Research Updates Homeopathy by IPRH Vol 7 Issue 4

ISSN 2278-4500
Creating Avenues | Spreading Truth
A Research Awareness E-Journal By
2018 | Volume 7, Issue 4 | Page: 94 – 116

www.researchinhomeopathy.org
Research Updates – Homeopathy by IPRH. Creating Avenues | Spreading Truth
Conceptualized, edited, designed and published by Dr. Saurav Arora

Initiative to Promote Research in Homeopathy (IPRH)
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Contents
Studies to be read
Fundamental Research
• Ameliorative effect of Cephalandra indica homeopathic preparation in STZ induced diabetic nephropathy rats. 94
• Could the Olfactory System Be a Target for Homeopathic Remedies as Nanomedicines? 95
• The physical features -size and granularity- of solid materials are strongly affected by trituration in lactose, before turning
them into homeopathic solutions. 95
• Assessment of the effects of Zincum metallicum in maternal deprivation-induced behavioral disturbances in female rats.
96
• Evaluation of antipyretic activity of Belladonna and Pyrogenium ultrahigh dilutions in induced fever model. 97
• Screening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane alkaloids determination
and untargeted analysis. 97
• Extremely Dilution of Strychnos Nux vomica Mitigates Alcohol-Induced Reduction in Enthalpies Associated With Free
Water Molecules in a Fish Brain. 98
• Nanoparticle Characterisation of Traditional Homeopathically Manufactured Cuprum metallicum and Gelsemium
sempervirens Medicines and Controls. 99
• Cantharis 200c counters heat stress in germinating seeds of Vigna unguiculata (L.) Walp. 100
• High-diluted thymulin on Ehrlich tumor growth in mice and the importance of tumor microenvironment. 101
Clinical Research
• The Value of Treatment Processes in Germany: A Discrete Choice Experiment on Patient Preferences in
Complementary and Conventional Medicine. 102
• Individualized Homeopathic Therapy in a Case of Obesity, Dysfunctional Uterine Bleeding, and Autonomic Dystonia.
103
• My best case: homeopathic management of adverse effects of tamoxifen. 103
• Complementary individual homeopathy in paediatric cancer care: A case series from a University Hospital, Switzerland.
104
• Symptoms associated with teething and response to three treatments, including homeopathic medicine: a multicenter
prospective observational study among 190 French pediatricians. 104
• Case Reports of Five Cancer Patients with Unusual Course. 105
• Homeopathic Treatment of Insomnia and Symptom Clusters Related to Cerebral Chemotoxicity in Oncology. 105
Review
• Systematic Review and Meta-Analysis of Randomised, Other-than-Placebo Controlled, Trials of Individualised
Homeopathic Treatment. 106
• Quantitative and Qualitative Pathogenetic Indices for Review of Data Derived from Homeopathic Pathogenetic Trials.
107
Survey
• Use of Self-Medication with Homeopathy in Germany: Results of an Online Questionnaire Survey. 108
• A Pilot Study of Prospective Data Collection by Italian Homeopathic Doctors. 109
Agro Homeopathy
• Evaluation of Eucalyptus growth with application of homeopathic preparation. 110
Veterinary
• Reduction of stool bacterial counts and prevention of diarrhea using an oral homeopathic product in newborn lambs.
111
Appeal 112
In the News 114
Be a Research Voice 115
IPRH Sitemap 116
Studies to be Read
Abstracts of peer-reviewed studies published during July – September 2018. The original links are
provided with each article. For citations, original links, authors and journals should be referred.
Fundamental Research
Ameliorative effect of Cephalandra indica homeopathic preparation in STZ induced diabetic

nephropathy rats.
J Ayurveda Integr Med. 2018 Nov 16. pii: S0975-9476(17)30088-8.
Abstract
Background: Diabetic nephropathy (DN) is the foremost cause of morbidity and has become the
most recurrent cause of end-stage renal disease among diabetic patients. Thus, agents having
antidiabetic effect along with safety potential in the kidneys would have a higher remedial value.
Objective: The present study aimed to investigate possible protective effect of homeopathic
preparation of Cephalandra indica Mother tincture, 6C and 30 C potencies on DN in Wistar rats.
Materials And Methods: DN was induced by intraperitoneal injection of STZ (60 mg/kg) 15 min
after Nicotinamide (230 mg/kg, i.p.) administration. Rats were divided into six groups (n = 6).
Group 1 and 2 was kept normal control and diabetic control respectively whereas Groups 3-5 consist
of diabetic nephropathy rats treated with different doses of C. indica Mother tincture, 6C and 30 C
potencies for 45 days. Glimepride (10 mg/kg) was used as standard. DN was assessed by determining
serum glucose, urea, uric acid, creatinine level and tissue histological examination. Tissue antioxidant
enzymes (SOD, GSH, LPO) level was measured to assess the oxidative stress. Also, the level of
advanced glycation end products in kidney was determined.
Results: Mother tincture, 6C and 30 C potencies of C. indica produced significant attenuation in the
biochemical parameters used to assess diabetic nephropathy. Moreover, oxidative stress and AGE's
level in kidney was also found to be significantly reduced.
Conclusion: We conclude that Mother tincture, 6C and 30 C potencies of C. indica confers

protective effect against diabetic nephropathy via inhibition of Oxidative stress and AGE's.
Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30455071
(c) IPRH | Research Updates – Homeopathy | Read Online at www.researchinhomeopathy.org | Vol 2 Issue 4 Page 94
Could the Olfactory System Be a Target for Homeopathic Remedies as Nanomedicines?

J Altern Complement Med. 2018 Nov;24(11):1032-1038. doi: 10.1089/acm.2018.0039.
Abstract
Homeopathic remedies (HRs) contain odorant molecules such as flavonoids or terpenes and can lose
their efficiency in presence of some competitive odors. Such similarities, along with extreme
sensitivity of the olfactory system, widespread presence of olfactory receptors over all organic tissues
(where they have metabolic roles besides perception of odors), and potential direct access to the brain
through olfactory nerves (ONs) and trigeminal nerves, may suggest the olfactory system as target for
HRs. Recent works highlighted that HRs exist in a dual form, that is, a still molecular form at low
dilution and a nanoparticulate form at high dilution, and that remnants of source remedy persist in
extremely high dilutions. From the literature, both odorants and nanoparticles (NPs) can enter the
body through inhalation, digestive absorption, or through the skin, especially, NPs or viruses can
directly reach the brain through axons of nerves. Assuming that HRs are recognized by olfactory
receptors, their information could be transmitted to numerous tissues through receptor-ligand
interaction, or to the brain by either activating the axon potential of ONs and trigeminal nerves or, in
their nanoparticulate form, by translocating through axons of these nerves. Moreover, the
nanoparticulate form may activate the immune system at multiple levels, induce systemic various
biological responses through the pituitary axis and inflammation factors, or modulate gene expression
at the cellular level. As immunity, inflammation, pituitary axis, and olfactory system are closely linked
together, their permanent interaction triggered by olfactory receptors may thus ensure homeostasis.
The physical features -size and granularity- of solid materials are strongly affected by trituration in
lactose, before turning them into homeopathic solutions.
Mater Sci Eng C Mater Biol Appl. 2018 Dec 1;93:305-318. doi: 10.1016/j.msec.2018.07.038.
Abstract
Trituration is a mechanical process (a form of comminution) for reducing the particle size of a
substance. In this manuscript, six different Raw Solid Materials (RSM) which are used in Homeopathy
after successive grindings are studied before they are turned into homeopathic solutions. The impact
of trituration, with the presence of α-lactose monohydrate (milk sugar) seems to be quite great and
interesting because of the variety of grain size which largely differentiate the properties of the
materials. The grain sizes obtained triturations by hand according to C. Herring's suggestion leads,
finally, measurement scale dimensions. The obtained results can be useful information for all the
pharmacy industries, as well as for preparing any kind of powder.
Assessment of the effects of Zincum metallicum in maternal deprivation-induced behavioral

disturbances in female rats
International Journal of High Dilution Research 2018, 17(3-4): 42
Abstract
Background: Clinical studies have shown that adverse events in early life are quite stressful and can
lead to the development of psychiatric disorders, such as anxiety, in adolescence and adulthood in
humans. Experimental models of maternal deprivation (MD) in rats can be a useful tool for the
understanding how these events in the early period of development can lead to behavioral changes in
adulthood.
Aims: The objective of this study was to evaluate the long-term effects of Zincum metallicum (Zinc
met) homeopathic treatment in rats subjected to maternal deprivation (MD) in their early days of life.
Methods: Newborn female rats were subjected to MD during 10 days, one hour per day, from
PND10 to PND21, and treated from the 10th day of lactation (PND10) up to weaning (PND21). On
the PND21 the rats were divided in 4 groups (N=8): a) treated with Zinc met 30c; b) treated with
Zinc met 6c; c) treated with 10% hydroalcoholic solution (HS); and “blank control”, rats without any
treatment nor experienced deprivation (ND). The medicines were administered in blind trials,
identified by codes. The animals were weighed weekly, from weaning until the end of the experiment,
and evaluated in the Open Field (OF) and in the Elevated Plus Maze (EPM) devices, to evaluate
mobility, emotionality and anxiety, in 3 moments of life: in PND21 (childhood), during puberty
(PND 40) and adulthood (PND75). Data were analyzed statistically by ANOVA, followed by the
Bonferroni's Multiple Comparison Test, being p?0.05.
Results: 1) relative to ND group the Zinc met 6c showed reduced body weight while no differences
were observed between the other groups; 2) In the OF, the MD group showed increased rearing
behavior at PND 40. The Zinc met 6c group reversed this effect showing similar profile as the ND
group. Moreover, Zinc met 6c group showed increase in the immobility time at this age; 3) In the
EPM, the MD group showed increased time in closed arms and decreased head dips relative to ND
group in PND21 period of observation. Treatment with Zinc met 6c but not with Zinc met 30c was
effective to reduce this anxiety-like behavior in PND21.
Conclusion: According to the proposed model, Zincum metallicum 6c seems to be able to prevent in
anxiety-like behavior induced by maternal deprivation in the childhood, mainly in behavioral models
related to anxiety. However, other studies still need to be developed to understand the physio-
pathological basis of these effects.
Link to study: http://highdilution.org/index.php/ijhdr/article/view/949
Evaluation of antipyretic activity of Belladonna and Pyrogenium ultrahigh dilutions in induced

fever model.
J Complement Integr Med. 2018 Oct 17.
Abstract
Background: Belladonna and Pyrogenium are commonly used to treat fever in homeopathy. But in
vivo antipyretic activity of these medicines is not reported yet. The study was conducted to evaluate
the effectiveness of ultrahigh dilutions of Belladonna (Bell) and Pyrogenium (Pyro) in fever model of
rabbits induced by Baker's yeast.
Methods: Healthy, local strain rabbits (♂ and ♀) were divided into seven groups (n=42): Normal
control, negative control, standard control, pyro 1000c, pyro 200c, Bell 1000c and Bell 200c. Fever
was induced by intra peritoneal injection of 135 mg/kg Baker's yeast suspension. Rectal temperature
was measured hourly. All the medicines were administered once a day. The results were expressed as
mean ± SEM. ANOVA and least significant difference post hoc test were applied for checking the
level of significance, p-value of ≤0.05 was considered significant statistically.
Results: Pyro in both potencies significantly reduced fever in rabbits compared to negative control
group, while both potencies of Bell were ineffective. Paracetamol and Pyro 1000c reduced by 1.2 °C
(39.7 ± 0.1 to 38.5 ± 0.1), while Pyro 200c reduced by 1 °C temperature (39.7 ± 0.5 to 38.7 ± 0.2).
Conclusions: Pyro possesses marked antipyretic activity in rabbit's Baker's yeast fever model. It
would embolden its clinical use in fever with more guarantee of its efficacy. However, caveat of small
sample size necessitates replication of experiment in large sample size.
Screening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane
alkaloids determination and untargeted analysis.
Drug Test Anal. 2018 Oct;10(10):1579-1589.
Abstract
Homeopathic products are still a controversial issue in modern medicine, understood as
complementary or alternative medicine (CAM). In this particular case, homeopathic products
prepared from Atropa belladonna extracts may present specific problems due to the effects derived
from its components. This article applies a simple, rapid, reliable method to the analysis of different
homeopathic products obtained from Atropa belladonna; drugs containing high concentration of
plant extracts; and Atropa belladonna seeds. The method was based on a simple solid-phase
preconcentration method followed by ultra-high pressure liquid chromatography (UHPLC) coupled
to high resolution mass spectrometry using Exactive-Orbitrap as an analyser.
An in-house database was set and atropine and scopolamine were the compounds detected at
highest concentrations in homeopathic products from Atropa belladonna extracts (4.57 and 2.56
μg/kg, respectively), in Belladonna ointment (4007 and 1139 μg/kg, respectively) and Belladonna
seeds (338 and 32.1 mg/kg, respectively). Other tropane alkaloids such as tropine, apoatropine,
aposcopolamine, tropinone, homatropine, and anisodamine were detected at lower concentrations
(0.04-1.36 μg/kg). When untargeted analysis was performed, other tropane alkaloids were
identified in the tested samples, such as ecgonine (0.003 μg/kg), benzoylecgonine (0.56 μg/kg),
calystegines A (19.6 μg/kg), B (33.1 μg/kg), and C (1.01 μg/kg). Finally other compounds present
in the homeopathic products, such as sugars (fructose, glucose, and lactose) or amino acids
(valine, ornithine, leucine, and phenylalanine), were identified.
Extremely Dilution of Strychnos Nux vomica Mitigates Alcohol-Induced Reduction in

Enthalpies Associated With Free Water Molecules in a Fish Brain
Abstract
Introduction: Alcohol intoxication affects aquaporins in the glial cells of brain resulting in
oedema. Nux vomica, a homeopathic drug of plant origin, is known to counteract alcohol effect.
The objective of this present study is to find out the level of free water molecules in the brain of
a teleost fish under ethanol intoxication. The second objective is to determine whether Nux
vomica could restore the level of free water in the alcohol treated fish.
Materials and methods: One group of fish was exposed to 456 mM ethanol for 30 min, another
exposed first to a solution of Nux vomica 200c for 20 min and then to 456 mM ethanol for 30
min. The third group served as an untreated control. The mid brain of each fish was kept in an
aluminium sample pan and its free water level was assessed by differential scanning calorimetry
(DSC).
Results: All alcohol treated fish showed significant reduction in the level of free water molecules
as compared to the untreated control. Treatment with Nux vomica increased the level of free
water in the brain significantly as compared to the untreated alcoholic group.
Conclusion: Alcohol intoxication reduces free water molecules in the fish brain. Nux vom might
have acted on aquaporins in the glial cells thereby increasing the level of free water in the brain.
Nanoparticle Characterisation of Traditional Homeopathically Manufactured Cuprum metallicum

and Gelsemium sempervirens Medicines and Controls
Homeopathy 2018; 107(04): 244-263
Abstract
Background: Homeopathy is controversial due to its use of very highly diluted medicines (high
potencies/dynamisations).
Methods: We used a multi-technology approach to examine dilutions of two commonly used

homeopathic medicines: an insoluble metal, Cuprum metallicum, and a soluble plant tincture,
Gelsemium sempervirens, for the presence of nanoparticles (NPs) of original substance. The
homeopathic medicines tested were specially prepared, according to the European pharmacopoeia
standards. We compared the homeopathic dilutions/dynamisations with simple dilutions and controls.
Results: Using Mass Spectrometry (Single Particle-Inductively Coupled Plasma-Mass Spectrometry)

and Dynamic Light Scattering (DLS) we could not find the expected copper in the 4cH potentisation
and could not confirm the results previously obtained by Chikramane et al (2010). For Gelsemium
medicines, using sensitive chromatography (HPLC-UV) up to a dilution level of 6 dH (3cH = dilution
10e-6), there was no significant difference in alkaloid content between a simple dilution and a
homeopathic potency. For higher potentisations, however, NP tracking analysis findings revealed the
presence of particles in all samples (except for pure water). The measurements showed large
differences in particle quantities, mean particle sizes and standard deviations of the mean sizes
between manufacturing lines of different starting material. There was always more material in
potentised medicines than in potentised pure water. Gelsemium yielded the largest quantity of
material (36 times more than that from copper at the same potentisation, 30 cH). The shapes and the
chemical composition of the material are differentiable between different medicines and controls.
Conclusion: Potentisation influences specifically the nature of NPs detected. This material
demonstrates that the step-by-step process (dynamised or not) does not match with the theoretical
expectations in a dilution process. The Avogadro/Loschmidt limit is not relevant at all. It was not
possible to reproduce the findings of Chikramane et al (2010) using inductively coupled plasma-mass
spectrometry with copper. Copper NPs could not be detected at 4cH and above.
Link to study: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-

0038-1666864
Cantharis 200c counters heat stress in germinating seeds of Vigna unguiculata (L.) Walp.
Abstract
Background: Thermal stress during early imbibitional phase of germination causes disruption of
redox-homeostasis by increasing accumulation of ROS Reactive Oxygen species (assessed in terms of
hydrogen peroxide) and significant reduction of antioxidative defense (assessed in terms of catalase
and peroxidase) in germinating tissues of cowpea (Vigna ungiculata). It also induces oxidative damage
to newly assembled membrane system by aggravating membrane lipid peroxidation [measured in
terms of thiobarbituric acid reactive substances (TBARS)]. Cantharis is a homeopathic remedy used
for treating burn injuries in humans. The objective is to see whether potentized Cantharis could
ameliorate heat stress in germinating seeds of cowpea.
Methodology: Seeds, imbibed in water overnight, were divided into four groups (n=50/group):
Control I (Water 200c), Control II (Ethanol 200c), treated with Cantharis 200c and untreated and
unstressed. Water soaked seeds were dipped in control/drug solution for 5 min and then washed.
Control II and Cantharis 200c were diluted with water 1:1000 to minimize the ethanol effect. Except
the fourth group, all other groups were subjected to heat stress (450C for 8 hours). All the groups
were allowed to germinate for 5 days in germination chamber at 25 Â± 20C. Groups 1 and 2 (Control
I and II) served as systematic negative controls throughout the experiment. Ten independent
replications were performed for each group in parallel. All experiments were randomized and blinded.
Results: The systematic negative controls (I, II) did not produce any significant effect. The results in
terms of germination, growth, soluble sugar, protein, accumulation of reactive oxygen species and
loss of membrane permeability clearly exhibit that Cantharis 200c could mitigate heat stress
significantly (p<0.05) as compared to the controls I, II. Final germination percentage after 120 hrs
was found to be 60%, 48%, 86%, 88%, for groups 1, 2, 3, 4, respectively. Total chlorophyll (Chl-a +
Chl-b), carotenoids and total chl/carotenoid ratio were found to be highest in groups 3 and 4.
Assessment of membrane lipid peroxidation in terms of TBARS and accumulation of reactive
oxygen species (H2O2) showed minimum concentration in group 3 and 4.
Conclusion: Cantharis 200c can counteract the deleterious effects of heat stress on juvenile tissues
and membranes and can be used effectively to counter heat stress in tropical countries especially
during summer.
High-diluted thymulin on Ehrlich tumor growth in mice and the importance of tumor
microenvironment
Abstract
Introduction: The aim of the present study was to describe different biological aspects of Ehrlich
tumor in mice, such as body weight evolution, tumor growth rate, histological organization and
systemic immune response after treatment with high-diluted thymulin (10-9 M, named 5CH).
Methods: Tumor assessment was focused on macro- and microscopic aspects; parameters included
occurrence of necrosis, embolism and tumor development, in addition to quantitative analysis of
apoptosis (caspase-3), cell proliferation (Ki-67) and angiogenesis (vascular endothelial growth factor -
VEGF) by means of specific immunohistochemistry markers. Spleen cell populations were evaluated
by flow cytometry analysis.
Results: Mice treated with thymulin 5CH exhibited changes in the tumor microenvironment, such as
reduced micro-embolism incidence and cytokeratin expression, with increased caspase-3 expression in
the tumor cells. These findings indicate some apoptotic activity by the tumor cells induced by the
treatment, even though no reduction of the macroscopic tumor mass occurred. No changes in the
systemic immune response were detected, as the balance among spleen cell populations remained
unchanged.
Conclusions: The results indicate that treatment of mice bearing Ehrlich tumor with thymulin 5CH
induces some specific changes in the tumor environment. However, it did not influence systemic
immunity parameters. Adjuvant use of thymulin 5CH in oncological clinical practice is still a matter
of discussion.
Clinical Research
The Value of Treatment Processes in Germany: A Discrete Choice Experiment on Patient
Preferences in Complementary and Conventional Medicine
Patient. 2018 Dec 19. doi: 10.1007/s40271-018-0353-1

Abstract
Background: The effects of health interventions are often complex, and it is argued that they
comprise more than pure changes in clinical parameters. Aspects of the treatment process, so-called
'benefits beyond health', are often overlooked in the evaluation of health interventions but can be of
value to the patients.
Objectives: The aim of this study was to assess patients' preferences and willingness to pay
regarding the treatment process and its attributes in patients using acupuncture, homeopathy or
general medicine (GM).
Methods: A systematic literature search, six semi-structured interviews and a stakeholder

involvement were conducted to determine the attributes of the treatment process. Five process
attributes and one cost attribute were used to construct the experimental design of the discrete
choice experiment (DCE) (6 × 3), a cross sectional survey method. Patients were recruited by
outpatient physicians practicing in Berlin and Munich, Germany. Process attributes were effects-
coded. Data were analyzed in a conditional logit regression.
Results: Data from 263 patients were analyzed. DCE results showed that the treatment process
attributes 'active listening' and 'time' were most relevant to all patients. Preferences for the attributes
'holistic treatment' (more relevant to the acupuncture and homeopathy groups) and 'information'
(more relevant to the GM group) seemed to differ slightly between the groups. Willingness-to-pay
values were higher in the acupuncture and homeopathy groups.
Conclusions: The time physicians take and the extent to which they listen attentively are most
important and are equally important to all patients. These results may contribute to the debate about
more patient-centered healthcare. They support a strengthening of medical consultations in the
German healthcare system. We suggest giving physicians the opportunity to spend more time with
their patients, which may be achieved by changing the general conditions of remuneration (e.g.,
improved reimbursement of medical consultations).
Individualized Homeopathic Therapy in a Case of Obesity, Dysfunctional Uterine Bleeding, and

Autonomic Dystonia.
Am J Case Rep. 2018 Dec 12;19:1474-1479. doi: 10.12659/AJCR.913328..
Abstract
Background: Obesity is one of the leading causes of morbidity and mortality globally and
challenging to treat because of the multifactorial etiology and presentation. Individualized
homeopathy takes into account factors that led to a patient's health condition and hence may have a
role in the treatment of obesity and related co-morbidities; co-morbidities that may arising from the
same etiology may respond as a whole to homeopathy treatment.
Case Report: A 39-year-old Russian female who developed multiple problems after severe
emotional stress was treated with individualized classical homeopathic therapy. Obesity,
dysfunctional uterine bleeding, and dysautonomia were pathologies that showed improvement.
Conclusions: The response in this patient's case, supports the need for further investigation on the
relevance of individualized homeopathy in these related conditions.
My best case: homeopathic management of adverse effects of tamoxifen.

Wien Med Wochenschr. 2018 Dec 11.
Abstract
Background: Nearly half of patients discontinue tamoxifen hormone therapy early because of side
effects, thus increasing the risk of breast cancer recurrence. Could a homeopathic treatment
improve compliance?
Methods: A patient suffering from side effects of tamoxifen was seen in consultation every 2
months for 10 months by a senior homeopathic doctor and a registrar.
Results: Case analysis and repertorisation led to the identification of Pulsatilla as the simillimum
drug and tamoxifen 7c as the etiological treatment. This treatment resulted in a rapid and lasting
improvement of all the symptoms.
Conclusions: The combination of a homeopathic medicine and a hetero-isotherapic illustrates both

the principles of "similarity" and "the identical". It has proved to be an excellent response to the
side effects of tamoxifen. By enhancing the patient's quality of life, this combined approach also
improved adherence to treatment.
Complementary individual homeopathy in paediatric cancer care: A case series from a University
Hospital, Switzerland.
Complement Ther Med. 2018 Dec;41:267-270.
Abstract
The Department of Haematology/Oncology at the University Children's Hospital Bern (HONK), has adopted
an integrative approach in addition to state of the art oncological care and implemented a collaboration with the
Institute of Complementary Medicine IKOM, University of Bern, over the past 10 years. Stakeholder
satisfaction with this service was high. We present descriptive data and report on 4 exemplary patients treated
with additional individualized homeopathy (iHOM). Data concerning frequency of consultations, pathologies,
follow-ups and clinical results were reviewed and summarized using descriptive statistics. 94 paediatric oncologic
patients consulted for iHOM. Indications for the complementary treatment was wide-ranging. No interactions
with conventional treatment and no adverse side-effects of iHOM were detected. We present four characteristic
patient histories, in which iHOM was used in addition to standard treatment for mucositis, permissive tissue
infection, insomnia and affective dysfunctions. All four patients clinically improved in an immediate temporal
relationship to the additional treatment. CONCLUSION: The collaboration between HONK and IKOM
established iHOM in paediatric oncology in Bern. In this setting, iHOM was a safe and supportive additional
treatment for various indications during the conventional cancer care. However, no generalizable results can be
deducted from these data. We emphasize future research on this topic.
Symptoms associated with teething and response to three treatments, including homeopathic
medicine: a multicenter prospective observational study among 190 French pediatricians.
Minerva Pediatr. 2018 Dec;70(6):519-528.
Abstract
Background: Primary tooth eruption in infants is associated with a range of local and systemic symptoms
although this remains a subject of much debate. In addition, data are limited on the role of physicians in
managing infant teething, and on the benefit of homeopathic treatments.
Methods: We conducted an observational, multicenter, prospective survey evaluating teething symptoms, and
symptom course following routine medical management by French pediatricians in 597 infants aged from 3 to
24 months. We also examined the response to treatment with routinely prescribed teething medications; the
homeopathic agent, Camilia® and topically applied gingival agents (Delabarre® or Dolodent®).
Results: Most infants (96.6%) had buccogingival symptoms and 93.3% had at least one general symptom. Fever
(≥38 °C) was reported in 15.2% of infants. For teething, 212 infants were prescribed Camilia®, 172 a gingival
solution (Delabarre® or Dolodent®) and 213 received Camilia® along with a gingival agent. Infants prescribed
both a homeopathic and a gingival treatment had a significantly higher number of symptoms at presentation
compared with those prescribed a single agent. There were no significant differences in symptom course across
these three treatment groups. Systemic analgesics/antipyretics were prescribed in 68.8% of cases. Parent
satisfaction with medical management and prescribed treatments was high.
Conclusions: Teething is frequently associated with transient local and systemic upset in infants and is a
significant concern to parents. Camilia® provides a similar benefit to topical therapy, and is frequently used by
pediatricians in France.
Case Reports of Five Cancer Patients with Unusual Course

Homeopathy 2018; 107(04): 280-291
Abstract
Introduction: The analysis of the periodic table of elements by Jan Scholten opened the way for a new kind of
classification and repertorisation of homeopathic remedies. Thereby, group analysis (resorting to series and
stages) makes precise prescriptions possible. This approach appears to yield striking results, even in severe cases.
Whereas Hahnemann stressed the emotional state (‘Gemüthssymptome’, Organon § 210) when choosing a
remedy, Scholten 200 years later investigated the mental picture that represents a life conflict or even a life
theme that may maintain the disease process. The person's environment, emotional traumas or a conflict drives
him or her to suppress and dissect painful emotions. Such compensations can become subconscious and so
strong that they can no longer be controlled; they then influence the patient with a highly destructive energy.
Methods: We present five case reports, each dealing with an unusual clinical course of severe cancer associated
with homeopathic treatment using the Scholten method.
Results: By presenting these cases, we consider how the constitution (lifelong signs and symptoms of the
patient) and the mental state are interwoven and, as a complex mechanism, might provoke disease.
Conclusion: The appropriate homeopathic remedy, reflecting the Scholten approach, seemed to have beneficial
impact on the disease process of the five individuals presented.
Link to study: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1660456
Homeopathic Treatment of Insomnia and Symptom Clusters Related to Cerebral

Chemotoxicity in Oncology
Homeopathy 2018; 107(04): 292-298
Abstract
Background: During chemotherapy, the correlation between insomnia and fatigue, anxiety, pain, depressed
mood, and cognitive disorders makes these subjective complaints a ‘symptom cluster’ with common biological
mechanisms. The theory of cerebral inflammation following the production of pro-inflammatory cytokines (high
level of interleukin 1-β [IL1-β], IL6 and tumour necrosis factor-alpha) is currently the most generally accepted.
Understanding these mechanisms should allow us to propose a chemoprotective homeopathic treatment of the
nervous system.
Methods: By retaining the inflammatory aetiology, we combined the rubrics ‘Inflammation of the brain’,
‘Inflammation of the meninges’, ‘Inflammation of the nerves’ with the symptom cluster: insomnia, fatigue,
depressive state and memory disorders.
Results: After repertorisation, we propose the following homeopathic protocol: Belladonna 15c, Phosphorus
15c, Cerebral cortex 4c and Nerves 4c, two pills of each medicine to be sucked together before breakfast, lunch
and dinner, on each day of chemotherapy and for the following 2 days.
Conclusion: This selected protocol, derived from a physiopathological knowledge of the symptoms, seems to
be well suited to the prevention and treatment of post-chemotherapeutic cerebral inflammation. It is essential to
start the homeopathic treatment before the chemotherapy session to anticipate the emergence of the ‘chemo-
brain’ side effects. This proposed prevention protocol must be confirmed and quantified by randomised studies.
Review
Systematic Review and Meta-Analysis of Randomised, Other-than-Placebo Controlled, Trials of

Individualised Homeopathic Treatment
Homeopathy 2018; 107(04): 229-243
Abstract
Background: This study focuses on randomised controlled trials (RCTs) of individualised homeopathic treatment
(IHT) in which the control (comparator) group was other than placebo (OTP).
Aims: To determine the comparative effectiveness of IHT on health-related outcomes in adults and children for
any clinical condition that has been the subject of at least one OTP-controlled trial. For each study, to assess the
risk of bias and to determine whether its study attitude was predominantly ‘pragmatic’ or ‘explanatory’.
Methods: Systematic review. For each eligible trial, published in the peer-reviewed literature up to the end of
2015, we assessed its risk of bias (internal validity) using the seven-domain Cochrane tool, and its relative
pragmatic or explanatory attitude (external validity) using the 10-domain PRECIS tool. We grouped RCTs by
whether they examined IHT as an alternative treatment (study design Ia), adjunctively with another intervention
(design Ib), or compared with a no-intervention group (design II). For each RCT, we identified a ‘main outcome
measure’ to use in meta-analysis: ‘relative effect size’ was reported as odds ratio (OR; values >1 favouring
homeopathy) or standardised mean difference (SMD; values < 0 favouring homeopathy).
Results: Eleven RCTs, representing 11 different medical conditions, were eligible for study. Five of the RCTs
(four of which in design Ib) were judged to have pragmatic study attitude, two were explanatory, and four were
equally pragmatic and explanatory. Ten trials were rated ‘high risk of bias’ overall: one of these, a pragmatic study
with design Ib, had high risk of bias solely regarding participant blinding (a bias that is intrinsic to such trials); the
other trial was rated ‘uncertain risk of bias’ overall. Eight trials had data that were extractable for analysis: for four
heterogeneous trials with design Ia, the pooled OR was statistically non-significant; collectively for three clinically
heterogeneous trials with design Ib, there was a statistically significant SMD favouring adjunctive IHT; in the
remaining trial of design 1a, IHT was non-inferior to fluoxetine in the treatment of depression.
Conclusions: Due to the low quality, the small number and the heterogeneity of studies, the current data
preclude a decisive conclusion about the comparative effectiveness of IHT. Generalisability of findings is limited
by the variable external validity identified overall; the most pragmatic study attitude was associated with RCTs of
adjunctive IHT. Future OTP-controlled trials in homeopathy should aim, as far as possible, to promote both
internal validity and external validity.
Quantitative and Qualitative Pathogenetic Indices for Review of Data Derived from
Homeopathic Pathogenetic Trials
Homeopathy 2018; 107(04): 274-279
Abstract
Introduction: Analysis of data derived from homeopathic pathogenetic trials (HPTs,
homeopathic drug provings) has been a challenge. Most parts of the homeopathic pharmacopeia
were sourced from Hahnemann's Materia Medica Pura (1825–1833), TF Allen's Encyclopedia
(1874) and Constantine Hering's Materia Medica (1879–1891), well before randomised controlled
trials were in use. As a result, such studies and their outcomes harbour a large risk of inclusion
of unreliable symptoms.
Aims and Objective: The main purpose of this article is to introduce Quantitative and
Qualitative Pathogenetic Indices to improve the method of analysis of symptoms.
Materials and Methods: The data from HPTs for human immunodeficiency virus nosode,
hepatitis C nosode, capsaicin alkaloids (capsaicin and dihydrocapsaicin) and hydroquinone (HQ)
were extracted and analysed in terms of novel Qualitative and Quantitative Pathogenetic Indices.
Taken into the consideration were the qualitative aspect of a symptom (i.e. its intensity), and the
quantitative aspect by calculating the number of symptoms per volunteer per day. The
pathogenetic effects and data evaluation indices were calculated for each HPT. A comparison was
made of symptoms of verum versus placebo provers in terms of their quantity and quality.
Results: Four HPTs involving 81 volunteers (56 on verum and 25 on placebo) generated 555
symptoms or pathogenetic effects (excluding run-in phase symptoms), of which 448 (81%) were
reported by volunteers who were in the verum arm, and 107 (19%) were reported by volunteers
on placebo. The overall mean incidence of pathogenetic effects for the four HPTs was thus 8 per
verum prover and 4.28 per placebo prover. The corresponding mean Quantitative Pathogenetic
Index was 0.23 symptoms per volunteer per day for the verum arm and 0.12 symptoms per
volunteer per day for the placebo arm. The overall mean incidence of pathogenetic effects in the
run-in phase was less. The overall mean Qualitative Pathogenetic Index (number of symptoms,
of a given intensity, per volunteer per day) for the verum arm was 0.09 versus 0.05 for the
placebo arm.
Conclusion: The symptoms exhibited by volunteers in the verum arm were more numerous and
more intense than those in the placebo arm. An innovative and logical method of reporting of
symptoms and analysis has been introduced by the use of these pathogenetic indices, which can
be used in future as measurement tools for analysis of data from HPTs.
Link to study: https://www.thieme-

connect.com/products/ejournals/abstract/10.1055/s-0038-1668536
Survey
Use of Self-Medication with Homeopathy in Germany: Results of an Online Questionnaire

Survey.
Complement Med Res. 2018;25(6):383-390.
Abstract
Background: Little is known about self-medication with homeopathic drugs in Germany. The aim of this
study was to gain information about users, sources of information and the selection process of the drugs.
Methods: An online questionnaire survey among users of self-medication with homeopathy was
conducted via social media and email newsletters.
Results: A total of 665 users who responded to the questionnaire were included. Most of the respondents
were women (92%) in their mid-forties with high educational status. In total, 43% of the participants
reported a household member working in the health sector. Books (65%) and Internet (47%) were the
most common sources of information. Consultations in pharmacies - with a mean duration of 10 min -
were likely to be used (60%). Homeopathic drugs were mainly used in the potency D12 (55%), for a
duration of 5 days, 3 times daily, with 5 globules. Homeopathic drugs were mainly used due to good
therapeutic experiences in the past (82%). Indications for use were acute diseases (91%), particularly colds
(86%), as well as chronic diseases (51%) and prevention (47%). The selection of a homeopathic drug took
the participants 25 min on average.
Conclusion: Homeopathic self-medication is understood by users as a resource to regain, maintain, and

promote health. Further research about the quality and applicability of information for homeopathic self-
medication is necessary.
A Pilot Study of Prospective Data Collection by Italian Homeopathic Doctors.

Homeopathy 2018; 107(04): 264-273
Abstract
Objective The main purpose of this article is to report the systematic data collection pertaining to the
consultations of a group of qualified homeopathic physicians. Studies have been performed concerning: (1)
the most frequently treated pathologies; (2) the symptoms reported by patients, with a particular focus on
“fear” symptoms; and (3) the evaluation of the outcomes of the treatment, including likelihood ratio (LR)
for fear symptoms of mostly prescribed remedies.
Design Prospective observational study.
Setting Individualized homeopathic treatment at private homeopathic surgeries in Italy.
Participants Adult patients asking for homeopathic therapy for a series of common ailments.
Outcome Measures Types of diseases and remedies used and clinical parameters (frequency of acute
attacks, and their intensity and duration); the overall outcome of the cure was registered using the
Outcome Related to Impact on Daily Living (ORIDL) scale.
Results Only 94 patients could be enrolled by eight homeopathic doctors in a 2-year period between
2015 and 2017. Ninety (72 females, 18 males) patients completed the observation period. The most
represented pathologies belonged to the group “Anxiety and anxiety disorders” followed by
gastrointestinal ailments. The most prescribed remedy was Phosphorus (9 cases), followed by Natrum
muriaticum (4 cases) and Ignatia (4 cases). The intensity of the symptoms and the frequency of the attacks
decreased during the course of the study. Most patients reported a positive outcome (ORIDL scale). In the
“Phosphorus” group, LR values were calculated for fear symptoms: LR+ for fear of dark = 2.25 (95%
confidence interval [CI] = 0.56 to 9.02), LR− for fear of crowds = 1.27 (95% CI = 1.13 to 1.42), and LR−
for fear of ghosts = 1.12 (95% CI = 1.04 to 1.22).
Conclusion The recruited group was smaller than expected, but data from most participants could be
collected. Positive clinical outcomes were recorded and LR of a few specific fears contributed to
distinguish Phosphorus patients from the remaining population.
Link to study: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-

1667069
Agro Homeopathy
Evaluation of Eucalyptus growth with application of homeopathic preparation
Abstract
The use of less impacting techniques in agricultural systems is the global trend, so the use of High
dilutions on these systems has been studied as ecologically sound technology. This study had the
object to study the interaction between the High dilutions and the development of Eucalyptus
urophylla S. T. Blake seedlings. Was conducted from May 2007 to July 2007, in the greenhouse of the
Department of Plant Science at the Federal University of ViÃ§osa. Applications were made in one
day intervals and preparations utilized were: Phosphorus, Calcarea carbonica, Kali muriaticum,
Magnesia carbonica, in dynamizations 3CH and 12CH and water and alcohol dynamised CH3.
Morphological parameters of quality seedlings were analyzed over time and the end of the
experiment. The prepared Kali muriaticum 12CH promoted increased root length of approximately
55% compared to control water . The prepared Phosphorus 3CH differed from other treatments in
the green total mass variable. The High dilutions Phosphorus 3CH and Kali muriaticum 12CH
promoted increase in root growth. The responses obtained with the application of Phosphorus 3CH
indicate the viability of agronomic use to the increase of the root exploration and absorbing elements
necessary for plant growth.
Link: http://highdilution.org/index.php/ijhdr/article/view/814
Veterinary
Reduction of stool bacterial counts and prevention of diarrhea using an oral homeopathic
product in newborn lambs.
Microb Pathog. 2018 Dec 13;127:347-351.
Abstract
Lamb farming is generally a secondary activity for farmers, and many breeding systems suffer from
management failures that impair production. One reason for decline in performance is enteritis,
usually affecting newborn lambs. Enteritis can be fatal, especially in dairy herds. Generally, lambs
are fed sucrose or unprocessed milk from sheep or cow that is heated and fed to animals two or
three times a day in baby bottles. However, on most farms, milk temperature differs among feeds,
as often the process of alteration among diet adaptations is deficient, contributing to enteritis and
consequent diarrhea. Therefore, the objective of the present study was to verify the administration
of the homeopathic product (Dia 100®) in newborn and bottle-fed lambs, in order to prevent or
minimize the occurrence of diarrhea. We studied 60 lambs, divided into two groups with ten
repetitions each (n = 30) and during the nursing period (1-45 days of life). Animals in the treated
group received the homeopathic product (36 g) orally divided into three doses (1, 7 and 14 days of
life). We measured weight gain, mortality, bacterial counts (Escherichia coli and total coliforms) in
feces, hematological analysis (leukocytes, hematocrit, hemoglobin and erythrocytes) and
biochemical analyses (glucose, triglycerides, cholesterol, albumin, globulin, urea and total protein) at
four time-points. There were no differences in weight gain between groups (P > 0.05); however,
there was a higher mortality rate in the control group (13%) than in the treated group (6%). E. coli
counts were significantly higher in the stools of control group lambs on days 15 and 45 of the
experiment (P < 0.05). Total leukocyte counts were greater in treated animals due to greater
numbers of lymphocytes on day 15 of the experiment (P < 0.05). In the treated group, we found
higher serum levels of total protein, urea (day 15), globulin and triglycerides (days 15 and 30). In
the period of administration of the homeopathic product, there was substantial and significant
reduction of cases of diarrhea (up to day 14); however, after this period, there were no difference
between groups. Based on these results, we concluded that the homeopathic product had moderate
efficacy in terms of control of diarrhea. The treated lambs made better use of nutrients,
contributing to the development of their immune responses.
Link: https://www.ncbi.nlm.nih.gov/pubmed/30553908
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2018 | Volume 7, Issue 4 | Page: 94 – 116

Conceptualized, edited, designed and published by Dr. Saurav Arora

© IPRH 2018. All Rights Reserved.

Ameliorative effect of Cephalandra indica homeopathic preparation in STZ induced diabetic

Conclusion: We conclude that Mother tincture, 6C and 30 C potencies of C. indica confers

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30455071

Could the Olfactory System Be a Target for Homeopathic Remedies as Nanomedicines?

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/29889551

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30274063

Assessment of the effects of Zincum metallicum in maternal deprivation-induced behavioral

Link to study: http://highdilution.org/index.php/ijhdr/article/view/949

Evaluation of antipyretic activity of Belladonna and Pyrogenium ultrahigh dilutions in induced

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30335611

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/29808589

Extremely Dilution of Strychnos Nux vomica Mitigates Alcohol-Induced Reduction in

Link to study: http://highdilution.org/index.php/ijhdr/article/view/908

Nanoparticle Characterisation of Traditional Homeopathically Manufactured Cuprum metallicum

Methods: We used a multi-technology approach to examine dilutions of two commonly used

Results: Using Mass Spectrometry (Single Particle-Inductively Coupled Plasma-Mass Spectrometry)

Link to study: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-

Link to study: http://highdilution.org/index.php/ijhdr/article/view/909

Link to study: http://highdilution.org/index.php/ijhdr/article/view/948

Patient. 2018 Dec 19. doi: 10.1007/s40271-018-0353-1

Methods: A systematic literature search, six semi-structured interviews and a stakeholder

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30565073

Individualized Homeopathic Therapy in a Case of Obesity, Dysfunctional Uterine Bleeding, and

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30538215

My best case: homeopathic management of adverse effects of tamoxifen.

Conclusions: The combination of a homeopathic medicine and a hetero-isotherapic illustrates both

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30539320

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30477851

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/27668452

Case Reports of Five Cancer Patients with Unusual Course

Link to study: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1660456

Homeopathic Treatment of Insomnia and Symptom Clusters Related to Cerebral

Link to study: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1666807

Systematic Review and Meta-Analysis of Randomised, Other-than-Placebo Controlled, Trials of

Link to study: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1667129

Link to study: https://www.thieme-

Use of Self-Medication with Homeopathy in Germany: Results of an Online Questionnaire

Conclusion: Homeopathic self-medication is understood by users as a resource to regain, maintain, and

Link to study: https://www.ncbi.nlm.nih.gov/pubmed/30286479

A Pilot Study of Prospective Data Collection by Italian Homeopathic Doctors.

Design Prospective observational study.

Setting Individualized homeopathic treatment at private homeopathic surgeries in Italy.

Link to study: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-

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Peer-reviewed homeopathy study sparks uproar in Italy. Read

Research group from IIT Bombay recognised for their work

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