Pathophysiology of BPH

Growth Factors (epidermal growth factor,

Hormone (sex fibroblast growth factor, and transforming
Age Genetics
steroid) growth factor-β

Changes in cellular Inflammation and Clinically Type II 5α estrogens and

mitogenesis microvascular link due to reductase through selective estrogen stimulate or Induce stromal
&hormonal disease inheritable DHT/androgen receptor inhibit cell cell
homeostatsis in disease receptor signaling modulators division and
prostate gland differentiation
Provoke ischemia processes in Significant tissue
and oxidative Testosterone is regulating remodelling
prostatic
stress converted to stromal-epithelial epithelium and
Chromosomal Dihydrostestostero interactions stroma
aberration ne (DHT) Prostate
Providing involved in
prostatic cellular enlargement
favourable
environment growth
for BPH Influence cell
proliferation
differentiation, Metabolic
morphogenesis, and Syndrome
Produce Its degree functional
Affect total Low Level
inflammatory affects prostate maintenance Obesity
Prostate volume of HDL
infiltrate volume and
weight
Inflammation
activate the
BPH
release of
Alter the risk of Heavy smoking
cytokines and
symptomatics and low physical
raise the
BPH and LUTS activity
concentration of
growth factors

increasing level
of C-reactive
protein