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Preliminaries
DMT
DMT (1/19)
Preliminaries
DMT
1 Preliminaries
Sources
Phenethylamines and Tryptamines
Serotonin-like Psychedelic Drugs, Receptor Chemistry
2 DMT
N,N-DMT
5-MeO-DMT
Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin
(4-hydroxy-DMT)
DMT (2/19)
Sources
Preliminaries
Phenethylamines and Tryptamines
DMT
Serotonin-like Psychedelic Drugs, Receptor Chemistry
http://erowid.org
DMT (3/19)
Sources
Preliminaries
Phenethylamines and Tryptamines
DMT
Serotonin-like Psychedelic Drugs, Receptor Chemistry
DMT (4/19)
Sources
Preliminaries
Phenethylamines and Tryptamines
DMT
Serotonin-like Psychedelic Drugs, Receptor Chemistry
DMT (5/19)
Sources
Preliminaries
Phenethylamines and Tryptamines
DMT
Serotonin-like Psychedelic Drugs, Receptor Chemistry
Additional speculation on
major source of serotonin
activity:
Pontine (dorsal) raphe
filters incoming sensory
stimuli
Eliminates
“unimportant, irrelevant,
or commonplace”
Image courtesy of the National Institute on Drug Abuse.
sensations and
perceptions flooding the
body
DMT (6/19)
Sources
Preliminaries
Phenethylamines and Tryptamines
DMT
Serotonin-like Psychedelic Drugs, Receptor Chemistry
1 2
3 4 5 6 7
A,B,D A,B,C
Ketanserin Experimental
Ondasetron
cyproheptadine compounds e.g. No selective
Spiperone tropisetron
LSD GR113808 antagonist
granisetion
methysergide SB207266
Ligand-
gated
cAMP IP3 / DAG cAMP Not known
cation
channel
DMT (7/19)
Sources
Preliminaries
Phenethylamines and Tryptamines
DMT
Serotonin-like Psychedelic Drugs, Receptor Chemistry
DMT (8/19)
Sources
Preliminaries
Phenethylamines and Tryptamines
DMT
Serotonin-like Psychedelic Drugs, Receptor Chemistry
DMT (9/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
DMT (10/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
1
R. J. Stassman, C. R. Qualls, E. H. Uhlenhuth, and R. Kellner, Archives
of General Psychiatry 51 (1994): 98-108.
DMT (11/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
DMT (12/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
DMT (13/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
DMT (14/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
DMT (15/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
psychiatric disorders.
DMT (16/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
DMT (17/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
DMT (18/19)
N,N-DMT
Preliminaries 5-MeO-DMT
DMT Bufoteneine (5-hydroxy DMT)
Psilocybin (4-phosphoryl-DMT) and psilochin (4-hydroxy-DMT)
2
M. E. Crahan, Bulletin of the Los Angeles County Medical Association 99
(1969): 17.
Bhaskar Mookerji DMT (19/19)
http://www.drugabuse.gov/pubs/teaching/Teaching4/largegifs/slide8.gif
http://www.drugabuse.gov/pubs/teaching/Teaching4/largegifs/slide8.gif5/6/2009 3:51:33 PM