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BIO-100
• Overview of mitosis
– Nuclear division in which chromosome number remain constant
– DNA replication produces duplicated chromosomes
– Each duplicated chromosome is composed of 2 sister chromatids held together by a
centromere
– Sister chromatids are genetically identical
– During mitosis, the centromere divides and each chromatid becomes a daughter
chromosome
– Occurs when tissues grow or repair occurs
Mitosis overview
• DNA Replication during Interphase
• Chromosomes are duplicated into 2 sister chromatids
• Centromeres divide
• Chromatids separate
• Become daughter chromosomes
• Before nuclear division, the DNA replicates
• Chromosomes duplicate – 2 sister chromatids
• Held together by the centromere
• Sister chromatids are genetically identical
• By the end of mitosis, each chromosome
divides into a single chromatid
Early Prophase
• Visible duplicated chromosomes
• Centrosomes begin to move apart
• Nuclear envelop is fragmenting
• Nucleolus disappears
Late Prophase
• Spindle formation and centromeres of Chromosomes become attached to
centromeric spindle fibers
Metaphase
• Chromosomes are lined up at the equator
• Each chromosome consists of 2 sister
Anaphase
• Centromeres divide
• Daughter chromatids towards poles of the spindle
Telophase
• Daughter cells form
• Spindles disappear
• Nuclear envelopes and nucleoli appear
• Chromosomes become indistinct chromatin
• Cytokinesis takes place