PHARMACOLOGY 172

Endocrines

ENDOCRINES A. Focus of action

B. Onset and duration of action
1. Steroids C. Mode of biotransformation
A. Steroids reduce the rate of repair of tissues thus D. None of the above
delays the healing
B. Exacerbate the inflammatory response 7. Which of the following synthetic sterioid shows
C. Can be safely given to immunocompromised predominantly mineralocorticoid action?
patients A. Hydrocortisone
D. Indicated in oral thrush B. Spironolactone
C. Dexamethsone
2. All of the following are true about tolbutamide D. Fludrocortisones
except
A. It is taken orally 8. Drugs causing hyperglycemia
B. It is used in type – I diabetes mellitus A. β- blocker
C. It causes alcohol intolerance B. Glucocorticoids
D. It acts on pancrease to stimulate release of C. Acetylcholine
insulin D. α- blockers

3. Which of the following drugs is not 9. Which of the following drugs is used to treat both
hypoglycemic? diabetes mellitus and diabetes insipidus
A. Ethosuxinide A. Chlorpropamide
B. Tolbutamide B. Glibenclamide
C. Glibenclamide C. Glicazide
D. Chlorpropamide D. Glipizide

4. An oral hypoglycemic agent is 10. Which one of the following does not act by I
A. Warfarin increasing insulin secretion
B. Insulin A. Glyburide
C. Glibeneclamide B. Repaglinide
D. Gluengon C. Tolbutamide
D. Biguanide
5. The highest risk associated with use of oral
contraceptives in 11. Mode of action of sulphonyl ureas includes all the
A. Hepatic necrosis following except
B. Permanent sterility A. Activating receptors on beta cells of pancreas
C. Thromboembolic disorders to release insulin
D. Cancer of breast B. Inhibiting gluconeogenesis in liver
C. Enhancing insulin mediated post receptors
6. The various insulin preparations useful in the enzyme reaction
treatment of diabetes mellitus differ primarily in D. Decreasing Glucose absorption from the gut

Bengaluru: No. 75, Apoorva Complex, Next to Vijaya Bank, Behind Police Station, R T Nagar – 560032
Hyderabad: H. No: 3-4-758, LBK Nivas, Opp. Andhra Yuvathi Mandali, Barkatpura Main Road – 500 027
Tirupathi: C/O, CKS Teja Institute of Dental Sciences, Chadalawada Nagar, Renigunta Road – 517 006
Chennai: Flat No. 8A, 8th Floor, H. No. 808, Calve Chateau, Next to Ega Theater, Kilpauk – 600 010

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 PHARMACOLOGY 173
Endocrines

C. Mestranol
12. All of the following glucocorticoids can be given D. Diethyl Stilboestrol
by inhalation except
A. Dexamethasone 18. Following are antiandrogenic substances EXCEPT
B. Beclomethasone A. Cyproterone
C. Budesonide B. Flutamide
D. Fluticasone C. Finasteride
D. Mesterolone
13. All of the following have receptors which are
transcription factors except 19. Following are the effects of hormone replacement
A. Insulin therapy EXCEPT
B. Estrogen A. Reduced risk of coronary artery disease
C. Vitamin D B. Prevention of osteoporosis
D. Glucocorticoid C. Reduction of breast cancer incidence
D. Suppression of symptoms of menopause
14. With which of the insulin preparations soluble
insulin can bind and SHOULD be mixed only 20. Which of the following antithyroid drugs
with regular insulin prevents peripheral conversion of T4 to T3
A. Semilente insulin A. Carbimazole
B. Protamine zinc insulin B. Perchlorate
C. Ultra lente insulin C. Propylthiouracil
D. Lente insulin D. Thiocyanate

15. Which of the following oral antidiabetic drugs has 21. Which of the following is an action of
additional antiplatelet aggregatory action sulphonylurea
A. Glibenclamide A. Increases formation of insulin
B. Gliclazide B. Produces release of insulin
C. Glipizide C. Effective in complete insulin deficiency
D. Tolbutamide D. Blood sugar reduction occurs only in diabetics

16. Antabuse like reaction can occur with which of 22. Which action is produced by metformin
the following antidiabetic drugs A. Increases sensitivity of peripheral tissues to
A. Metformin insulin
B. Chlorpropamide B. Stimulates insulin release from pancreas
C. Insulin zinc suspension C. Increase glucose absorption from intestine
D. Acarbose D. Reduces blood sugar level in normal and
diabetic individuals
17. Which one of the following is an antioestrogen
A. Clomiphene 23. Which of the following is NOT TRUE regarding
B. Dienestrol betamethasone

Bengaluru: No. 75, Apoorva Complex, Next to Vijaya Bank, Behind Police Station, R T Nagar – 560032
Hyderabad: H. No: 3-4-758, LBK Nivas, Opp. Andhra Yuvathi Mandali, Barkatpura Main Road – 500 027
Tirupathi: C/O, CKS Teja Institute of Dental Sciences, Chadalawada Nagar, Renigunta Road – 517 006
Chennai: Flat No. 8A, 8th Floor, H. No. 808, Calve Chateau, Next to Ega Theater, Kilpauk – 600 010

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 PHARMACOLOGY 174
Endocrines

A. It is effective in small doses C. Ultralente insulin

B. It is a potent mineralocorticoid D. Protamine Zinc insulin
C. Its ester can be used by inhalation
D. Its adverse effects are similar to those 29. Glibenclamide can be used for treatment of
produced by hydrocortisone A. Type I diabetes mellitus
B. Type II diabetes mellitus
24. Which of the following is NOT an effect produced C. For diabetic coma
by combined oral contraceptives D. Carbuncle in a diabetic patient
A. Combination of oestrogen and progestin
increases efficacy 30. Which of the following corticosteroids is given by
B. Withdrawal bleeding is predictable inhalation
C. Break through bleeding is very common A. Hydrocortisone Hemisuccinate
D. Both oestrogen and progestin contribute to the B. Fludrocortisones
contraceptive action C. Betamethasone Dipropionate
D. Triamcinolone
25. Which of the following is an action of
glucocorticoids 31. Radio-active iodine (I131) is administered
A. Promote protein synthesis A. Orally as solution
B. Produce hypercalcaemia B. Intravenously
C. Suppress inflammatory response C. Intramuscularly
D. Produce hypoglycaemia D. Orally as a capsule

26. Indications for the use of glucocorticoids include 32. Which of the following is used in treatment of
all the following except endometriosis
A. Anaphylactic shock A. Diethylstilbestrol
B. Rheumatic carditis B. Danazol
C. Addisons disease C. Clomiphene
D. Glaucoma D. Mestranol

27. Adverse effects of glucocorticoids are all the 33. Which of the following drugs is used in treatment
following EXCEPT of infertility
A. Peptic ulceration A. Tamoxifen
B. Osteoporosis B. Diethyl stilbestrol
C. Hyper sensitivity reaction C. Clomiphene
D. Increased susceptibility to infection D. Desogestrel

28. Which of the following insulin preparations is 34. Following are side effects of combined oral
given intravenously contraceptive agents EXCEPT
A. Lente insulin A. Hypotension
B. Regular insulin B. Weight gain

Bengaluru: No. 75, Apoorva Complex, Next to Vijaya Bank, Behind Police Station, R T Nagar – 560032
Hyderabad: H. No: 3-4-758, LBK Nivas, Opp. Andhra Yuvathi Mandali, Barkatpura Main Road – 500 027
Tirupathi: C/O, CKS Teja Institute of Dental Sciences, Chadalawada Nagar, Renigunta Road – 517 006
Chennai: Flat No. 8A, 8th Floor, H. No. 808, Calve Chateau, Next to Ega Theater, Kilpauk – 600 010

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 PHARMACOLOGY 175
Endocrines

C. Breast tenderness D. Weight loss

D. Increased incidence of venous thrombosis
41. Uses of mifepristone are following EXCEPT
35. Active form of vit D in man is A. Antiprogestin
A. Cholecalciferol B. Contragestational agent
B. Calcifediol C. Gluocorticoid antagonist
C. Calciferol D. Termination of pregnancy in 3rd trimester
D. Calcitriol
42. Iodides are used in thyroid disorders for the
36. Which of the following drugs is an antiprogestin following indications EXCEPT
A. Misoprostol A. Preoperative for thyroidectomy
B. Mifepristone B. Thyroid storm
C. Gestodene C. Prophylaxis of endemic goitre
D. Norgestrel D. Long –term treatment of thyrotoxicosis

37. In prevention of osteoporosis following drugs are 43. Which of the following drugs is used for
useful EXCEPT treatment of thyroid crisis
A. Hormonal contraceptives A. Methimazole
B. Biphosphonates B. I131
C. Norethindrone C. Propylthiouracil
D. Vit D3 + calcium D. Thiocyanates

38. Synthesis of thyroid hormone is inhibited by 44. Glibenclamide is used in treatment of diabetes
A. Percholates mellitus because
B. Potassium iodide A. It stimulates insulin release from beta cells
C. Radio active iodide B. It is safe in the presence of liver damage
D. Carbimazole C. It has a very short duration of action
D. It is useful for juvenile diabetes
39. Mode of action of acarbose in treatment of
diabetes mellitus is 45. Which of the following insulins is suitable for use
A. It stimulates insulin secretion in management of diabetic ketoacidosis
B. Increases insulin action in tissues A. NPH insulin
C. It inhibits intestinal alpha glucosidase B. Lente insulin
D. Increases peripheral utilization of glucose C. Regular insulin
D. Semilente insulin
40. Which of the following adverse effects is NOT
produced by metformin 46. Adverse effects of corticosteroid therapy are
A. Metallic taste following EXCEPT
B. Anorexia A. Hypotension
C. Hypoglycaemia B. Hyperglycaemia

Bengaluru: No. 75, Apoorva Complex, Next to Vijaya Bank, Behind Police Station, R T Nagar – 560032
Hyderabad: H. No: 3-4-758, LBK Nivas, Opp. Andhra Yuvathi Mandali, Barkatpura Main Road – 500 027
Tirupathi: C/O, CKS Teja Institute of Dental Sciences, Chadalawada Nagar, Renigunta Road – 517 006
Chennai: Flat No. 8A, 8th Floor, H. No. 808, Calve Chateau, Next to Ega Theater, Kilpauk – 600 010

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 PHARMACOLOGY 176
Endocrines

C. Peptic ulcer 52. Insulin requirement in a diabetic patient is

D. Muscle weakness increased during following situations EXCEPT
A. Surgery
47. Long – term use of oral contraceptives produces B. Hyperthyroidism
following adverse reactions EXCEPT C. Infection
A. Hypertension D. Weight loss
B. Osteoporosis
C. Hyperglycaemia 53. Which one of the following is a short acting
D. Venous thrombosis glucocorticoid
A. Prednisolone
48. Which of the following is an indication for use of B. Hydrocortisone
progesterone C. Dexamethasone
A. Prostate cancer D. Betamethasone
B. Termination of pregnancy
C. Breast cancer
D. Endometriosis

49. Long-term use of combined oral contraceptive

may lead to the following EXCEPT
A. Hyperuricaemia Tripathi Essentials of Medical
B. Hyperglycaemia 1. A
Pharmacology, 7/E, p.293
C. Hypertension Tripathi Essentials of Medical
D. Venous thrombosis 2. B
Pharmacology, 7/E, pp.270, 271
Tripathi Essentials of Medical
50. Which of the following is an action of leuprolide 3. A
Pharmacology, 7/E, pp.270, 412
A. It is an androgen Tripathi Essentials of Medical
B. It is an oestrogen 4. C
Pharmacology, 7/E, p.270
C. It is a gonadotropin releasing hormone (GnRH)
Tripathi Essentials of Medical
agonist 5. C
Pharmacology, 7/E, p.326
D. It is a gonadotropin releasing hormone (GnRH)
Tripathi Essentials of Medical
antagonist 6. B
Pharmacology, 7/E, p.263
Tripathi Essentials of Medical
51. Tamoxifen is used for treatment of carcinoma of 7. D
Pharmacology, 7/E, p.289
breast because it is
Tripathi Essentials of Medical
A. An alkylating agent 8. B
Pharmacology, 7/E, p.293
B. An antimetabolite
Tripathi Essentials of Medical
C. A hormone antagonist 9. A
Pharmacology, 7/E, pp.266, 267, 578
D. A radio – active isotope
Tripathi Essentials of Medical
10. D
Pharmacology, 7/E, pp.270

Bengaluru: No. 75, Apoorva Complex, Next to Vijaya Bank, Behind Police Station, R T Nagar – 560032
Hyderabad: H. No: 3-4-758, LBK Nivas, Opp. Andhra Yuvathi Mandali, Barkatpura Main Road – 500 027
Tirupathi: C/O, CKS Teja Institute of Dental Sciences, Chadalawada Nagar, Renigunta Road – 517 006
Chennai: Flat No. 8A, 8th Floor, H. No. 808, Calve Chateau, Next to Ega Theater, Kilpauk – 600 010

Quick Contact: (0) 97422 32037  drpnnreddy@brihaspathiacademy.com  www.brihaspathionline.com

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 PHARMACOLOGY 177
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Tripathi Essentials of Medical Pharmacology, 7/E, pp.290,230

11. D
Pharmacology, 7/E, pp.270,271,274
Tripathi Essentials of Medical
Tripathi Essentials of Medical 31. A
12. A Pharmacology, 7/E, p.255
Pharmacology, 7/E, p.289,290
Tripathi Essentials of Medical
Tripathi Essentials of Medical 32. B
13. A Pharmacology, 7/E, p.301
Pharmacology, 7/E, p.
Tripathi Essentials of Medical
14. B Satoskar 20/e p 877 33. C
Pharmacology, 7/E, pp.312
Tripathi Essentials of Medical Tripathi Essentials of Medical
15. B 34. A
Pharmacology, 7/E, p.272 Pharmacology, 7/E, pp. 325, 326
Tripathi Essentials of Medical Tripathi Essentials of Medical
16. B 35. D
Pharmacology, 7/E, p.267 Pharmacology, 7/E, pp. 340, 341
Tripathi Essentials of Medical Tripathi Essentials of Medical
17. A 36. B
Pharmacology, 7/E, p.312 Pharmacology, 7/E, p. 319
Tripathi Essentials of Medical Tripathi Essentials of Medical
18. D 37. C
Pharmacology, 7/E, p.296 Pharmacology, 7/E, p. 327
Tripathi Essentials of Medical Tripathi Essentials of Medical
19. C 38. D
Pharmacology, 7/E, pp.310, 311 Pharmacology, 7/E, pp.252,253
Tripathi Essentials of Medical Tripathi Essentials of Medical
20. C 39. C
Pharmacology, 7/E, p.247 Pharmacology, 7/E, p. 277
Tripathi Essentials of Medical Tripathi Essentials of Medical
21. B 40. C
Pharmacology, 7/E, p.270 Pharmacology, 7/E, p. 276
Tripathi Essentials of Medical Tripathi Essentials of Medical
22. A 41. D
Pharmacology, 7/E, p.269 Pharmacology, 7/E, pp. 319,320
Tripathi Essentials of Medical Tripathi Essentials of Medical
23. B 42. D
Pharmacology, 7/E, p.289 Pharmacology, 7/E, pp.255,256
Tripathi Essentials of Medical Tripathi Essentials of Medical
24. C 43. C
Pharmacology, 7/E, pp. 314, 315 Pharmacology, 7/E, p. 253
Tripathi Essentials of Medical Tripathi Essentials of Medical
25. C 44. A
Pharmacology, 7/E, p.285 Pharmacology, 7/E, p. 270
Tripathi Essentials of Medical Tripathi Essentials of Medical
26. D 45. C
Pharmacology, 7/E, pp.293 Pharmacology, 7/E, p.268
Tripathi Essentials of Medical Tripathi Essentials of Medical
27. C 46. A
Pharmacology, 7/E, pp. 293,294 Pharmacology, 7/E, pp.293,294
Tripathi Essentials of Medical Tripathi Essentials of Medical
28. B 47. B
Pharmacology, 7/E, p.263 Pharmacology, 7/E, pp.325, 326
Tripathi Essentials of Medical Tripathi Essentials of Medical
29. B 48. D
Pharmacology, 7/E, pp. 270,272 Pharmacology, 7/E, p.319

30. C Tripathi Essentials of Medical 49. A Tripathi Essentials of Medical

Bengaluru: No. 75, Apoorva Complex, Next to Vijaya Bank, Behind Police Station, R T Nagar – 560032
Hyderabad: H. No: 3-4-758, LBK Nivas, Opp. Andhra Yuvathi Mandali, Barkatpura Main Road – 500 027
Tirupathi: C/O, CKS Teja Institute of Dental Sciences, Chadalawada Nagar, Renigunta Road – 517 006
Chennai: Flat No. 8A, 8th Floor, H. No. 808, Calve Chateau, Next to Ega Theater, Kilpauk – 600 010

Quick Contact: (0) 97422 32037  drpnnreddy@brihaspathiacademy.com  www.brihaspathionline.com

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 PHARMACOLOGY 178
Endocrines

Pharmacology, 7/E, pp.325, 326

Tripathi Essentials of Medical

50. C
Pharmacology, 7/E, p.243
Tripathi Essentials of Medical
51. C
Pharmacology, 7/E, p.312
Tripathi Essentials of Medical
52. B
Pharmacology, 7/E, p.266
Tripathi Essentials of Medical
53. B
Pharmacology, 7/E, p.289

Bengaluru: No. 75, Apoorva Complex, Next to Vijaya Bank, Behind Police Station, R T Nagar – 560032
Hyderabad: H. No: 3-4-758, LBK Nivas, Opp. Andhra Yuvathi Mandali, Barkatpura Main Road – 500 027
Tirupathi: C/O, CKS Teja Institute of Dental Sciences, Chadalawada Nagar, Renigunta Road – 517 006
Chennai: Flat No. 8A, 8th Floor, H. No. 808, Calve Chateau, Next to Ega Theater, Kilpauk – 600 010

Quick Contact: (0) 97422 32037  drpnnreddy@brihaspathiacademy.com  www.brihaspathionline.com

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