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ABHITOSH DEBATA
INTRODUCTION
DEFINITION
EVENTS OF DEVELOPMENT
EMBRYOLOGICAL DEVELOPMENT
DEVELOPMENT OF BRANCHIAL (ARCHES ,
POUCHES AND CLEFTS)
DEVELOPMENT OF FACE
DEVELOPMENTAL ANOMALIES OF FACE
CONCLUSION
REFERENCES
Anatomical structures are more diverse in the mouth
than in any other region. Human development is a
continuous process and does not stop at birth. An
individual spends about 9 months/ 38 weeks/266 days or
nearly 383040minutes of his life in his mother’s womb.
The human face begins to form during the 4th week of
embryonic development. By the 6th week the external face
is completed. Between the 6th and 8th weeks the
development of the palate subdivides nasal and oral
cavities. This development continues into the 12th week
with completion of the soft palate.
Embryology:
Science of the origin & development of the organism
from fertilization of the ovum to the end of the eighth
week.
Development:
Development refers to all the naturally occurring
unidirectional changes in the life of an individual from
its existence as a single cell to its elloboration as a
multifunctional unit terminating in death. Thus it
encompasses the normal sequential events between
fertilization and death.
Third week Development of ear
Formation of Stomatodaeum.
Fifth week Formation of Nasal placode, Medial and lateral nasal process.
Development of mandible.
- At first there are 6 arches. The 5th arch disappears and then
only 5 arches remain.
3. Nerve :
- Facial nerve.
- Special sensory component
- Chorda tympani nerve
(Ant 2/3rd of Tongue)
4. Artery :
- Stapedial artery
- Transient i.e. disappears during fetal life.
COMPONENTS:
1.MUSCLES –
STYLOPHAYNGEOUS MUSCLE
2.NERVE –
GLOSSOPHAYNGEAL NERVE
3.ARTERY-
PROXIMAL 1/3RD OF INTERNAL CAROTID ARTERY.
SMALL CONTRIBUTION OF COMMON CAROTID ARTERY.
4. SKELETON –
Greater horn
Lower body of hyoid
COMPONENTS:
1. MUSCLES-
Constrictor muscles of pharynx.
2. NERVE –
Superior laryngeal nerve
3. ARTERY –
Arch of aorta
Proximal part of subclavian
4. SKELETON –
Thyroid cartilage
COMPONENTS:
1.MUSCLES-
Intrinsic muscles of larynx
2.NERVE-
Recurrent laryngeal nerve
3.ARTERY-
Pulmonary artery
Ductus arteriosum
4.SKELETON-
Cricoid
Arytenoid
1st pharyngeal pouch –
• It forms a star like diverticulum “tubotympanic recess”,
which comes in contact with the epithelial living of the 1st
pharyngeal cleft, the future external auditory meatus.
• The distal portion of the diverticulum widens into primitive
middle ear cavity and the proximal part remains narrow
forming the eustachian tube.
• The lining of tympanic cavity later aids in formation of the
tympanic membrane or eardrum.
2nd pharyngeal pouch:
-INTERNAL EAR:
• OTIC PLACODE
• Eyes develop from three sources:
Neuroectoderm of the forebrain - retina, optic nerve.
Surface ectoderm of the head- lens
Mesoderm between these layers - eye muscle and
vascular tissues
• 1st indication of eye formation is optic sulcus which is
formed in the 4th week.
- Tongue develops in relation to P.A in floor of
developing mouth.
- The medial most part of M.A proliferate to form
Lingual swellings.
- They are partially separated from each other by
another swelling in midline called Tuberculum Impar.
- Immediately behind Tuberculum Impar the
epithelium proliferates to form a downgrowth from
(thyroglossal duct) which thyroid gland develops. This site is
marked by Foramen Caecum.
- Hypobranchial eminence- midline swelling in relation
to medial ends of 2nd, 3rd, & 4th arch. It has a cranial part
called Copula (2nd, 3rd ), & caudal part ( 4th) forming
epiglottis.
- Anterior two-thirds of tongue forms by fusion of –
2 lingual swellings & Tuberculum impar
- It is derived from Mandibular arch so supplied by
lingual nerve, branch of Mandibular nerve which is
post- trematic nerve of the 1st arch & chorda- tympani
which is pretrmatic nerve of the arch.
- Posterior one-thirds is formed from cranial part
of H.E (copula)
- The 2nd arch mesoderm buries below the surface,
3rd arch mesoderm grows over it to fuse with mesoderm
of 1st arch.
- Thus it is formed by 3rd arch mesoderm.
Supplied by glossopharyngeal nerve, of 3rd arch.
- The posterior most part is formed from 4th arch,
so it is supplied by superior laryngeal nerve of 4th arch.
- Musculature is derived from occipital myotomes,
supplied by hypoglossal nerve.
• Begins at 6th week- for primary palate
• From each Max. P, a plate like shelf grows medially, this
is called Palatine process.
• Palate forms from 3 components fusing with each other--
1) 2 Palatal processes, fuse in midline beginning from anterior
to posterior
2) Primitive palate from FNP, each palatal process fuses with
posterior margin of P.P
• The medial edge of P.P fuse with free lower edge of nasal
septum thus separating 2 nasal cavities from each other & from
mouth.
• At later stage mesoderm in palate undergoes
intramembranous ossification to form hard palate. Ossification
does not extend into posterior most portion which remains as
Soft palate.
• The part of palate derived from FNP is Premaxilla which
carries 4 incisors.
• The maxilla develops from a centre of ossification
in the mesenchyme of the 1st arch. The centre is in the
maxillary process. No arch cartilage or primary cartilage
exists in the maxillary process.
• Centre of ossification appears in the angle
between the division of the nerve, where the
anterosuperior dental nerve is given off from the infra
orbital nerve. From this centre bone formation spreads
backward below the orbit towards the developing
zygoma and forward towards the future incisor region.
• Ossification also spreads upward from this
forward extension to form the frontal process.
Ossification also spreads into the palatine process to
form the hard palate. A secondary cartilage, a zygomatic
or malar cartilage appears in the developing zygomatic
process and for a short time adds considerably to the
development of the maxilla.
- On lateral aspect of Meckel’s cartilage (1st arch
cartilage) during 6th week of embryonic development, a
codensation of mesenchyme occurs in the angle formed by
division of Inferior Alveolar Nerve and its incisive and
mental branches
INCIDENCE
Cleft lip is common among males while cleft palate is
more common among females.
Unilateral clefts - 80% of the incidence
Bilateral clefts - remaining 20%.
Most accepted.
GROUP I:- cleft of the soft palate only.
Fissured tongue
Also called cleft lip syndrome
Also called lip pit syndrome
Characterized by :
lip pits
Absent teeth
Isolated cleft lip and palate
Abnormal fusion of palate and lips
Both genders are equally affected
Unilateral or bilateral lip pits
classical symptoms is its association with cleft lip and cleft palate
Usually medial or vermilion portion of the lower lip
Associated with accessory salivary glands that empty into pits .
Patients may have maxillary hypodontia.
Missing maxillary pre molars
Localized hyperplasia/ hypertrophy of minor
accessory glands
Aplasia :
Development of xerostomia
Found in cases of hemifacial microsomia
treacher collin’s syndrome
Atresia
Aberrancy
Macrostomia
Microstomia
Caused by:
Rubella virus
Poliomyelitis
Erythroblastosis fetalis
Diabetes
Hypothyroidism
toxoplasmosis
EXTERNAL EAR DEFECTS:-
Proboscis:
AGNATHIA
MICROGNATHIA
MACROGNATHIA
C/F:
Mandibular protrusion (when mandible is affected)
"Gummy smile" (when maxilla is affected)
Ramus of mandible forms a less steep angle with body of
mandible
Mandibular prognathism caused by excessive condylar
growth
Chin appears prominent
FACIAL HEMIHYPERTROPHY:-
Asymptomatic growth of one or more body parts
Involvement of one side of the face
FACIAL HEMIATROPHY:-
Slowly progressive atrophy of soft tissue of essentially
half the face characterized by progressive wasting of
sub cutaneous fat accompanied by atrophy of skin ,
cartilage , bone and muscle.
Occasionally spread one side of neck and body
Clinical features :
commonly early sign is painless cleft near the midline of face or
forehead
The marks the boundary between the normal and atrophic tissues
Bluish hue may appear in the skin overlying atrophic fat
Neurolgical disorders in 15 % cases may be accompanied by
pigmentation, pigmented facial naevi, contralateral jacksonian
epilepsy , trigeminal nerve , occular complications.
More in female, more on left side
Occurs mostly 1st and 2nd decade
Dental abnormalities:
incomplete root formation
Delayed eruption
Severe facial asymmetry difficulty with mastication
In 1897 Marie and Sainton coined the name cleidocranial
dysostosis
Autosomal dominant(A gene on one of the non-sex
chromosomes that is always expressed, even if only one
copy is present) with wide variability in expression.
C/F:
shortness of stature.
Brachycephaly(head is disproportionately wide) with
bossing of frontal, parietal, and occipital bones;
Mineralization of sutures
Late or incomplete development of accessory sinuses
Small sphenoid bones.
Midfacial hypoplasia with low nasal bridge, narrow high-arched
palate.
Hypertelorism(abnormal increased distance between 2 organs or
body parts)
small thorax with short oblique ribs.
Dentition:-
Late eruption,
Malformed roots,
Retention cysts,
Enamel Hypoplasia,
Caries,
Supernumerary teeth.
Atresia (is a condition in which a body orifice or passage in
the body is abnormally closed or absent) of the cavity at the
external nares, at the posterior nasal aperture or in the cavity
This may be unilateral or bilateral
Congenital defect in the cribriform plate of ethmoid bone
may lead to communication between cranial cavity and
nose
Nasal septum may not be in midline i.e., deflected to one
side
Septum may be absent
Nasal cavity may communicate with the mouth
Teratogens are any agents from the environment that
can cause harm to the developing fetus.
Many harmful agents cause damage only if exposure
occurs during a sensitive period of prenatal
development.
Critical factors that influence the degree of harm a
teratogen will cause:
– The amount and length of exposure
– Individual differences in susceptibility
Damage from teratogens is not always evident at birth
but may appear later in life.
Impact of teratogens often depends on quality of
postnatal environment.
About 45% or more pregnancies end in miscarriage,
that is, spontaneous abortion.
Most miscarried fetuses have severe defects, such as
missing chromosomes, that make further development
impossible.
Ninety percent of fetuses that survive the danger of
miscarriage are born normal
RISK FACTORS:-
SMOKING
ALCOHOL
DIETARY DEFICIENCIES
DISEASES viz. cytomegalovirus, herpes virus, parvovirus B19,
rubella virus (German measles), syphilis, toxoplasmosis,
Venezuelan equine encephalitis virus
DRUGS viz
Aspirin
- pregnant women - blood disorders in offspring.
Thalidomide
- deformations of the eyes, nose, ears cleft plate, facial palsy and
fusing of fingers and toe , dislocations of the hip joint and
malformations of the heart and digestive and urinary tract
Illegal drugs
Marijuana:
prenatal exposure to marijuana leads to infants reduced
weight and size, short term changes in behaviour e.g.
increased startle and a high pitched cry.
Cocaine:
effect of maternal cocaine use - children tend to be
impulsive, highly distractable and difficult to control
and to have problems in language development as they
grow old.
Father’s exposure to toxin viz Lead , Mercury ,
Radiation.