Documente Academic
Documente Profesional
Documente Cultură
Abstract
Etiology
Further causes
References:[1]
Clinical features
General symptoms
o Diffuse abdominal pain with abdominal guarding and/or rebound tenderness
o Nausea, and vomiting
o Fever and chills (esp. in underlying infection, e.g., SBP)
o Possibly shoulder pain
o Ascites in SBP
Physical examination
o Distressed patient, knees drawn up when supine , avoids movement
o Abdominal pain and rigidity, rebound tenderness
o Sparse peristaltic sounds (none in cases of ileus)
Peritonitis is considered a surgical emergency, as it may cause sepsis with shock and organ
failure!
References:[1]
Diagnostics
Laboratory tests
o CBC significant for leukocytosis
o Peritoneal fluid analysis (diagnostic paracentesis)
Primary peritonitis (SBP)
Neutrophil count of > 250 cells/μL
Positive bacterial culture and/or Gram stain
Serum-ascites albumin gradient (SAAG) > 1.1
Secondary peritonitis
Glucose < 50 mg/dL
Peritoneal fluid LDH > serum LDH,
pH < 7.0
Imaging
o Ultrasound may detect
Underlying disease: e.g., pancreatitis, appendicitis, cholangitis
Peritoneal fluid
o Abdominal x-ray may detect:
Air-fluid levels (e.g., in ileus)
Free air secondary to organ perforation
o CT scan of the abdomen and pelvis
Should not cause delay for surgical intervention if the diagnosis is
clinically made
Test of choice for suspected visceral abscess
Indicated if diagnosis is unclear based on clinical or other imaging
findings
References:[1]
Differential diagnoses
In certain conditions, patients show symptoms of peritonitis, although actual inflammation of
the peritoneum is absent.
Treatment
Primary peritonitis
Treatment indications: fever > 37.8°C (100°F), neutrophil count in ascitic fluid > 250
cells/μL; altered mental status
Broad-spectrum antibiotics : 3rd generation cephalosporins (e.g., cefotaxime,
ceftriaxone
Secondary peritonitis
Approach: remove the source of infection and treat the underlying cause via
interventional procedures, eliminate bacteria via antibiotics, and maintain organ
function via fluid resuscitation and supportive care
Interventional procedures
o Surgery
o Extensive laparoscopic irrigation (lavage), debridement, drainage
o Ultrasound or CT-guided percutaneous drainage of abscesses
o Scheduled revision surgery (second-look surgery) frequently necessary for
extensive disease
General
o Hospital monitoring (possibly intensive care)
o Fluid replacement
Medical
o Broad-spectrum antibiotics (several treatment options are possible)
Piperacillin + tazobactam
Ampicillin + sulbactam, possibly in combination with gentamicin
Ciprofloxacin +/- metronidazole
In severe peritonitis: carbapenems, e.g., imipenem or meropenem
o Analgesics, thrombosis prophylaxis
References:[2][1][3]
Complications