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request to edit Name Common

enhancer,Positives Common pain,
Replenishes Stomach Negatives
5-HTP
Acetyl-L-Carnitine Seretonin alertness
Enhances Serotonin Syndrome
depression and
(ALCAR) and mental
More energy.than Often
bioavailable sleepyness.
comes with
Acetyl-L-Tyrosine L-Tyrosine
Memory enhancing folate
Acorus calamus activity
mood, focus and (monitoring highly
Adrafinil
Afamelanotide attention
cancer prevention, recommended)
(Melanotan I) antioxidant Tanning
Afobazol(e) AnxiolyticBoosts HGH Unknown
brainfog.
Alpha GPC levels.
ALCAR, recycles
Alpha Lipoic Acid vitamin
preventsCL-DOPA anticholinergic, highly
Amantadine caused
Memory, dyskinesia
focus, anti- toxic in overdose
Amla berries
Aniracetam anxiety
Also has a longer half- Headaches, Brain-fog
Armodafinil life thangrowth,
Muscle Modafinil.
Sleep, same as Modafinil
Ashwagandha
Aspirin (acetylsalicylic Confidence, Alertness
ischemic stroke risk, upset and gastric
acid)
Atomoxetine food preservative ulcers
(Strattera)
Avena Sativa gains to clarity of
Bacopa thought. Residual drowsiness
Benfotiamine time, improvement in
Boron short-term memory Cognitive impairment.
Bromocriptine euphoria (at high Nausea
headaches, heartrate
Caffeine doses)
Anti-oxidant, increase, increased BP
Carnosine neuroprotective.
headaches and
CDP Choline brainfog
attributed to its
Celastrus paniculatus antioxidant
brainfog. Also effects
Centrophenoxine improves mood lead to plaque buildup
Cerebrolysin HDL can reduce in arteries
Cholesterol atherosclerotic
headaches and plaque
Choline Bitartate brainfog
headaches and
Choline Citrate brainfog
Vasodilator, Arousal,
Citrulline
D,L-Amphetamine Sleep enhancer? Arousal
long-term, stimulant-
(Adderall)
Desmopressin Focus, attention induced psychosis
Hypotension,
(Vasopressin)
Dimethylamylamine/ Enhances recall
Thermogenic, fast increased
Easy urination
to exceed
Methylhexaneamine
DLPA (D,L acting effective dose
supposed to be better
Phenylalanine) remove lipofuscin - for thoseand
epilepsy users.
bipolar
DMAE age spots. depression worse
Donepezil (Aricept) Good bronchodilator,
in whites and choline intolerance to egg
Eggs burns
in yolkfat,to brain when
delivery Difficult
whites. to sleep if
Entacapone vasoconstrictor
used with Carbidopa (good taken late in day, hurts
Ephedrine for common
Enhances cold)
long-term sleep quality.
Fisetin memory.
Fursultiamine Some users report
GABA Purported possible
anxiolytic, relaxation brain fog.
Gabapentin euphoria
GABOB Diarrhea
Galantamine vivid dreams
dopamine release Increases
breathing REM sleep
difficulties
GHB (anti-hangover!)
Activates various in high doses
Gilatide memory genes
Enhances cerebral users report swollen
Gingko Biloba blood flow, vasodilator testicles.
reports of nosebleeds
Ginseng Increased Energy
Neuroplasticity, Sleep and vaginal bleeding.
Glycine enhancer
Gotu Kola Energy Level
Anticancer inboost
large Obstipation, see
Green and white tea doses (ECGC). caffeine for high doses
Huperzine A Memory, Vivid
considered dreams
a good Headachesuse could
"all- Sustained
Hydergine rounder" nootropic.
reported cognitive lead
(but to fibrosis.
usually cheaper
Idebenone benefits rapid tolerance and
than CoQ10)
Kratom feels great! Arousal, addiction potential
Vasodilator,
L-Arginine Sleep enhancer
Stress reduction, Arousal
L-Lysine mood elevator.
L-methylfolate Memory,
dopamine. recall
Promotes
L-Theanine relaxation
deficiency causes sweating, stress-like
L-Thyroxine (T4) depression
Mood elevator, Sleep symptoms
L-Tryptophan enhancer
NTs. Increases Stomach pain
dopamine receptors.
L-Tyrosine dopamine Sleepyness, brain fog.
Levetiracetam Expensive, can induce
Levodopa+Carbidopa
Lion's Mane Well-being,
NGF promotionfocus
Neuroprotection, Dyskinesia
fatigue in apathy,
Sedation, some users.
Can
Lithium mood stabilization
Dopamine Level affect Kidney Function
Maca enhancement
muscle tension from
Magnesium Aspartate other supplements.
which can help Larger pills than other
Magnesium Glycinate neuroplasticity
headaches and Mg formulations
Mega BC5 II,
Melanotan brainfog sexual
increases Tanning, spontaneous
Bremelanotide arousal
promotes immune erections
depression, delayed
Melatonin function
by acting on a gene gut transit
MEM 1414 called CREB
amphetamine worsening of short-
Memantine
Methylcobalamin tolerance memory
Short-term term memory
(symptom your body
(methyl-B12) improvement
focus, alertness, is saturated?)
circular thoughts,
Modafinil
Mucuna Puriens motivation
Relaxation andand focus
agility. emotional
Peripheral dulling.
dopamine
(Velvet bean)
NAC (N-Acetyl- (for some)
influenza, chelates side effectsin very high
mucolysis,
Cysteine) heavy metals doses - nausea
Nicergoline A milder Hydergine lightheadedness,
Nicotine Stimulation,
more potent anxiolytic
than vertigo
Noopept
(EPA, DHA) (Fish Oil, piracetam
neuroprotective, anti-
Flaxseed Oil) Oil,
(GLA) (Borage inflammatory
Evening
PEA Primrose
Oxiracetam Oil) Memory,
Focus, Recall and
attention Pro-inflammatory
without MAO-B
(Phenylethylamine) stimulation,
Relaxation euphoria
without
Improves tolerance to inhibitorunrelieved by
attacks,
Phenibut
Phenylpiracetam sedation
cold weather and benzos
amphetamine-like
Phentermine
(Phenotropil)Choline
Phosphadiyl Weight-loss drug
increases productivity compounds)
(PC) Good decongestant,
Phosphatidyl Serine reduced
Clarity,
increased stress,
Memory,
BMR verbal Headaches, Brain-fog,
(PS) Memory,
improved focus,
mood Expensive,
transport
Verbal
(weight of
loss),GABA
Fluidity, anti-
Focus
fluidity, stimulating blood from
Hyperactivity,
High soy
pressure,
Picamilon
Piracetam through
vertigo the
improvement
Increased
goal-oriented BBB
(for
attention paradoxical
Sweating,
Expensive; sleepiness
cannot buy
Stomach
Piribedil
Pramiracetam those with ADHD),
and focus
behaviour in bulk (precursor to
pain
Pregnenolone Increased energy methamphetamine
Pseudoephedrine levels and regulated)
Purslane Neuroprotective?
hangover tool (higher
Pyritinol doses)
ALCAR, recycles possible diarrhea
R-Lipoic Acid
Rasagiline vitamin
No C
methamphetamine when it becomes
(Azilect/Agilect) metabolites
Mental Energy, Mood, generic)
Rhodiola Rosea Relaxation
Rivastigmine Memory
Rolipram
Ropinirole mild relaxation, slight cataractogenesis,
Saint John's Wort sedation interacts with drugs
SAM-e (S-adenosyl Mood elevation, anti-
methionine)
Selegiline (L- depressant
probably Expensive
metabolite; might
Deprenyl) neuroprotective cause drug test failure
Semax Hypertensive crysis,
Sibutramine Appetite
brainfog. Suitable for suicidal
suppresant commonideation
allergy and
Soy Lecithin
lovastatin, Vegitarians
increases HDL intolerance to soy
rhabdomyolysis
atorvastatin) cholesterol
Focus, stimulation, (muscle death)
Sulbutiamine high/relentless energy Loss of creativity
Sulpiride
Synephrine Anxiolytic, anti- Linkedeffects,
notice to heartnot
failure
sold
Tianeptine
TMG (Stablon) depressant in US or UK
(Trimethylglycine) Mood elevation disabling withdrawal
Tramadol syndrome.
Tribulus (HSV-1), anticancer, stains everything
Turmeric (Curcumin) nootropicimproved
promote yellow, chelates iron
Uridine mood Benzodiazepines and
Valerian relaxation
round brain GABA
NMDA/AMPA receptor
Vinpocetine improvement
scurvy, recycles antagonist
diarrhea, somewhat
Vitamin C cysteine (e.g. NAC) diuretic
Xanthinol Nicotinate slight appetite
Yerba Mate suppression
helps prevent copper overdose might cause
Zinc excess, helps burn fat copper deficiency
 Comments - Comments - Mode of
Low Daily Dose High Daily Dose ROA/Interactions
dose Action
spaced out helps that can cross the
100mg 200mg alleviate problems. blood-brain barrier
500mg 3000mg increases aldosterone? L-Arginine precursor

stomach, effects start Metabolized to

200mg 600mg after 2 hrs
subcutaneous modafinil
stimulating hormone
injection analog
one choline source.
300mg Better bioavailability
100mg 300mg Able to cross the BBB. anticholinergic, DA and
NE effects
Fat soluble. Also anenantiomer
Active Ampakine of
25-50mg 150mg same as Modafinil modafinil
500mg
25mg symptoms, some Irreversible COX
(cardioprotective) 1000mg people are sensitive inhibitor
NRI (Norepinephrine
reuptake inhibitor)
to take at night due to 50% available
100mg 700mg drowsiness. commercially
Thiamine (B1)
derivative
< 3 mg. > 3 mg.
doses up to 1.5g
50mg (cup of tea) aren't uncommon
100mg 600mg faster acting than
AlphaGPC
Probably only need
one choline source
membranes, source of
one choline source. most sex hormones,
Lowcholine
one bioavailablity.
source.
500mg 3000mg Low bioavailablity.
(Best absorbed on an
10g longer thanstomach)
cognitive DA/NE into synaptic
empty
5mg 60mg effects cleft.

25mg 60mg (per dose) subtler effect than PEA

alone
weeks showed no
100mg improvement..
Reversible ACh-ase
interaction with inhibitor
biotin. Inhibits peripheral
Caution with MAO COMT
90mg inhibitors

There are other

5000mg derivatives?

Reversible ACh-ase
16mg inhibitor

40mg 240mg
receptors by
glutamate
1 double brewed 5 double brewed caffeine. ECGC may be
cup cups weak MAO-B
inhibition andinhibitor
NMDA
50mcg 1000mcg receptor antagonism
4.5mg tolerance
decreasesdevelops fast Bioavailable form of
with larger
30mg 200mg dose. Fat soluble. CoQ10
500mg 3000mg
500mg 3000mg Precursor to
THB/BH4
100mg
25ug 200ug Thyroid hormone
Interacts with
tryptophan forMAOI 5-HTP precursor
epinephrine, thyroid
500mg 4g crossing BBB hormones
Carbidopa inhibits
depends
500mg on a lot peripheral AADC

Commonly found in
take together with ZMA NMDAR at
Blocks
400mg calcium sources
Probably only need specific binding site
one choline source
administration causes stimulating hormone
increased
autoimmune BP analog
.3 mg 60mg conditions Phosphodiesterase
with ACh-ase blocker by
(displaced
10mg 30mg inhibitors appropriate
Injections stimulus)
also
1mg 10mg Sublingual
difficult within 8 - 12 available via Rx
25-100mg
50mg L-DOPA 400mg
content (very high hours
content end) Source of L-DOPA
More stable analog of
500mg 2000mg cysteine
Alpha-1 adrenergic
10mg gum: see
strength dangerous) safest antagonist
links) Chainsmoking ROA.
Multiple small doses
10mg? 50mg? needed

300mg 1200mg Water soluble.

selegeline (MAO-B
250 mg 2.5 gr inhibitor) GABA derivative - 6
500mg 3000mg GABA-B agonist

Fat soluble
Water (usually
soluble. Leads
comes
GABA
to sourcebase)
in oil that
hyperactivity when
1000mg 6000mg crosses BBBcaffeine.
taken with Also provides niacin
50mg
100mg 1200mg Fat
Maysoluble.
cause hair loss D2, D3 agonist
5-10mg 100mg and skin problems.
30mg
with methylphenidate
(Ritalin) Active enantiomer of
150mg 1200mg ALA
Excellent MAO-B
specificity
500mg butyrylcholinesterase
inhibitor
agonist at D3 (strong)
D2, D4 (weaker)
 coated, take on empty
200mg
neuroprotection: 1600mg
inhibition: stomachtablet,
Liquid, specificity in high
1 mg 3x/week 10mg/day transdermal available doses)
Mode of action
unknown
UK market (Meridia,
one choline source. Reductil)
Weak source.
metabolized by HMG-CoA reductase
10mg 80mg CYP3A4
Fat soluble - take with inhibitor
100mg 400mg food
D2, D3 antagonist
per day. Do not use dopaminergic actions
12.5mg x 3 with SSRIs. as well
every 4 to 6 hours or
50mg 400mg as needed
"few times a (black pepper) and hippocampus, inhibits
month" level oil-solubilized mTOR

which is a
10mg
100mg (110% 40mg vasoconstrictor.
RDA) 3000mg

Zinc Picolinate is most

10 mg (RDA) 150mg bioavailable form
Comments - Other
Tolerance/dependenc Link/Info
m/altmedrev/.fulltext
y over time /3/4/271.pdf

Not controlled
Melanotan II isin US
different
Shipped from Russia
only?
Expensive
Bitter taste, stronger
than Piracetam,
shorter duration
becoming generic
(possibly won't be)
improves
cardiovascular risk

active molecules have

been identified.

Headaches/fatigue
upon cessation.

long term
cardiovascular health
Cheap.
Cheap. Tastes SOUR
prescribed. Not easily
available online
taken late in
Controlled inthe day.
most
Vasoconstrictor,
countries (still
available in US in
combination
cause major with
expectorants).
depression.
people not likingSee Available in US OTC as
http://en.wikipedia.or
chicken
and little without Bronchaid and
verybatteries)
g/wiki/Ephedrine#Le
L-DOPA and Carbidopa Primatene (and store
gality brands)

Also consider valerian

for similar effects

Available w/oCan
jurisdictions. Rx in
beUS
substituted with GBL.
forlower
At bedtime use oracts
dosages, if
stacking
like a stimulant. At
higher dosages, acts as
a sedating agent,
which feels similar to
many opiates.

can cause thyroid

deficiency
bacterial
Not from a lion, not an
contamination
herb, actually a
mushroom. Takes
months of daily use for
Antiparkinsonian drug
effects to be noticeable

Watch out for

counterfeits
turning off the light for
maximum effect
upregulation in
nAChR7
of action,receptors.
only slightly
better retained
hypersensitive/allergi
c60% extracts http://en.wikipedia.org/wiki/Modafinil
available.
bioavailability, sour
smell and taste
MAOI. (MAOIs are
found in tobacco) http://www.ftc.gov/foia/frequentrequests/foia2007-00482.pdf
certain fatty fish (e.g.
cod family)
Almost tasteless. More
Expensive.
cap of Rhodiola extract
(GAIA herbs)
Cheap
taken lateonly
Available in the day.
in/from
Vasoconstrictor,
Russia. Expensive.
Can cause vivid
Controlled in most
Seems
dreams.ineffective
countries May alsoto
(Available
supplement
prevent
OTC sleep.
in US). Tastes
Tolerance
bitter.
builds overstronger
Foul taste, about 2
weeks. Cycle 1 week
than Piracetam
on 1 week off to avoid
adrenal fatigue

Purchase
standardized.

Strongly interacts with

CYP3D4
Russian
Do nootropic
not confuse with
Sulbutiamine
Very cheap. Suitable
for vegetarians.
mushrooms and red
yeast rice
Tastes awful
response in some
areas
supps but available
alone
few foreign sources on
Internet

conditions, major
constituent of curry

unprocessed fruits,
vegetables and meat)

Few people have zinc

deficiency