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Nu: Nu L Nu :L
L
Nu
Nomenclature
1. indicate ring size being formed
3 membered ring = 3
4 membered ring = 4
etc.
X:
Z Z
Y Y
X: X:
Exo Endo
BALDWIN'S RULES FOR RING CLOSURE 136
4. Ring forming reaction is designated as Favored or Disfavored
disfavored does not imply the reaction can't or won't occur- it only means
the reaction is more difficult than favored reactions.
X: X: X: X:
Y Z X: Y Z Y Y Y
Z Z Z
3- 4- 5- 6- 7-
- - - - - - - - - - - - - - - - - - - - - - - - --Favored- - - - - - - - - - - - - - - - - - - - - - - - -
Z Z
Y
Y
X:
X:
5- 6-
- - - - -Disfavored- - - - -
X: X: X:
X: Y Z X: Y Z Y Y Y
Z Z Z
3- 4- 5- 6- 7-
- - - - - - - - - - - - - - - - - - - - - - - - --Favored- - - - - - - - - - - - - - - - - - - - - - - - -
Z Z
Z Z Y
X: Y Y X: Z
X: Y X:
X: Y
3- 4- 5- 6- 7-
- - - - - - - - - - - - -Disfavored- - - - - - - - - - - - - - - - - -Favored- - - - - -
BALDWIN'S RULES FOR RING CLOSURE 137
- 3-Exo-Dig and 4-Exo-Dig are disfavored; 5-Exo-Dig, 6-Exo-Dig, 7-Exo-Dig, etc.
are favored
X: X: X: Y X: X:
Y Y Y
Z Y
Z Z Z Z
3- 4- 5- 6- 7-
- - - - - -Disfavored- - - - - - - - - - - - - - - - - - -Favored- - - - - - - - - - - -
Z Z
Y
Z Z Y X: Z
X: Y
Y X: Y
X: X:
3- 4- 5- 6- 7-
- - - - - - - - - - - - - - - - - - - - - - - - - - --Favored- - - - - - - - - - - - - - - - - - - - - - - - - - - - -
EXCEPTION:
There are many !!! (see March p 212-214)