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from these spots by mass spectrometry is Type 2 diabetes is associated with in- The symposium also included a pres-
underway. creased frequency of vascular restenosis entation of research papers both oral and
P. Venkatesan (Tuberculosis Research due to accelerated vascular smooth muscle poster by Ph D students and junior faculty
Centre, Chennai) briefed how computational cell motility from the media to neointima. of several prestigious Indian university
tools could be used to classify biological Nitric oxide (NO) is an established in- and research institutions and also from
sequences, detect weak similarities, sepa- hibitor of growth factor-induced vascular Sweden. Through this symposium it was
rate protein-coding regions from non- smooth muscle cell (VSMC) motility. made possible to bring together researchers
coding regions in DNA sequence, predict Contrary to this, Madhulika Dixit (Ger- working on different aspects of genomics
molecular structure and function, and re- many) showed data that NO stimulates and proteomics of diabetes and its com-
construct the underlying evolution his- the motility of VSMCs cultured for several plications on a single scientific platform
tory as a means to our understanding of days in the presence of insulin. Additio- to focus on current trends and needs and
life and evolution as well as to the dis- nally, chronic insulin exposure of these emphasize on what should be the future
covery of new drugs and therapies. His cells also abrogated the ability of NO directions for translational research ap-
talk on ‘computational molecular biology’ to inhibit PDGF-induced motility. Show- plication in this field.
majorly dwelt around machine learning ing a role for both tyrosine phosphatase
approaches such as artificial neural net- and kinases in NO-mediated motility of
works, hidden Markov models, Markov VSMCs, Dixit related how these molecular M. Balasubramanyam*, M. Rema and
chain Monte Carlo and belief networks mechanisms underlie the pathogenesis of V. Mohan, Madras Diabetes Research
that are ideally suited for analysing bio- vascular disease in hyperinsulinemic Foundation, Gopalapuram, Chennai 600 086,
logical data. diabetes. India. *e-mail: drbalu@mvdsc.org
MEETING REPORT
COMMENTARY
Debal Deb
Although contribution of genes from wild An apparently uncontrollable source of other varieties, it is sufficient to keep an
relatives has over centuries enhanced the varietal intermixing is cross-pollination, isolation distance of 3 to 5 m.
genetic base of rice, genetic ‘contamina- which occurs at a considerably low fre- However, it may not be feasible for
tion’ from modern rice cultivars, especially quency between the cultivated rice and its small and marginal farmers in South and
hybrids incorporating genes from japon- wild relatives (especially O. rufipogon), South East Asia to leave gaps of 110 m –
ica and indica varieties of cultivated rice and between landraces of the former. The or even 5 m – between plots of rice crops
(Oryza sativa), may cause loss of many frequency of out-crossing does not exceed on their typically small farms growing
characteristics (like aroma, slenderness 1%, even when panicles of donor rice two or more local rice landraces. Besides,
or colour of grains) of an established land- plants were clipped with those of the ac- a spatial gap of 5 m may not ensure zero
race preferred by folk farmers. Trans- ceptors, and when the acceptors had out-crossing, as far as wind-borne trans-
genic rice varieties may further enhance longest stigmas and highest degree of mission of pollen is concerned. The al-
chances of contamination of farmers’ land- stigma exsertion6. The principal factors ternative measure of maintaining barrier
races with alien or incompatible genes1, that physically reduce cross-pollination isolation with sorghum, pigeonpea or
and raise concerns of biosafety2. frequencies include a short style and stigma, sugarcane, with 30–40 m distance10 is
Genetic impurity in rice varieties is short anthers, limited pollen availability, not an economical option for small farm-
caused more frequently from anthropogenic short-lived pollen, progressive decline of ers. Besides, plant barriers often have
seed dispersal during planting than due pollen viability, and a brief period (bet- wide holes sufficient to allow pollens to
to cross-pollination at flowering3,4. With ween 30 s and 9 min) between opening fly across into plots on both sides.
the erosion of traditional practices regard- of florets and release of pollen4,7. Rice As a more practicable alternative, I
ing careful separation of seeds of differ- flowers often remain open for periods of suggest here to maintain a temporal dis-
ent varieties, mixing of breeders’ seeds is less than 3 h, and only during daytime8, tance between cultivars in terms of flow-
a frequent phenomenon. Most modern which further delimits the scope of out- ering time. Some scholars recommend
farmers in the global South have either crossing. keeping a gap of at least 30 days between
forgotten or tend to neglect the traditio- Nevertheless, low rates of cross-polli- the flowering stage of the parental lines
nal practice of ‘roguing’ for retaining nation can occur in cultivated rice when in the seed-production field and that of
genetic purity of their preferred landraces. plants with synchronous or overlapping other varieties grown within the area to
Roguing is the removal of off-type rice flowering times grow in close proximity9,10. avoid contamination by pollen5. How-
plants from both parents5, on the basis of In order to prevent the risk of cross- ever, I argue here that a temporal separation
morphological characters (like plant stat- pollination, rice researchers recommend by 12 h between the onset of flowering
ure, leaf length and width, flag leaf angle, a spatial isolation of about 110 m from of one cultivar and the beginning of the
panicle shape and panicle size). With the seed production plots to other rice varie- milking stage of its neighbour is suffi-
erosion of the knowledge and practice of ties10,11. Some authors5 recommend an cient to check out-crossing.
rouging, physical and genetic mixing is now isolation distance of up to 200 m for male The rice flower biology ensures that a
commonplace in most local rice varieties. sterile (A line) multiplication, while for small time gap between pollen release
CURRENT SCIENCE, VOL. 91, NO. 2, 25 JULY 2006 155