ANALISIS JURNAL KEPERAWATAN KRITIS

FAKTOR- FAKTOR YANG MEMPENGARUHI TERJADINYA

PRESSUREULCER DI INTENSIVE CARE UNIT (ICU)

Oleh: Iman Ari Wibowo

No Komponen Hasil penelitian

yang dikritisi
1. Judul Faktor- faktor yang mempengaruhi terjadinya pressureulcer
di Intensive Care Unit (ICU)

Kekurangan: belum dicantumkannya waktu penelitian pada

judul jurnal ini.
Saran: perlu dicantumkan tahun kapan penelitian
berlangsung
2. Abstrak Latar Belakang:Pressure ulcer adalah salah satu kondisi
yang paling diremehkan pada pasien sakit kritis. Meskipun
banyak muncul berbagai pedoman praktek klinis dan
kemajuan teknologi medis, prevalensi pressureulcerpada
pasien rawat inap terus meningkat. Saat ini yang kita lihat,
konsensus yang kurang pada faktor-faktor risiko terpenting
pada pressure ulcer pada pasien sakit kritis, dan tidak ada
skala penilaian risiko secara eksklusif untuk pressure ulcer
pada pasien kritis ini.
Tujuan: Untuk menentukan faktor risiko yang paling
prediktif pada pasien dewasa kritis dengan pressureulcer.
Faktor risiko yang diteliti antara lain skor total pada Skala
Braden, mobilitas, aktivitas, persepsi sensorik, kelembaban,
gesekan / geser, gizi, umur, tekanan darah, lama tinggal di
unit perawatan intensif, skor pada the Acute Physiology and
Chronic Health Evaluation II, administrasi vasopresor, dan
kondisi komorbiditas.
Metode: Desain, retrospektif korelasional digunakan untuk
menguji 347 pasien dirawat di ICU medical bedah dari
Oktober 2008 sampai Mei 2009.
Hasil: Menurut analisis regresi logistik, usia, lama tinggal,
gesekan mobilitas, / geser, infus norepinephrine, dan
penyakit kardiovaskular menjelaskan bagian utama dari
varians dalam pressure ulcer.
Kesimpulan: skala penilaian risiko saat ini untuk
pengembangan pressure ulcer mungkin tidak termasuk
faktor risiko umum pada orang dewasa yang sakit kritis.
Pengembangan model penilaian risiko untuk pressure ulcer
pada pasien-pasien itu dibenarkan dan dapat menjadi dasar
untuk pengembangan alat penilaian risiko.
 Kekuatan: abstrak yang ditampilkan dalam penelitian ini
cukup lengkap mulai dari latar belakang, tujuan, metode
yang digunakan, hasil serta kesimpulan.

3. Latar Pada pasien perawatan kritis, pressureulcer merupakan

belakang ancaman komorbiditas tambahan pada pasien yang
secarafisiologis dikompromikan. Faktanya, pressure
ulceradalah salah satu masalah kesehatan paling diremehkan
pada pasien perawatan kritis [1] Meskipun banyak kemajuan
teknologi medis dan penggunaan program pencegahan
formal berdasarkan pedoman praktek klinis, prevalensi
pressureulcer selama rawat inap terus meningkat.. Pada
tahun 2008, Russo dkk [2] dari Health Care Cost and
Utilization Projectmelaporkan peningkatan 80% dalam
terjadinya pressure ulcer 1993-2006 pada pasien dewasa
dirawat di rumah sakit dan diperkirakan bahwa biaya
kesehatan total terkait perawatan adalah $ 11 miliar. Di
antara semua pasien rawat inap, tingkat prevalensi pressure
ulcer yang tertinggi terdapat pada pasien di unit perawatan
intensif (ICU), dari 14% menjadi 42%. [3-5]
Pada tahun 2006, the Centers for Medicare and Medicaid
Services[6]menyatakan bahwa rumah sakit yang terdapat
pressureulcer stadium III atau IV merupakan tahap yang
merugikan pasien, atau "kejadian yang tidak mungkin
terjadi," yang secara wajar dapat dicegah dengan
menerapkan pedoman pencegahan berbasis bukti.
Langkah pertama dalam mencegah pressure ulcer adalah
menentukan apa yang merupakan risiko yang tepat. Banyak
faktor resiko telah diidentifikasi secara empiris, namun
belum diketahui faktor-faktor risiko apa yang paling
berpengaruh.
Di Amerika Serikat, Skala Braden [14] merupakanalat
penilaian risiko yang paling banyak digunakan dalam
pengaturan perawatan, termasuk ICU, dan pedoman praktek
klinis saat ini [15-17] merekomendasikan penggunaannya.
Skala Braden, berasal dari kerangka konseptual Braden dan
Bergstrom, [18] 6 sub-skala yang digunakan untuk
mengukur risiko pressure ulcer: persepsi sensorik, aktivitas,
mobilitas, nutrisi, kelembaban, dan gesekan / geser. Potensi
skor berkisar 6-23, skor yang lebih rendah menunjukkan
risiko yang lebih besar. Skor dari 15 sampai 18
menunjukkan risiko atau risiko ringan, 13 sampai 14, risiko
moderat; 10 sampai 12, risiko tinggi;. Dan skor dari 9 atau
kurang, resiko yang sangat tinggi [19] Stratifikasi risiko
pressureulcer dapat berguna secara klinis untuk menentukan
dan melaksanakan sesuai tingkat pencegahan. [20]
 Faktor-faktor lain yang tidak termasuk dalam Skala Braden
tetapi juga dapat meningkatkan tingkat pasien dari risiko
pressureulcer. Bukti empiris menunjukkan bahwa faktor-
faktor berikut dapat menjadi prediksi pressure ulcer pada
pasien perawatan kritis: usia lanjut; [1,4,21,25,26] tekanan
arteriol rendah; [27-29] lama tinggal di ICU; [1,21, 26,30]
keparahan penyakit seperti yang ditunjukkan oleh nilai pada
Acute Physiology and Chronic Health Evaluation
(APACHE) II; [1,31] kondisi komorbiditas, termasuk
diabetes mellitus, sepsis, dan penyakit pembuluh darah;
[21,25,27] dan faktor iatrogenik, seperti penggunaan agen
vasopressor [1,25,27]. Meskipun penelitian telah
menunjukkan bahwa banyak faktor ini berhubungan secara
signifikan dengan perkembangan pressure ulcer pada pasien
ICU, temuan itu tidak konsisten di semua studi di mana
hubungan ini diuji.

Kekuatan: dalam penelitian ini sudah dijelaskan dengan

terperinci latar belakang alasan mengapa peneliti memilih
untuk melakukan penelitian mengenai hal tersebut, dilihat
dari fenomena yang ada terjadi peningkatan angka kejaian
pressure uler pada pasien dewasa dengan penyakit kritis
terutama di ICU. Penelitian ini tampaknya juga sudah
menyampaikan beberapa sumber penelitian terdahulu yang
berhubungan dengan penelitian sekarang.
4. Tujuan Tujuan dari penelitian adalah untuk menentukan faktor
penelitian risiko yang berasal dari Skala Braden dan literatur empiris
lainnya yang paling berpengaruh pada peningkatan angka
kejadian pressureulcer pada pasien kritis dewasa. Faktor-
faktor risiko yang diteliti adalah: total skor Braden,
mobilitas, aktivitas, persepsi sensorik, kelembaban, nutrisi,
gesekan / geser, lama tinggal diICU, usia, tekanan arteriol,
administrasi vasopresor, skor pada APACHE II, dan kondisi
komorbiditas.

Kekurangan: dalam penelitian ini tidak dijelaskan secara

eksplisit mengenai tujuan umum dan tujuan khusus dari
penelitian.
Saran: sebaiknya dijelaskan tujuan penelitian baik umum
maupun khusus, sehingga penganalisi dapat membaca arah
yang dikehendaki peneliti.
5. Variabel- Variable bebas: faktor- faktor yang berpengaruh terhadap
variabel pressure ulcer yaitu skor Skala Braden pada saat masuk ke
penelitian MSICU; nilai pada sub-skala Braden di masuk ke unit; usia;
tekanan arteriol, lama tinggal di ICU; jumlah jam pemberian
agen vasopressor selama tinggal di MSICU: norepinefrin,
 epinefrin, vasopressin, dopamin, dan fenilefrin; keparahan
penyakit sesuai dengan skor APACHE II , dan ada atau
tidak adanya salah satu kondisi komorbiditas berikut:
diabetes mellitus, penyakit jantung, penyakit pembuluh
darah perifer, dan infeksi bersamaan / sepsis.
Variabel terikat: kejadian pressure ulcer ( dicatat dengan
ada atau tidaknya kejadian pressure ulcer)

Kekuatan: baik variabel bebas maupun variabel terikat

sudah dijelaskan secara rinci.
7. Definisi Kekuatan: sudah dijelaskan mengenai variable- variable
operasional yang digunakan dalam penelitian.
Kekurangan: Dalam jurnal penelitian ini belum
menjelaskan mengenai komponen definisi operasional
yaitudefinisi operasional masing- masing variabel, alat
ukur, hasil ukur dan skala ukur.
8. Metode Penelitian ini menggunakan deskriptif retrospektif, desain
penelitian korelasional. Tempat penelitiannya di12-tempat tidur
dan medical-surgical ICU (MSICU) di Englewood Hospital and
pengambilan Medical Center di Englewood, New Jersey.
sampel Semua pasien dewasa yang dirawat di MSICU dari Oktober
2008 sampai dengan Mei 2009 yang memenuhi kriteria
inklusi dimasukkan dalam sampel. Pasien dilibatkan jika
mereka berumur 18 tahun atau lebih dan memiliki biaya
MSICU lebih dari 24 jam. Pasien tidak masuk kriteria
inklusi jika mereka harus tinggal MSICU kurang dari 24
jam atau memiliki pressureulcer pada saat masuk ke
MSICU. Untuk mencapai kekuatan 80%, ukuran sampel
minimum dari 163 yang dibutuhkan untuk ukuran efek
moderat, tingkat signifikansi α = .05.
Data lainnya meliputi data demografi dan karakteristik
pasien termasuk etnis, jenis kelamin, dan diagnosis MSICU.
Selain itu, untuk pasien dengan pressureulcermeluas,
jumlah jam menjadi pressureulcerdan lokasi anatomi dan
tahap pressure ulcer sesuai dengan National Pressure Ulcer
Advisory Panel staging system tahun 2007 juga dicatat.[35]

Kekuatan: Metode penelitian dan pengambilan sampel

sudah dijelaskan secara rinci.
9. Pengolahan SPSS, versi 16.0 for Windows, perangkat lunak (SPSS Inc,
data Chicago Illinois) digunakan untuk analisis data. Statistik
deskriptif meliputi distribusi frekuensi untuk variabel
penelitian dan data demografis. Uji korelasi Pearson product
moment digunakan untuk analisis korelasional dari variabel
penelitian. Regresi logistik langsung digunakan untuk
menentukan factor apa yang paling berengaruh pada
 perkembangan pressureulcer pada pasien ICU. Uji t dan uji
χ2 digunakan untuk membandingkan antara pasien dengan
dan tanpa pressure ulcer.

Kekuatan: sudah di jelaskan juga mengenai teknik

pengolahan data yang digunakan yakni dengan uji analisis
distribusi frekuensi, uji korelasi product moment pearson,
uji t dan uji χ2, serta uji regresi logistic untuk mengetahui
faktor apa yang paling berpegaruh terhadap kejadian
pressure ulcer.
Kekurangan: seyogyanya ditambahkan mengenai tahap
pengolahan data, mulai dari editing, coding, entry data dan
tabulating.
10. Hasil Dari 579 pasien yang dirawat di MSICU selama masa
penelitian, 347 memenuhi kriteria inklusi dan termasuk
dalam sampel akhir. Para pasien berumur antara 20-97 tahun
(rata-rata 69; SD, 17). Diagnosa terbanyak antara lain gagal
nafas (20,7%), sepsis atau syok septik (17,3%), dan masalah
neurologis (15%).
Di antara 347 pasien dalam sampel, pasien yang mengalami
pressureulcer65 (18,7%). Dari jumlah tersebut, sebagian
(35%) adalah tahap II, dan sakrum adalah lokasi anatomis
yang paling umum (58%). Waktu sampai pengembangan
pressure ulcer adalah 133,61 jam (rata-rata 90,0; range, 5-
573; SD, 120,13).
Mean skor Skala Braden pada seluruh pasien adalah 14,28
(SD, 2,68; jangkauan, 6-23), 12,73 (SD, 2,65) untuk pasien
yang mengalami pressure ulcer, dan 14,63 (SD, 2,65) untuk
pasien tanpa pressure ulcer. Dari 65 pasien denganpressure
ulcer, 28% (n = 18) digolongkan sebagai beresiko, 28% (n =
18) pada risiko sedang, 35% (n = 23) pada risiko tinggi, dan
9 % (n = 6) pada resiko yang sangat tinggi.
Faktor-faktor risiko berikut adalah prediktor signifikan
terhadap kejadian pressureulcer: mobilitas (B = -0,823, P =
0,04; rasio odds [OR] = 0,439, 95% confidence interval
[CI], 0,21-0,95), umur (B = 0,033; P = .03; OR = 1,033,
95% CI, 1,003-1,064), lama tinggal di ICU (B = 0,008; P
<.001; OR = 1,008, 95% CI, 1,005-1,011), dan penyakit
kardiovaskular (B = 1,082, P = 0,007; OR = 2,952, 95% CI,
1,3-6,4).
Faktor-faktor risiko berikut secara signifikan berperan
dalam pengembangan pressure ulcertahap II atau lebih
besar: gesekan / geser (B = 1,743, P = .01; OR = 5,715, 95%
CI, 1,423-22,950), panjang ICU menginap ( B = 0,008; P
<.001; OR = 1,008, 95% CI, 1,004-1,012), administrasi
norepinefrin (B = 0,017, P = 0,04; OR = 1,017, 95% CI,
 1,001-1,033), dan penyakit kardiovaskular (B = 1,218, P =
.02; OR = 3,380, 95% CI, 1,223-9,347).

Kekuatan: sudah dijelaskan secara terperinci

11. Pembahasan Dalam contoh penelitian, Skala Braden dengan skor 18 tidak
menyebabkan berkembangnya pressure ulcer. Faktanya,
75% (n = 261) dari pasien digolongkan sebagai berisiko
untuk pressureulcer (Braden Skala skor = 18) tetapi masih
bebas dari pressureulcer.
Dari 6 sub-skala Braden, hanya mobilitas dan gesekan /
geser yang menjadi prediktor signifikan pressure ulcer.
Mobilitas didefinisikan pada Skala Braden sebagai
kemampuan pasien untuk mengubah dan mengendalikan
gerakan tubuh. [18] Menggerakkan dan mereposisikan
pasien adalah prinsip dasar asuhan keperawatan dan
dianjurkan dalam semua pedoman praktek saat ini sebagai
strategi untuk mencegah pressure ulcer. Beberapa bukti [38]
juga mendukung penggunaan kasur decubitus pada pasien
ICU. Penggunaan kasur decubitus dan reposisi
pasienmerupakan 2 strategi penting untuk mencegah luka
dekubitus pada pasien perawatan kritis.
Dalam penelitian terbaru [39] di ICU trauma bedah, 41
pasien yang berisiko tinggi untuk pressure ulcer menerima
aplikasi dari busa silikon, nonadherent foam ke daerah
sakral untuk meminimalkan kekuatan gesekan, geser, dan
kelembaban. Aplikasi inisecara signifikan mengurangi
terjadinya pressure ulcerke nol. Penelitian sedang
direplikasi untuk memvalidasi temuan.
Pasien sakit kritis sepenuhnya tergantung pada petugas
kesehatan reposisi dan transfer. Para advokat prosedur
penanganan pasien merekomendasikan penggunaan
lembaran meluncur dan perangkat pemindahan pasien untuk
mengurangi efek buruk dari gesekan / geser pada kulit dan
sekaligus melindungi staf dari cedera muskuloskeletal. [40]
Faktor-faktor tambahan seperti elevasi kepala
berkepanjangan sakit kritis, intubasi pada pasienuntuk
mencegah ventilator-associated pneumonia.

Kekuatan: dalam pembahasan sudah dijelaskan tentang

faktor- faktor yang berpengaruh terhadap kejadian pressure
ulcer serta teori- teori yang mendukung hasil penelitian.
12. Kesimpulan Hasil penelitian menunjukkan penyebab multifaktorial
pressure ulcer pada pasien kritis. Meskipun nilai pada 2
faktor risiko subskala Braden (mobilitas, gesekan / geser)
adalah penyebab kejadianpressure ulcer, faktor risiko lain
yang tidak diukur dengan Skala Braden, termasuk usia, lama
 tinggal ICU, administrasi norepinefrin, dan penyakit
kardiovaskular, juga adalah prediktor yang signifikan dalam
analisis multivariat.
Banyak penelitian lebih lanjut yang diperlukan untuk
menentukan tindakan- tindakan pencegahan terhadap
pressure ulcer, seperti penggunaan alas kasur yang
mensupport, perangkat penahanan tinja, frekuensi reposisi,
penggunaan dressing topikal pada sakrum untuk
meminimalkan gesekan / geser, program mobilitas progresif,
dan penggunaan glide sheets dan peralatan transfer pasien.
Pada akhirnya, dengan mengetahui factor resiko yang
berpengaruh pada pressure ulcer, kita dapat menerapkan
strategi pencegahan berbasis bukti dapat mengakibatkan
penurunan baik dalam terjadinya pressure ulcer dan biaya
perawatan kesehatan dan dapat mempromosikan hasil
kesehatan positif pada pasien perawatan kritis.

Kekuatan: kesimpulan sudah tepat sesuai dengan tujuan

penelitian.

Implikasi Keperawatan

Berikut ini adalah beberapa macam implikasi keperawatan dari analisis

jurnal diatas:

1. Tenaga kesehatan dalam hal ini perawat di ICU seyogyanya mampu untu
mengidentifikasi kejadian pressure ulcer menurut skala Braden dan factor
penyebab lainnya sehingga angka kejadian pressure ulcer dapat menurun
yang berefek pada menurunnya biaya kesehatan.
2. Pentingnya untuk melakukan tindakan pencegahan terhadap stress ulcer
seperti penggunaan kasur decubitus, mobilisasi miring kanan kiri sesuai
indikasi, penggunaan lotion pelembab, dan tindakan pencegahan lainnya
sesuai dengan kapasitas kita sebagai perawat.
 From American Journal of Critical Care

Predictors of Pressure Ulcers in Adult Critical Care Patients

Jill Cox, RN, PhD, APN, CWOCN

Posted: 09/21/2011; American Journal of Critical Care. 2011;20(5):364-

375. © 2011 American Association of Critical-Care Nurses

Abstract and Introduction

Abstract

Background Pressure ulcers are one of the most underrated conditions in

critically ill patients. Despite the introduction of clinical practice guidelines and
advances in medical technology, the prevalence of pressure ulcers in hospitalized
patients continues to escalate. Currently, consensus is lacking on the most
important risk factors for pressure ulcers in critically ill patients, and no risk
assessment scale exclusively for pressure ulcers in these patients is available.
Objective To determine which risk factors are most predictive of pressure ulcers
in adult critical care patients. Risk factors investigated included total score on the
Braden Scale, mobility, activity, sensory perception, moisture, friction/shear,
nutrition, age, blood pressure, length of stay in the intensive care unit, score on the
Acute Physiology and Chronic Health Evaluation II, vasopressor administration,
and comorbid conditions.
Methods A retrospective, correlational design was used to examine 347 patients
admitted to a medical-surgical intensive care unit from October 2008 through May
2009.
Results According to direct logistic regression analyses, age, length of stay,
mobility, friction/shear, norepinephrine infusion, and cardiovascular disease
explained a major part of the variance in pressure ulcers.
Conclusion Current risk assessment scales for development of pressure ulcers
may not include risk factors common in critically ill adults. Development of a risk
assessment model for pressure ulcers in these patients is warranted and could be
the foundation for development of a risk assessment tool.

Introduction

Development of pressure ulcers is complex and multifactorial. In critical care

patients, pressure ulcers are an additional comorbid threat in patients who are
already physiologically compromised. In fact, pressure ulcers are one of the most
underrated medical problems in critical care patients.[1] Despite advances in
medical technology and the use of formalized prevention programs based on
clinical practice guidelines, the prevalence of pressure ulcers during
hospitalization continues to increase. In 2008, Russo et al[2] of the Health Care
Cost and Utilization Project reported an 80% increase in the occurrence of
pressure ulcers from 1993 to 2006 in hospitalized adult patients and estimated that
total associated health care costs were $11 billion. Among all hospitalized
patients, prevalence rates of acquired pressure ulcers are the highest in patients in
the intensive care unit (ICU), from 14% to 42%.[3–5]

In 2006, the Centers for Medicare and Medicaid Services[6] declared that hospital-
acquired stage III or stage IV pressure ulcers are adverse patient safety events, or
"never events," that could reasonably be prevented by implementing evidence-
based prevention guidelines. As a result, beginning in 2008, reimbursement
limitations were enacted for acute care hospitals for care associated with stage III
or stage IV pressure ulcers not documented as present when a patient was
admitted.[7] This change has sparked a renewed urgency and awareness related to
preventing pressure ulcers. Although the implementation of comprehensive
prevention programs can reduce the prevalence of hospital-acquired pressure
ulcers,[8,9] pressure ulcers do develop in hospitalized patients, despite quality care
and best practice. Furthermore, the risk for pressure ulcers may be greater for ICU
patients than for other patients.[10–12]
The first step in preventing pressure ulcers is determining what constitutes
appropriate risk. Many risk factors have been identified empirically; however,
consensus on the most important risk factors is lacking.

Review of Relevant Literature

The lack of a risk assessment scale exclusively for determining the risk for
pressure ulcers is an impediment to accurately determining risk in critical care
patients.[3,13] In the United States, the Braden Scale[14] is the most widely used risk
assessment tool in most care settings, including the ICU, and current clinical
practice guidelines[15–17] recommend its use. With the Braden Scale, derived from
the conceptual framework of Braden and Bergstrom,[18] 6 subscales are used to
measure risk for pressure ulcers: sensory perception, activity, mobility, nutrition,
moisture, and friction/shear. Potential scores range from 6 to 23; lower scores
indicate greater risk. Scores of 15 to 18 indicate risk or mild risk; scores of 13 to
14, moderate risk; scores of 10 to 12, high risk; and scores of 9 or less, very high
risk.[19] Stratification of risk for pressure ulcers can be useful clinically for
determining and implementing the appropriate level of prevention.[20]

Although evidence[4,21–23] supports the total score on the Braden Scale as a

predictor of pressure ulcers in critical care patients, investigation of the
contributions of the subscale scores has been limited, and the findings have been
inconclusive. Although the sub-scales of sensory perception,[22,24] moisture,[21,24]
mobility,[21] and friction/shear[24] have been found to be significant predictors of
pressure ulcer development in ICU patients, the activity and nutrition subscales
have not.

Other factors not included in the Braden Scale may also increase a patient's level
of risk for pressure ulcers and thus be important determinants in adult critical care
patients. Empirical evidence suggests that the following factors can be predictive
of pressure ulcers in critical care patients: advanced age;[1,4,21,25,26] low arteriolar
pressure;[27–29] prolonged ICU stay;[1,21,26,30] severity of illness as indicated by
scores on the Acute Physiology and Chronic Health Evaluation (APACHE) II;[1,31]
comorbid conditions, including diabetes mellitus, sepsis, and vascular
disease;[21,25,27] and iatrogenic factors, such as the use of vasopressor agents.[1,25,27]
Although research has indicated that many of these factors are significantly
related to the development of pressure ulcers in ICU patients, the findings were
not consistent in all of the studies in which these relationships were tested.

The purpose of my study was to determine which risk factors derived from the
Braden Scale and the empirical literature are the best predictors of pressure ulcers
in adult critical care patients. The following risk factors were examined: total
Braden score, mobility, activity, sensory perception, moisture, nutrition,
friction/shear, ICU length of stay, age, arteriolar pressure, vasopressor
administration, score on APACHE II, and comorbid conditions.

Methods

This study received exempt status from the hospital's institutional review board.
The study posed no risk to the participants because the variables abstracted
reflected care parameters implemented and recorded during routine patient care.
All patient information recorded was deidentified to ensure patient anonymity.

Study Design and Setting

A retrospective descriptive, correlational design was used. The setting was an

intensivist-led, 12-bed medical-surgical ICU (MSICU) in Englewood Hospital
and Medical Center, a suburban Magnet teaching hospital in Englewood, New
Jersey.

Sample

All adult patients admitted to the MSICU from October 2008 through May 2009
who met the inclusion criteria were included in this convenience sample. Patients
were included if they were 18 years or older and had an MSICU stay of 24 hours
or greater. Patients were excluded if they had an MSICU stay of less than 24
hours or had a pressure ulcer at the time of admission to the MSICU. A power
analysis was conducted for regression analysis to determine an appropriate sample
size.[32] In order to achieve a power of 80%, a minimum sample size of 163 was
needed for a moderate effect size, a significance level of α = .05, and 22 predictor
variables.

Data Collection

Data were abstracted from the hospital's existing computerized documentation

systems and included the following study variables: pressure ulcer (recorded as
present or absent at discharge from the MSICU); score on Braden Scale at the
time of admission to the MSICU; scores on Braden subscales at admission to the
unit; age; arteriolar pressure (defined as the total number of hours in the first 48
hours that the patient had mean arterial pressure <60 mm Hg, and/or systolic
blood pressure <90 mm Hg, and/or diastolic blood pressure <60 mm Hg); length
of MSICU stay; total number of hours of administration of any of the following
vasopressor agents during the MSICU stay: norepinephrine, epinephrine,
vasopressin, dopamine, and phenylephrine; severity of illness according to the
APACHE II score; and presence or absence of any of the following comorbid
conditions: diabetes mellitus, cardiovascular disease, peripheral vascular disease,
and concomitant infection/sepsis. During the study period, routine protocols for
prevention of pressure ulcers were in place in the MSICU. The protocols were
based on the clinical practice guidelines[33,34] current at that time.

Demographic data and patient characteristics included ethnicity, sex, and

admitting MSICU diagnosis. In addition, for patients in whom a pressure ulcer
developed, the number of hours into the admission the pressure ulcer occurred and
the anatomical location and stage of the pressure ulcer according to the 2007
National Pressure Ulcer Advisory Panel staging system[35] (Table 1) were
recorded.
Data Analysis

SPSS, version 16.0 for Windows, software (SPSS Inc, Chicago Illinois) was used
for data analysis. Descriptive statistics included frequency distributions for study
variables and demographic data. The Pearson product moment correlation was
used for correlational analyses of the study variables. Direct logistic regression
was used to create the best model for predicting the development of pressure
ulcers in ICU patients. For comparison of study variables between patients with
and without pressure ulcers, t tests and χ2 analysis were used.

Results

Description of the Sample

Of the 579 patients admitted to the MSICU during the study period, 347 met the
inclusion criteria and were included in the final sample. The patients were 20 to
97 years old (mean, 69; SD, 17). The top 3 admitting diagnoses were respiratory
failure or distress (20.7%), sepsis or septic shock (17.3%), and neurological
problems (15%). Demographic characteristics of the sample are summarized in
Table 2.

Descriptive Statistics of the Study Variables

Descriptive statistics of the study variables are summarized in Table 3. Among the
347 patients in the sample, a pressure ulcer developed in 65 (18.7%). Of these
ulcers, most (35%) were stage II, and the sacrum was the most common
anatomical location (58%). Mean time until development of a pressure ulcer was
133.61 hours (median 90.0; range, 5–573; SD, 120.13). The distribution of
pressure ulcers by stage and hours to development is summarized in Table 4.

Mean Braden Scale scores were 14.28 (SD, 2.68; range, 6–23) for the entire
patient sample, 12.73 (SD, 2.65) for patients in whom pressure ulcers developed,
and 14.63 (SD, 2.65) for patients who remained ulcer-free. Of the 65 patients in
whom a pressure ulcer developed, 28% (n = 18) were classified as at risk, 28% (n
= 18) as at moderate risk, 35% (n = 23) as at high risk, and 9% (n = 6) as at very
high risk. Predictive validity of the Braden Scale was measured by using
sensitivity and specificity values in addition to negative and positive predictive
values[36] (Table 5). At a cut-off score of 18, the sensitivity was 100%, specificity
was 7%, positive predictive value was 20%, and negative predictive value was
100%. According to the scores on the Braden Scale, 94% of the sample was
predicted to be at risk for pressure ulcers; the actual occurrence rate was 18.7%.

Logistic Regression Analyses

Independent variables significantly associated with the dependent variable

development of a pressure ulcer were included in direct logistic regression (Table
6). The following risk factors were significant predictors of pressure ulcers:
mobility (B = −0.823; P = .04; odds ratio [OR] = 0.439; 95% confidence interval
[CI], 0.21–0.95), age (B =0.033; P = .03; OR = 1.033; 95% CI, 1.003–1.064),
length of ICU admission (B = 0.008; P< .001; OR = 1.008; 95% CI, 1.005–1.011),
and cardiovascular disease (B = 1.082; P = .007; OR = 2.952; 95% CI, 1.3–6.4;
Table 7).

In order to better understand the risk factors that lead to actual breaks in skin
integrity, a second direct logistic regression was done for a subsample of the
population (n = 327) that excluded all patients in whom a stage I pressure ulcer
developed. The following risk factors were significantly predictive of the
development of a stage II or greater pressure ulcer: friction/shear (B = 1.743; P =
.01; OR = 5.715; 95% CI, 1.423–22.950), length of ICU stay (B =.008; P< .001;
OR = 1.008; 95% CI, 1.004–1.012), norepinephrine administration (B =.017; P
=.04; OR=1.017; 95% CI, 1.001–1.033), and cardiovascular disease (B = 1.218; P
= .02; OR = 3.380; 95% CI, 1.223–9.347; Table 7).

Discussion
In this study sample, a Braden Scale score of 18 was not predictive of the
development of a pressure ulcer. In fact, 75% (n = 261) of the patients were
classified as at risk for pressure ulcers (Braden Scale score =18) but remained
ulcer-free (see Figure). When the Braden Scale was used, the risk for pressure
ulcers was overpredicted, as indicated by the low specificity and low positive
predictive value. Because of the overprediction, drawing any important
conclusions about the capability of the scale in predicting development of pressure
ulcers in the patients in the study is difficult. Either use of the Braden Scale led to
successful identification of patients at risk, subsequently mobilizing clinicians to
implement appropriate strategies to prevent pressure ulcers and thus averting the
occurrence of the ulcers, or potentially unnecessary strategies to prevent pressure
ulcers were implemented, resulting in excessive health care costs and potential
inefficient use of caregivers' time.

Figure.

Score on the Braden Scale and occurrence of pressure ulcers

(blue bars, present; red bars, absent).

(Enlarge Image)

Of the 6 Braden subscales, only mobility and friction/shear were significant

predictors of pressure ulcers. Mobility is defined on the Braden Scale as the
ability of a patient to turn and control body movement.[18] Compared with patients
who were ulcer-free, patients in whom pressure ulcers developed had significant
lower scores on the mobility subscale, with a mean subscale score of 2.0, defined
as very limited mobility. Turning and repositioning an immobile patient is a basic
tenet of nursing care and is recommended in all current practice guidelines as a
strategy to prevent pressure ulcers. Although evidence for the optimal frequency
for repositioning immobile patients is lacking,[37] the guidelines[16,17] indicate that
regular repositioning is vital. Some evidence[38] also supports the use of low air
loss mattresses for pressure redistribution in ICU patients. The use of low air loss
mattresses and regular turning and repositioning of immobile patients may be 2
essential strategies for preventing pressure ulcers in critical care patients. The
effect of progressive mobility programs on reduction of pressure ulcers in ICU
patients is an area ripe for empirical study.

Development of a stage II or greater pressure ulcer was almost 6 times more likely
in patients with higher exposure to friction/shear than in patients with low
exposure. Previous studies in critical care patients have yielded inconclusive
evidence for this subscale. Although Jiricka et al[24] found a significance
difference in the mean Braden friction/shear sub-scale scores between patients in
whom pressure ulcers developed and patients who remained ulcer-free, other
investigators[21,22] found no relationship between the subscale and development of
pressure ulcers in critical care patients. In a recent study[39] in a surgical trauma
ICU, 41 patients at high risk for pressure ulcers received an application of a
silicone-bordered, nonadherent foam dressing to the sacral area to minimize the
forces of friction, shear, and moisture. Application of this topical dressing
significantly reduced the occurrence of pressure ulcers to zero. The study is being
replicated to validate the findings.

Immobile, critically ill patients are totally dependent on caregivers for both
repositioning and transfers, increasing the risk for exposure to the forces of
friction/shear and subsequent development of pressure ulcers. Advocates of safe
patient handling procedures recommend the use of glide sheets and patient
transfer devices to reduce the deleterious effects of friction/shear on the skin and
simultaneously protect staff from musculoskeletal injuries.[40] Additional factors
such as prolonged head elevation in critically ill, intubated patients to prevent
ventilator-associated pneumonia or in enterally fed patients to prevent aspiration
also increase the risk for exposure to friction/shear. Continued research into the
effects of prolonged head elevation on skin integrity is warranted to better
understand the sequelae of shear forces and to develop interventions to counteract
these forces.
In my study, patients in whom pressure ulcers developed had lower mean scores
on the Braden sensory perception subscale than did patients who remained ulcer-
free. However, this subscale was not a significant predictor. Diminished levels of
sensory perception experienced by all patients in the sample may have rendered
this risk factor nonsignificant when analyzed with other risk factors. In 2 previous
studies[22,24] in critical care patients, however, scores on the Braden sensory
perception subscale were predictive of pressure ulcers. Current pressure ulcer
guidelines[17] recommend that practitioners consider the impact of the score on the
Braden sensory perception subscale when determining a patient's risk for pressure
ulcers.

In my sample, the activity subscale was not related to development of pressure

ulcers, a finding consistent with the results of previous studies[21,22,24] in critical
care patients in which the Braden activity subscale was used. Because most
patients in the MSICU were bed bound, the patients in my sample had little
variation in activity levels.

A possible explanation for the finding that the score on the Braden moisture
subscale was not predictive of pressure ulcers in my study is the frequent use of
indwelling devices that minimize skin exposure to moisture from 2 primary
sources: urine (indwelling urinary catheters) and liquid stool (fecal containment
devices). In 2 previous studies[21,24] in ICU patients, scores on the Braden moisture
sub-scale were predictive of pressure ulcers, and in another study,[1] fecal
incontinence was a significant risk factor for pressure ulcers. Bowel management
systems, also called fecal containment devices, were introduced to the clinical
market in 2004, after the aforementioned studies were published. In a study by
Benoit and Watts,[41] use of these devices in combination with strategies to
prevent pressure ulcers decreased the prevalence of pressure ulcers for patients
exposed to high levels of moisture from liquid stool incontinence.

Although scores on the Braden nutrition subscale were related to the development
of pressure ulcers in my study, the scores were not a significant predictor,
consistent with the findings of previous studies[21,22,24] in ICU patients. The score
on this sub-scale is a measure of the usual food intake of a patient, and most
critically ill patients may have difficulty articulating a diet history or be unable to
do so, especially in the initial days of an ICU admission, diminishing the value of
the subscale in these patients. In a previous study[26] in ICU patients, however,
nutrition, measured as the number of days without nutrition, was a significant
predictor of the development of pressure ulcers. Additionally, the results of
measurements of many biological markers of nutrition, such as body weight,
serum levels of albumin, and, in some instances, serum levels of prealbumin, may
be erroneous because of fluid shifts that occur in critical illness, thus creating
greater challenges in determining appropriate objective nutritional markers.
Currently, there is a lack of consensus among researchers and clinicians regarding
the best metric of nutritional status.[42]

In my study, risk factors not included in the Braden Scale, that is, age, length of
ICU stay, norepinephrine administration, and cardiovascular disease, were all
significant predictors. The mean age of patients in whom pressure ulcers
developed was 73 years, whereas the mean age in patients who remained ulcer-
free was 67 years. Strong empirical evidence supports the relationship between
advanced age and development of pressure ulcers in critical care patients, and
perhaps this risk factor should be given stronger consideration for inclusion in a
risk assessment scale.[1,4,21,25,26]

In my study, development of pressure ulcers was more likely in patients with

longer ICU stays than in patients with shorter stays. This result is consistent with
the findings of previous studies.[1,21,26] In my study, the mean MSICU stay was
281 hours (11.7 days) for patients in whom a pressure ulcer developed and 81
hours (3.3 days) for patients who remained ulcer-free.

The most vulnerable time for development of pressure ulcers during the MSICU
stay was the first week; 66% of the sample had development of a pressure ulcer in
the first 6 days of their MSICU stay, a finding consistent with the results of other
studies[22,23,43] in critical care patients. On the basis of this finding, the first week
of a patient's ICU stay should be a period of hypervigilance to assess the risk for
pressure ulcers, and strategies to prevent such ulcers should be aggressively
implemented. Paradoxically, the first week of an ICU stay may also be the most
likely period in which a patient experiences the greatest physiological instability,
requiring nurses and other members of the health care team to manage multiple
life-saving technologies while simultaneously preventing pressure ulcers. During
this time, communication among all members of the health care team of the
potential for pressure ulcers is crucial. Moreover, a multidisciplinary forum can
underscore the premise that prevention of pressure ulcers is the responsibility of
all members of the health care team, not just nurses.

In my study, norepinephrine was the only vasopressor that was a significant

predictor for pressure ulcers, a finding consistent with the results of previous
studies[1,27] in ICU patients. Of note, 32 of the 65 patients (49%) in my study who
had a pressure ulcer develop received norepinephrine. Moreover, the mean
number of hours of norepinephrine infusions in patients who had stage II or
higher pressure ulcers was significantly higher (55 hours) than in patients who
remained ulcer-free (4 hours). Evidence to support norepinephrine as a predictor
of pressure ulcers in critical care patients is increasing.[1,27]

Cardiovascular disease was the only comorbid condition in my study that was a
significant predictor of pressure ulcers. In my sample, 57% of patients in whom
pressure ulcers developed had cardiovascular disease. Although cardiovascular
disease has been associated with the development of pressure ulcers in non-ICU
patients and in cardiac surgery patients,[44–47] this comorbid condition has not been
studied extensively as a risk factor in general ICU patients. Further research is
needed to elucidate the importance of this unmodifiable risk factor in the
development of pressure ulcers in general critical care patients.

In my study, patients in whom a pressure ulcer developed had significantly lower

mean diastolic blood pressures, lower mean arterial pressure, and lower mean
systolic blood pressures than did patients who remained free of pressure ulcers.
However, none of these variables was a significant predictor. In 3 previous
studies[27,28,43] in ICU patients, no significant relationships were found between
any measure of blood pressure and development of pressure ulcers. In another
study,[29] diastolic blood pressure was lower in critical care patients in whom
pressure ulcers developed; however, this relationship was not statistically
significant. The finding that none of the blood pressure variables was a predictor
of pressure ulcers in my study and in other studies is noteworthy and may be due
to the frequent monitoring of blood pressure in critical care patients, resulting in
quicker implementation of interventions to increase arterial pressure. In my study,
the finding may also represent a methodological limitation, because measurement
of blood pressures was confined to the first 48 hours of the MSICU stay.

Although severity of illness was not predictive of pressure ulcers in my sample,

patients in whom pressure ulcers developed had significantly higher mean
APACHE II scores (21.89; SD, 6.71) than did patients who remained ulcer-free
(mean, 14.63; SD, 2.65), suggesting that patients with pressure ulcers had a
greater disease burden. This finding is consistent with the results of a previous
study[31] in ICU patients. The APACHE II score (at =13) was predictive of
pressure ulcers in only one study.[1] A total of 36 of the 347 patients in my sample
died, an overall mortality rate of 10%. Among the patients who died during their
MSICU stay, almost half (17) had a pressure ulcer at the time of death. Although
APACHE II scores are a valid measure of severity of illness and mortality risk,
they may not be a reliable empirical indicator for severity of illness as a risk for
development of pressure ulcers.

Limitations

The retrospective nature of this study is a limitation. However, most of the data
abstracted represent objective clinical data that would not vary on the basis of the
study design. Using only the Braden Scale measurements recorded in the first 24
hours of the ICU stay may also be a limitation; however, determining risk early
during a patient's stay is crucial because the determination may result in earlier
implementation of prevention strategies. The inability to assess and stage
developing pressure ulcers is also a limitation of a retrospective design. Pressure
ulcers were staged and recorded in the patients' record by staff nurses who are
educated annually on assessment and staging of pressure ulcers and use of the
Braden Scale. Use of a single study site also diminishes the generalizability of the
study findings.

Conclusions

Critical care patients are a unique subset of hospitalized patients and are the
sickest patients in the health care system. ICU patients are repeatedly confronted
with multiple, concomitant risk factors for development of pressure ulcers, and no
consensus exists on how best to measure these factors.[3,13] Although specific
measures of risk for pressure ulcers are available for other populations of patients,
including children, neonates, patients who receive care at home, patients who
receive hospice and palliative care, and patients with spinal cord injuries,[17,18,48]
no such tool exists for critical care patients, creating a barrier to accurate
assessment of risk for pressure ulcers in ICU patients.

Accurate identification of risk factors is a prerequisite for determining appropriate

strategies to prevent pressure ulcers. However, even with consistent and ongoing
skin assessment, early identification of skin changes, and the implementation of
appropriate prevention strategies to minimize damage, skin and tissue damage can
occur in critically ill patients.[49] Certain prevention strategies, such as turning of a
patient whose hemodynamic status is unstable, may be medically contraindicated,
and adequate prevention of pressure ulcers in patients with multiple risk factors is
difficult.[50] Paradoxically, occurrence of pressure ulcers in hospitalized patients,
including critical care patients, is considered an adverse event by the Centers for
Medicare and Medicaid Services, leaving caregivers in a challenging situation of
trying to prevent a pressure ulcer that may not realistically be preventable.
Continued research on risk factors for pressure ulcers in critical care patients is
imperative, not only to ultimately decrease the prevalence of pressure ulcers but
also to help caregivers identify and implement risk appropriate evidence-based
strategies to prevent the ulcers. Additionally, research will validate the existence
of risk factors for pressure ulcers that cannot be controlled and thus are not
preventable.

My results demonstrate the multifactorial causes of pressure ulcers in critical care

patients. Although scores on 2 Braden subscale risk factors (mobility,
friction/shear) were predictive of pressure ulcers, other risk factors not measured
by the Braden Scale, including age, length of ICU stay, norepinephrine
administration, and cardiovascular disease, also were significant predictors in
multivariate analysis.

My findings underscore the need for development and testing of model for
assessing the risk for pressure ulcers in ICU patients, in order to provide a basis
for explaining the development of pressure ulcers in these patients. This model
could serve as the foundation for development of a pressure ulcer risk assessment
scale for critical care patients. Although Pancorbo-Hildago et al[51] have stated
that use of a risk assessment scale increases the implementation of pressure ulcer
initiatives, the ultimate test is the ability to translate the findings of such an
assessment into a reduction in the occurrence of pressure ulcers. Little evidence
supports such a reduction when current risk assessment tools are used.[16,17,51–53]

Many opportunities exist for research on the effects of various prevention

strategies, such as support surfaces, fecal containment devices, frequency of
repositioning, the use of topical dressings applied to the sacrum to minimize
friction/shear, progressive mobility programs, and the use of glide sheets and
patient transfer equipment, on the development of pressure ulcers in ICU patients.
Ultimately, accurate identification of the risk factors for pressure ulcers and
testing and implementing evidence-based prevention strategies can lead to
reductions in both the occurrence of pressure ulcers and health care costs and can
promote positive health outcomes in critical care patients.
References

1. Theaker C, Mannan M, Ives N, Soni N. Risk factors for pressure sores in

the critically ill. Anaesthesia. 2000;55:221–224.
2. Russo C, Steiner C, Spector W. Hospitalizations related to pressure ulcers
among adults 18 years and older, 2006. Healthcare Cost and Utilization
Project, Statistical Brief 64. Agency for Healthcare Quality and Research
Web site. http://www.hcup-us.ahrq.gov/reports/statbriefs/sb64.pdf.
Published December 2008. Accessed June 3, 2011.
3. Keller P, Wille J, van Ramshorst B, van der Werken C. Pressure ulcers in
intensive care patients: a review of risks and prevention. Intensive Care
Med. 2002;28(10):1379–1388.
4. Shahin ES, Dassen T, Halfens RJ. Pressure ulcer prevalence in intensive
care patients: a cross-sectional study. J Eval Clin Prac. 2008;14:563–568.
5. VanGilder C, Amlung S, Harrison P, Meyer S. Results of the 2008–2009
International Pressure Ulcer Prevalence Survey and a 3-year acute care,
unit-specific analysis. Ostomy Wound Manage. 2009;55(11):39–45.
6. Centers for Medicare and Medicaid Services. Eliminating serious,
preventable and costly medical errors–never events. Centers for Medicare
and Medicaid Services Web site.
http://www.cms.hhs.gov/apps/media/press/release.asp?Counter=1863.
Published May 18, 2006. Accessed June 3, 2011.
7. Centers for Medicare and Medicaid Services. CMS proposes additions to
hospital-acquired conditions for fiscal year 2009. Centers for Medicare
and Medicaid Services Web site.
http://www.cms.gov/apps/media/fact_sheets.asp. Published April 14,
2008. Accessed June 3, 2011.
8. Institute for Healthcare Improvement. Relieve the pressure and reduce
harm. Institute for Healthcare Improvement Web site.
http://www.ihi.org/IHI/Topics/PatientSafety/Safety-
General/ImprovementStories/FSRelievethePressureandReduceHarm.htm.
Published May 21, 2007. Accessed June 4, 2011.
9. Agency for Health Care Research and Quality, Innovations Exchange.
Comprehensive, interdisciplinary guidelines, combined with tools to
increase adherence, significantly reduce hospital-acquired pressure ulcers.
Agency for Health Care Research and Quality Web site.
http://www.innovations.ahrq.gov/content.aspx?id=2589. Published March
3, 2010. Updated April 13, 2011. Accessed June 4, 2011.
10. Baumgarten M, Margolis D, Berlin J, et al. Risk factors for pressure ulcers
among elderly hip fracture patients. Wound Repair Regen. 2003;11(2):96–
103.
11. Baumgarten M, Margolis DJ, Localio AR, et al. Extrinsic risk factors for
pressure ulcers early in the hospital stay: a nested case-control study. J
Gerontol A Biol Sci Med Sci. 2008;63(4):408–413.
12. Krapfl L, Mackey D. Medicare changes to the hospital inpatient
prospective payment systems: commentary on the implications for the
 hospital-based wound care clinician. J Wound Ostomy Continence Nurs.
2008;35(1):61–62.
13. de Laat E, Schoonhoven L, Pickkers P, Verbeek A, vanAch -terberg T.
Epidemiology, risk and prevention of pressure ulcers in critically ill
patients: a review of the literature. J Wound Care. 2006;15(6):269 275.
14. Bergstrom N, Braden B, Laguzza A, Holman V. The Braden Scale for
predicting pressure sore risk. Nurs Res. 1987;36(4): 205–210.
15. Lyder CH, Ayello EA. Pressure ulcers: a patient safety issue. In: Hughes
R, ed. Patient Safety and Quality: An Evidence-Based Handbook for
Nurses. Rockville, MD: Agency for Healthcare Quality and Research;
2008. AHRQ publication 08–0043.
16. Wound Ostomy and Continence Nurses Society. Guideline for the
Prevention and Management of Pressure Ulcers. Mt Laurel, NJ: Wound,
Ostomy and Continence Nurses Society; 2010.
17. National Pressure Ulcer Advisory Panel and European Pressure Ulcer
Advisory Panel. Prevention and Treatment of Pressure Ulcers: Clinical
Practice Guideline.Washington, DC; National Pressure Ulcer Advisory
Panel; 2009.
18. Braden B, Bergstrom N. A conceptual schema for the study of the etiology
of pressure sores. Rehabil Nurs. 1987;12(1): 8–12,15.
19. Braden B. Protocols by level of risk.
http://www.bradenscale.com/images/protocols_by_level_of_risk.pdf.
Published 2001. Accessed June 4, 2011.
20. Ayello EA, Braden B. How and why do pressure ulcer risk assessment?
Adv Skin Wound Care. 2002;15(3):125–133.
21. Bours G, De Laat E, Halfens R, Lubbers M. Prevalence, risk factors and
prevention of pressure ulcers in Dutch intensive care units. Intensive Care
Med. 2001;27:1599–1605.
22. Carlson E, Kemp M, Shott S. Predicting the risk of pressure ulcers in
critically ill patients. Am J Crit Care. 1999;8(4):262–269.
23. Fife C, Otto G, Capsuto E, et al. Incidence of pressure ulcers in a
neurologic intensive care unit. Crit Care Med. 2001;29(2): 273–290.
24. Jiricka M, Ryan P, Carvalho M, Bukvich J. Pressure ulcer risk factors in
an ICU population. Am J Crit Care. 1995;4(5): 361–367.
25. Frankel H, Sperry J, Kaplan L. Risk factors for pressure ulcer development
in a best practice surgical intensive care unit. Am Surg. 2007;73:1215–
1217.
26. Eachempati S, Hydo L, Barie P. Factors influencing the development of
decubitus ulcers in critically ill surgical patients. Crit Care Med.
2001;29(9):1678–1682.
27. Batson S, Adam S, Hall G, Quirke S. The development of a pressure area
scoring system for critically ill patients: a pilot study. Intensive Crit Care
Nurs. 1993;9:146–151.
28. Pender L, Frazier S. The relationship between dermal ulcers, oxygenation
and perfusion in mechanically ventilated patients. Intensive Crit Care
Nurs. 2005;21:29–38.
29. Seturan L, Karabacak U, Ozdilek S, et al. The relationship among pressure
ulcers, oxygenation, and perfusion in mechanically ventilated patients in
an intensive care unit. J Wound Ostomy Continence Nurs.
2009;36(5):503–508.
30. Sayar S, Turgut S, Dogan H, et al. Incidence of pressure ulcers in intensive
care unit patients at risk according to the Waterlow scale and factors
influencing the development of pressure ulcers. J Clin Nurs.
2008;18(5):765–774.
31. Shahin E, Dassen T, Halfens R. Incidence, prevention and treatment of
pressure ulcers in intensive care patients: a longitudinal study. Int J Nurs
Stud. 2009;46:413–421.
32. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed.
Hillsdale, NJ: Lawrence Erlbaum Assoc; 1988.
33. Wound Ostomy and Continence Nurses Society. Guideline for the
Prevention and Management of Pressure Ulcers. Glenview, IL: Wound,
Ostomy and Continence Nurses Society; 2003.
34. Agency for Health Care Policy and Research. Pressure Ulcers in Adults:
Prediction and Prevention. Rockville, MD: Agency for Health Care Policy
and Research; 1992. AHCPR publication 92–0047.
35. National Pressure Ulcer Advisory Panel. Updated staging system: pressure
ulcer stages revised by NPUAP. National Pressure Ulcer Advisory Panel
Web site. http://www.npuap.org/pr2.htm. Published 2007. Accessed June
4, 2011.
36. Bolton L. Which pressure ulcer risk assessment scales are valid for clinical
use? J Wound Ostomy Continence Nurs. 2007;34(4):368–381.
37. Krapfl L, Gray M. Does regular repositioning prevent pressure ulcers? J
Wound Ostomy Continence Nurs. 2008;35(6): 571–577.
38. McInnes E, Bell Syer SE, Dumville JC, Legood R, Cullum NA. Support
surfaces for pressure ulcer prevention. Cochrane Database Syst Rev.
2008;8(4):CD001735.
39. Brindle CT. Outliers to the Braden Scale: identifying high risk ICU
patients and the results of prophylactic dressing use. WCET J.
2010;30(1):11–18.
40. Sibbald R, Norton L, Woo K. Optimized skin care can prevent pressure
ulcers. Adv Skin Wound Care. 2009;22(9):392.
41. Benoit R, Watts C. The effect of a pressure ulcer prevention program and
the bowel management system in reducing pressure ulcer prevalence in an
ICU setting. J Wound Ostomy Continence Nurs. 2007;34(2):163–175.
42. Doughty DB. Prevention and early detection of pressure ulcers in
hospitalized patients. J Wound Ostomy Continence Nurs. 2008;35(1):76–
78.
43. Compton F, Hoffmann F, Hortig T, et al. Pressure ulcer predictors in ICU
patients: nursing skin assessment versus objective parameters. J Wound
Care. 2008;17(10):417–420, 422–424.
44. Bergstrom N, Braden B, Kemp M, Champagne M, Ruby E. Multi-site
study of incidence of pressure ulcers and the relationship between risk
 level, demographic characteristics, diagnoses and prescription of
preventive interventions. J Am Geriatr Soc. 1996;44(1):22–30.
45. Lindgren M, Unosson M, Fredrickson M, Ek A. Immobility—a major risk
factor for development of pressure ulcers among adult hospitalized
patients: a prospective study. Scand J Caring Sci. 2004;18(1):57–64.
46. Lewicki L, Mion L, Splane K, Samstag D, Secic M. Patient risk factors for
pressure ulcers during cardiac surgery. AORN J. 1997;65(5):933–942.
47. Pokorny M, Koldjeski D, Swanson M. Skin care interventions for patients
having cardiac surgery. Am J Crit Care. 2003;12(6):535–544.
48. Spinal Cord Injury Rehabilitation Evidence. Outcome Measures. Spinal
cord injury pressure ulcer risk scale. Spinal Cord Injury Rehabilitation
Evidence Web site. http://www.scireproject.com/outcome-measures.
Published 2010. Accessed June 6, 2011.
49. Langemo D, Brown G. Skin fails too: acute, chronic and endstage skin
failure. Adv Skin Wound Care. 2006;19(4):206–211.
50. Wound, Ostomy and Continence Nurses Society. Wound, Ostomy and
Continence Nurses Society position statement on avoidable versus
unavoidable pressure ulcers. J Wound Ostomy Continence Nurs.
2009;36(4):378–381.
51. Pancorbo Hildago T, Garcia Fernandez F, Lopez Madina I, Alvarez Nieto
C. Risk assessment scales for pressure ulcer prevention: a systematic
review. J Adv Nurs. 2006;54(1):94–110.
52. Anthony D, Papanikolaou P, Parboteeah S, Saleh M. Do risk assessment
scales for pressure ulcers work? J Tissue Viability. 2010;19(4):132–126.
doi:10.1016/j.jtv.2009.11.006.
53. Stechmiller J, Cowan L, Whitney J, et al. Guidelines for the prevention of
pressure ulcers. Wound Repair Regen. 2008; 16(2):151–168.