BLNBHIVOIGSW V7 asusnay sulovsu “ye ‘oppRayeoypene sor oreo i) smears 2p phpuos wf s6isap0 jas elustony PEALE sTURTEUNIS (yeu AGEIeL 270p eI Tams ‘soncen ajs0 “seusape wiseos ap dq aus ua cmp pdnp ‘osinape syyiers ancud = ‘prvarpesur op [22p “AIpou ssloe9 oan 1 soruremposrtaey s]HOpOH 2=129)9 = -muyep ep sofa sensapomy rans we oie]? iseigo Ydasp si Hfopoorvorodoue SLNVdOd STaLNSINVOIGSW ‘vINSGNSdad ‘SSVOLNSWVOIGSIN. SinoV STULLVOMOLNI ‘SINAINVOIGSIN 3G asnGoud AODOTOLVd SUYyis IS asuaAav 2uloway “€ land poe sag zoetunowenn) (590) os eine ‘puome eaemeantny W (fenenwowle (Cifele clinice a medicementelor acis de aseme- spins Tae , produse de digitlice asupra i oir cave sate nesses 0 enpraveghere sae ba Re RES Tg BET Se TS BE atetetor apa cu att mai mare cp cat doze ras ae Terepeul eet mporsl DL SIDE $0, care DL, 50 = doze leit ta 50 % lowe seit be WS om steam in 50'S ee askance or soso ne1 ‘omsoyrte coz ea =P | ‘aso ajgnvaodsa: jens? op amend woe sossed juauma yo grepaide og vfeazng et fam eicao0u poydio 29 co “x fmuozour Soap a8 panzqpooy 2099-129 9p 3982] IP “si Syumsuen o¢ govjoqmiau simmons meecoy ‘sjupo sowsoe sopmeqmaN nin Team earsuieom sued ong sows “ap “ar RyREONNNYS 8 pom eazpRoE aoa STREP OP sh09-s 9p of ‘pose Bp: syennougl yens 20 =TESuNput snore aute 1S 2uzeybupry “RprEerwoH? 2p “oun gud sorrersnsone ayaa sic. TEPER? mmporg if onousd vensens un no 2oFeED 2 © proauroue> vaLouuiofmini iu 38 slunisqns 2foum ¥9 osu RE, ouonoyemsie “epioneed ‘ormpmments sscadzotomm@ % 280}0} aeoRtOION TENE vusfemus 95: no cweouesypotn aemectonted sojoyesamegipoae ‘emsfoxs oje9 sceo8 cyt Year yénp seyqo — Ss ‘mo “mmdnouss ofp aquamstaed yogtpou imposes idosp me susdoima 2790947 38 (moonenont igasoapat) Syeryoosorsreoupmy HF EmgD oie sp tiem 2[o2op ‘vere sezounjendans “somemns o[crae] * (Boar 2 sme oe suefi00 wlemajyrar nee owe ooe 40um Those EIS sid greproonmsonam 9p ‘uzuoypou ap set qa cosy “ownif soyresoway siuaptans 800 ‘mod toundss no sojaymenseoonime rareto fan qresiaayod “njdaioxo 2p ‘sqsondsjeinae nes siawweeyomesy “or -exypooeturey nes sRouisoormm; TES su upd ‘anfeniod mes misrBioms 9p Tet ‘38 oun gipbrep ‘copwey sust0Ns} BEES? “3p tod srvonieuoorpow squmfsauoruyCateva reacfil Kdlosinerazice provocate de medieamente (Gece la es)See ee Jotannegias yooeeeyot yay eesasverm| oat seg sorweee oes | eee # zocor “Se enerome sens)“ nmemy Soeoes poy a svi asia “sur on symone pusuo ~ someSues eade Br vey -sovowaurompt Spimd sopsyss ea RETA va {818 promotor sito ‘supucpBorrasd ‘owes sonst ‘uray ‘puny — reiouR copou Haisqys ns apnoseve5 ‘syozea © ‘ayporseer ~ 2ynjso oun wiapeaéns gredeoe ‘ammo ‘auygea! nes G8] no monetace tat catdea sp sissouced yane 1 stefpoan sora setar spbSaye0 wip und 28) stg aoqdors syemeosied uy stacey wor vate p ahr op [88 ouop fou de op a 8iopo omnloooyy ‘omy squeal ‘msyosoeur upd osoqatoup ce nino "SIasOe Blows op undp epg uorapoormy Somuuojsuen yovosout nas aanes osen > sfumegns som earesoqK> no “aneEegse BEpoe geyeny gummed eseecy “opssaron viepuine of” 2 Mioidesar aney nes ospee EOP aN eeaderpasd 9 = 89 ¥5 ‘unum SfenEapa! ofaaserp eRe S9TEMe Bftpuoo ey “rows099, 2p aiejeates 1 sopupsaics ezeq ad yezioaud oF aisod ‘mo sy soiGsoye soytfooss ymaery “so}30| = We 28 so[UNTED BEM LICr EY es aomeoIpem ep TORE aureo} Shige oor some ges emo ‘ommgnfomnay yeromto ‘reatepoun sus0ytan fasvodates nays a | 2518:0]8 aesnepe oftiowsy, rose “uis1we8:0 Hip gppdedod o ase grpeoad o zo19usqv ‘no Masqen03 wasezo] Head pen(b0> ses Bsuaaay auLovau “ELe es FOR FIncs[out eect owes eT “rm eats ean ae RE TP, Wea oe eee utes ee ee sf pd toe ee Sra! rer raee > 29 [8 opaseidoo: iuincs © nied yoppods as wisusty japonis ot oeX Afrasteamere TABELUL 200 (coum) ‘msbot state oo Fig, 66 ~ Diese j- arate cunoscnte es foarte ant Eontraindioata. Trebule excluse ir te locel, con “ulfamide, Este nece- 127 126scr ‘espmorpeng Fup op nad uocun ‘RO nes MODES 2p ‘aeadse wopiqtit 10d seisape oqnlono, SLNBWVOIG3W 3a Ssnaoua BOISMOLV TWHyLS “ze sjesisenss esohold eed edopoet = sas "HONE 2p 2zm09 10% omnes ‘ulosoon[s ‘ane s0ui03 pooeee HF 9p vunaT greaced ateo “ymmporoussd “oid jniay 2p SoPBuswespeenag (Gave =20p uy). euosjay “eprmeTo od ormsayrse yexede. raat af erngaa Beon0ud tod syuemmeaipom ap SLD O ainaweoian sa Sit net a Coe asngous Suvinosynoid “evo s51eovolve wows ze * 824 umzusjodar myumsyomsy ayo ~ 2 = sejtoures4 sodorss trmuw eaorToo weeosoid (qaomporre "apr lenis sranme epmIA nGOd yn\qeevoderpm eos “ope aise fezes prascuespaus ramndsp +5 soareoop "purnodiat ows seworeeueorp {23 seoferd copes eaiaseomnoy ee AJSRPES “soHojored ume ays amet meson sp aid 8 oor eer; poses comet soo) emma tenon “enc tera Tee Pow peoreyygie sonore? é ges ypramerence “oosraqnene Toor Sromeseoe soe sores sum omementy ‘ooaord yod a] aura syusuo1pour 7 stpredpouad § mppBupe aye TEIN AopsNUsUD|S (MPAIU ef sooo eI ‘anu op pivot 2p 2189 sep ‘wosrer omy. sp spine) rouiseds edioopme opt sensaey yoSispe-gmiew op aoa (HOMOue (ees “onuooen ejloyat aco Gio givsioayy "eur woo weuto) sfney slujzorvo9 fo poses fnow mip gzsefeefoep of "oma ae em § casio jod eeuouose 2p ‘sopsedsoqnose —— gu 2p rqasosp smash ‘poe sues: ete tm adap "Zor wap 0 pnp Ton DOO STI 9p 2189 Biasoag 1 aed 0 ea001d ays0d (No “oqney Teareymezor> 29 psnp" cnpom otis ais njdimaes codoyeureg migureses pupiosze “gompau ei22180 weno vod awestenpeM Sse Com mpoiays yertee) surmmps siscend cis sqeomss = tuiusd soqammpeg savers 18 teyoBoes (ojos “asso oe no ope “sorpamr rama cud ‘onesd syeepiese som = shewiyoud op ofuinsgar ezvonap 36 eld nd oq "Says op sojaqond rammarnodsty sp umin mse moprouteig “Tye soosd nes euicortomoq ‘CRanDae up wee souayued) remy sjeomaye genre Steamainy “somesousowpa nes soigacte ‘somot stsjaesear som efivoacnay ad ‘wueBups nudase amorgangp pasion yuan “SS Ata “lamxs sod SINSUNSOTy BuNaWvoIaaN 3a_ssndoud InTseNys 31v 30D07OLvd Steyls ‘eee unsbaye aie (8 preacey steoq mp orumax 8 sqemmgins yrecaesbe ‘pouahied eyfyae Hosoron pugetioats Tae poyocnoid "Jordnore: rarcori se produce hemoplobiurie 5 prot at # ‘smal retrompective an dovedit 0 ngouri ucbule flosite si doosto eu prudent, mk se eS Tleciuailor trombeembolice iad mult intrvaal Ginwe doze, to foxcie eepbotbi. emote ime bork cerebs ‘par bemoragil le nivelul i, raroori singerdri ms- bone dal 3.28. STARILE PATOLOSICE ebliefsbuloiicatile ete) oa necro eile favori= RENALE PRODUSE DE tubule. Frecvenje acest accident este seam: MEDICAMENTE fia! aed peute cefotch, Asosires ot tte subsiane nefzotosioe (gatbiotice amino samente ~ enticoagu slicozidiee ele.) seu cu furos crests ‘siraile & supradozare), parcetamolal Gn roidiene, slopurinal, compus! rogucerea inavesoasa, iterul Jina gi tceritina, doaele pesiclint, Istamoxeful, pot provoes, de (Gromul este fa general benign. Uneor pa- ogenia este alorgic#, afectarea rinichisini tind tosoqied de erupf cutanate, febré, 135Date SOEs joie Saas TNS es Seine mopmeo Gramone Spey Sees eee SENG “PRSGH ‘eesuese Wormnagiy on foarte Bf aeonee come qaopsatoam T Seemeeee (Guow> s00) pera“ sasopp sasone “Trenrces see “ony (aise Fa emeao of ed sor ever Peoria | oueend et TNE “G HPpaerms Fepihaay Ta re 2 ipnoI seme Soon Sopenowtee Dhotle [ome ce ymree Baia oy ‘erpesd rod of s1eo sumouteoqpour 2piediayd FE ayemar oyforoed ug ae ages “queimoyS my sireyaaijo sent sxafaai09 ‘9p yueundap se-apupiotep Yorsispe panies{| on | | Sonn ipou sarmnay insu; no qeemog ep soucaeaat oo “S! pvr 2ys20p soy ran apn "papSruOpE (0 ‘ated nes yejorss BELSTUOAS nneod me = Rene snp SiNswwolaay so. (2eeieredoa iter ypoqnem mm varios BOlivesH 3 ‘stents vf ‘ipaiop eg “simsice ee 3 Eines a foeea tests ee fe “Bre Mom ango enjons tod Iep one “K emnedoq wp 29 “awed azmjcojo “snus seayiiep sm rent tn ad “awaoud one ‘onmsetoo smmsy exede 5 et : ‘sdoptnom “termmossq> "Tete hoco meoapeces eae aromas a no aog Te wouromeres mars RroIsuOTESIS op BzMUD “woUSUIOSE OP“ “yoyre ‘soisoyoonce sxe 1 gonlane ‘on united “20304 Up a pg afciowep 3 yee eee eee sundnsasd ¢g -otxoy sores sjupe anuod jozummopad ade 8489 sep ‘porBojounts: pam ‘omonsy "BiDA2s mmoy eevep aust: Foowen aa mAeden ousyouns Uy qiste> a sot0355 BN ‘ne ap yiincuioa "wuozenaitisy “aoa crow “rooeessjounmy “ezoyoojamelse 2s 1g ted stusuresypour SANSWYOIOSNN 30 ty sede aro 219 8 2 "yseorsmp wos 5 “areas ay Ws 200 Sep meme etme pepas [iis ad prescoau 3i¢q "78 s20p 25080}03 36. PES guint e-7 uy — Zo|damp © SmIoe) 9D soipRooiomjus soRo|gNE® AOUN w=}EyPIXOIOIO ‘Wrayan ogg, sised curses gfenascass -ordang ame nutad gone; pom 220 epmoons EAH 9 oa OUNGE sso FajoNMOaNY [RMON 2350 gre “32 moory puz> joe sxete 9p ae ayy ns [yen geo op commer soneusetd eaisoo 8 pf 28a op s20cl ve up mins japesaany #6 3—SuSRIe MPN “Si Foon, say ap oqoizmns nnd sqescopey injure senspioid nes eaeneranp apd smearaets vod spspRoongoatas te -grsoy ‘Riotesmuien esmado tanp tater ‘re ra sHfos! nw cfovoucway “pyr 7 sad op ey Eages emma (ome 5 ap spas BIE IAN of aed op atieo o Sy8a oor a88. INTOXIGATIILE ACUTE pot produce acccasi reacic. Patogenia este EDICAMENTOASE gies sau toxict. Disgnosticul 8.8.1. CUANTIFICAREA TOXICIT DIGAMENTELOR, toxice, observate 18 in jeolagi, su un caracter gradat cresciad 0 dati oa doze. Observate asupra ‘raRELo sack Princtpalcle react catanate medicamentoase si uncle dintre ipalele react Sunjale care le proveacl REACTILE CUTANATE PRODUSE DE MEDIGAMENTEoreod aeeorasureapant iomsgas eoimore <0 Te Ryu oo 8 Or aamy— Ho amar OE ojso op — youttdno pesy Saou 9 srlomy wy mel? op ame if maton 4 9p roovloey emmy geetea ‘speroommedas lone of sunopea man wamionor Wwo v1 BSvOLNaMIVOIGaN Binoy SuULVOXOIN! ‘zee mmo nf sea8opog 26 ayermsuecrpom (ous 05 ase “Goma eet 32 ono ap sajaeaa “sonnaortases S20} 22 esieutgmmodepoig denwacesd sundopyCTARELUL WOO (caine) aan a mae OF pene 510 sia Ty Enea Sst, = ETS “ee coma cu amepon oo aS VE 20 ae [seeennk Commins BO See ® (Sina oo ia, Tol 8 SS ashen 10 al Ged SVT Ganesh lois Ge Sto aaa Tae EOS Eiioce ae 3050 aoe y= 55 oe a 0 rg Se 3 os SED = 3 gig, ose Tp anes aE © [Mets mete # oc oo mle #0 mek assor om ad syismusdeg “opsmanssh (enesye | anoe glonsgns op bru! plensoon: 6 ((emim apocdsad {0 OR war afos ope eleep ‘wodp eoronoud ys agedso oimnrang "somercovonied = ‘afasunsey ap yrmorpay ~ seensrmer rnsdnsen wf side amo “cad toson STewmameys wp assige eiupade mcut 185 mInoqwos wena TnOpGOD ¥ op Sedo 2p ne EES FEA omscooe goIpe poy sponse ‘undo op sopiuroyen aje amare o[sr spevsoos moa surlgo “Goud | eoistiace Sdapen I sated fzop funfaso series EcRmp empess 2p siaqpa oy Ee o2ore aqnidoae: ae oe afdtmaxe oe HEROD ne eteorcerm wenofpym wnonm 1 5 “ord FETE As0=8tere] compensstor, dind nestere, prin (Ge sxempiz naloxons sa: IG extazonist 2 morfine, dup8 tenminarea curei de de2- 3.5, MEDICAMENTELE $I ALTE SUBSTANTE DOPANTE * muanipolsi menite #8 modifice pro- belo de unin’. sant nodlnin dopant a spo, Medicine, Modern, eras enelog f‘aud 2an ne mes oyind « nest "yeder =p Sens VISUYA IS JTSLNEWVOIGSN ‘y 1 51 02 “a6 si pepe semen “no see Ss icin on Pan, ooo femme = wag i aw oy many Sasa *r otiod Wear aE Oe Uae ed wat ‘Enbsing st sow minenang WY = nde 7 S861 “Wg “Sy os Seg igor eat Ws Seber Seopasper eenmsens | aL so Sgeoe 9p sn] ounce Reet X sagnooma sora, eepany teas nodose somsposne apo = Tae prion apes yu3t rod 9289 ‘008 ap ats Bt ae nee seunquitpes 29 “aanerss wees, drys cupjaushs oe S0np 328 ‘eis onmpea rom 4 ' sopweunapen = PES “ojamiruoaipase vostans $8 opprapanp ‘wpiqiosgo fed yor wee at un "geese soe uns suqpsdodey aud Pesso opunsjoage sjeoy jeu up 1 zou cmsuonodiy “moot Smoineye sOjLmaNRS era ROeeD ¥ tbmes wsquafio wy oy wonewte bamouTD sour wl iojsaeunoam scaoere tod enqnosesorpino opg0q extsp yaVinoswaoiauyo ViDovOLvd NL OOO WiNEVs snilyuevinouava “re smcrlts puptoaep venoedeed 1 ‘gonnadem Tunued Fimeiiodum amar 2 16 Teen rma “erage 2p aqosszoad rordio ope jeuooens tk fonfoana "ence fame ‘mmseyfog © Ruse zamareaqe wt aeyGS ap 1 soyneders, smoyos wes simeMoopest ay IPHLENLOD “SRINSTEIPE ap Top npaui e nes terSojosod eateourpone oT sum snd coertoep ‘aypams ap sinasoun i AOIDO10LVd IWyLS 37aNn NI 300109 WWHWs STL LVINOLYva. Ssreporie de 60-70% if prin wind, afeo~ | sind eparet, mm mare masur8,atuoci cand tmece pria ficat. Decerece el na gf micgorearh este mult bmp. a 25 de ore (al ‘area di condi. impune prudenfa fa egeste ‘Tiopenald,bacbitrc flosit per anes- teaia generald pe Gotoreste durata foarte scurt a efect ‘Sdipos (bogat in gr2simi, pont care an tezieul are sfinitate mare), pe misura re i sdugeli. la iasuicienta cardiac’, alnamic, Sin’ fa candifiie unui miocard bobay, @ hiper 1 pe cid convatle seca calc intravenoas unde se acum ‘anELOL = hfodificést fiiopatotogice la cordiact care pot influenga reactivitatea tisulard la patologics la ore medleamente aia Saoposianed a pet ae Te aaa Tana RSW En Sa [eas SET) Tearias teen gd | soomcce Se: cae a SR [Oa aT ES poise ‘aces Se em See ae ae alae esa ‘Sea erase pe tt ‘Sova ene 7Jodo geass sfaszuase : “pofom jeredoyay seomcesy wad joumo 25 epaal elberoyaeay yivnse vinaiolinsn ny golpoioovmuy arilyawinounva zs "eeRwol? vas sre 8 wgomme m 0 peearzorey 09 abd “apeeny opgar sed gaaqHoR Tue Pzopioe op aiiozur ob 3p otis oy soeayany juns swore sonoumuoredans 21 18 sateeampeion, ei Le ud oom 33 sarensiurpe 041 nalnsxo op reso Sf aironpuos swoon mem efzazai od ounmsjosoies 8 atdo:oe ear Tresioreq ered RSID 29 sereasteipe ‘date varednuonay “consmae ‘aigsdo ypoew: ad ‘ed ep gsitod 25 yeeatoifony sia sjoaies az8 ay Su ‘og sapanoss rages JOpNCOpEoE Sa egos 1 anne yesna94 yur 30‘rape. xu rebate evitate in prezeafa insuficieapt re iscal ecm ages Sears epi Te ae» pial te ‘isin aka Baas weal | {200 000 wu. cuprind Tedusl, dar reporta dine aaularea cafonulsi ‘restora intervalulaé tute doze le 12 ore la 2 compris Gontsindics chimioterapicul. igoxiaa esto glicozidd tonicardiect cere 26 climind reas, nemodiical® fa pro- Sonic de circa 2/3 fi cae ero ua indicewosade + waite: Ba) 2 3 FE a ores | _ ose [am] ina) Raa eae See yeu ejaspa "F sveojpujeruos june nes OTerop FONEIONT OU 9109 spmaemeMpETY ree taza 28 emo sjomsuroypem anead “pay “to (sous =p atlony ty ‘aBoqosud je UNSTES Image ap nes aN esise}2 2p atomny of sofazop eadnae nm tap area ‘suaiSouoa. year ‘peas HssiogseY Ys cope ¥ soaieo yop un vamp] (PNG sem Jowrundssiog sy g8 dig “en wissss-guempom gener giesegnact seupoa Bf s7soi0y 220g “THeyooten ea ‘etaaiegne vam oa sompo:d 25 nn 2p spe ‘one! 208 Tap ‘eprmedasoqsclimind im proporie mare, aeschimbate, oon angles @ ace cm fn cazal vitaminet D spare o insuicienit ‘Modifier ficlopatologice fn tnsuficienfa renal, eare pot influente proprictiile farmacodinarsice 31 toxicolagice ale medicamentelor Teas Enger pares Bescon "la Sein cava Taga vases, | aloe esc igs aoa cry Tita Sac, Fanoa ls mae Se) wlocasea, ania] as Ze eco ‘uncon pata al Fae aanme Oa naa aaa ae a mas | 184 sudt eficactatea oft dorsle mici, foaomencle de Glen Risoul eresout de hiperkaliemis fc si Remoragile Is ecidul SESE cvteren spiroolasaci, temter- salle sunt mal feovere fa fas Roja gf alr, churetiee care wefia por renal fice antes 8.3, PARTICULARITATILE ficient rene FARMACOLOGICE IN ets esa de seni de potas. Sut” AFECTIUNILE TRACTULUL curasizaat depolerizent, peal DIGESTIV pecuroolinesteraze (6 stutis parcalart sto oon madion rmentelor aniee pore rnici, care WbOHe up Setccle mercurnle (pot provoce necrozé na (poate saetoxilurs renal "Prantl intestinal accelerat tm ente- = ucts acute Gisiatens’ sbeobfia. Feno- ‘eutfes datoait acfonl lor de ssldsre & penal poste # semnificativ cliaic penta venti Oi, rene, de creslere & uedicaientle pofia ligosolubile — butl- Catabolism! prota. epelamint, propaatsint, ncostigsmint rane Sentt ets grind tot- Ge cee gf tm mod normal se absorb I cua simone pour cle organe. Aste, miiat § itegal, De asemcnss, forméle Sosteatle clotoxice ia enitiotcle emise : Sheondice qi la acidul eucraic sont mai de : reparatele Recreate le wemic, fenoteizele 22 Teplice provoact axcod s doorle obi ‘omprimate are 0 biodixponibil- Sais i inegall, se absoasbe mai "enultranalt. gastro saa vapid “Siniroamele obseruceive 1a nivel 85 185sat euseou reese geesaou 3 2289 {018} sp 25E ed ‘syerteueonpens armifoe YOSEF seus wot sod TONES eho rOLvasH arnniloaay 30100100 vHEVS sulyuvinouava Ys 109 wifojorasoydms preaueste 16 weap sp wuss qos mise JQneE yaeaaqorey aro wou 3p 729 38 aod ~ pt ans ep sniea0x9 mon zane op IMOEUEIS © pelafzove at ee ‘sraseeid od gomaae)$ orodacen@ oy ~Wppols sp panto Wie o YATE ATSOSTP TOTOpat induce 0 si de enzime microzomale hepatice, metabo ‘cporaea hepat eee oe oregte Fssul tox Cpurets fa proporils mare de clue Acat, 2 flitua de cele eu tropism toxic be rival prin conjugee le aivelal cet ee deficiert in insuficieals Tape xiv Ccateva medicaments care pot provoce ress toxice lo epael | areeebad seston Stecanismnl gesstora Tria seco jaa Gotennoe Tie Bie aaa ane gga NST SSIS He oe agi Wpoicala wie [ad wee est gon a Go Som ID ‘Fiona ornate jipaciaide coos —_‘[opones bape ea fades asniag ESAT [ipa Ses GuREOTES) O jaa teince plasmstice. Coneceativ concentrais fanguiai creste gi, pemim dozele mari, cee ml tice pot avea reper fi se Axeaz’ In propo matice, Erect sie acs fxts malt grelungit ‘Preduisooul tnde ot reallzeze aivelust ‘msi mel insnfichene parece, hipoalbaminemie ~ Sefece eB creased pro ust peo este Sing; eceste amibitice tind 3B se aow 189sempeceminy uspo area so “arspennys emp ASVOLNANVOIGAIN yumm sn op aundsp aro ‘yasspour a aTNALLOWHALNI “9. apew. XLVE (esos) 6.4, INCOMPATIBILITATILE En eS Bin mead = oe mane Sails, etude, baie, opie, pecomecral, aperimentate, do Ia anime 62:1, INTERACTIUNILE ASUPRA ; PROCESULUI DE ABSORSTIEser Hb. 1 eosroose ‘sj orm sowon por eee snefnfsoaoyfas Sermspauayip 29 FeO 2 warensiunnpe gorD eenoegE yronfom o] eNO “epee sue usp i a om ‘9p tmusse03d sssam03p ssmussnoo ses nereld 2 poupe poe ‘mes wary goronaid ‘serapHSe bs FamnfarD jaoderparg wamnoiypout aja iodswp ato od ayu=uR-neagd ia domenil eandfovascular efit, protongind efestl 1o- vovizeerh dieses Deplasarea de pe procebels plasmatice 1e rea proce de epurare « glicozid ‘seeea, aioiaistare de ch suprevegherce bi = Geren dozel de digoxin ‘hind. dlspost Se edminstenat Gmp fedelungst. ABELL XLV 1 fi relevante lini, datorite deplasieit Weuntlsde Legare Usulard, cn eresterca SF sperices riseul toxle 6.2. INTERACTIUNILE ASUPRA METABOLIZARIL MEDICAMENTELOR smedicementoese Ia nive-ABELL 1 censhmatice, care fea eflesciati Citeva exemple de pot f releyante prin s ABELOL LE ‘modifiearea ellmingrit eracjunl eredicementonse prig fnare, care pot ft Felevante fai Trine eed caine aaa Tim imide come Faxon Teves ant, ae, rei fae Se = oo Sr SS aaariae ager a Meadconante care se eiinarss | Matconante 2 corel 7 Be sige wa YC, Tin iofueantsiok, prcke- Feaivi n ca 6.24. INTERACTIUNILE ASUPRA EXCAETIE! URINARE cl, seo sae ene = pen: ‘3 peotra un pH al ail is § qi pevie 30%, fad pial este 5 Dicicamcatele sab seide se elimintez g0190701Z140WOLYNY aVaLSIS HONN IM3AIN 7 'BOIWWNIGOOVNY sunsilovesini zee Suposeo oo 1p jnaipou eaqensisp seo 3c soyodsmen, isueacar yfejooe gezsquoyq 20200099 “ona, oe enn a oo wn pug “um ayy ty 38 rots Wap nto 1rtowfoe omo shansgns 7 ¥ narsoosy uvinosion, ‘sommumsrggue ated (earEe ynexdoad bd euqeuad “ouy 98 sortssuapeeg sim aja = “qordone INU ase oqo, ma oaja page Bune “eH spied npr 2] fajstes 2p atfoony ay 2p und Z soj20 © negeig “sseoxzmadesie9 aside ‘opeetsqns agrseds pracrqeodeyre ty 200 ontoe of Be Bag “erence otuviigoownuvs Niguo 3a 3svoLNaNyoiaH ‘sTINniLoveaLNI “ee veqmorcey zema sofoqg@t espos ep seeogmoia ep eases “MSDE "JARS BELO} qe EmeQU sea) op& {TABELIL UT (ona) cc. eazd PaS trot sb. ae oct inh, coutioue AV 6 inamie, fim oe miowich re. sma (ia mipsatens) ©) fh Se Suess is 1 2 taco, ato SS, pelcoenis cu poet vse ru tamstpene | 3 teerd 902 oi eee | RISE SH cp von 29 sated “yogoou Ie apis J “Sows Seatpost aaa | soni 2 pear #00 a Gao | seats op seemed 2 | nn a taaeHE z Gmina 1 Tae‘TsRB10. 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INTERACTIUNILE MEDICAMENTE-BAUTURI ALCOOLICE $I MEDICAMENTE-ALIMENTE sau produse latte, care sant bogate 2 sbiorb: 6.4.1, INTERACTIUNILE MEDICAMENTE-BAUTURI ALCOOLICE 042, INTERACTIUNLE dacine gt exoxacins). Absorb flerdl me MEDIGAMENTE-ALIMENTE dlcamentos este micgoratt de eftre uncle ‘componente aie alimeatelor ~ tanin, ca Gin, protine ia exses. Levadopa se ab- Souike mai pois cind ae adsiaistesat cu o diets boss In protene, espectiy feni- feleclat, eauinoseld cu care fot fa com- 5 veghere telor fn stomac Gimp de 2-3 ore face w fgusttiniestinale) tsi, dupa a1, evi- mm 220ewe wane ‘ans “ups ‘mesa imazapig TO -aBan wy Rog {eae Seay oh we Samumojsten ye o suse sojsuemopem © pojuents > EEDI|NUD U8 apoguion op dopereanrd oncassey opemisueoipP Poimnize wg rooyyduy sumo sioongat tod ayucmsye wy emtfoes aprguimny “im mid teipRes eaptoN® Fier nega fue) 2p "oiy solace e'ytum Hud semanas papofom See “im [wut safes swod = song 8 suo, “ade no ~ eos mem TRY Te se eerie. boned gas oa 8 oom) pp extnemnie, uumct soxper Genemane. atc: ors RGINOONpIT yeweARICS oF ‘sengigo od wpsnguioa wud) mgd | goer pamitoe jnaiey Tenojeesn G0 9p svow says semeu> © to oR amp Hpvttord nw snenuayo aay jg Mis nkreemopea tommy SOUS Oia) (as 3 sponimesé sp suxy op atu peHoaied emmeune opment 2p sine. 3 uy atefoq yt OF-og ap aise ayenzn ejszop mraad smnailge wyfenusou0> “(pr fajendaid need a1 ¢) suensiemupe 9 op alan ine erfeqeosoo Freee 222), fad ot pny “quid ido oduan sjetocl SonweRos Tsa0e FHT ado sys no varenormacide praersOHeS rape wp ames OZ Wop ome Ta oj ‘onuneso dopa oe 2e0 aieoup “puase sumaporoual iemmudoud aycut de miocard, daci na exist contain ica Asocieree ex trombolitice intrave~ toe Gajectate fa primele ore ale infarct ff semaclor de isehemie pe electocandio- i Numlnl erizelor Rony een J angine de piept Se adminis. ‘tesa ra, fncepind en doze mist ~ 10 mg Ge 3 onl - gi ecosednd progresiv pind la pana Asecierea cu alte categorit de medies- Insufiioge renslt, wade ta inmficicaye carne 3 te feo 6 periosdi eupriash tou 3 sia miocerdic este att ria ciminuares Cuyului sanguin hepatic. Bradicardin marcedi (cub SO/minu) gi blo feotl ps (ele beta edrenergice la bolnevi on infarct ABELL LX Baar | Foros licence. In conde tratamentahe cro- tear inijal fic, beta blocentsle pot provoce suodifi- met cu 50 mg oral de 1 or/s, eresoind tatea profil lipproteinslor plasmatice Ja 100 mg de 2 ori Soa | Nope a3 338 335aap ea: apn pce emeongy apm as Joyal» aeaeny com opie aR © TRIE tp PEE gy 4 seen sors rane, ope gern mE tegen ne aia sues AV p> le TS sasha ena satis Fae > ace eee ajo etek Jor i Smpiedie& spasmul arterial corona exgommezing, Ia angina cro- isthe Coles. Mosioa anak” Mii satpenense™, 338We 1 2 sonst eooosanes, Wf eam Au ogy og (umedessa enstamps wom 188 oy gaHBHE no weUeg Ym yopsedsores wmgue UP weoqpay as, “a coojamzaso|s impo sotacooise resoupaco i pcs ped sump a selon dase some ‘HUB “(coussenoy peesooley 26 POE “puood ‘pioyes uoqes uadioonoug “pcndoion) yogareder> 4 “Sem ‘aaqajeo yum oymanoayy yest 300 nibeoy “yimuodas ong [esas frau of satay sprzanp manos ~ 5 J T ad meanttpete ~ se — armory a : 2 Sion ] z i 2 a || tora “I Son | SS [mee | Se | cay | eam PIE Jopreues os suNoy] SpoMESIpM OPH aye TwUPEHM SAL snot trav i | sap ~ gopedeg aremjoqnam ted psinds ‘mmenoag, Aes i sincol) “isopan cuomoNsy SIV G55) noKEHOHD our ‘aurea 2 gosnig sosido Edn ‘oses yuHBus 9 Haro BL NCIS musmoue “Tmuetreoypem ypHyenvos no symtosied v| OPN y 200d Qa “ase appr sil guseaoy sezop oso1ou “greaynmnf sise NE Yenyuneed "pow‘Verapamil re 0 biodispont sdmiaistriit sugar. Dozele necesare rapetgl Dov fetiyile farmacocinetice ale principalelor blocante ale canalelor calciuiui Verspanil | _Dildazen $50 > % Ta 30 3 ‘pai, Fal 5 Prope + 15 noverapani} larespand (0%wee ‘ toms ARRON ope ea ms ret op) op sod jeu axfors pmsseen 5p UU anar stop no swords ee 2 nuyigo ne-s oxsar> yoauiean =p TEP omen mado oy pmedezma 2p yee REDE facto wy Yoeojtind Mesteenay 2p yet ‘9pm | ps usage oem sept yan sara soy Jeeeriop oe en cepap 3e= Seen aofann 209 ppmmcoe STOP snueAsp ED soeyEUED LOPE 2p asGeNNENUENRA MFT BANE toox aareeR| * fn angina vasospastici. primente ale nimi, 10.4, ALTE ANTIANGINOASE Amiodarona (aniedarone, canilor, bergice. ‘Farmacocizetics emiodaronei este e+ yacterizald printr-on rronzit fim i o acumulare Gepsa IWorul dine eport gt eliminare 40 siabi- legte dupi cicea o hint de uacament. Tim pl de fnjomatatve ese de 25-52 alle (cu * Capt Asta 346 _. 300 mg de 3 os, apol cfs 200-400 mgs + ecaptarea; de 26 at se edutiaisteazB, ca ant- anginos, pe cal oral, primele 8 le cite 4, 5 alle to fiecare siptimiad. Este indi- cath fn angina or tail Bt gf ponevea la soar, Lion Fipiisetal de tratament rispuasal Ta efor diminceank. Blectl Yor Sniagoniem compedty cu ionii de ealeiu ‘trougsler netezi vascular. Bfi- acitetca in angise pootorla este mode fi, Se administeacd ora, ote 60 mg de ‘Porili Ge Sncepe on doze mai miei). RRedsfle adverse sunt fae: fbn it 5 Ga 3 prize). fa flee infarc terspentics To angina tits conehi- dovedité ou eeritudibe ‘Se sdminiseazé oral, cite 150 mg de ania de dared & vee ease pot f allatste miedicameatos. injecteati intravenos Tents pundsmaoal ae prope easagre- clic 40 mg de 2-8 onl stu pesfure, 400 meta ibsoarbe bine din Re fn lest gi elimi-aalat cee ede mkamitajre intrevenoast rapidi posto fi canzk de wep ote ge admiaisteadd orl, doza obig- Bpotensione arterial jie adverse sunt rare, S-au seat~ MEDIGAMENTE ANTIANGINOASE INREGISTRATE IN ROMANIA Tho Mack (Mack, Germanis), spray 125 mgldoa8, cpr. 20 mg, 49 me, 60 mg (reterd) ° nonis (Oren, Fiend), ops. 20 23. Cord, Corait opr ret 40 mg Pec Romanie, Dexsoo, Ise, Isosorb retard Zéravje, Yugoslavia), voagyes 10 mg, 20 mg, ope net 40 mg. opt. 20 7 Peo round (Pbarwacia, ‘TBesorbld (Aatibitice, Roms), cpt ‘oe ee 2 mg 10 me. 20 mg. ee "Gencve,, — Issorbid dnivar (Laburmed, Romizis), 8 ‘pr. 10 3g. Cts Chemical, see), Isosorbide dinate (EIPICO, Esp), pe. 5 mg, 10 mgbre 32 002 Se og may ade “eusep, silo “(ersancig “VaWS) euourps03 Sa 092 ado Cemmmey “Tame Rucwmponey Peosoponey oorepoguy ssvoursacunie ary wz fe 5 go ort 0 3 oF "any '3do pam “woWD) pundion, ae og Buoy as Cepmmey unpang nny) faery AO “de Bug sto (emeuoy OC % or stern ~ anew pesinay, —VARED Pre apiog “ding i wb emntan “o8—) xepepico Mi go og tr ado ha Gy ate ermal) pie more mepy my ema ERISOAY LoTINT Ceomy weusnt inp wong buon, 8 do “(epaiy “uumpry) sidiecnoug "Bar 0g wo (id Sly) wore donot = sw ot Sm of % ado “(enepso8ing “aljsep2) sma 3 Bm pg var sd Xda “(ermopooeyg “poOTeTY) uaRiPIY “Geant uexeg) ys or eudieoay aaron Ba ¢ Jar ad “memes aay Su gf “Bu g alo WHS) Pevies opis oc db “RRL GET 8 Mppe AD OF eRHOS ‘8a of Bar € x “Oyng “naRE) armuoye Padeopury ImimP[ JopeUED ye UEDA“ 1 gf 5 sg ado Yerepeon ‘pouteoy) ve Bar OF ‘(ommmoy! samaoy) Bu 08 “roy “9 ‘wonmnaowaugd aeiv) emmoypir FYB { =u “Sa 08 “Foy at OF TS ake (OBEY "eSOET-ISD rove Proueadons fur do por ‘soporg) a on 2 opt “tm op abs eh “aso lone mare ‘ ogg “no “(elanig ‘suoy ouaqneg se0y) son97= . 210th Su | ado “efong “opmng) wlowepuny 3a of do “ormmmusg “gary OF ave ‘don orery “But og do 0 ‘EARMEEY 19) JD uoK gpptomeary epemeaoy soiRrouespe-eeg 2ques0ng, Bu og “3d “emu “wmegg se) Buoqoney Ba 02 slo “omopmey“eydas2y) uo ouuaen a {ups (emp “pemyy) werogjaty Sat $2 8 ‘Gepap ‘eam pseu ‘0 gz vat ‘Mo rope sp Saade ‘aR reg re 1/8 ¢ of sb "(oremaing “eges0p) sat xo ‘Bu op Bug ido “eos “wox0) US 09 ‘Op ‘02 puoreuoyy fax gp “Bar gz ido “(renmand ‘suea 28g 21900) sooty owoyy “aa ors alo “Bu op iD 2840) sedep on owe oON OHO sumo pigionony iw ado emguoy ‘poman) apomuoy, Str gp "tng do (rtm, ‘suc eq 22900) pris sooKoyy 3 oF iP eas std) ev 9004)BIBLIOGRAFIE SELECTIVA Tin, Now Yor, 196 Rudurrd J. ~ Phen 35080s stesso someon pale 5 em pf 84 mo eeepc some W sue sme SP ES Sap Ma ~ aE fA cogs gonsuseyd wfens20u09, eed oad of Form wu aod a SN ers ojdeosiosu too nd conte aiounsucdouucig ~ (20 24 bit qicmnl [Bie (OTROS PABST inepco) epeateo esnay myo plea sp yosoise oxduraxe op ‘sfansqas 2p eareyeges wid YVNOWINd ININVLOVAHNS ‘ATELNWHOLOSdXS IS FTSAISMLILNY “8b65 agin. Volumal aparent de dis- kg fer titagul de ang de 3-4 ori. Poste 6 carl mat ‘nibd marin, care este robeil respon sill de efeciul analgesic pot provoca broahospa Uitonith elibeaci dei ful deprimant central. Lat ‘mai mari de 03 mglkg a spimorphine, codstnne, iyrocadone, d- ‘od rin sioteas, 20 propria asemingioae codeine. Riel Scgendenje! este ceva mal mare pentru Dozele wile eant de 25 Decele mazi pat proveca ussciuuce gun, pam bas Go cha, cpl ea administrarca de - ate. * Sireagd gi somacleage. Nu provoacé Pentosiverina (pentoxyerine,carbeto- practic dependeayt at fenal (tevopropoxyphens), Tarudit cu mstadona, are de opioide. Are progriett gl ese slab bronbodiatetoae. Se administeezh or racic scfuae 50 mg dimineas sh seara. La copii s© pol ‘pentty ceime- injroduee supozitoare coafiuéad 20 mg, espe 8 mg i cl sugar (ou se ads-- Sind de 40 mg de 2-3 ris (Comprimste ikea la drste mai aici de 4 Juni). sau capsule retard ated att deprimit inhibin componea- fea, pentru preparatle retard, 50mg rift; dozele recoman congestie nezal, diaee, erupii utanate, 1) dorer-retard, poseladine), un compue de sintexB fi Firudize ou opicidele gi eathistaminicele, 48.2. EXPECTORANTELE Expectorantele sunt substanje care fo- vorizeard expostoraia, crescénd cantaces Ore c-e frets Ao a an-o-on anu Hs = tr ‘ip, 105 ~ Suc cml» wer meicanet eiveas (si wnepoinyie) ores 2p pepe aud se] sacessjodsa ap pau? pseooe TE Co-s0'0 =p e2op af ‘quo of sepydea ‘symm ref un we etppoy ‘qumylod =p aL} gas f20 2 3p) 219 9 samoay af BSE QE =p wise ouopendsor sfeamgasm my 1 propwe =p oud unm sjozoq, eaeys aise gonnadeis aERs w NUS aMGaN HOME sp LAE vereyoeays “omesoadr> ruled aiLEyIp -oID Hosp wf eR wy ~ gleoeTmOME ‘9 eponeov ous‘ tn op ST etn we ato a emer dung oiase® ploerqown no p> Tes ben op @ Sahaape ye p> ION ‘eed woosost ted aroun op SHARS "BIE §-> 2p BO OOE 9P PEE 17E sda docs ty sfepueeioaal 2220p “f2 1 36 BLOT 9p BIRO Soup sp aouop~ mie soy 2 au ee Sys mtg nes pinged sanasrapy us plead onme vo genase? alot + ep weneo y yod aueicyadas vo sysop syeuly “porbuougoryou oyfecoecindy 0 amyf case wo expe sizaneus oqoqued putoyey fsnonar mmmcen © owe 4p sarERU Nevesopoodee wtizodaos wayere i fn, SLNYINWISOLguORS SIINVUOLOaaa “Tze “iu 3 voseoyipnmy to "pseoonas apenas dcp movant sudeeo weap ouHl? od es minstonmeiuscodmes wp io mp rike ‘jruse vouaslaws no “aorbuougoryai 40 fat nes qe “Buco syeedaad op area aur uA, ‘aoe feusip aud jnimona "sm ‘2p jynxoyss konpa 785} oFoupyy op lund “eyeey sep ges ho} “somo Emaydej — prog8et. 9p md ‘uueyp = suansrat md ReETIERS “NCI 18 sou Oy grBoq amIpRY wafer OnE) ~eyooigrongbaye Sg © “IEEE HP “aus no ‘ogsqoj Ts efamiooadig j obey REFAROBOTPEE BOSGE 38) HOS