Pathology: LMN? UMN?

Progressive (or) Motor symptoms Sensory Unique Features:

Non-progressive symptoms
Guillain Barre YES NO Non-Progressive Flaccid paralysis, Parathesias - Recovery of function
fasciculations,
areflexic
Post-polio YES NO Atrophy and Secondary - Could present in some muscles in one LE and
syndrome weakness radiculopathies not in another (or other muscles involved)
- Imbalances – scoliosis
- Cold intolerance
- Pain from joint instability
ALS Yes yes Yes Weakness, flaccidity, Usually spared/ok - Doesn’t usually impair cognition or basic
paralysis, senses
fasciculations, - respiratory system becomes compromised
increased tone, - fast moving disease
increased reflexes - specific in what areas of the nervous system it
attacks (regionally/can be asymmetrical)

MS Yes Yes Yes—can be Weakness, spasticity Decreased - autoimmune response related to stress
progressive/remittent sensation - exacerbation, relapse, flare
o symptoms >24hrs
can go into remission - Heat sensitivity
with or without return o Ambient/core temp
of previous level of - Lhermitte’s Sign
function… o Momentary electric like sensation
evokes by neck flexion or cough
- Fatigue
- Variable disease course/rate of progression
based on type
PD No No YES Bradykinesia, - fatigue: more related to generating tension
rigidity, resting and difficulty moving vs. neurological fatigue
tremor, flat affect, - tremor/freezing/rigidity
postural muscle - slow rate of progression
weakness - can take higher intensity exercise