KNEE WEBINAR

WORKBOOK
Regenexx Knee Webinar Workbook
Why Regenexx for the Knee Is Very Different

This workbook accompanies the Regenexx Knee Webinar by Chris Centeno, MD, founder of
Regenexx and author of Orthopedics 2.0 and soon-to-be-published The Knee Owner’s Manual.
You can register for and access the free webinar at http://www.regenexx.com/knee-webinar/,
and the books can be downloaded for free from the Regenexx library at www.regenexx.com/
library-complimentary-regenexx-resources/.

During the 55-minute webinar, you will learn about the number-one stem cell and platelet
procedures for treating knee arthritis, injuries, and pain. Dr. Centeno also covers the following
and much more:

• How the future of knee treatment is shifting toward nonsurgical, needle-based procedures

• Who Regenexx knee procedures are for and who they are not for

• Why Regenexx knee procedures are superior to other stem cell and platelet procedures

• Why Regenexx is responsible for a major percentage of the published research on orthopedic

stem cell procedures

• Knee structures, conditions, and injuries that can occur

• Knee case studies / stories of actual patients

• Regenexx knee arthritis registry data and live updates via the Regenexx Patient Outcome
Reporting Application

You can use this accompanying Regenexx Knee Webinar Workbook as a learning tool to help you
follow along and make sure you fully grasp the key points of Dr. Centeno’s webinar. Additionally, it
is a take-away tool you can refer to often while you seek solutions to your knee issues.

If you are unable to keep up in the workbook as you listen to the webinar, do not worry. You will
receive a recorded version of the Regenexx Knee Webinar via e-mail following the webinar that
you can listen to and play back as many times as necessary to help you complete the workbook.
Additionally, all of the correct answers can be found at the end of this workbook.

Disclaimer: Any references to Regenexx-C (cultured stem cell procedure) refer to an independently
owned and operated facility in Grand Cayman that licenses our technology and where we see
patients who require this more advanced technology.

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Topic 1: Surgical Orthopedics Won’t Be the Dominant Form
of Care in the Twenty-First Century

1. The dominant form of orthopedic care in the twenty-first century is likely going to be
_______________ _______________.

2. Four randomized controlled trials now show that knee arthroscopy to treat a meniscus tear is
no better than a sham or placebo surgery. (true or false)

3. Cartilage loss on a knee MRI is/is not (circle one) associated with pain.

4. Stem cells and platelets are biologics. (true or false)

Topic 2: Interventional Orthopedics and Injections

5. Of the three injections (blind, low accuracy guided, and precise guided), which uses no guidance
and is like injecting with a blindfold on? __________

6. Does interventional orthopedics use ultrasound, fluoroscopy, or both to image the body?

7. Interventional orthopedics uses even more advanced injection techniques, and only about _____
percent of US physicians are trained to do this.

Topic 3: Stem Cell Basics

8. Everything Regenexx does is ____________: this means using your own stem cells.

9. Regenexx focuses only on embryonic stem cells. (true or false)

10. An adult stem cell is an ____________ cell that’s held in reserve until replacement or repair
is needed.

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Topic 4: Types of Stem Cell Procedures Provided by Regenexx

11. Same day / Cultured (circle one)—the cells are harvested, isolated, and reimplanted in the
same day.

12. Same day / Cultured (circle one)—the cells are harvested and then grown to bigger numbers
and reimplanted 1–2 months later.

Topic 5: Common Structures in the Knee and What Can Affect Them

13. The spacer that protect the joint surfaces is called the _________________________

14. The internal ligament that keeps the tibia from moving forward on the femur is called
the___________

15. The cushioning structure on the ends of the bones is called ____________

16. Dr. Centeno discusses a study showing that two-thirds of teens who have ACL reconstructions
have arthritis by age __________.

Topic 6: Show Me the Knee Data

17. Our data are maintained in our stem cell registry, which includes almost 500 / 5,000
(circle one) knee patients.

18. About 1 in 10 patients who are currently told they need ACL surgery are candidates for an
advanced and precise ligament stem cell injection using fluoroscopy guidance. (true or false)

Topic 7: Other Types of Stem Cell Procedures Being Performed for Orthopedic Injuries

19. Fat does / does not (circle one) have more stem cells than bone marrow.

20. Amniotic, or placental, stem cells treatments actually contain living / dead (circle one) stem
cells.

21. __________ __________ stem cells are also a dead cell product.

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22. Regenokine (aka orthokine) is a natural anti-inflammatory shot commonly used by
veterinarians; it is not a stem cell procedure. (true or false)

23. Alpha-2-macroglobulin (A2M) is already in high / low (circle one) concentrations in the
Regenexx same-day stem cell procedures, so there is no need to concentrate it separately for use.

Wrapping It All Up
Thank you for watching the Regenexx Knee Webinar and completing this workbook. My hope is
that it helps you learn more about nonsurgical, needle-based knee procedures available to you
through interventional orthopedics. Visit the following links to learn more about Regenexx and our
treatment solutions:

• Watch our videos: www.regenexx.com/about-regenexx/regenexx-videos/

• Visit our library at www.regenexx.com/library-complimentary-regenexx-resources/ and download

one, or all, of our free books: Orthopedics 2.0, The Knee Owner’s Manual (coming soon),
ProActive, Nutrition 2.0.

• Consider our lab-engineered stem cell support formula:

www.regenexx.com/regenexx-advanced-stem-cell-support-formula/

• Contact us at http://www.regenexx.com/contact-regenexx/

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Answer Sheet
Topic 1: Surgical Orthopedics Won’t Be the Dominant Form
of Care in the Twenty-First Century
1. Interventional orthopedics
2. True
3. Is not
4. True

Topic 2: Interventional Orthopedics and Injections

5. Blind
6. Both
7. 1 percent

Topic 3: Stem Cell Basics

8. Autologous
9. False
10. Undifferentiated

Topic 4: Types of Stem Cell Procedures Provided by Regenexx

11. Same-day
12. Cultured

Topic 5: Common Structures in the Knee and What Can Affect Them
13. Meniscus
14. ACL
15. Cartilage
16. 26–30

Topic 6: Show Me the Knee Data

17. 5,000
18. False

Topic 7: Other Types of Stem Cell Procedures Being Performed

for Orthopedic Injuries
19. Does not
20. Dead
21. Cord blood
22. True
23. High
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Bonus Material
What to Look for in a Clinic…
• A protocol that’s been used in thousands of patients
• Imaging guidance to take and place cells
• Specific outcome research on their specific protocol (not general research published by others
on some other protocol)
• A clinic that’s constantly innovating
• Collecting and publishing data
• Research publications (be careful of the research bait and switch—clinics listing research studies
that have little to do with the procedure they offer)

When You Should Run from a Clinic…

• Treats every A–Z disease
• Promises extremely high success rates that seem too good to be true
• Claims that a doctor took a “stem cell fellowship” from AAAAM (this is a for-profit weekend
course). A fellowship should be a year-long fellowship where doctors are paid to train, not where
the doctor pays to train.
• The “physician” is not an MD or DO
• The clinic just opened but claims to have treated thousands of patients

Regenexx at a Glance
• Regenexx is advanced and precise interventional orthopedics
• We’ve been doing this longer than anyone else in the U.S.
• We have more published and online registry data than anyone else
• We spend more resources than anyone else, stacking the deck in our patients’ favor
• We have more treatment options than anyone else

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 www.regenexx.com

For more information or to schedule

and appointment call 888-525-3005