Documente Academic
Documente Profesional
Documente Cultură
DRUG DEVELOPMENT
Arranged by:
Ayu Rahmawati (SBF19840418)
Arifin Chandra (SBF19840420)
istiqomah (SBF191840426)
FACULTY OF PHARMACY
UNIVERSITY OF MIND AND FAITHFUL
Surakarta
2018
Effect of Genetic Medicine Against Drug Metabolism Carbamazepine
I. preliminary
In general, drug metabolism have a sense of a process of change in chemical drugs caused by
the interaction of drugs with endogenous enzyme system that the end result will increase the polarity of
the drug in the body. During the metabolic processes can occur some of the following:
a. Changes drug into a form that is easier for the metabolites excreted
b. Changes pharmacologically active drug into inactive metabolite form
c. Changes the active drug is excreted into the form of its active metabolite
d. Changes inactive drug into its active metabolite form
e. Modification of a drug into metabolites that have a toxic response.
Pharmacogenomics is the science that is believed to explain that the difference in the response
of each individual to a given drug is closely related to genetic differences of each of the individual. The
more information that is known about the role of genetics in particular drug response at the molecular
level will help researchers in drug development. That requires a device that is able to identify a specific
marker that can predict the occurrence of a negative response or positive response in drug
development based on the genomic technology approach.
BIBLIOGRAPHY
Tatyana, B., Kudriakova, Lev.A. Sirota, Galina and Vladimir I. Rozova A.Gorkov. 1992.Autoinduction
and Steady-state pharmacokinetics of Carbamazepine and It's Major metabolites, Br.J. Clin. Pharmac.
(1992), 33, 611-615.