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ELIMINATION OF A DRUG
Sumdili 12:29:00 AM Pharmacology

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Red Lesions of the

Oral Mucosa-
 Differential
Diagnosis, Clinical
Features and
Treatment
Red lesions are a large,
heterogeneous group of disorders
of the oral mucosa. Traumatic
lesions, infections,...

280 Head and Neck

Anatomy MCQ
(Multiple Choice
Questions)
Questions with Answers
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Gross Anatomy All Cervical Vertebra
have a: body spine bifid spinous
process carotid tuber...

White Lesions of
Oral Mucosa
Elimination of a Drug White lesions of the
oral mucosa are a
Termination of drug effect > biotransformation > inactive > multifactorial group of
excreted disorders,the color of which is
produced by the scattering of the
light throu...
Organs of Excretion
Oral
Kidney, Liver.Lungs,Skin (sweat)
manifestations of
vitamin
Kidney > Glom.Filtration,Tubular secretion Re-absorption by deficiencies
passive diffusion Oral manifestations of nutritional
deficiencies include nonspecific
o Glom. Filtration > passive process signs and symptoms that involve
the mucous membrane, the teeth

o Removes mols. Size of small proteins and th...

Neck Swellings-
o Protein bound drug > less Glom.Filtration
Types, definitions,
Etiology, Clinical
o Free drug more filtration > rate approximates cratinine Features,
clearance Investigations, Differential
Diagnosis and Treatment
o Tubular secretion > actively secreted by proximal This is a heterogeneous group of
convoluted tubule lesions, presenting clinically as
fluctuant, soft or firm, lateral or
midline neck swellings. The lesions
o Lipid membrane of nephron reabsorbs lipid soluble
m...
mol.

Urinary System
o Water soluble mol. excreted
and Male and
Female Genital
 Liver Systems Anatomy and
Physiology Diagrams Free
Download
o Actively secreted into bile after metabolism

Equipments,
o Enters G.I.T & may be reabsorbed into the blood >
Instruments and
entero hepatic circulation Materials used in
Oral Surgery
o E.g/ cardiac glycosides and some anti microbials (Armamentarium)
This Post describes the necessary
o Gastro Intestinal Tract > passive diffusion armamentarium,that is equipment
and instruments, as well as the rest
of the materials the dentist may
o Drugs > blood>lipid membrane > lumen of G.I.T.
use ...

Clinical importance of excretion into General Pathology

lumen of gut Multiple choice
questions (MCQ)
o Weakly basic drugs like morphine in high 1. Regarding cell injury
concentrations diffuses into acidic environment of and death a) Initially there is a
reduction in cell size during cell
stomach > poorly re absorbed as it is 100% ionized.
necrosis b) Apoptosis...
Hence can be removed by gastric lavage.

Guess What ????

o If not removed, it is re absorbed in the small intestine
63 year old male
patient presented to
Other organs of excretion the X clinic
complaining of burning sensation in
o LUNGS > Gaseous anaesthetics left side floor of the mouth for 2
weeks. Past medi...

o SWEAT
Acute
inflammation -
o SALIVARY GLANDS
General Pathology
Multiple Choice
o MILK Questions (MCQ) - With
Answers
DRUG CLEARANCE True and False type MCQ's
01. Acute inflammation a. Heal
o Rate of elimination is relative to the conc. Of drug any by suppuration with abscess
formation b. ...
biological fluid e.g. plasma, blood.

CL= Rate of elimination

Pages
Plasma conc.

Oral Medicine
o CL(renal) =
Oral Surgery
Oral Pathology
Rate of elimination(Kidney)
General Medicine
conc.in plasma (Cp) General Surgery
o CL(liver) = Restorative Dentisrty
Prosthetic Dentistry
Rate of elimination(liver) Anatomy
Dental Materials
Cp
Pharmacology

o Rate of elimination Crowns and Bridges

Radiology
o For an organ =QxC(in) – Qx C(o)

Q = rate of bl.flow

C(in) = amt of drug entering Join This site

Followers (170) Next

C(o) = amt of drug leaving

o Bioavailability(F) = 1 – ER(extraction ratio)

o Dosing Rate = CL x Css (IV infusions)

o Half life proportional to VD & CL

Follow
o t1/2 =

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0/693VD or 0.7VD

CL

Loading Dose = VD x Cpss

o Used for long t1/2 drugs > raise conc of drug to steady
state value > amt. of drug in the body when steady
state is reached

o E.g. If reqd. ss conc is 15microgms/ml and VD is 35L

Then LD = 15 x 35 = 525mg

Dosage Regimen
o 1. Dose of drug

o 2. Route of administration

o 3. Dosing interval

o 4. Period of administration Total Pageviews

o Clinical significance of dosing rate

 o Eg. Desired Pl.conc of drug A is 15microgms/ml CL =
48ml/min/70Kg

o Dosing rate = 48 x 15 = 720mugm/min =0.72mg/min =

43.2mg/hour = rate of IV infusion

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