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SULFONYLUREAS 1-2
KESIHATAN
For new patients to be
PENAMPANG initiated on sulfonylureas
(SU), the immediate release
(IR) formulation should be
PHARMACY UNIT started first, not the modified
(DRUG INFORMATION release (MR) formulation.
CENTRE) Gliclazide IR can be taken
NEWSLETTER once daily as a single dose up
Issue 1/2019 to 320mg, with higher doses
to be divided in a day
(standard practice of BD
dosing).
HIGHLIGHTS:
This treatment with MR
➢ Gliclazide MR 30mg = formulation should only be
Gliclazide IR 80mg prescribed if the patient is
likely to have a regular food
➢ Recommended vildagliptin intake (including breakfast).
dose as add-on combination The single daily dose of the
therapy with SU: 50 mg OD MR formulation may be
between 30 mg and 120 mg.
In any case, the maximum dose of gliclazide MR should not exceed 120
mg/day.
The hydrophilic matrix of hydromellose-based polymer in the new
formulation brings about a progressive release of the drug which parallels
the 24-hour glycemic profile in untreated patients with type 2 diabetes
mellitus. The formulation shows high bioavailability and its absorption
profile is unaffected by coadministration with food.
Prepared by CLL02/19
EQUIVALENT DOSES BETWEEN GLICLAZIDE IR AND MR
FORMULATIONS 3