PICOT:

In hospitalized patients, what is the effect of Therapeutic Temperature Management (TTM) on preserving brain function compared with no temperature intervention?

By: Mallory Jennings, Molly Murphy, Caroline Nolan, Stephanie Olson, Sydney Plum

Authors, title, Year Purpose Variables Subjects Data Results

journal pub Dependent Independent #, sex, age Sample Design Source Yr collected
Andrews, P. “Evaluation for 2013 To compare the Survival to Whether the 77 random randomized Clinical data Septe 21 of 43 patients
treatment of comatose effects of hospital patient patients control trial collected using mber treated with
survivors of out-of-hospital moderate discharge received tympanic or 1996 hypothermia survived
cardiac arrest with induced hypothermia with treatment bladder - June compared with 9 of 34
and sufficiently with thermometers, 1999 patients treated with
hypothermia.” ​F1000-Post
normothermia good normothermi ABGs, other normothermia that
publication Peer Review of in patients who a or
neurologic lab values, survived.
the Biomedical Literature remained function hypothermia pulmonary
unconscious artery catheters,
after and
resuscitation documentation
from in the
out-of-hospital computer.
cardiac arrest.

Bernard, S et. al. “Treatment 2002 To determine if Patient Hypothermia 77 (43- Randomized The data of Septe -Hypothermia
of Comatose Survivors of moderate outcome or hypotherm control trial, outcomes was mber improves outcomes in
Out-of-Hospital Cardiac hypothermia (hospital Normothermi ia, theoretical obtained 1996- these patients
Arrest with Induced improves discharge a 34-normot framework, dependent on a June
outcomes in with good hermia) using specialists 1999
Hypothermia” ​New England
patients with neurologic male and biophysiologi review of each
Journal of Medicine coma from female, c measures
function) patient at
cardiac arrest. 41-85 discharge.
Hemodynamic,
biochemical,
and
hematologic
data was
obtained
throughout.
 Authors, title, Year Purpose Variables Subjects Data Results
journal pub Dependent Independent #, sex, age Sample Design Source Yr collected

Brännström, M et. al. 2018 Explore the Lived type of 7, male Descriptive Interviews 2013 Having a near-death
“Experiences of surviving a perception of experience of patient and qualitative event can increase the
cardiac arrest after therapeutic TTM from someone (treated with female, 29 design; type ability to live in the
hypothermia treatment. An those who treated with therapeutic -79) of present, but can also
experienced it therapeutic hypothermia phenomenolo decrease the sense of
interview study”, ​International
hypothermia post cardiac gy research well-being, which can
Emergency Nursing arrest) create anxiety.

Chandrasekaran, P., Dezfulian, C., 2015 The purpose of Participants participants 939 randomized measure of No More patients died in
& Polderman, K.“What ​is the right this study was were targeted were targeted participant controlled all-cause time the 33 degrees C group
temperature to cool post-cardiac to determine to 36 degrees to 33 degrees s of trial mortality, perio than in the 36 degrees
arrest patients?” ​BMC Critical whether celsius for celsius for unconscio neurological d C group.
hypothermic body body us adults function as given
Care
goal of 36 temperature temperature older than evaluated by
degrees celsius to warm to 37 to warm to 18 years of cerebral
decreases degrees 37 degrees age who performance
mortality rates celsius celsius survived category scale
compared to 33 an out of and modified
degrees celsius hospital ranking scale
cardiac
arrest
Cronberg, T et al. “Neurologic 2015 To compare the Cognitive Type of 939 Randomized Cognitive Nov. Quality of life was
Function and Health-Related effects of 2 function. person - random clinical trial function was 11, similarly good in both
Quality of Life in Patients target Assessed multicenter, patients measured by 2010 the 33°C and 36°C
Following Targeted Temperature temperature with the international, from 36 the - group. Cognitive
regimens on Mini-Mental randomized ICUs in Mini-Mental Janua function was similar
Management at 33°C vs 36°C
long-term State 939 Europe State ry but many patients
After Out-of-Hospital Cardiac cognitive unconscious and 10th,
Examination Examination experienced
Arrest” , ​JAMA Neurol. function and and patients Australia (MMSE) and 2013 impairment.
quality of life IQCODE. Informant
after cardiac Questionnaire
arrest on Cognitive
Decline in the
Elderly
(IQCODE), as
well as Medical
Outcomes
Study 36-Item
Short Form
Health Survey,
version 2
 Authors, title, Year Purpose Variables Subjects Data Results
journal pub Dependent Independent #, sex, age Sample Design Source Yr collected

Kim, Y., Lee, S., Jin Jo, S., & 2015 Identify barriers Questions interviewed 40 longitudinal interviews Dece Out of 34 hospitals that
Park, K.“​Implementation of the to and facilitation asked to people 2 interviews qualitative mber participated in the
guidelines for targeted of guidelines for people who months after and two study 2010- TTM training, 26 said
temperature management after targeted did not the TTM focus Febru they were likely to
participate in groups ary implement TTM after
cardiac arrest: a longitudinal temperature training
training 2012 the training.
qualitative study of barriers and management course
course
facilitators perceived by hospital after cardiac
resuscitation champions” ​BMJ arrest.
Journals
Laver, SR et. al. “Therapeutic 2006 To ​assess the N/A N/A 246 Descriptive Data collected 1-mo Out of 246 ICU’s, only
hypothermia after cardiac arrest: a extent to which intensive qualitative through survey nth 64 were implementing
survey of practice in intensive care therapeutic care units study using over the perio TTM. Reasons for not
units in the UK” ​Journal of the hypothermia is in the UK content telephone, d using included not
being used for analysis analyzed durin being aware of the
Association of Anaesthetists of
unconscious through g evidence supporting it
Great Britain and Ireland patients after May
Microsoft and not knowing about
cardiac arrest, Excel and TTM at all.
how it is being spreadsheet. June
achieved and of
the reasons for 2005
non-implement
ation on each
ICU.
Macrae, D., Tasker, R., & 2014 To compare Patient Targeted 950 (476 Experimental Obtained from Nove No significant
Elbourne, D. “Targeted two target Outcomes body pts-33 Design, national/hospita mber difference between the
Temperature Management after temperatures (mortality/ne temperature- degrees, Randomized, l registries; 2010- two. Hypokalemia
Cardiac Arrest” ​New England and determine urologic 33 or 36 474 pts- 36 blinded Neurological Janua more frequent in the 33
if one is more function) degrees degrees), Data from ry degrees group
Journal of Medicine
effective in celsius male and in/out of 2013
regard to female, hospital visits,
cardiac arrest 51-77 telephone;
patient Remaining data
outcomes. from direct
observation