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The breast generally refers to the front of the chest and medically specifically to the mammary gland.
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(The word "mammary" comes from "mamma," the Greek and Latin word for the breast, which
derives from the cry "mama" uttered by infants and young children, sometimes meaning "I want to
feed at the breast.")
Mammary Gland Design
The mammary gland is a milk-producing structure that is composed largely of fat cells (cells capable
of storing fat). The fat deposits are laid down in the breast under the influence of the female hormone
estrogen.
Just as the surge of estrogens at adolescence encourages this process, androgens, such as
testosterone, discourage it.
Within the mammary gland there is a complex network of branching ducts (tubes or channels). These
ducts exit from sac-like structures called lobules.
The lobules in the breast are the glands that can produce milk in females when they receive the
appropriate hormonal stimulation.
The breast ducts transport milk from the lobules out to the nipple. The milk exits the ducts from the
breast at the nipple.
the chest wall. The characteristic bounce of the breast comes from the elasticity of the matrix of connective
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throughout life, women may experience various kinds of breast pain and other breast changes. Some of these
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changes normally occur during the menstrual cycle, during pregnancy, and with aging. Breast lumps,
tenderness, and other changes may occur. Most breast lumps and other changes are not cancer.
The breast is composed of several glands and ducts that lead to the nippleand the surrounding colored
area called the areola. The milk-carrying ducts extend from the nipple into the underlying breast tissue like
the spokes of a wheel. Under the areola are lactiferous ducts. These fill with milk during lactation after a
woman has a baby. When a girl reaches puberty, changing levels of hormones cause the ducts to grow and
cause fat deposits in the breast tissue to increase. The glands that produce milk (mammary glands) that are
connected to the surface of the breast by the lactiferous ducts may extend to the armpit area (axilla).
There are no muscles in the breasts, but muscles lie under each breast and cover the ribs. These normal
structures inside the breasts can sometimes make them feel lumpy. Such lumpiness may be especially
noticeable in women who are thin or who have small breasts.
Lumps within breast tissue are usually found unexpectedly or during a routine monthly breast self-
exam. Most lumps are not cancer but represent changes within the breast tissue. As your breasts
develop, changes occur. These changes are influenced by normal hormonal variations.
Breast pain is a common breast problem in younger women who are still having their periods, and
happens less often in older women. Although pain is a concern, breast pain is rarely the only
symptom of breast cancer. Most breast cancers involve a mass or lump.
Cyclic mastalgia: About two-thirds of women with breast pain have a problem called cyclic
mastalgia. This pain typically is worse before your menstrual cycle and usually is relieved at the time
your period begins. The pain may also happen in varying degrees throughout the cycle. Because of
its relationship to the menstrual cycle, it is believed to be caused by hormonal changes. This type of
breast pain usually happens in younger women, although the condition has been reported in
postmenopausal women who take hormone replacement therapy.
Noncyclic mastalgia: Breast pain that is not associated with the menstrual cycle is called noncyclic
mastalgia. It occurs less often than the cyclic form. It typically occurs in women older than 40 years
and is not related to the menstrual cycle. It is sometimes linked to a fibrous mass (called a
fibroadenoma) or a cyst.
Breast pain or tenderness may also occur in a teenage boy. The condition, called gynecomastia, is
enlargement of the male breast which may occur as a normal part of development, often during
puberty.
Breast infection: The breast is made up of hundreds of tiny milk-producing sacs called alveoli. They
are arranged in grapelike clusters throughout the breast. Once breastfeeding begins, milk is produced
in the alveoli and secreted into tube-shaped milk ducts that empty through the nipple. Mastitis is an
infection of the tissue of the breast that occurs most frequently during the time of breastfeeding. This
infection causes pain, swelling, redness, and increased temperature of the breast. It can occur when
bacteria, often from the baby's mouth, enter a milk duct. This causes an infection and painful
inflammation of the breast.
What Causes Breast Lumps and Pain?
Many possible causes exist for pain or tenderness in one of your breasts or in both breasts. Most often the
pain can be attributed to harmless causes such as puberty or pregnancy. It can also be a recurrent problem
for women with cyclical pain associated with the menstrual cycle. Although cancer is a major concern for
most women, it is rarely the cause of isolated breast pain.
Some causes of breast pain are:
Fibrocystic breast disease
Premenstrual syndrome, cyclic mastalgia
Normal hormonal fluctuations
Onset of puberty or menopause
Pregnancy
Breastfeeding (nursing)
Estrogen therapy
Chest wall tenderness (costochondritis)
Injury to the breast (trauma, after breast surgery)
Shingles (pain is only in 1 breast, usually accompanied by a rash)
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Use of certain medications such as digoxin
(Lanoxin), methyldopa(Aldomet), spironolactone (Aldactone), oxymetholone (Anadrol),
and chlorpromazine (Thorazine)
An infection in the breast (breast abscess, mastitis)
Breast cancer
If you have a lump in your breast, your doctor will check for the following:
Fibrocystic changes: Fibrocystic changes, previously called Fibrocystic Disease, are the most
common benign or harmless (does not threaten health or life) condition of the breast. Changes can
occur in one or both breasts, most commonly in the upper and outer sections. You may feel a
thickening of the fibrous tissue that supports your breasts. Common lumps, called fibroadenomas,
occur during the reproductive years. They feel rubbery and moveable. They often occur with
fibrocystic changes.
Cysts: Breast cysts are fluid-filled lumps. They can be tender, especially before your period.
Breast cancer: Some lumps may be cancer. Breast cancer is usually associated with the risk factors
of age, genetics, or hormones. About 75% of breast cancers occur in women older than 50 years,
23% occur in women ages 30 to 50 years, and 2% occur in women under 30 years of age.
o Genetics is believed to play a role if your mother or sister (referred to as first-degree
relatives) were diagnosed with breast cancer before menopause. You have a two to three
times higher risk than the general population of developing breast cancer.
o Hormonal factors may play a role. If you have had the following conditions, you may have an
increased incidence of breast cancer (possibly because of longer exposure to a hormone
called estrogen).
Had your first period at an early age
Had menopause at a later age
Have never had a child or your first pregnancy was after age 30
o Cancer may also be explained by one of many theories including exposure to viruses,
chemicals, radiation, dietary factors, and genes (for example, BRCA-1). No single theory
explains all types of breast cancer.
What Are the Symptoms of Breast Lumps and Pain?
Breast lump: Although alarming when you find one, most breast lumps are not cancer.
Breast pain: Most commonly associated with fibrocystic changes, pain may occur in both breasts,
though one may be more painful than the other. With fibrocystic changes, the pain occurs about a
week before your menstrual period. The pain usually goes away gradually with the onset of your
period.
o Cyclic breast pain is typically most severe before your period and gets better during your
period.
It is usually described as bilateral (in both breasts), in the upper outer areas of your
breast, and is often associated with lumpiness.
Women tend to describe this pain as dull, aching, heavy, or sore, and it can radiate to
your armpit or even down your arm.
The intensity of pain can vary widely with the range of severity from mild to severe
enough to limit clothing selections,sleep positions, or hugging.
o Noncyclic breast pain is typically unilateral (only on 1 side) with no relationship to your
menstrual cycle.
This pain may be constant or on and off and irregular. It is described as a sharp,
stabbing, burning pain that appears to be right below the area around your nipple.
If it is localized and persistent, it may be due to the presence of a fibroadenoma or
cyst. But other more serious causes must be ruled out.
Nipple discharge: May occur from an infection, or from cancer, or from very small tumors within a
part of the brain called the pituitary gland, which influences secretions from the breast. In cases of
infection, the discharge is usually brown or greenish. The color and characteristic of nipple
discharge, however, cannot be used reliably as an indicator for, or against, the diagnosis of cancer.
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o Mammograms are the best tool for the early detection of breast cancer.
o The test is more sensitive in women over the age of 30. Mammograms detect 85% of cancers,
but up to 15% can be missed. Thus, if a suspicious lump is found, and mammography is
normal or the doctor cannot distinguish the lesion as having a cancerous appearance, then the
doctor may order an ultrasoundor fine-needle aspiration to be performed. An alternative
would be to repeat the mammogram in another 6 to 12 months.
Ultrasound: If a lump is found, an ultrasound scan helps distinguish between a fluid-filled sac (cyst)
in the breast and a solid lump. This distinction is important because cysts are usually not treated, but
a solid lump must be biopsied to rule out cancer. In a breast biopsy, a piece of the lump is taken out
and tested for cancer.
Aspiration: If a cyst-like lump is found, fluid may be drawn out of it by suction (aspiration) with a
syringe and needle. Examination of the fluid and repeat exams will help your doctor decide what
other tests to do.
Fine needle aspiration: Special techniques of aspiration (drawing out a sample of fluid or tissue with
a needle) may be used on certain masses.
Excisional biopsy: Occasionally, the surgeon may prefer to remove the whole lump and send it for
analysis in a lab. In this case, you will be scheduled for surgery to remove the lump.
If you have a family history of breast cancer, your doctor may also suggest genetic testing to see if
you have any genes known to put you at higher risk for breast cancer.
Your doctor will be able to classify your breast pain as cyclic or noncyclic by taking a thorough history.
After performing a physical examination, the different causes of noncyclic breast pain can be found. Both
components of your visit to the doctor will determine an appropriate management strategy for you.
Questions that your doctor will ask you to help decide if you have cyclic or noncyclic breast pain
include your age, the position of the pain, the character of the pain, and the relation of the pain to
your menstrual cycle.
You should inform your doctor if you have a history of taking hormone replacement therapy or oral
contraceptives, previous history of breast problems, breast surgery, or a family history of breast
cancer.
It is also important to tell your doctor if you have any other breast symptoms such as nipple
discharge or a lump that you can feel.
The diagnosis of mastitis and breast abscess can usually be made based on physical examination.
If it is unclear whether a mass is due to a fluid-filled abscess or to a solid mass such as a tumor, a test
such as an ultrasound may be done. An ultrasound may also be helpful in distinguishing between
simple mastitis and abscess or in diagnosing an abscess deep in the breast. This noninvasive test
allows your doctor to directly visualize the abscess by placing an ultrasound probe over your breast.
If an abscess is confirmed, aspiration or surgical drainage, and IV antibiotics, are often required.
Cultures may be taken, either of breast milk or of material aspirated (taken out through a syringe)
from an abscess, to determine the type of organism causing the infection. This information can help
your doctor decide what kind of antibiotic to use.
Non-breastfeeding women with mastitis, or those who do not respond to treatment, may have a
mammogram or breast biopsy. This is a precautionary measure because a rare type of breast cancer
can produce symptoms of mastitis.
Breast Lumps and Pain Self-Care At Home
Limit your intake of caffeine in coffee and soft drinks, theophyllines in tea, and theobromine
in chocolate. Although the role of these methylxanthines is controversial, some women report
improvement in pain when they limit these.
Daily vitamin E can reduce fibrocystic changes. Avoid doses higher than 600 mg per day.
Wear a well-fitted bra or sports bra for support, especially if you have large breasts. You may want
to wear a comfortable bra to bed.
Apply warm compresses to your breasts for pain relief.
Over-the-counter pain medication may help.
Make note, and avoid, any foods that may seem to cause the pain.
Keep a diary of pain, documenting frequency and severity for at least a two month period. This may
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be enough to convince you and your doctor that the pain is cyclic and not severe enough to warrant
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does not cause cancer, but some cancers can mimic mastitis in appearance. If a breast infection is
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slow to go away, your health care professional may recommend a mammogram or other tests to rule
out cancer.
Breast Lumps and Pain Prevention
Once you reach age 20, you should begin to do a monthly breast self-exam. The best time to examine
yourself is about seven to eight days after your period begins. If you have passed menopause, do it the same
time each month. If you find any suspicious masses, report them immediately to your health care
professional for testing. Tumors found during your monthly self-exam are usually in an early stage. You
have a better outcome and a higher long-term survival in these cases if cancer is found. Most lumps are not
cancer.
Performing regular breast self-exams will allow you to familiarize yourself with your body and alert
you when a change in your usual breast tissue is found.
Repeating the breast exam and completing a pain diary for a few consecutive menstrual cycles will
also help establish whether your breast pain is cyclic or not.
The American Cancer Society Guidelines for the Early Detection of Cancer recommend yearly
mammograms starting at age 40. Also, Women in their 20s and 30s should have a clinical breast
exam (CBE) as part of a periodic health exam by a health professional, preferably every three years.
After age 40, women should have a breast exam by a health professional every year.
If you are younger than 40 and in a high-risk category (for example, many women in your family
have breast cancer), you should ask your doctor about how early you should have your first
mammogram.
Sometimes mastitis is unavoidable. Some women are more susceptible than others, especially those
who are breastfeeding for the first time.
Breast Lumps and Pain Prognosis
Premenstrual breast pain usually increases with age and then generally stops at menopause. Most women are
able to control their symptoms without hormonal treatment.
When treated promptly, the majority of breast infections go away quickly without serious complications.
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