Here is a list of drugs contraindiacated in pregnancy and the side effects which occur due to using these

medications:

(1)NSAIDS (Asprine, Diclofenac, Ibuprofen, Indomethacine… etc) during 3rd trimester. May has effects on
the fetal cardiovascular system (closure of the ductus arteriosus).

(2) Statins (Atrovastatine, Simvastatine, Levostatine… etc). Cholesterol is needed 00 i3 aa6 90 for fetal
growth and its reduction by statins could harm the fetus.

(3) Warfarin:- Causes multiple birth defects.

(4) Testosterone:- Can cause birth defects.

(5) Misoprostol:- Miscarriage.

(6)Sulfamethoxazole/trimethoprim (Bactrim) during 3rd trimester. May increase bilirubin levels leading
to kernicterus.

(7) Nitroimidazole, (Metronidazole and Tinidazole) during 1st trimester.

(8) Griseofulvin:- May increased risk of spontaneous abortion.

(9) Methotrexate:- Causes cleft palate along with multiple defects.(10) Estradiol:- Urogenital
abnormalities in offspring that manifest later in life. May couse uterine cervix, vaginal and testicular
cancer have developed later in life in offspring.
(11) Thalidomide:- Seal like limbs and other defects.

(12) Clomiphene citrate:- Can cause birth defects.

(13) Medroxyprogesterone acetate:- Can cause birth defects.

(14) Vitamin A and its derivatives:- Birth defects, miscarriage.

(15) Danazol:- Causes malformations in sex organs of female fetus.(16) Finasteride:- Even pregnant
women should not handle broken or crushed tablets since it can get absorbed through the skin and
affect the sexorgan development of the male fetus.

(16) Tetracyclines:- Get deposited in fetal bones and retard their growth, also affect teeth causing them
to be discolored and deformed.

(17) Chloramphenicol:- Gray baby syndrome..

(18) Isoniazid:- Neuropthy and seizures in fetus, liver damage in mother.

(19) Sodium Valproate:- Defects of the nervous system.

(20) ACE inhibitors (Enalapril, Captopril, Lisinopril…etc):- Growth retardation, birth defects, fetal death.

(21) Lithium:- Affects fetal thyroid, heart beside causing other abnormalities.
(22) Phenytoin:- Cleft lip/ palate along with other deformities.(23) Anti convulsants:- Trimethadione,
Valproic acid, Carbamazepine – Multiple birth defects.

(24) Androgens:- Multiple defects.list of drugs contraindicated in pregnancy.

FDA categorization of drugs in pregnancy.

Category A; Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the
first trimester of pregnancy (and there is no evidence of risk in later trimesters).

Category B; Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no
adequate and well-controlled studies in pregnant women.

(kategori aman A dan B)