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Introduction:
The human stem cell was first isolated in 1998 (just 20 years
ago). Because the stem cell has the unlimited capacity to
proliferate and to give rise to every cell in the body, prominent
scientific leaders and pioneers proposed that the stem cells could
therefore be used to solve the most elusive & devastating human
diseases. At that time, 1998-2000, there were there very few
scientists doing stem cell research and very little funding to do so.
Because of the vision of the citizens of California, patient
advocates and researchers, some of whom you will hear from
today, the California Institute for Regenerative Medicine was
formed in 2004 and California has played a critical role as a
leader in a medical revolution called---REGENERATIVE
MEDICINE.
Clinical Trials:
(3) While these previous examples are with blood stem cells,
we are also funding trials using stem cells that are not
from the patient such as the use of gene-modified
allogeneic (from donor tissues) neural stem cell therapy
for ALS (Lou Gehrig’s disease) – in a trial being
conducted at Cedars Sinai
We do not yet have a clinical trial with iPSC in the US but the
promise for these iPSC cells is tangible & will take a few more
years to mature – for instance in taking a skin biopsy, turning it
into dopamine secreting neurons and treating Parkinson’s
Disease. That will require the type of early investment, expertise
in translational research and specialized systems that CIRM has
put in place.
Conclusion:
California is the birthplace of biotech, an industry built on the use
of the natural biology of microorganisms to produce therapies,
California is now also in the lead in the new field of regenerative
medicine, a field that harnesses the natural biology of the human
cells to produce therapies that were previously unimaginable.