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• Many aspects of our body, or our daily functions require the use
of at least one protein in one way or another.
• There are 3 different types of RNA with unique responsibilities.
• There are also similar signals to tell RNA to stop the process of
transcription.
LEARNING TARGETS
1. Identify the genetic code and explain how it is read.
2. When an anticodon is complete, it joins the amino acid it codes for. On the
ribosome, the amino acid is “removed” from the tRNA (the “transfer” is
complete).
• The ribosome joins all of the amino acids into a polypeptide chain
3. This process continues until the ribosome reaches a “stop” codon, signaling
that that is the last amino acid and the polypeptide chain is now complete.
DNA--DNA DNA--RNA RNA--RNA
A T A U A U
T A T A U A
C G C G C G
G C G C G C
LET’S PRACTICE!
Example 1:
DNA: A T G G T A G C T A A C C T T
T A C C A T C G A T T G G A A
mRNA: A U G G U A G C U A A C C U U
tRNA: U A C C A U C G A U U G G A A
DNA: C A G G A A T T G C T C G A T
G T C C T T A A C G A G C T A
mRNA: C A G G A A U U G C U C G A U
tRNA: G U C C U U A A C G A G C U A
• Despite the variety among living things, we all share the same
genetic code and the same mechanism for gene expression.
GENE MUTATIONS
• These are a result of a change in one (or a few) nucleotide.
• Due to the nature of replication & cell division, once DNA has
been mutated, every cell that develops from the “original” will
also contain the error.
EXAMPLE: THE—FAT—CAT—ATE—THE—RAT
SUBSTITUTION: THE—FAT—HAT—ATE—THE---RAT
INSERTION/DELETION
• When a nucleotide base is ADDED (insertion) or REMOVED
(deletion) from the DNA sequence
• They change the amino acid sequence from the point of the
mutation on and can alter a protein to the point that it no longer
functions.
EXAMPLE: THE—FAT—CAT—ATE—THE—RAT
INSERTION: THE—FAT—CAT—AAT—ETH---ERA--T
EXAMPLE: THE—FAT—CAT—ATE—THE—RAT
DELETION: THE—FAT—ATA—TET—HER---AT
CHROMOSOMAL MUTATIONS
• Effect the entire chromosome
• Translocation: when part of one chromosome breaks off and attaches to another
EFFECTS OF MUTATIONS
• Mutations can be caused by natural or artificial means.
• Sickle Cell Anemia changes shape of RBC (and the ability to carry oxygen)
• Pain, stunted growth, high rate of infections
BENEFICIAL MUTATIONS
• Mutations often produce proteins with new or altered functions
that can be useful to organisms in different or changing
environments
• Mutations in humans
• Increases in bone density (less common to break a bone)
• Increased resistance to HIV (virus that causes AIDS)