Anticoagulant Comparison Chart

Which anticoagulant is right for me?

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Brand Name
What is the name of the
drug I am taking?

Warfarin Dabigatran Rivaroxaban Apixaban Edoxaban Betrixaban

Generic
Is there a generic Yes No No No No No
available?

FDA Approval Pre-1982 October 2010 July 2011 December 2012 January 2015 June 2017
When was this drug first Warfarin was first
approved by the FDA? used in humans in
1954, before the
FDA regulated
drugs.

FDA Approved For Stroke Stroke Stroke Stroke Stroke The prevention
What conditions is this prevention in prevention in prevention in prevention in prevention in of deep vein
drug approved for? atrial fibrillation non-valvular non-valvular non-valvular non-valvular thrombosis
and valve atrial fibrillation atrial fibrillation atrial fibrillation atrial fibrillation (DVT) and
replacements pulmonary
Treatment Treatment Treatment Treatment
embolism (PE)
Treatment and and secondary and secondary and secondary of deep vein
in hospitalized
prevention prevention prevention prevention thrombosis
medically-ill
of deep vein of deep vein of deep vein of deep vein (DVT) and
patients.
thrombosis thrombosis thrombosis thrombosis pulmonary
(DVT) and (DVT) and (DVT) and (DVT) and embolism (PE)
pulmonary pulmonary pulmonary pulmonary
embolism (PE) embolism (PE) embolism (PE) embolism (PE)
VTE prevention VTE prevention VTE prevention
after hip after hip after hip
replacement and knee and knee
surgery replacement replacement
surgery surgery

Drug Image and Variable 75 mg, 110 10 mg, 15 mg, 5 mg or 2.5 mg 15 mg, 30 mg, 40 mg or 80
Available Drug mg, or 150 mg or 20 mg tablet tablet or 60 mg tablet mg capsule
capsule
Strengths

Dosing Frequency Once Daily Twice Daily Once Daily Twice Daily Once Daily Once Daily
How often do I take (following a three (following a one (following an inital
this drug? week loading week loading single dose of 160
period of twice daily period of 10 mg mg, then 80 mg
for PE and DVT) twice daily for PE once daily for 35 to
and DVT) 42 days)

Onset
How long does it take Slow: Fast: Fast: Fast: Fast: Fast:
for the drug to be Several Days A Few Hours A Few Hours A Few Hours A Few Hours A Few Hours
working in my body?

Kidney Function No Yes Yes Yes Yes Yes

Should my kidney Kidney function Kidney function Kidney function Kidney function Kidney function
function be considered affects the dosage affects the dosage affects the dosage affects the dosage affects the dosage
before starting this drug?

Food Effect Yes No Yes No No Yes

Do I need to take this Speak with your Xarelto should Bevyxxa doses
drug with food or can provider about be taken with the should be taken at
vitamin K intake dinner meal. the same time of
this drug be affected
and warfarin. day with food.
by the food I eat?
Drug Interactions
How many other drugs Many Few Few Few Few Few
may interfere with the
way this drug works?

Routine Lab
Monitoring Yes No No No No No
Do I need to monitor my
anticoagulation level?

Reversal Agents Yes Yes Soon Soon Soon Soon

Are there agents to (Vitamin K, Fresh Praxbind (May use (May use (May use (May use
reverse major bleeding? Frozen Plasma, (idarucizumab) Prothrombin Prothrombin Prothrombin Prothrombin
Prothrombin Complex Complex Complex Complex
Complex Concentrate in Concentrate in Concentrate in Concentrate in
Concentrates) emergencies) emergencies) emergencies) emergencies)

This chart is for informational purposes only. Always consult with your healthcare provider before starting a new medication.