Male Reproductive Hormone

BIOCHEMISTRY
DEPARTMENT
 REPRODUCTIVE HORMONES
PRODUCED IN THE MALE BODY

™ Pituitary gland produces both FSH and

LH
→In
I response to:
t gonadotropin-
gonadotropin
d t i -releasing
l i
hormone (GnRH)
Gonadotropin--Releasing Hormone
Gonadotropin

™synthesized in hypothalamus:
- carried to p
pituitary
y by
y hypophyseal
yp p y p
portal
system
™secreted in pulses:
p
- at 60–
60–90 minute intervals
™Control rates of secretion of:
– FSH and LH
– testosterone (released in response to LH)
 REPRODUCTIVE HORMONES
PRODUCED IN THE MALE BODY

™ FSH stimulates spermatogenesis

(production of sperm)
™ LH stimulates
i l the
h secretion
i off
testosterone
Luteinizing Hormone

™ Targets interstitial cells of

testes
™ Induces secretion of:
– testosterone
– other androgens
FSH and Testosterone

Target cells of seminiferous tubules

These cells:
– promote spermatogenesis and
spermiogenesis
– secrete androgen
androgen--binding protein (ABP)
Negative Feedback
™ Spermatogenesis
p g is
regulated by:
- GnRH, FSH, and inhibin
™ As
A spermatogenesis
t i
accelerates:
– inhibin secretion increases
Inhibin inhibits FSH
production:
Suppresses secretion of
GnRH at hypothalamus
Inhibin and FSH
Elevated FSH levels:
– increase inhibin
production
– until FSH returns to
normal
If FSH declines:
d li
– inhibin production falls
– FSH production
increases
 TESTES
™ Testosterone
™ Estrogen
™ Inhibin
I hibi
SYNTHESIS
Mechanism of action
Functions of Testosterone
™ Stimulates spermatogenesis:
promoting functional maturation of
spermatozoa
™ Affects CNS function:
libido ((sexual drive)) and related behaviors
™ Est. male secondary sex characteristics:
– distribution of facial hair
– increased muscle mass and body size
– characteristic adipose
p tissue deposits
p
™ Maintains accessory glands and organs