Caffeine Sigma

Parameter USP 34 Specification Reagent Plus (C0750) Reference

Standard (C1778)

Appearance (Color) White White

Appearance (Form) Powder Powder
Solubility (Color) 50 mg/mL, CHCl3 Clear

Conforms to USP
Identification A Infrared spectrum Compares to standard Conforms to Structure
RS Lot J1D241
Residue on ignition Not more than 0.1% 0.00%
Residual Solvents Meets the requirements Pass (no solvents)
Heavy Metals Method II Not more than 0.001% <0.001%
Not more than 0.1% of any individual
Chromatographic Purity impurity is found; and not more than Pass
0.1% of total impurities is found.
Assay High performance liquid Not less than 98.5% and not more than
> 99.0 % 100.20%
chromatography 101.0% on the anhydrous basis
Retention time of the caffeine peak in
the chromatogram of the Assay
Identification B preparation corresponds to the Pass
chromatogram of the Standard
preparation in the Assay
Water (by Karl Fischer) Not more than 0.5% < 0.5 % 0.00%
Initial Melting Point > 233 °C
Final Melting Point < 238 °C
Purity (HPLC)
Recommended Retest Period (4 years)
Rate 1920/- for 5 G 9440/- for 250 mG
Caffeine, certified reference material,
Caffeine,TraceCERT
Pharmaceutical
(56396)
Secondary Standard; Certified Reference Material (PHR1009)

traceable to BP 766
traceable to PhEur
C0100000
traceable to USP
1085003

7470/- for 100 mG 5813/- for 1G