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Abstract
Background: Over the past few decades, advancements in computer science and engineering
have led to the development of augmented reality technologies, which superimpose 3-
dimensional virtual objects onto the real-world view, providing an enhanced experience for the
user. One application of augmented reality is in minimally invasive surgery, where patient
imaging can be overlaid on the surgeon’s field of view to provide vital information about
anatomical structures that are otherwise obstructed or hidden. Despite the applicability of
augmented reality to minimally invasive surgery and its potential contribution to the future of
medical science, its benefit to the patient is largely unknown and unproven.
Objective: This systematic review investigates the patient outcomes of augmented reality-
assisted minimally invasive surgery reported in the literature.
Methods: PRISMA standards were followed. Nine studies were selected from a search of
MEDLINE, Pubmed, EMBASE, OVID Healthstar, Web of Science, Engineering Village, and CINAHL
databases. Information was extracted about technology design, patient outcome measures,
surgical procedure, and clinical implications.
Results: Nine studies met the inclusion criteria of this review. Implementation of augmented
reality in minimally invasive surgery can be characterized by the method of image integration
onto the operative field of view. Overall, very few studies were found that reported patient
outcomes, with most focusing instead on subjective accounts and comments on technological
feasibility.
Conclusions: Although a variety of patient outcome measures were reported in the studies
included this review, there is still a considerable opportunity to improve the rigor with which
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augmented reality-assisted surgical research is done. More studies featuring randomized
controls are needed to prove the benefit of this technology to patients.
Table of Contents
Abstract ........................................................................................................................................ i
Introduction ................................................................................................................................ 1
Methods ...................................................................................................................................... 4
Study Eligibility ........................................................................................................................ 4
Search Strategy ....................................................................................................................... 4
Study Selection........................................................................................................................ 5
Data Extraction and Synthesis ................................................................................................ 6
Results ......................................................................................................................................... 7
Study Characteristics............................................................................................................... 7
Patient Outcomes ................................................................................................................... 8
Methodological Quality .......................................................................................................... 9
Publication by Year ............................................................................................................... 10
Discussion.................................................................................................................................. 11
Emergent Themes ................................................................................................................. 11
Quality of Research ............................................................................................................... 16
Ongoing Challenges .............................................................................................................. 20
Limitations of the Review ..................................................................................................... 21
Conclusions ............................................................................................................................... 22
Appendix A: Study Characteristics by Theme ........................................................................... 23
Appendix B: Search Strategy by Database ................................................................................ 25
Appendix C: Medline Search Strategy (OVID Search Engine) ................................................... 26
Appendix D: PRISMA Checklist .................................................................................................. 27
References ................................................................................................................................ 29
ii
Introduction
Modern advancements in engineering and medical science have led to the development
of new technologies that make surgical procedures faster, safer, and less traumatic for the
patient [1]. Improvements in medical device engineering and imaging technology have made it
possible for surgeons to perform highly complex surgical procedures through very small incisions,
limiting the risk of infection for the patient [2]. Over the past twenty years, minimally invasive
surgery has become the preferred technique across many specialties of medicine because it
drastically decreases the length of hospital recovery time for the patient [2]. Unlike traditional
open surgery, minimally invasive procedures are performed using a combination of thin-needles
and an endoscopic camera to guide the operator through the procedure [3]. Although minimally
invasive techniques reduce postoperative pain and offer patients improved cosmetic outcomes,
there are several setbacks associated with this approach [4]. For example, with limited access to
internal organs, surgeons cannot rely on their tactile feedback for palpation of anatomical
landmarks or tumor boundaries which are visually hidden [4]. Additionally, endoscopic
navigation in minimally invasive surgery is often done on a two dimensional display, which
eliminates the operator’s depth perception and encumbers hand-eye coordination, leading to a
potential increase in operative time [4]. To help combat challenges from the restricted field of
vision, the adoption of augmented reality techniques in minimally invasive surgery have allowed
for an enhanced surgical view by incorporating additional medical images onto the operative
field. In this way, the use of augmented reality combines the advantage of direct visualization
that is achieved through the traditional open surgery with the patient benefits of minimally
invasive surgery.
1
With the use of ultrasound, CT scans, MRIs, and other imaging techniques, physicians are
anatomy to make informed decisions for disease treatment and surgical intervention [5]. These
reconstructions can be used during surgery where the surgeon has real-time access to the
reconstructed images fused with the real environment, creating an augmented reality. In the
broad sense, augmented reality is defined as adjusting the natural feedback to the operator using
simulated cues [6]. This augmentation can be accomplished using an optical head-mounted
display where the user can see directly through a semi-transparent display medium to the real
world fused with projected virtual images [6]. Alternatively, a monitor-based display can be used
in which the computer generated images are digitally overlaid onto live or stored video feeds [6].
As this technology has developed, it has been found to have many potential applications in
surgical practice ranging from training simulations to use in the operating room [7].
room requires three main steps to take place (Figure 1) [8]. Using modern imaging techniques,
pre-operative or intraoperative scans are taken of the area of interest. These images are then
digitally overlaid onto the patient in real time, enhancing the surgeon’s field of view.
2
Patient •Ultrasound, CT scans,
Imaging MRIs
•Augmented realty is
Enhanced presented to surgeon
Surgical View via "see-through" or
monitor based display
Because of the relative infancy of both augmented reality and minimally-invasive surgery,
few studies have examined the clinical implications of the combined use of these technologies.
Previous reviews have investigated the use of augmented reality in training only [9] and in
neurosurgery [10], but few have focused on the broad impact of this technology on patient
outcomes. Another review published in 2004 by Shuhaiber investigated the current state of
augmented reality and its bearing on surgical training, education, and patient treatment. The
authors concluded that due to the preliminary stage of the technology, further research was
required to fully assess its long term clinical impact on patients, surgeons and hospital
administration [11]. Since 2004, several advancements have been made in the field of
augmented reality, from improved rendering capabilities, image quality, and the popularization
of head-up displays. As such, this systematic review aims to included more recent developments
3
in augmented reality-assisted minimally invasive surgery reported in the literature, specifically
Methods
This review was planned, conducted, and reported in adherence to PRISMA quality standards
[12].
Study Eligibility
Inclusion criteria were established following the Cochrane Review Protocol and organized
according to the PICOS framework [12], [13]. The search included: Population: human surgical
surgeries with and without augmented reality assistance; Outcome: patient outcomes.
were included in this review. To ensure consistency and reliability of outcome measures, we
excluded studies featuring surgeries performed by medical students or surgical trainees. We also
excluded studies that included robotic co-intervention and those that used augmented reality for
preoperative planning purposes only. Lastly, studies that used cadavers or phantom patients
were excluded. No exclusions were made based on publishing year, age of participants, medical
Search Strategy
A database search strategy was initially developed by the team of researchers (E.J., C.G.,
and K.V.) and further refined after consultation with a librarian from the Bracken Health Sciences
Library of Queen’s University. The following seven databases were chosen and searched in
4
February 2018: MEDLINE, Embase, Ovid Healthstar, Pubmed, Cumulative Index to Nursing and
Allied Health Literature (CINAHL), Engineering Village, and Web of Science. These databases were
research literature, nursing research, engineering research and patents, and multidisciplinary
scholarly journals.
Combinations of key terms were used to generate a text string which was used to search
databases and can be seen in Appendix B. These three groupings of key terms were used to
search for studies involving augmented reality and similar technologies, minimally invasive
surgery, and reported patient outcomes. These groups were combined to give a final search
result with studies containing all three term categories. Search results were further refined to
only include studies written or translated to English, the spoken and written language of the
research team. A summary of the search protocol and number of results can be found in
Study Selection
To identify all papers relevant to our topic, a multistage review process was adopted. For
each stage, two raters independently reviewed each reference and disagreements were resolved
by discussion. Every effort was made to avoid bias between reviewers by ensuring the review
In the first stage of the review, titles and abstracts were screened for studies that
surgery. Sources were classified in Excel as either “yes,” “no,” or “maybe” based on their
5
adherence to the inclusion and exclusion criteria. Articles that focused on the use of augmented
reality for medical simulation or surgical training purposes were excluded. In the second stage
of the sorting process, we further refined our inclusion criteria to studies which reported patient
outcomes in the abstract or title. We searched specifically for terms including operative time,
postoperative complications, self-reported pain, and length of hospital stay. During the third and
final stage of the review, a list of full text papers that fit the criteria of the review was compiled.
For some titles, only abstracts were available and full text articles were not accessible online. In
these cases, the review team contacted authors directly for full-text access.
Each full text article was then assessed independently by two reviewers using the
McMaster School of Rehabilitation Science Critical Review Form for Quantitative Studies [14]. As
a group, the authors compiled the critical review forms to summarize the main results that were
applicable to this review. A key objective of this review was to discover whether the use of
augmented reality assistive technology improved patient outcomes when used in the context of
minimally-invasive surgery. As such, a coding scheme was developed to extract the following
information from each study: name of authors, year of study, number of patients, study type,
surgical procedure, branch of medicine, imaging type, AR design, technology development stage,
outcome measures, clinical implications, and study bias. The stage of technological development
was determined as “prototype” if the software was developed by the researchers themselves
and “developed” if commercially available licensed software was used. The quality of each article
was also assessed according to the Sackett’s Level of Evidence guidelines [15].
6
Results
The initial database searches yielded a total of 2228 titles after the removal of duplicates
(Figure 2). Three hundred and forty-four articles met the criteria of the first stage of the review
and 23 sources went to full text review. A total of eight studies remained that met the criteria
for the review and one additional relevant paper was found through reference screening. Two
of the nine total papers were only available in abstract form [16], [17]. All first authors of these
abstracts were contacted via email, but unfortunately, we were unable to gain access to any of
Study Characteristics
The nine final papers resulted in a total of 208 participants on which surgical interventions
were performed. One hundred and thirty-four surgeries were done with the use of augmented
reality technology and 74 were done without the use of augmented reality. Only two studies
7
reported a surgical control without the use of augmented reality [18], [17]. Seven of nine studies
featured augmented reality technologies in the design and prototype stage of development,
The design features of each study were also noted, including the type of image capture,
time of image capture in relation to the surgery, method of image overlay, and software used.
All studies used one or more forms of medical imaging to generate visualizations of the target
area for the surgery. The medical imaging techniques used in the studies were
immunofluorescence, CT scans, ultrasound, and MRI. CT scans were the most commonly used
technique with four studies solely using it [18]–[21] and one study using a combination of CT
scans and MRI [22]. Methods of image overlay and software varied across studies. Lastly, clinical
implications of the technology were noted and included subjective accounts on technological
feasibility and expert opinions. A summary of the extracted study characteristics can be seen in
Appendix A.
Patient Outcomes
The reported patient outcomes were not consistent across studies. Figure 3 shows a
breakdown of the patient outcomes most commonly reported in the literature. Due to the
variety of surgical procedures included in this review, outcomes pertaining to specific surgeries
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8
7
6
Number of Studies
5
4
3
2
1
0
Operative time was the most commonly reported outcome with seven of nine studies
reporting this measure. Only two studies were found that compared the surgical times between
the particular surgery performed with or without the AR technology [18], [17]. One study
investigated the use of augmented reality in single incision laparoscopic surgery (SILA) [] and the
other examined the use of ICG immunofluorescence in pure laparoscopic hepatectomy []. The
reduction in operating time was only found to be significant in the study involving SILA (p=0.05)
[18]. These two studies also compared the blood loss and hospital stay of the patients, but
Methodological Quality
Overall, the levels of evidence of the articles reviewed were very low. Seven of the nine
articles were case series studies, where information was only presented regarding the outcomes
of the group of patients and contained no comparison between patients with and without the
selected intervention [15]. This yielded a level of evidence of five [15]. Two articles reported
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nonrandomized historical cohort comparisons between those patients who did and did not
receive the intervention of augmented reality-assisted surgery. For these studies, a level of
evidence of four was assigned, as the patients used for the comparison without the use of
augmented reality had undergone the surgery in an earlier time period at the same institution
[15]. Lastly, one article was determined to be a nonrandomized concurrent control trial and was
Publication by Year
Figure 4 shows the resulting numbers of studies per year from the initial search results
after deduplication before screening was done. The result shows that research on the application
of augmented reality in surgery has increased greatly within the last decade. It should be noted
that many titles were excluded because they reported the use of augmented reality for surgical
training and planning purposes but did not actually implement augmented reality in the
operating room.
10
Discussion
Emergent Themes
From the nine total studies included in our review, three main themes were developed, based
on the method of image integration onto the operative field of view. In preoperative imaging
augmented reality, patient imaging is captured prior to surgery and three dimensional models of
internal structures are rendered prior to surgery and overlaid onto the endoscopic screen. In
contrast, intraoperative imaging augmented reality renders patient data in real time with the use
of live-imaging techniques such as open MRI and ultrasound. Lastly, inside out tracking uses
special markers and motion tracking cameras to define organ boundaries that can deform with
tissue movement. A breakdown of each theme and the relevant papers is featured in Appendix
A.
i. Preoperative Imaging
Preoperative imaging augmented reality involves the use of medical images of the patient
taken prior to surgery of the area of interest. One of the primary benefits of this form of
augmented reality is the lack of pre-processing required to create 3D visualizations from CT and
MRI scans [23]. The use of preoperative images in forming an augmented reality is most common
in the areas of neurosurgery, otolaryngology, and orthopedics, where the target organs are rigid
and have a constant spatial relationship to anatomical landmarks [24]. There were three studies
reviewed which involved the use of this augmented reality technique. One using CT scans and
another both CT scans and MRI images that were reconstructed in 3D and superimposed onto
the laparoscopic or endoscopic video screen during surgery [18], [22]. The third study was
conducted using the Android app “Sina Neurosurgical Assist” to view CT scan images
superimposed onto the patient’s head using a smartphone’s camera and screen [21].
11
The use of preoperative CT scans to enhance the endoscopic video was able to
significantly reduce the time taken to perform single-incision laparoscopic adrenalectomies [18].
It was found that during minimally invasive cardiac surgery, the operation time, rather than the
length of skin incision, had a greater impact on the patient’s postoperative outcomes [25]. As
such, a reduced operative time through the use of augmented reality in minimally invasive
Surgery performed to remove intracerebral hematomas using the Android app to create
and segment reality resulted in good patient outcomes overall and a relatively short duration of
surgery; however, these statements did not include quantitative results or comparisons [21].
that is associated with poor postoperative outcomes [21],[26]. The mean preoperative Glasgow
Coma Scale (GCS) score (6.7 ± 3.2) was compared to those recorded one week after the
hematoma evacuation occurred (11.9 ± 3.1) and showed significant improvement (p<0.01) [21].
Although the increase GCS scores is promising, it is still unclear whether there is benefit to the
hematomas [27].
Another study found the addition of augmented reality very useful for tumor location
during pediatric surgery, as six tumors were successfully detected using the augmented reality
navigation system and were resected without complications [22]. However, the preoperative
image augmented reality system could not be used for tumor detection and resection in one
patient due to intraoperative organ deformation of the liver [22]. This study exemplifies the
drawback to this imaging technique; static CT or MRI images are no longer accurate when
12
intraoperative tissue displacement has occurred [7]. Overall, the use of preoperative imaging in
augmented reality is useful for positioning and locating areas of interest, but is not useful when
that do not reflect changes in anatomy due to organ deformation and shift during surgery [24].
The inability to reflect these changes has caused inaccurate targeting and major limitations to
navigation [7]. By providing real-time updates throughout the surgical process, the navigation is
made more accurate throughout the entire procedure [28]. The intraoperative imaging studies
in this review used immunofluorescence, CT scans, laparoscopic ultrasound, and MRI to image
during the surgeries. Although perioperative imaging is commonly performed in the operating
room, augmented reality technologies allow the fusion of these images onto the endoscopic
intraoperative imaging techniques. All augmented reality systems were found to be helpful in
visualization during the surgeries, allowing the additional visualization of structures or tumors
that would not normally be visible through traditional means. The stereoscopic augmented
reality reported a small five minute addition to the operating room setup time with the inclusion
of the augmented reality system [16]. As the operating room setup time for a conventional
laparoscopic cholecystectomy only takes approximately ten minutes, the additional cost of five
minutes was deemed acceptable [16]. The study featuring radiofrequency trigeminal rhizotomy
(RFTR) surgery for trigeminal neuralgia (TN) using the addition of virtual images concluded that
13
through the more accurate guidance, there is potential to decrease complications and pain
thoroughly highlight the liver tumor throughout the surgery. Indocyanine green (ICG) is a sterile,
anionic, water-soluble, tricarbocyanine molecule which, when injected into the vascular system,
binds to plasma proteins and can highlight areas of interest. Based on the ability for ICG to
evaluation can be used in clinical applications, such as the detection of cancerous tissue [29]. The
study from The University of Hong Kong concluded that the short-term outcomes from the
technique were equally viable compared to the conventional technique [17]. This method lead
to the identification of three additional tumors which would have otherwise been missed, which
implies a positive patient outcome of the use of this technology [17]. Therefore, the use of
how to account for the movement of “unconstrained” organs in the thoracic and abdominal
cavities that occur during the surgery, as pre-operative imaging techniques only provide static
organ location, reducing the value of this data [7]. Unlike rigid anatomy, soft tissues are prone
to unpredictable organ shift and tissue deformation, often caused by patient movement, patient
breathing, and heartbeat as well as movement resulting from surgical manipulation itself [7]. In
endoscopic thoracic and abdominal surgeries, there is a lack of anatomical reference points,
14
making it difficult to create constant spatial relationships between target structures to provide
adequate orientation [7]. To overcome the organ shift and tissue deformation that occurs in soft
tissue surgery, the inside-out tracking method has been developed. First, custom navigational
aids are inserted into the organ of interest. An algorithm is run that allows for the tracking of the
navigational aids, enabling real time tracking of the target organ. Using preoperative images, a
3D reconstruction is created and a colour code is used to identify each anatomical structure of
interest. The reconstructed virtual images of the organ in real time are superimposed onto the
The inside-out method of augmented reality was used in two studies, each requiring
precise removal of cancerous soft tissue. Both studies were conducted without complications
and no surgeries were reported to require conversion to open surgery. All surgeries performed
using inside-out tracking reported negative surgical margins, indicating that the resected tissue
did not contain any cancerous cells at the outer perimeter [20], [30]. In two surgeries, it was
noted that the use of augmented reality allowed for the visualization of hidden accessory vessels
additional surgical time was required to perform repairs [20]. In a preliminary study using this
technology during a laparoscopic radical prostatectomy, it was suggested that this method of
navigation system can help in nerve sparing, leading to improved patient continence and potency
following the surgery [30]; however, these reported values were not compared to those obtained
without the use of augmented reality. Overall, it was concluded that the use of inside-out
tracking is feasible for clinical use and has the potential to simplify the surgery and increase tool
15
Quality of Research
Levels of Evidence
A general low level of evidence was common among the studies reviewed, with few
featuring a control group. Although case series studies can be useful in determining the feasibility
of augmented reality in minimally invasive surgery, the lack of a control group prohibits
conclusions regarding patient outcomes. For example, operative times were reported in most of
the case series studies, but without comparison to a control group, this measure does not provide
any insight into the patient benefit of this technology. As each of the studies included in this
review involved different types of minimally invasive surgery, it was not possible to compare the
operating times between the studies either. The operative times reported may have been
influenced by the additional time required for the implementation of augmented reality in the
operating room. To inform the benefit of augmented reality as a clinical intervention, all variables
must be controlled, which can be very challenging for in vivo interventional experiments [8].
It was noted that a large number of titles returned in the initial search were feasibility and
proof-of-concept studies that did not critically examine the benefits of the technology to the
patient and only provided qualitative parameters of a subjective nature. Although expert opinion
holds value in clinical settings, only quantitative measures of patient outcomes provide concrete
evidence of clinical feasibility of new technologies. As such, future studies featuring the use of
augmented reality in minimally invasive surgery should take care to report quantitative measures
of patients.
benefit to the patient when augmented reality is used. The median operating times were shorter
16
for the patients undergoing augmented reality assisted surgery; however, only in SILA was the
time found to be significantly improved [18], [17]. The median blood loss and hospital stays in
both studies were found to be less when AR techniques were employed, but the difference was
not statistically significant from those in which conventional minimally invasive surgeries were
performed on only a small group of patients, limiting how the generalization of the results of
these studies can be applied to augmented reality assisted surgery as a whole. Another limitation
of the study performed using ICG is that the surgeries performed using conventional minimally
invasive surgical procedures were recorded over a three-year period and compared
retrospectively. By using historical data from previously conducted surgeries, is possible that
inappropriate comparisons may have been formed limiting the level of evidence of this study
[15]. Due to the limitations of these comparison studies, it can only be concluded that there is
potential benefit to patient outcomes with the use of augmented reality in minimally invasive
surgery, but further studies with a higher level of evidence are required to make definitive
conclusions.
Stage of Development
A significant number of studies were excluded from the first title and abstract screening
process because they tested augmented reality technology in surgery on animal models,
phantom patients, or cadavers. This observation suggests that augmented reality as a medical
intervention is still in the design and testing stage of research and that studies involving human
patients and controls may be on the horizon. Figure 5 shows typical life cycle of clinical trials as
reported by the Ontario Institute for Regenerative Medicine. Because there are relatively few
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studies involving live patients reported in the current literature, it is likely that research in
augmented reality-assisted minimally invasive surgery is still in the beginning phases of animal
Augmented reality technology has risen in popularity over the past ten years, which has
sparked the development of several new commercially-available devices such as Google Glass
and Microsoft HoloLens [32]. Prior to the release of these devices, augmented reality
technologies were considered to be bulky and cumbersome and were unsuitable for use in
surgery [33]. When plotted by year in Figure 4, our search results show a steady increase in
publications each year, with a spike in 2012. We hypothesize that this peak in publications may
correspond to the release of Google Glass in 2012 and its subsequent decrease in popularity since
then [32]. One editorial reports that using the currently available goggles in the operating room
is impractical and that the ideal augmented reality device in surgery should have a see-through
lens, such as a head-mounted device or mobile application, so that the surgeon can see the real
world in case there is a problem [34]. With mobile device processing speeds and image rendering
capabilities constantly improving, it is likely that new trends in augmented reality technology will
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Identification of Bias
There were several sources of possible bias identified in the studies included in this
review. The risk of bias was consistent across all nine full text articles reviewed. Because the
topic of this review is centered on the success of a new technology in surgery, it is likely there is
some level of reporting bias in the literature. That is, only studies which show acceptable or
favourable patient outcomes are published [14]. For each study, there is a risk of sampling bias
for patients who underwent this experimental treatment [14]. Although most studies reported
that participants gave informed consent prior to surgery, it is not stated how participants were
chosen for study inclusion. Therefore, it is possible that patients were selected based on the
their disease or overall health at the time of treatment. For most studies, surgeons self-reported
the perceived usefulness of augmented reality in minimally invasive surgeries after operation
completion, which may have been influenced by recall bias. For qualitative measures such as
these, it is difficult to assess the reliability of outcomes, especially when researchers may directly
benefit from the technology’s success. Similarly, several studies were performed during the
prototype stage of technology development, with the creators of the technology being its
operators in the experiment. As such, it is probable that performance bias was present
throughout, since surgeons may have been influenced to perform better to improve study
outcomes [14]. To ensure quality and reliability of evidence in future studies involving
augmented reality- assisted minimally invasive surgery, care should be taken to minimize these
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Ongoing Challenges
Due to the complex nature of merging the surgical field of view with patient data,
discrepancies between images and reality can cause considerable challenges to implementing
abdominal surgery, where organs may shift with movement and respiration [7]. For this reason,
augmented reality is currently most reliable for surgeries where the target is rigid, such as
orthopedics. However, as our review has shown, new advancements in soft tissue tracking offer
a promising solution to overcoming these issues. Although inside-out tracking is a fairly new
method, this surgical intervention is likely paving the way for the future of augmented reality-
assisted surgeries.
Because the field of augmented reality-assisted surgery is still in the early stages, efforts
to implement this technology have been widely independent and duplicative. For example, most
of the studies included in this review featured augmented reality devices made in-house using a
combination of existing imaging equipment and did not utilize commercially available
technologies, likely because there is no industry standard for modeling and communication of
intraoperative imaging data, tracking, and surgical planning [35]. This lack of standard obliges
researchers to develop most of the components of their own navigation systems, which increases
expense and time. For this reason, collaboration between institutions at the forefront of
augmented reality research may lead to more substantial advancements in the field, especially
for the newer and more complex inside-out tracking methods. Of the nine papers included in
this study, none were done in collaboration with engineering teams. One potential reason for
the lack of engineer involvement is that the presence of extra people in the operating room may
20
impede surgical workflow [36]. However, as an interdisciplinary research interest, the
computer scientists, and engineers to build a more robust and reliable technology that will
was to compare patient outcomes in studies which conducted surgeries both with and without
the use of augmented reality assistance, only two studies featured control. As such, the review
criteria were modified to include papers which reported patient outcomes, even those that did
not have a control group. The issue with this approach is that the reported patient outcomes do
not bear much significance or scientific integrity without a control to compare them to. Although
measures like operative time and blood loss may be meaningful in other contexts, the clinical
implications of augmented reality in surgery are difficult to assess unless matched with controls.
Also, it is possible that relevant papers were missed in the initial sorting procedure because they
did not report patient outcomes in the abstract but did report them in the manuscript text.
Papers may have been missed that were not catalogued in the seven databases that were
searched, which would constitute database bias [37]. Furthermore, because we only searched
databases and did not hand-search journals or search engines, it is possible that source-selection
bias was present [37]. Additionally, because only English articles were reviewed, it is likely that
some papers that were published in languages other than English may have met our inclusion
criteria but were not found in the initial search [37]. Lastly, although every effort was made to
include a broad scope of search terms to encompass relevant articles, it is possible that some
21
surgical techniques or patient outcomes were not included in the search and may have been
Conclusions
This systematic review sought to investigate whether the use of augmented reality in
minimally invasive surgery improved patient outcomes. Although the initial database search
results seemed promising, very few papers were found to actually report patient outcomes of
these procedures, and instead featured case studies with subjective accounts on technological
feasibility. Of the nine studies that did report patient outcomes, the measures themselves varied
across studies, with only two including control groups. As such, the methodological quality of
the studies included in this review was generally very low, with small sample sizes throughout.
More studies featuring randomized controls are needed to evaluate the clinical implications of
this technology, and care should be taken to avoid bias of the operator. Furthermore, as there
are several methods of integrating patient imaging onto the operative field of view, there is likely
a lack of industry standard for augmented reality and a need for further collaboration between
medical specialists and engineers. Overall, the results of this review suggest that the use of
augmented reality assistive technology during minimally invasive surgery is useful for enhancing
surgical view, but there is currently not enough quantitative evidence to prove benefit to the
patient.
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Appendix A: Study Characteristics by Theme
Table 1: Intraoperative Imaging
Level of Technology
Number of Study Branch of
Title Author Evidence Surgical Procedure Imaging Type AR Design Development Outcome Measures Clinical Implications
Patients Type Medicine
(Sackett's) Stage
The role of augmented reality by Operative time
Two group Promising technique that
ICG immunofluorescence in pure Total: 80 Immunofluorescence Blood loss
Cheung cohort Laparoscopic hepatectomy might facilitate easier tumor
laparoscopic hepatectomy for HCC With AR: 20 4 General Surgery Immunofluorescence overlaid onto laparoscopic Prototype Hospital stay
(2017) study, ad (partial liver resection) identification during
and cirrhosis: A propensity score Without AR: 60 view Postoperative
hock laparoscopic hepatectomy.
analysis complications
Accuracy and success level
Virtual reality imaging technique in Radiofrequency trigeminal rate of RFTR can be improved.
Total: 2769
percutaneous radiofrequency Meng Case series rhizotomy for the Intraoperative CT scan Surgical complications Accurate location guided by
With AR: 26 5 Neurosurgery CT Developed
rhizotomy for intractable (2009) studies treatment of trigeminal images Reoperation need 3D CT VR has the potential to
Without AR: 0
trigeminal neuralgia. neuralgia decrease complications and
pain recurrence after RFTR.
Total: 7 The technology will aid in the
Real-time laparoscopic
Stereoscopic augmented reality With AR: 4 visualization and accurate
Shekhar Case series Laparoscopic ultrasound images merged
visualization for laparoscopic Without AR: 0 5 General Surgery Laparoscopic Ultrasound Prototype Operation time resection of sub parenchymal
(2015) studies cholecystectomy with live stereoscopic
surgery-initial clinical experience *Error with first lesions by minimally invasive
laparoscopic video
3 approaches.
Hospital stay
Tumor ablation therapy of liver Prototype - Morbidity
Total: 34 Intraoperative open MRI Using open MRI, a navigation
cancers with an open magnetic Maeda Case series combination of Postoperative
With AR: 34 5 Percutaneous liver ablation General Surgery MRI and Ultrasound imaging combined with image integrating MRI and US
resonance imaging-based (2008) studies developed complications
Without AR: 0 ultrasound enabled real-time tumor
navigation system technologies Intraperitoneal
hemorrhage
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Table 3: Preoperative imaging
Level of Technology
Number of Surgical Branch of
Title Author Study Type Evidence Imaging Type AR Design Development Outcome Measures Clinical Implications
Patients Procedure Medicine
(Sackett's) Stage
Hematoma volume
pre-op and post-op
Image-guided endoscopic Operation time
Total: 25 Smartphone camera and Resulted in good outcomes and
surgery for spontaneous Sun Case series Laparoscopic Endoscopic op time
With AR: 25 5 Neurosurgery CT Android smartphone app Developed relatively short duration of
supratentorial intracerebral (2017) studies hematoma removal Blood loss
Without AR: 0 "Sina neurosurgical assist" surgery.
hematoma Pre-op and post-op
(1 week) GCS score
Pre-op planning
The AR navigation system is
very useful for detecting
An augmented reality Various tumor removal unrecognized tumor location
Postoperative
navigation system for pediatric Total: 6 procedures Laparoscopic video screen during pediatric surgery,
Souzaki Case series Pediatric complications
oncologic surgery based on With AR: 6 5 2 Laparoscopic CT and MRI with superimposed CT and Prototype especially endoscopic surgery.
(2013) studies Oncology Operative time
preoperative CT and MRI Without AR: 0 2 Thoracoscopic MRI images The system could not be used
Prognosis
images. 2 Laparotomy for tumor detection with liver
resection because of intra-
operative organ deformations.
Augmented reality single Perioperative
Image-overlay system
incision laparoscopic Nonrandomized complications The AR method can reduce the
Total: 19 Single incision between real-time
adrenalectomy: Comparison concurrent Morbidity operative time without causing
Lin (2018) With AR: 8 3 laparoscopic General Surgery CT laparoscopic view and a Developed
with pure single incision cohort Operative time any additional mortality or
Without AR: 11 adrenalectomy reconstructed 3D surgical
laparoscopic technique comparison Blood loss morbidity.
model
Hospital Stay
24
Appendix B: Search Strategy by Database
MEDLINE Search performed through Ovid Search Engine. See Appendix C for search. 667 Limited results
to English
Pubmed ("AR" or "VR" or "augmented reality" or "mixed reality" or "virtual reality" or 868 Limited results
"head-up display" or "head mounted display" or "virtual displays" or “augmented to English
reality surgical”) AND TOPIC: (“minimally invasive” OR “laparoscopic” OR
“endoscopic” OR "surgery" OR "surgical") AND TOPIC: (“patient outcomes” OR
“patient care” OR “hospital stay” OR “self report” OR “operation time” OR
“operating time” OR “recovery time” OR "post operative")
Ovid Search performed through Ovid Search Engine. See Appendix B for search. 372 Limited results
Healthstar to English
Embase Search performed through Ovid Search Engine. See Appendix B for search. 1255 Limited results
to English
Web of ("AR" or "VR" or "augmented reality" or "mixed reality" or "virtual reality" or 885 Limited results
Science "head-up display" or "head mounted display" or "virtual displays" or “augmented to English
reality surgical”) AND TOPIC: (“minimally invasive” OR “laparoscopic” OR
“endoscopic” OR "surgery" OR "surgical") AND TOPIC: (“patient outcomes” OR
“patient care” OR “hospital stay” OR “self report” OR “operation time” OR
“operating time” OR “recovery time” OR "post operative")
Engineering ("AR" or "VR" or "augmented reality" or "mixed reality" or "virtual reality" or 872 Limited results
Village "head-up display" or "head mounted display" or "virtual displays" or “augmented to English
reality surgical”) AND TOPIC: (“minimally invasive” OR “laparoscopic” OR
“endoscopic” OR "surgery" OR "surgical") AND TOPIC: (“patient outcomes” OR
“patient care” OR “hospital stay” OR “self report” OR “operation time” OR
“operating time” OR “recovery time” OR "post operative")
CINAHL ("AR" or "VR" or "augmented reality" or "mixed reality" or "virtual reality" or 18 Limited results
"head-up display" or "head mounted display" or "virtual displays" or “augmented to English
reality surgical”) AND TOPIC: (“minimally invasive” OR “laparoscopic” OR
“endoscopic” OR "surgery" OR "surgical") AND TOPIC: (“patient outcomes” OR
“patient care” OR “hospital stay” OR “self report” OR “operation time” OR
“operating time” OR “recovery time” OR "post operative")
25
Appendix C: Medline Search Strategy (OVID Search Engine)
Database: Ovid MEDLINE(R), Ovid MEDLINE(R) Daily and Epub Ahead of Print, In-Process & Other Non-Indexed
Citations <1946 to Present>
Search Strategy:
--------------------------------------------------------------------------------
1 augmented reality.mp. (1171)
2 AR.mp. (47012)
3 exp virtual reality/ or virtual reality.mp. (7436)
4 mixed reality.mp. (153)
5 head-up display.mp. (66)
6 head up display.mp. (66)
7 virtual display.mp. (26)
8 augmented reality assisted surgery.mp. (2)
9 augmented reality surgical.mp. (12)
10 VR.mp. (6144)
11 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 (59236)
12 minimally invasive.mp. (64077)
13 laparoscop*.mp. (124446)
14 endoscop*.mp. (215220)
15 surgical.mp. (1198468)
16 surgery.mp. (1140465)
17 12 or 13 or 14 or 15 or 16 (2054207)
18 patient outcome*.mp. (43258)
19 patient care.mp. or exp patient care/ (968924)
20 hospital stay.mp. or exp hospitalization/ (246028)
21 self report.mp. (61580)
22 operation time.mp. or exp operation duration/ (10554)
23 operating time.mp. or exp operation duration/ (10321)
24 recovery time.mp. (9034)
25 postoperative.mp. (706947)
26 post operative.mp. (51612)
27 post-operative.mp. (51612)
28 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 (1659097)
29 11 and 17 and 28 (1075)
26
Appendix D: PRISMA Checklist
Reported
Section/topic # Checklist item
on page #
TITLE
Title 1 Identify the report as a systematic review, meta-analysis, or both. i
ABSTRACT
Structured summary 2 Provide a structured summary including, as applicable: background; objectives; data sources; study eligibility i
criteria, participants, and interventions; study appraisal and synthesis methods; results; limitations; conclusions
and implications of key findings; systematic review registration number.
INTRODUCTION
Rationale 3 Describe the rationale for the review in the context of what is already known. 3
Objectives 4 Provide an explicit statement of questions being addressed with reference to participants, interventions, 4
comparisons, outcomes, and study design (PICOS).
METHODS
Protocol and registration 5 Indicate if a review protocol exists, if and where it can be accessed (e.g., Web address), and, if available, 4
provide registration information including registration number.
Eligibility criteria 6 Specify study characteristics (e.g., PICOS, length of follow-up) and report characteristics (e.g., years considered, 4
language, publication status) used as criteria for eligibility, giving rationale.
Information sources 7 Describe all information sources (e.g., databases with dates of coverage, contact with study authors to identify 4-5
additional studies) in the search and date last searched.
Search 8 Present full electronic search strategy for at least one database, including any limits used, such that it could be 28
repeated.
Study selection 9 State the process for selecting studies (i.e., screening, eligibility, included in systematic review, and, if 5-6
applicable, included in the meta-analysis).
Data collection process 10 Describe method of data extraction from reports (e.g., piloted forms, independently, in duplicate) and any 6
processes for obtaining and confirming data from investigators.
Data items 11 List and define all variables for which data were sought (e.g., PICOS, funding sources) and any assumptions and 6
simplifications made.
Risk of bias in individual 12 Describe methods used for assessing risk of bias of individual studies (including specification of whether this 21-22
studies was done at the study or outcome level), and how this information is to be used in any data synthesis.
27
Summary measures 13 State the principal summary measures (e.g., risk ratio, difference in means). NA
Synthesis of results 14 Describe the methods of handling data and combining results of studies, if done, including measures of NA
consistency (e.g., I2) for each meta-analysis.
Risk of bias across studies 15 Specify any assessment of risk of bias that may affect the cumulative evidence (e.g., publication bias, selective 21-22
reporting within studies).
Additional analyses 16 Describe methods of additional analyses (e.g., sensitivity or subgroup analyses, meta-regression), if done, NA
indicating which were pre-specified.
RESULTS
Study selection 17 Give numbers of studies screened, assessed for eligibility, and included in the review, with reasons for 7-8
exclusions at each stage, ideally with a flow diagram.
Study characteristics 18 For each study, present characteristics for which data were extracted (e.g., study size, PICOS, follow-up period) 26-27
and provide the citations.
Risk of bias within studies 19 Present data on risk of bias of each study and, if available, any outcome level assessment (see item 12). 21-22
Results of individual studies 20 For all outcomes considered (benefits or harms), present, for each study: (a) simple summary data for each NA
intervention group (b) effect estimates and confidence intervals, ideally with a forest plot.
Synthesis of results 21 Present results of each meta-analysis done, including confidence intervals and measures of consistency. NA
Risk of bias across studies 22 Present results of any assessment of risk of bias across studies (see Item 15). 21-22
Additional analysis 23 Give results of additional analyses, if done (e.g., sensitivity or subgroup analyses, meta-regression [see Item NA
16]).
DISCUSSION
Summary of evidence 24 Summarize the main findings including the strength of evidence for each main outcome; consider their 11-18
relevance to key groups (e.g., healthcare providers, users, and policy makers).
Limitations 25 Discuss limitations at study and outcome level (e.g., risk of bias), and at review-level (e.g., incomplete retrieval 21-24
of identified research, reporting bias).
Conclusions 26 Provide a general interpretation of the results in the context of other evidence, and implications for future 24-25
research.
FUNDING
Funding 27 Describe sources of funding for the systematic review and other support (e.g., supply of data); role of funders 25
for the systematic review.
28
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