Treatment of hypertrophic scars and
keloids using intense pulsed light (IPL). Aesthetic Plast Surg 2003; 32:902-
9.
11
Table legends
Table 1 Characteristics of the study group.
Under- Small Dark
FWC eye- Periorbital Eyelid Hyperpigmen vascular circles
No. Age Sex Phototyp S** bags puffiness drooping tation changes under
e FC* the eyes
1 54 Female III III - - - - - -
2 61 Female III III - - - - + -
3 53 Female III II + + - + - -
4 57 Female II II - - - - - +
5 53 Female II II - + - - - -
6 44 Female III II - + + - - +
7 38 Female III I - - - + - -
8 43 Female III II - - - + - -
9 47 Female III II - - - + + -
10 46 Female III II - - + - - +
11 43 Female II I - + - + - -
12 47 Female II II - - - - - +
13 46 Female II II - - - + - +
14 48 Female III II - - - + - -
15 42 Female III III - - - - - -
16 43 Female II II - + - + + -
17 51 Female II III - - - - - -
18 40 Female III I - - - - - +
19 47 Female II II - - - - - -
20 56 Female II III + - - + - +
21 44 Female II I - - - - - +
22 43 Female III II - - - - - -
23 63 Female II III - - - + - -
24 44 Female II II + - - - - -
12
Table 2 Treatment parameters used in the therapy.
13
Table 3 R2 and R6 parameters according to place and time of measurement.
14
Table 4 Pearson correlation coefficients (dependencies) between the R2 or R6 at
different time points (relative to 1).
Measurement 1 Measurement 2 Measurement 3 Measurement 4
2 cm in a straight line from the outer corner of the eye
Measurement 1 (R2) --- 0.716 -0.009 0.293
P<0.0001 P=0.966 P=0.164
Measurement 2 (R6) --- 0.453 0.262 0.564
P=0.026 P=0.217 P=0.004
2 cm from the pupil to the lower eyelid
Measurement 1 (R2) --- 0.398 0.144 0.289
P=0.054 P=0.503 P=0.171
Measurement 2 (R6) --- 0.581 0.549 0.490
P=0.003 P=0.005 P=0.015
At the top of the orbital bone at the outer corner of the eye.
Measurement 1 (R2) --- 0.511 0.294 -0.064
P=0.011 P=0.164 P=0.768
Measurement 2 (R6) --- 0.572 0.359 0.045
P=0.004 P=0.085 P=0.835
In all
Measurement 1 (R2) --- 0.540 0.087 0.192
N=72 P<0.0001 P=0.468 P=0.105
Measurement 2 (R6) --- 0.526 0.400 0.406
N=72 P<0.0001 P=0.001 P<0.0001
15
Figure Legends
Figure 1a Graph of measured values of R2 in various time points.
16
Figure 2 Patient AB, aged 54, before the first treatment session and 3 months
after the last one
17
Figure 3 Patient CD, aged 56, before the first treatment session and 3 months
after the last one.
18