Documente Academic
Documente Profesional
Documente Cultură
Ambulatory
blood pressure
monitoring
Key points
• Ambulatory blood pressure
monitoring (ABPM) is a
Beyond the simple BP
useful tool in diagnosing and
managing patients with an PATRICK G. LAN MB BS, MClinEpidemiol, FRACP
elevated clinic blood ADRIAN G. GILLIN MB BS, PhD, FRACP
pressure (BP) reading.
• ABPM assesses a patient’s Ambulatory blood pressure monitoring (ABPM) is a vital tool in the
BP more accurately than diagnosis and management of hypertension. A systematic approach is
clinic measurements and
provides additional key
required to properly interpret an ABPM recording.
information about the
T
patient’s BP profile, he most recent UK guidelines from the optimal care’ for patients with either suspected
including daytime (awake) National Institute for Health and Care or true hypertension.2 In addition, they have
and night-time (asleep) BP. Excellence (NICE) on the clinical man- identified a number of patient groups for whom
• ABPM can identify patients agement of primary hypertension in ABPM is indicated (Box).2
with masked hypertension adults state that ambulatory blood pressure Unfortunately, ABPM remains underused
© WELCH ALLYN AUSTRALIA. MODEL USED FOR ILLUSTRATIVE PURPOSES ONLY.
(hypertension not detected monitoring (ABPM) should be offered to all in Australia. Possible reasons include the cost
by clinic BP measurements). patients with a clinic blood pressure (BP) read- to patients, the limited availability of ABPM
• Key results from ABPM must ing of 140/90 mmHg or higher.1 Although no and the knowledge gap for many clinicians
be identified to interpret a such recommendation currently exists in about interpreting an ABPM recording versus
recording; these include the Australia, the Ambulatory Blood Pressure a clinic BP reading.
number of valid BP measure Monitoring Working Group (a subcommittee
ments, average daytime and of the National Heart Foundation of Australia WHY PERFORM AN ABPM?
night-time BPs, BP load and National Blood Pressure and Vascular Disease The Australian Ambulatory Blood Pressure
nocturnal dipping pattern. Advisory Committee and the High Blood Monitoring Working Group states that ABPM
Pressure Research Council of Australia) has is indicated for a number of patient groups
formed the consensus view that ABPM provides (Box).2 However, ABPM should be considered
‘considerable added value [on top of clinic BP] for all patients who are being seen for assess-
toward accurate diagnosis and the provision of ment and management of their BP. The key
Copyright _Layout
Dr1Lan
17/01/12 1:43 Fellow;
is a Research PM Page 4
and Professor Gillin is Clinical Associate Professor and Senior Staff Specialist in the
Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW.
Downloaded for personal use only. No other uses permitted without permission. © MedicineToday 2014.
CURRENT INDICATIONS FOR STEPS IN INTERPRETING AN AMBULATORY
AMBULATORY BLOOD PRESSURE
BLOOD PRESSURE RECORDING
MONITORING 2*
ABBREVIATION: BP = blood pressure. Adapted from Head et al. J Hypertens 2012; 30: 253-266. 2
Readings are usually taken over a carried out up to every 15 minutes when attempts result in a successful reading then
24-hour period, and can be performed up the patient is awake, and up to every 30 the recording should be considered satis-
to every 15 minutes when the patient is minutes when they are asleep.2,8 However, factory.2,8 Unsuccessful (‘error’) readings
awake, and up to every 30 minutes when it has been recognised that more than 14 can result from a movement artefact, sys-
they are asleep.2,8 ABPM should be under- BP measurements are required during the tolic BP outside the device’s range, signif-
taken during a normal ‘working’ day for day and more than seven are required at icant variation in the pulse rate and low
the patient, and they should keep a diary night for the ABPM to be considered battery/power.
of the day’s activities, including the time of satisfactory.13 Figure 2 shows the ABPM readout for
any medications, exercise and when they In addition, the percentage of successful Patient X, which can be considered satis-
went to bed. readings must be assessed. There is also factory. A total of 39 valid BP measure-
no international consensus on the mini- ments were obtained with one invalid
HOW TO INTERPRET AN ABPM mum percentage of successful readings (error) measurement, giving a success rate
As ABPM yields multiple BP readings, it required for the ABPM to be considered of 97.5%. Valid measurements comprised
can provide the clinician with information satisfactory. However, current guidelines 31 taken during the day (awake) and eight
beyond simple BP measurement. This suggest that if more than 70 to 85% of measurements taken at night (asleep).
includes average BP readings over the time
of measurement. It must be remembered
that the threshold values for hypertension 200
Patient’s blood pressure
on ABPM are lower than those for clinic 180
Nocturnal dipping Hypertension threshold
BP readings (see Table 1).
160
Blood pressure (mmHg)
40
Is the ABPM satisfactory?
20
The first question that needs to be
15:00 17:00 19:00 21:00 23:00 1:00 3:00 5:00 7:00 9:00 11:00 13:00
answered is whether the ABPM has been
Time
carried out satisfactorily, which is deter-
mined by:
• the number of BP readings during Figure 1. Ambulatory blood pressure recording for Patient X (red lines) compared
both the daytime and night-time with systolic and diastolic thresholds for hypertension (blue lines). Multiple patient
• the percentage of readings which readings during both the day and night are above the respective hypertension
have been performed successfully. thresholds. Nocturnal dipping is seen, with night-time BP measurements taken after
There is no single international protocol 23:00 being slightly lower than those taken before 23:00. However, overall the
stating how often BP should be
Copyright 1 17/01/12patient
measured
_Layout 1:43 PMis aPage
‘nondipper’.
4
during an ABPM, with readings being
Downloaded for personal use only. No other uses permitted without permission. © MedicineToday 2014.
Ambulatory blood pressure monitoring
CONTINUED
Downloaded for personal use only. No other uses permitted without permission. © MedicineToday 2014.
TABLE 2. SUMMARY OF AMBULATORY BLOOD PRESSURE MONITORING FOR PATIENT X
General
Number of measurements 39 31 8
Systolic
Number of measurements 20 (51%) ≥130 mmHg 13 (42%) ≥35 mmHg 5 (63%) ≥120 mmHg
Maximum 190 mmHg at 18:39 190 mmHg at 18:39 146 mmHg at 03:37
Diastolic
Number of measurements 8 (21%) ≥80 mmHg 8 (19%) ≥85 mmHg 3 (38%) ≥70 mmHg
Heart rate
Table 2 shows that the BP load for Dipper or nondipper? compared with their respective daytime
Patient X is more than 20%, given that the There is normally a diurnal variation in averages.2
proportion of BP readings above the BP, with BP being lower at night than Suggested causes of nondipping are
hypertension threshold was 42% for day- during the day, known as ‘dipping’. The both intrinsic and extrinsic. They include
time systolic BP, 63% for night-time sys- ABPM report should be assessed for noc- hormonal and metabolic factors such
tolic BP and 38% for night-time diastolic turnal nondipping, defined as a fall of as increased sympathetic activation of
BP. The BP load was less than
Copyright 20% 1only
_Layout less1:43
17/01/12 thanPM
10%Page
in either
4 the average systolic the autonomic nervous system and
for daytime diastolic BP (19%). BP or the average diastolic BP at night hypothyroidism, various disease states
PURPOSES ONLY.
treatment so as to mirror the normal cir- ABPM provides clinicians with important
cadian BP pattern.22,23 Current results information about the patient’s BP profile,
suggest that there may be some benefit which can be used to guide future man-
from nocturnal dosing of therapy in an agement. It should be considered in all
attempt to achieve the normal diurnal patients with an elevated or borderline What are the recommended
pattern of BP in hypertensive patients. In clinic BP reading. MT indications for ambulatory blood
contrast, some patients show extreme pressure monitoring?
dipping – more than 20%.2 The clinical REFERENCES
Review your knowledge of this topic and
significance of extreme dipping is cur- A list of references is included in the website version earn CPD/PDP points by taking part in
rently not well understood. (www.medicinetoday.com.au) and the iPad app MedicineToday’s Online CPD Journal Program.
Table 2 shows that Patient X is a non- version of this article. Log in to
dipper as his average systolic BP fell www.medicinetoday.com.au/cpd
less than 10% (6.9%) during the night. COMPETING INTERESTS: None.
19%*
Downloaded for personal use only. No other uses permitted without permission. © MedicineToday 2014.
MedicineToday 2014; 15(5): 34-40
Ambulatory blood
pressure monitoring
Beyond the simple BP
PATRICK G. LAN MB BS, MClinEpidemiol, FRACP; ADRIAN G. GILLIN MB BS, PhD, FRACP
REFERENCES
1. National Clinical Guideline Centre (UK). Hypertension: the clinical management blood pressure monitoring compared with ambulatory blood pressure monitoring
of primary hypertension in adults. NICE clinical guidelines, no. 127. London: Royal in diagnosis of hypertension: systematic review. BMJ 2011; 342: d3621.
College of Physicians (UK); 2011. 12. Hara A, Tanaka K, Ohkubo T, et al. Ambulatory versus home versus clinic
2. Head GA, McGrath BP, Mihailidou AS, et al. Ambulatory blood pressure blood pressure. The association with subclinical cerebrovascular diseases: the
monitoring in Australia: 2011 consensus position statement. J Hypertens 2012; Ohasama Study. Hypertension 2012; 59: 22-28.
30: 253-266. 13. O’Brien E, Coats A, Owens P, et al. Use and interpretation of ambulatory
3. Pickering TG. The role of ambulatory monitoring in reducing the errors blood pressure monitoring: recommendations of the British Hypertension
associated with blood pressure measurement. Herz 1989; 14: 214-220. Society. BMJ 2000; 320: 1128.
4. Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure: an 14. Pickering TG, Eguchi K, Kario K. Masked hypertension: a review. Hypertension
independent predictor of prognosis in essential hypertension. Hypertension Res 2007; 30: 479-488.
1994; 24: 793-804. 15. Kawano Y, Horio T, Matayoshi T, et al. Masked hypertension: subtypes and
5. Sega R, Facchetti R, Bombelli M, et al. Prognostic value of ambulatory and target organ damage. Clin Exp Hypertens 2008; 30: 289-296.
home blood pressures compared with office blood pressure in the general 16. Ogedegbe G, Agyemang C, Ravenell JE. Masked hypertension: evidence of
population: follow-up results from the Pressioni Arteriose Monitorate e Loro the need to treat. Curr Hypertens Rep 2010; 12: 349-355.
Associazoni (PAMELA) study. Circulation 2005; 111: 1777-1783. 17. Head GA, McGrath BP, Mihailidou AS, et al. Ambulatory blood pressure
6. Clement DL, De Buyzere ML, De Bacquer DA, et al. Prognostic value of monitoring. Aust Fam Phys 2011; 40: 877-880.
ambulatory blood-pressure recordings in patients with treated hypertension. 18. White WB. Blood pressure load and target organ effects in patients with
N Engl J Med 2003; 348: 2407-2415. essential hypertension. J Hypertens Suppl 1991; 9: S39-S41.
7. British Hypertension Society. Blood pressure monitors validated for clinical 19. Kanbay M, Turgut F, Uyar ME, Akcay A, Covic A. Causes and mechanisms of
use. Available online at: www.bhsoc.org/bp-monitors/bp-monitors/ (accessed nondipping hypertension. Clin Exp Hypertens 2008; 30: 585-597.
April 2014). 20. Verdecchia P, Clement D, Fagard R, Palatini P, Parati G. Blood pressure
8. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC guidelines for the monitoring. Task force III: target-organ damage, morbidity and mortality. Blood
management of arterial hypertension: the Task Force for the Management of Press Monit 1999; 4: 303-317.
Arterial Hypertension of the European Society of Hypertension (ESH) and of the 21. Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure. An
European Society of Cardiology (ESC). Eur Heart J 2013; 34: 2159-2219. independent predictor of prognosis in essential hypertension. Hypertension 1994;
9. Fagard RH, Van Den Broeke C, De Cort P, et al. Prognostic significance of 24: 793-801.
blood pressure measured in the office, at home and during ambulatory monitoring 22. Hermida RC, Ayala DE, Mojon A, et al. Influence of circadian time of hypertension
in older patients in general practice. J Hum Hypertens 2005; 19: 801-807. treatment on cardiovascular risk: results of the MAPEC study. Chronobiol Int 2010;
10. Mancia G, Facchetti R, Bombelli M, et al. Long-term risk of mortality associated 27: 1629-1651.
with selective and combined elevation in office, home and ambulatory blood 23. Hermida RC, Ayala DE, Mogon AE, et al. Bedtime dosing of antihypertensive
pressure. Hypertension 2006; 47: 846-853. medications reduces cardiovascular risk in CKD. J Am Soc Nephrol 2011; 22:
11. Hodgkinson J, Mant J, Martin U, et al. Relative effectiveness of clinic and home 2313-2321.
Copyright _Layout 1 17/01/12 1:43 PM Page 4
Downloaded for personal use only. No other uses permitted without permission. © MedicineToday 2014.