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14
Wellness and Fitness
After you have finished reading this chapter, you should be able to:
Compare and contrast the various factors that cause disease.
Identify the body’s defenses against disease-causing organisms.
Describe the structures and functions of the human immune system.
And it is well to superintend the sick to make them well, to care for the
healthy to keep them well, also to care for one’s own self, so as to observe
what is seemly.
Hippocrates, Precepts
Introduction
In the past, many people believed that evil spirits were the cause of
human illness. If someone became ill, the treatment prescribed was often
horrific. The patient might be beaten, tortured, or starved. One technique
used in some cultures involved drilling a hole in the ill person’s skull to
allow the evil spirit to leave. If a sick person didn’t die from the disease,
he or she might die from the “cure.” (See Figure 14-1 on page 296.)
How different is our understanding of disease today! We have achieved
this understanding from the careful thinking, experiments, and observa-
tions of many people over a long period of time. Twenty-four hundred
years ago, the physician and teacher Hippocrates lived on the small Greek
island of Kos. Through his work, Hippocrates did a great deal to move
medicine away from superstitions. For this, Hippocrates has been called
the “father of medicine.” An article, “Airs, Waters, and Places,” written by
Hippocrates—or one of his students—discussed how disease, rather than
coming from the gods, may have been related to the weather, drinking
water, and winds in the town. The idea that diseases have understandable
295
296 Maintaining a Dynamic Equilibrium
Homeostasis, the theme we have been studying, emphasizes the need for
organisms to maintain a carefully controlled internal set of conditions, a
dynamic equilibrium. Maintaining these conditions—including pH, tem-
perature, water and salt balance, and levels of CO2 and O2—allows an
organism’s cells to function normally. Living organisms allow changes
within very definite limits to occur. Changes outside normal limits disrupt
homeostasis, producing illness, disease, and possibly even death.
There are many reasons why the body can be pushed beyond its nor-
mal limits. These reasons, or factors, are often the causes of disease, causes
that ancient peoples did not understand. An inherited defect in a genetic
trait might be a cause of disease. The disruptions of homeostasis in such
a disease would be caused, in a sense, by a factor inside the body. Many
other diseases result from some influence outside the body, in the
environment.
diseases are more easily transmitted from one person to another than
other diseases.
◆ Harmful lifestyles. The way one lives can also be an important fac-
tor in causing disease. Specifically, tobacco, alcohol, and drugs in the
body can disrupt homeostasis, producing illness. In addition, overeat-
ing, not exercising, having unsafe sexual experiences, and living with
stress can lead to certain diseases. Hypertension, or high blood pres-
sure, is one such disease. Hypertension involves an increased pressure
on the walls of arteries. Untreated, hypertension can lead to heart
attacks, strokes, and damage to the kidneys, nervous system, and eyes.
While medications are used to treat severe hypertension, a less stress-
ful lifestyle combined with a diet that is low in sodium may help lower
a person’s blood pressure. Moderate exercise, on the advice of a physi-
cian, is also an important treatment for hypertension.
Our bodies are surrounded by microorganisms trying to get into us. Some
of them succeed, through the nose, through cuts in our skin, or along with
the food we eat. Many of these microorganisms cause serious problems if
they survive and reproduce inside us without challenge. Controlling these
300 Maintaining a Dynamic Equilibrium
Figure 14-5 Inflammation is the body’s second line of defense against disease.
Chapter 14 / Disease and Immunity, Wellness and Fitness 301
Figure 14-6
During
inflammation,
phagocytes engulf
and destroy
microorganisms,
which prevents
more serious
infection.
Bacterium
Phagocyte
observation that people who worked with cows often came down with
cowpox, but rarely if ever contracted smallpox, formed the basis of his
hypothesis. After the boy recovered from cowpox, Jenner deliberately
injected the boy with smallpox. The boy did not get sick! Did cowpox
protect the boy from smallpox? How could a previous illness protect a
person from getting sick again?
We now know that the immune system defends our bodies against
very specific invaders. Each invader—usually a bacterium or virus—has
specific protein molecules attached to its surface. Each such molecule is
called an antigen. It is these molecules that are detected by the body’s
immune system.
When the immune system detects an antigen, it produces antibodies
—the molecules that an individual produces as a defense against disease.
Antibodies provide this defense by binding to the antigens. Once this
Chapter 14 / Disease and Immunity, Wellness and Fitness 303
occurs, the invader can be destroyed by the body. As it turns out, the cow-
pox and smallpox antigens are almost identical. After he was injected
with cowpox, the boy’s immune system made antibodies against the cow-
pox antigen. Later, when he was injected with smallpox, the boy’s body
was ready with a defense. The smallpox virus was destroyed with the help
of the antibodies that the boy had made against cowpox antigens. That
is why he did not get sick. (See Figure 14-7.)
Antibody A
Antigen-binding sites
The immune system also includes B cells and T cells, actually two types
of macrophages. These macrophages are kinds of white blood cells that
are produced in bone marrow, the thymus gland, the spleen, the lymph
nodes, and the tonsils. (See Figure 14-8 on page 304.) Macrophages are the
cells (phagocytes) we have already mentioned, which move to infected
areas to engulf and digest invading microorganisms. B cells are the ones
that respond to specific antigens by beginning to produce antibody pro-
teins that will bind only with that antigen.
As time goes on, the body contains many different types of B cells, each
producing antibodies for one specific antigen. After having been invaded
once by an antigen, some special B cells that recognize that antigen remain
304 Maintaining a Dynamic Equilibrium
Tonsil
Thymus gland
Lymph nodes
Spleen
Bone marrow
Figure 14-8 Macrophages are
produced in bone marrow, the
thymus gland, the spleen, the
lymph nodes, and the tonsils.
in the body for the rest of your life. These are called memory B cells.
Because they are already present in the body, you instantly start making
LIVING ENVIRONMENT BIOLOGY, 2e/fig. 14-8 s/s
antibodies the moment you encounter the same invading microorgan-
isms again. That is why individuals usually do not get measles or chicken
pox a second time. The immune system remembers the first exposure to
the disease and is ready! This type of protection is called active immunity.
(See Figure 14-9.)
Passive immunity is related to active immunity. In passive immunity,
a person is injected with a large quantity of the correct already formed
antibodies to a particular antigen. These antibodies protect the body from
a disease only for as long as the antibodies remain in the body. However,
the body is passive, uninvolved in this protection. It did not make the
antibodies and, more important, does not “remember” how to make
them. You therefore have protection for a limited time from passive
immunity.
Antibodies are good at recognizing antigens on invaders only when
the invaders are in the fluids in your body but not inside your cells. The
problem is that many bacteria and all viruses quickly get inside body cells.
Once inside your cells, bacteria and viruses begin to multiply, to really
make you sick. To make matters worse, the antibodies cannot find the
Chapter 14 / Disease and Immunity, Wellness and Fitness 305
B Cell Populations
[Model Types]
1. Antibodies B B B B B
2. Assorted
Antigens
3. Antigen-
Antibody B B B B B
complexes
Figure 14-9 In active immunity, memory B cells in the body from a previous
exposure can instantly make antibodies when they encounter the same antigen.
Bone marrow
Figure 14-11 Mature B and T cells are white blood cells that circulate through the
body to fight infection.
LIVING ENVIRONMENT BIOLOGY, 2e/fig. 14-11 s/s (rev. 10/13/03)
how important helper T cells are is shown by the fact that they are the
cells destroyed by the human immunodeficiency virus (HIV), which
results in the disease called AIDS. (See Figure 14-11.)
reactions may be life threatening. These reactions may need other types
of medications. Allergies should be treated by a physician.
Sometimes the immune system begins to attack normal body tissues.
These are called autoimmune diseases and are very serious. Autoimmune
diseases include myasthenia gravis, rheumatic fever, lupus erythemato-
sus, and rheumatoid arthritis. (See Figure 14-12.) In all autoimmune dis-
eases, the body is literally rejecting its own tissues. A similar kind of
rejection also often occurs when an organ is transplanted from one person
to another. Medications that keep the organ recipient’s immune system
from attacking and rejecting the newly transplanted organ must be taken.
Sadly, life expectancy is short for such persons, but progress is being made.
Early detection of this condition, followed by bone marrow transplants,
has resulted in significant improvements in some children.
Drugs that are used to kill cancer cells in the body can also interfere
with the immune system. This is called depressed immunity and can
cause complications in the treatment of cancer.
What is wellness? Wellness is defined as a lifestyle, that is, how one lives.
How one lives is a result of many factors. Some factors are outside of one’s
control. The inherited characteristics that a person has from birth are one
such factor. Other factors are within one’s control. It is mostly these con-
trollable factors that determine how you live.
Wellness involves all the various components that make up one’s life.
These components are called dimensions. The dimensions of wellness
include:
What is fitness? Fitness is more specifically about one’s own body. Fit-
ness has been defined as the ability to carry out normal activities while
having enough energy and strength left over to meet an unusual chal-
lenge. A fit person can walk to work and then climb eight flights of stairs
to the office without suffering physical discomfort. A person who is not
fit runs out of breath very early in the climb up the stairs. (See Figure
14-13 on page 310.)
How does the body of a fit person differ from the body of a person
who is not fit? Remember that for the body to function, it always needs
matter and energy. To be fit, there must be an optimum relationship
among the different tissues in the body for matter and energy to be used
most efficiently. One way of comparing tissues is to look at the ratio of
muscle (matter) to fat (stored energy). The amount of fat in one’s body is
not as important as the percentage of fat and the amount of muscle. Too
little fat limits one’s energy; too much fat can cause many life-threatening
Figure 14-13
Fitness is the
ability to perform
normal activities
yet have enough
energy and
strength to meet
an unusual
challenge.
conditions, such as heart disease. The ideal body fat percentage for men
ranges from 15 percent to 18 percent and for women from 20 percent to
22 percent.
How does a person develop physical wellness and physical fitness? Eat-
ing properly is most important. A person’s daily diet should include the
proper amount of carbohydrates, fats, proteins, vitamins, minerals, and
water (see Chapter 8).
An individual requires a certain number of calories in the diet. For
example, the average teenage boy needs about 3000 calories and the aver-
age teenage girl needs about 2000 calories per day. The number of calo-
ries a person needs is also affected by his or her body size, age, general
level of activity, and physical health.
For physical wellness and fitness, it is also very important to exercise
regularly. Exercise includes aerobic activities, which concentrate on the
respiratory and circulatory systems, and strength-training activities,
which improve one’s muscles and skeletal system. A combination of both
kinds of activities should be a normal and regular part of one’s lifestyle.
Finally, adequate rest is essential to good health. Being well rested
helps a person feel less stress during the day. The reduction of stress is
one of the most important ways of promoting wellness.
LABORATORY INVESTIGATION 14
How Does an Earthworm Respond
to a Change in Temperature?
INTRODUCTION
In order to stay healthy, and thus alive, all organisms must maintain rel-
atively constant internal conditions, even when the environment around
them changes. In this investigation, you will study the circulatory sys-
tem of an earthworm as it experiences changes in the temperature of its
environment. It is easy to observe the rate of blood flow in an earthworm
by studying the pulsing of the dorsal blood vessel, which can be seen
through the earthworm’s skin.
MATERIALS
Paper towels, rectangular pan, live earthworm, clock or watch with second
hand, tap water, laboratory thermometer, ice, warm-water bath
PROCEDURE
1. Place an earthworm on a paper towel lining the inside of the pan.
2. Find the dorsal blood vessel, located in the middle of the worm’s dor-
sal surface. Observe the pulsing of the blood vessel. Count the num-
ber of beats in one minute.
3. Propose a hypothesis that explains the relationship of the pulse rate of
the dorsal blood vessel to the temperature of the worm’s environment.
4. Expose the worm to at least five different temperatures, from nearly
freezing to warm. Keep the temperature below 45°C, however. For each
temperature, mix hot and cold water, then pour a few centimeters of
water into the pan. It is not important to mix the water to an exact
temperature.
5. Let the worm adjust to the new temperature for at least three minutes.
Then take the temperature of the water and count the number of times
the earthworm’s dorsal blood vessel pulses in one minute. Pour off the
water and let the earthworm breathe for at least three minutes.
6. Repeat with water of a different temperature. After collecting your
data, let the worm rest again.
INTERPRETIVE QUESTIONS
1. Why was it necessary to wait for several minutes each time before you
took another pulse rate?
2. Why was it necessary to pour off the water to let the worm breathe?
3. Describe any relationship you see in the data on the maintenance of
body temperature in the earthworm.
4. What are some possible sources of error in this investigation?
5. Did your data support your hypothesis?
■■ CHAPTER 14 REVIEW
VOCABULARY
The following list contains all of the boldfaced terms in this chapter. Define
each of these terms in your own words.
DIMENSION DESCRIPTION
17. Select three dimensions from the table and describe how you can
improve them in your own life.
18. List three nonspecific defenses of the body and explain how each
protects against disease.
19. Relate disease to homeostasis.
20. How does a vaccine prevent disease?
21. State two explanations for the increasing number of deaths from
influenza in the United States.
22. Explain the connection between bacterial pneumonia and the flu.
23. Describe the actions that doctors are being advised to take to help
limit the number of deaths from the flu.