FN Clarivate Analytics Web of Science

VR 1.0
PT J
AU Ladio, AH
Acosta, M
AF Ladio, Ana H.
Acosta, Marina
TI Urban medicinal plant use: Do migrant and non-migrant populations have
similar hybridisation processes?
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Review
DE Urban society; Urban ethnobotany; Innovations; Fusion, change
ID AIRES-LA PLATA; BUENOS-AIRES; HERBAL MEDICINES; EL-ALTO;
ETHNOPHARMACOLOGICAL FIELD; DIETARY-SUPPLEMENTS; KNOWLEDGE; MARKETS;
ETHNOBOTANY; PRODUCTS
AB Ethnopharmacological relevance: Urban migrant herbal medicine is an important
topic on a global scale. Through bibliographical analysis of published studies we
can get an overview of the different hybridisation processes at work in cities
around the world, the main medicinal plants used and the principal ailments
treated. We analysed the differential characteristics of urban ethnobotanical
studies involving transnational migrant and non-migrant populations, in order to
contribute useful information for the design of public health policies.
Materials and methods: A systematic and integrative revision was conducted,
leading to a final selection of 66 primary sources, including studies with and
without immigrants. In both cases, richness (S), considered as the sum of all
species cited in the work, botanical families and reported ailments were recorded.
Based on the work of Ladio and Albuquerque (2014) the main hybridisation processes
identifiable in the literature were assessed. These were: fusion, relocation, re-
combination of different species, their restructuring as medicinal targets, spatial
segregation in usage, innovations found in the circulation and consumption of the
plants, and the presence of simultaneous coexistence of different symbolic
universes in plant medical practices.
Data Analysis: This was qualitative and quantitative, including both in-depth
interpretative content analysis of the studies and frequency analysis of numerical
data, such as species richness, botanical families, ailments and the hybridisation
processes detected. A multinomial logistic regression model was used to analyse
whether the probability of medicinal plant hybridisation processes occurring was
the same in literature with and without migrants.
Results: A total of 522 medicinal species formed part of the main urban
ethnobotany worldwide; the majority were cosmopolitan in distribution and belonged
to the Asteriaceae and Lamiaceae families. Only 21% of these species appeared in
both migrant and non-migrant studies. Most were used for gastrointestinal and
hepatic ailments. Surprisingly, culture-related illnesses were not frequently
mentioned, probably due to lack of recognition and re-interpretation by authors.
Logistic analysis showed that in the studies with migrants, relocation and
restructuring of plant use were the most frequently identified processes, while in
the studies involving only non-migrants fusion was 4 times more likely to be found
than in studies with migrants.
Conclusions: Our research on hybridisation processes shows that cities
constitute an environment that fosters a rapid exchange of practices and knowledge
about the available species. Studies with migrants have shown that they reproduce
traditional models in their use of plants, and so relocation and restructuring of
their herbal medicine are the principal processes. Health risks in this case are
related to the difficulties faced by these groups in obtaining their plants and
reproducing their practices. In the case of fusion processes observed in non-
migrants, who do not normally have a long history or much experience of plant use,
errors or poisoning may result from misuse. This information highlights the
importance of considering these processes in health policies, particularly when
there are no significant quality controls of these resources.
C1 [Ladio, Ana H.] Univ Nacl Comahue, CONICET, INIBIOMA, Grp Etnobiol, Quintral
1250, San Carlos De Bariloche, Rio Negro, Argentina.
[Acosta, Marina] UNJu, CONICET, INECOA, Lab Bot Sistemat & Etnobot LABOSyE, San
Salvador De Jujuy, Argentina.
RP Ladio, AH (reprint author), Univ Nacl Comahue, CONICET, INIBIOMA, Grp Etnobiol,
Quintral 1250, San Carlos De Bariloche, Rio Negro, Argentina.
EM ladioah@comahue-conicet.gob.ar
FU Consejo Nacional de Investigations Cientfficas y Tecnicas (CONICET) of
Argentina; Universidad Nacional de Jujuy
FX We are deeply grateful to Dra. Nilda Dora Vignale for her willingness to
help, and for sharing her knowledge and experience. We also thank the
four reviewers for their suggestions that greatly enriched this
manuscript. This investigation was supported by the Consejo Nacional de
Investigations Cientfficas y Tecnicas (CONICET) of Argentina, and the
Universidad Nacional de Jujuy.
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NR 118
TC 0
Z9 0
U1 4
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD APR 24
PY 2019
VL 234
BP 290
EP 305
DI 10.1016/j.jep.2019.01.013
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
Medicine; Pharmacology & Pharmacy
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
Medicine
GA HP1CZ
UT WOS:000461404300024
PM 30658184
DA 2019-04-06
ER

PT J
AU Sun, CZ
Wu, Y
Jiang, B
Peng, Y
Wang, MY
Li, JX
 Li, XB
AF Sun, Chongzhi
Wu, Yang
Jiang, Bei
Peng, Ying
Wang, Mengyue
Li, Jiaxun
Li, Xiaobo
TI Chemical components from Metapanax delavayi leaves and their anti-BHP
activities in vitro
SO PHYTOCHEMISTRY
LA English
DT Article
DE Metapanax delavayi; Araliaceae; Anti-BPH activity; Oleanane-type
triterpene saponin; Eudesmane glycoside
ID TRITERPENOID SAPONINS; BARK; SEED
AB Two previously undescribed oleanane-type triterpene saponins named
liangwanosides III-IV and one on described eudesmane glycoside named liangwanoside
A were obtained from the leaves of Metapanax delavayi, a Chinese folk medicine
especially for tea used in Yunnan, together with four known compounds. The
structures of the undescribed compounds were determined by detailed spectroscopic
(1D/2D NMR), HR-ESI-MS data analysis and chemical evidence. The activity against
human benign prostate hyperplasia was evaluated with BPH-1 cell line. Most of the
isolated compounds showed moderate inhibitory activity against BPH-1 cells at 100
and 50 mu M in vitro.
C1 [Sun, Chongzhi; Wu, Yang; Peng, Ying; Wang, Mengyue; Li, Xiaobo] Shanghai Jiao
Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
[Jiang, Bei] Dali Univ, Inst Mat Med, Coll Pharm & Chem, Dali 671000, Peoples R
China.
[Li, Jiaxun] Lanping Cty Bur Agr, Lanping 671400, Peoples R China.
RP Li, XB (reprint author), Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd,
Shanghai 200240, Peoples R China.
EM xbli@sjtu.edu.cn
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NR 25
TC 0
Z9 0
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD APR
PY 2019
VL 160
BP 56
EP 60
DI 10.1016/j.phytochem.2019.01.002
PG 5
WC Biochemistry & Molecular Biology; Plant Sciences
SC Biochemistry & Molecular Biology; Plant Sciences
GA HQ0RZ
UT WOS:000462104000008
PM 30711571
DA 2019-04-06
ER

PT J
AU Foley, DA
Burge, S
Tustin, P
Blackmore, T
AF Foley, David Anthony
Burge, Sarah
Tustin, Paul
Blackmore, Timothy
TI Choosing wisely in infectious serology: the merits of triaging send-away
tests
SO PATHOLOGY
LA English
DT Article
DE Choosing wisely; triage; send away infectious serology; cost saving
ID TRAVEL MEDICINE; DIAGNOSIS; DISEASE
AB Over-utilisation of pathology requests can incur unnecessary costs and be
detrimental to patient care. The choosing wisely campaign has helped to reduce the
use of tests with limited or no value. This report describes the estimated benefits
and costs of implementing a triage process of infectious serology requests in a
single mixed hospital and community laboratory.
Data analysis of triaging of send away infectious serology was conducted from 1
November 2016 to 31 October 2017. A total of 618 tests were triaged over a 1-year
period. Of these 379 (61.3%) were declined. The total gross savings was $45,066.
The total cost for implementing this change was estimated to be $4220 per year. The
total saving was $40,846.37. There was significant cost saving secondary to this
intervention, with other more difficult to measure tangible benefits including
fostering communication between laboratory staff and clinicians.
C1 [Foley, David Anthony; Burge, Sarah; Tustin, Paul; Blackmore, Timothy]
Wellington Reg Hosp, Wellington Southern Community Lab, Wellington, New Zealand.
RP Burge, S (reprint author), Wellington Reg Hosp, Wellington Southern Community
Lab, Dept Immunol, Riddiford St, Wellington 6021, New Zealand.
EM sarah.burge@wellingtonscl.co.nz
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0031-3025
EI 1465-3931
J9 PATHOLOGY
JI Pathology
PD APR
PY 2019
VL 51
IS 3
BP 313
EP 315
DI 10.1016/j.pathol.2018.12.414
PG 3
WC Pathology
SC Pathology
GA HP5HB
UT WOS:000461707100013
PM 30808509
DA 2019-04-06
ER

PT J
AU Awin, T
Mediani, A
Maulidiani
Leong, SW
Faudzi, SMM
Shaari, K
Abas, F
AF Awin, Tahani
Mediani, Ahmed
Maulidiani
Leong, Sze-Wei
 Faudzi, Siti Munirah Muhd
Shaari, Khozirah
Abas, Faridah
TI Phytochemical and bioactivity alterations of Curcuma species harvested
at different growth stages by NMR-based metabolomics
SO JOURNAL OF FOOD COMPOSITION AND ANALYSIS
LA English
DT Article
DE Food analysis; Food composition; Development stages; Curcuma;
Multivariate data analysis; PCA; PLS; Nuclear magnetic resonance;
Biosynthetic pathway
ID ESSENTIAL OIL; CHEMICAL-COMPOSITION; ZEDOARIA RHIZOMES; ANTIOXIDANT;
BIOSYNTHESIS; EXPRESSION; AERUGINOSA; COMPOUND; LEAVES
AB Curcuma species is a popular traditional folk medicine in India and Southeast
Asia. This study aims to profile the metabolites in four Curcuma species, including
C. zedoaria, C. xanthorrhiza, C. aeruginosa and C. mangga at three developmental
stages (seven, eight and nine months old) using nuclear magnetic resonance (NMR)-
based metabolomics. Principal component analysis (PCA) showed that there are
metabolites changes due to the month of harvest in each of the four species. A
large quantity of curcumin and demethoxycurcumin contributed to the separation of
C. xanthorrhiza, whereas the diterpenoids, such as curcumanggoside, (E)-labda-
8(17),12-diene-15,16-dial, calcaratarin A and zerumin B were responsible for the
discrimination of C. mangga. Eight-month-old C. xanthorrhiza exhibited the highest
nitric oxide (NO) inhibitory activity, while nine-month-old C. mangga exhibited the
highest alpha-glucosidase inhibitory activity. The correlation among the
bioactivities and phytochemical constituents was determined using partial least
square (PLS) analysis. Curcumin, demethoxycurcumin, germacrone, zedoarol and
xanthorrhizol were correlated with the NO inhibitory activity in C. xanthorrhiza,
whereas curcumanggoside, labda-8(17),12-diene-15,16-dial and zerumin B were
correlated with the alpha-glucosidase inhibitory activity in C. mangga. From the
phytochemical markers and metabolic changes among growth stages of C. xanthorrhiza
and C. mangga, the biosynthetic pathway was proposed to show the metabolites that
might contribute to their health benefits.
C1 [Awin, Tahani; Maulidiani; Leong, Sze-Wei; Faudzi, Siti Munirah Muhd; Shaari,
Khozirah; Abas, Faridah] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang
43400, Selangor, Malaysia.
[Awin, Tahani] Univ Benghazi, Fac Sci, Dept Chem, Benghazi, Libya.
[Mediani, Ahmed] Univ Teknol MARA, Atta ur Rahman Inst Nat Prod Discovery,
Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia.
[Faudzi, Siti Munirah Muhd; Shaari, Khozirah] Univ Putra Malaysia, Fac Sci, Dept
Chem, Serdang 43400, Selangor, Malaysia.
[Abas, Faridah] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci,
Serdang 43400, Selangor, Malaysia.
RP Abas, F (reprint author), Univ Putra Malaysia, Inst Biosci, Lab Nat Prod,
Serdang 43400, Selangor, Malaysia.; Abas, F (reprint author), Univ Putra Malaysia,
Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia.
EM faridah_abas@upm.edu.my
RI Maulidiani, Maulidiani/B-3053-2019; Abas, Faridah/B-9229-2015
OI Maulidiani, Maulidiani/0000-0002-3227-4191; Abas,
Faridah/0000-0002-8110-9424; Mediani, Ahmed/0000-0002-6892-1995
FU Fundamental Research Grant (FRGS) from Ministry of Higher Education
Malaysia (MOHE) [5524568]
FX The study was supported by Fundamental Research Grant (FRGS) from
Ministry of Higher Education Malaysia (MOHE, grant no.5524568). A
special thanks is extended to Mr. Tajudin, an in-house farm officer of
the Institute of Bioscience, Universiti Putra Malaysia for his help in
obtaining the samples.
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10.1016/j.jchromb.2006.12.036
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NR 44
TC 0
Z9 0
U1 5
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1575
EI 1096-0481
J9 J FOOD COMPOS ANAL
JI J. Food Compos. Anal.
PD APR
PY 2019
VL 77
BP 66
EP 76
DI 10.1016/j.jfca.2019.01.004
PG 11
WC Chemistry, Applied; Food Science & Technology
SC Chemistry; Food Science & Technology
GA HM5MQ
UT WOS:000459520200008
DA 2019-04-06
ER

PT J
AU Policarpo, V
Romano, S
Antonio, JHC
Correia, TS
Costa, S
AF Policarpo, Veronica
Romano, Sonia
Antonio, Joao H. C.
Correia, Tania Sofia
Costa, Suzete
TI A new model for pharmacies? Insights from a quantitative study regarding
the public's perceptions
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
DE Community pharmacy; Satisfaction; Pharmacy services; Evaluation of
pharmacy services; Portugal
ID COMMUNITY PHARMACY; SERVICES; HEALTH; SATISFACTION; SITUATION
AB BackgroundWorldwide community pharmacies are shifting their role in the
healthcare system from simple medication dispensers to health care providers. High
levels of satisfaction with pharmacy services were found in previous studies. This
study has two main goals. The primary goal is to describe the levels of
satisfaction and knowledge regarding pharmacy services in Portugal. The secondary
goal is to explore the perceptions and the utilisation of pharmacy services by the
Portuguese. This statement includes exploring the impact of a set of variables on
both perceptions and uses of pharmacies in regard to services that are currently
offered as well as to new services that may be provided in the future.MethodsA
face-to-face survey of closed-ended questions was applied to a nationwide
representative sample of the Portuguese population in September 2015. The sample
was weighted based on population distribution across regions, habitat, age and
gender. Data analysis comprises descriptive statistics and Multiple Correspondence
Analysis to explore different typologies of respondent's orientation toward
community pharmacy.ResultsA total of 1114 interviews comprised the study. Of the
respondents, 36% used the pharmacy as a first resource when seeking to treat a
minor ailment, and 54% reported that they use the pharmacy as a first resource when
seeking answers about medicines. Of those who visited their pharmacy at least once
in the previous year, 94% were either globally satisfied or very satisfied. The
level of acknowledgement of pharmacy services' was also high among the Portuguese.
Of the participants, 29% considered there could be more services available in
pharmacies that are currently provided by other health care facilities. The
construction of a typology of orientations towards community pharmacy practice
resulted in three outcome groups: Motivated (63%), those with a connection to a
pharmacy; Settled (23%), mainly those who had a pharmacy nearby; and Demobilised
(14%), those who are weakly tied to a pharmacy.ConclusionsThe vast majority of the
Portuguese population has a strong positive attitude towards their community
pharmacy, as expressed by the high levels of satisfaction with, and positive
evaluation of, the pharmacy's services.
C1 [Policarpo, Veronica] Univ Lisbon, Inst Ciencias Sociais, Av Prof Anibal
Bettencourt 9, P-1600189 Lisbon, Portugal.
[Romano, Sonia] ANF, Ctr Hlth Evaluat & Res CEFAR, Rua Marechal Saldanha 1, P-
1249069 Lisbon, Portugal.
[Antonio, Joao H. C.; Correia, Tania Sofia] Univ Catolica Portuguesa CESOP, Res
Ctr Publ Opin, P-1649023 Lisbon, Portugal.
[Costa, Suzete] ANF, USFarm Collaborat Care Project, Rua Marechal Saldanha 1, P-
1249069 Lisbon, Portugal.
RP Romano, S (reprint author), ANF, Ctr Hlth Evaluat & Res CEFAR, Rua Marechal
Saldanha 1, P-1249069 Lisbon, Portugal.
EM sonia.romano@anf.pt
FU Portuguese National Association of Pharmacies (ANF)
FX This study was funded by the Portuguese National Association of
Pharmacies (ANF) who contracted CESOP for the implementation of the
project. Joao Antonio and Tania Correia are employed by CESOP, and
Veronica Policarpo was, at the time of the study, technical director of
CESOP. Sonia Romano is employed by CEFAR, the Centre for Health Research
& Evaluation of ANF, and Suzete Costa was, at the time of the research,
the executive director of CEFAR. The funder body (ANF) had no
involvement in the design and conduct of the study or in the writing and
submission of the manuscript, respecting the authors' scientific
independence.
CR [Anonymous], 2015, CONSUMER NEEDS FULL
[Anonymous], 2012, EUR ACT PLAN STRENGT
[Anonymous], 2011, GOV HLTH 21 CENT STU
[Anonymous], 2015, PROGRAMA 21 GOVERNO
[Anonymous], 2015, PHARM CAN NAT SURV C
[Anonymous], 2016, EUROPE 2016 STATE HL, P210
[Anonymous], 2016, PHARM USAGE ATTITUDE
AntAo AA, 2018, SUSTENTABILIDADE DIS
Barros Pedro Pita, 2011, Health Syst Transit, V13, P1
Cavaco AM, 2005, PHARM WORLD SCI, V27, P54, DOI 10.1007/s11096-004-2129-z
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Duarte A, 2007, RESPONSABILIDADE SOC
Eades CE, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-582
Felix J, 2017, BMC HEALTH SERV RES, V17, DOI 10.1186/s12913-017-2525-4
Gallup, 2017, HON ETH PROF GALL HI
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7
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10.1016/j.healthpol.2015.02.007
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 Siddiqua A, 2018, INT J PHARM PRACT, V26, P63, DOI 10.1111/ijpp.12359
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD MAR 21
PY 2019
VL 19
AR 186
DI 10.1186/s12913-019-3987-3
PG 11
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA HQ2FD
UT WOS:000462214600004
PM 30898124
OA DOAJ Gold
DA 2019-04-06
ER

PT J
AU James, PB
Kaikai, AI
Bah, AJ
Steel, A
Wardle, J
AF James, Peter Bai
Kaikai, Angela Isata
Bah, Abdulai Jawo
Steel, Amie
Wardle, Jon
TI Herbal medicine use during breastfeeding: a cross-sectional study among
mothers visiting public health facilities in the Western area of Sierra
Leone
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Herbal medicine; Lactation; Prevalence; Maternal health; Sierra Leone
ID TRADITIONAL MEDICINE; PREGNANT-WOMEN; ANTENATAL CARE; COMPLEMENTARY;
PREVALENCE; ETHIOPIA; UGANDA
AB BackgroundThe use of medications, including herbal medicines during
breastfeeding is always a concern among women. Currently, there is no published
evidence on whether Sierra Leonean women use herbal medicine during breastfeeding.
This study investigates the prevalence, correlates and pattern of herbal medicine
use during breastfeeding.MethodologyWe conducted a cross-sectional study among 378
current breastfeeding mothers visiting public healthcare facilities within the
Western area of Sierra Leone. Descriptive statistics and logistic regression
analysis were used for data analysis.ResultsOver a third of mothers (n=140, 37.0%)
used herbal medicine during breastfeeding. However, very few herbal medicine users
(2.1%, n=3) used herbal medicine to augment breastfeeding. Dietary changes were the
most common method used to increase breast milk supply (93.9%, n=355) with cassava
leaves sauce and tubers being the most common dietary addition. Mothers with
children more than six months old were more likely to use herbal medicine than
mothers with younger children (OR:1.8; CI:1.13-2.85,p=0.013). Among herbal medicine
users, only 11.4% (n=16) disclosed their herbal medicine use to their conventional
healthcare providers.ConclusionThe use of herbal medicine among breastfeeding
mothers attending public health facilities in the Western area of Sierra Leone is
common. Whilst this use is not usually specific to increasing breast milk supply,
our study indicates that herbal medicines may be used to cleanse' initial breast
milk.
C1 [James, Peter Bai; Steel, Amie; Wardle, Jon] Univ Technol Sydney, Fac Hlth,
Australian Res Ctr Complementary & Integrat Med, Sydney, NSW 2007, Australia.
[James, Peter Bai; Kaikai, Angela Isata; Bah, Abdulai Jawo] Univ Sierra Leone,
Coll Med & Allied Hlth Sci, Fac Pharmaceut Sci, Freetown, Sierra Leone.
[Bah, Abdulai Jawo] Univ Sierra Leone, Coll Med & Allied Hlth Sci, Fac Basic Med
Sci, Freetown, Sierra Leone.
[Steel, Amie] Endeavour Coll Nat Hlth, 269 Wickham St, Fortitude Valley, Qld
4006, Australia.
RP James, PB (reprint author), Univ Technol Sydney, Fac Hlth, Australian Res Ctr
Complementary & Integrat Med, Sydney, NSW 2007, Australia.; James, PB (reprint
author), Univ Sierra Leone, Coll Med & Allied Hlth Sci, Fac Pharmaceut Sci,
Freetown, Sierra Leone.
EM Peter.B.James@student.uts.edu.au
RI James, Peter/P-8492-2015
OI James, Peter/0000-0002-6373-5704
FU Faculty of Health, University of Technology Sydney
FX We would like to thank the dean faculty of Pharmaceutical Science
COMAHS-USL and the management of the health facilities involved in this
study for creating the enabling environment for data collection.
Successful completion of this manuscript was made possible through
participation in the Twelve Weeks to Publication Program funded by
Faculty of Health, University of Technology Sydney and with the active
support and contributions made by the facilitators and other program
participants.
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NR 67
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD MAR 15
PY 2019
VL 19
AR 66
DI 10.1186/s12906-019-2479-7
PG 11
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA HP0GW
UT WOS:000461345200002
PM 30876454
OA DOAJ Gold
DA 2019-04-06
ER

PT J
AU Moyo, P
Kunyane, P
Selepe, MA
Eloff, JN
Niemand, J
Louw, AI
Maharaj, VJ
Birkholtz, LM
AF Moyo, Phanankosi
Kunyane, Phaladi
Selepe, Mamoalosi A.
Eloff, Jacobus N.
Niemand, Jandeli
Louw, Abraham I.
Maharaj, Vinesh J.
Birkholtz, Lyn-Marie
TI Bioassay-guided isolation and identification of gametocytocidal
compounds from Artemisia afra (Asteraceae)
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria; Gametocytes; Transmission-blocking; Artemisia afra;
Sesquiterpene lactone; Natural products; Plasmodium falciparum
ID HIGH-THROUGHPUT ASSAY; SESQUITERPENE LACTONES; MEDICINAL-PLANTS;
MALARIA; DRUGS; DISCOVERY; GUAIANOLIDES; PRIMAQUINE; PARTHENIN
AB BackgroundOptimal adoption of the malaria transmission-blocking strategy is
currently limited by lack of safe and efficacious drugs. This has sparked the
exploration of different sources of drugs in search of transmission-blocking
agents. While plant species have been extensively investigated in search of malaria
chemotherapeutic agents, comparatively less effort has been channelled towards
exploring them in search of transmission-blocking drugs. Artemisia afra
(Asteraceae), a prominent feature of South African folk medicine, is used for the
treatment of a number of diseases, including malaria. In search of transmission-
blocking compounds aimed against Plasmodium parasites, the current study
endeavoured to isolate and identify gametocytocidal compounds from A. afra.MethodsA
bioassay-guided isolation approach was adopted wherein a combination of solvent-
solvent partitioning and gravity column chromatography was used. Collected
fractions were continuously screened in vitro for their ability to inhibit the
viability of primarily late-stage gametocytes of Plasmodium falciparum (NF54
strain), using a parasite lactate dehydrogenase assay. Chemical structures of
isolated compounds were elucidated using UPLC-MS/MS and NMR data
analysis.ResultsTwo guaianolide sesquiterpene lactones, 1,4-
dihydroxybishopsolicepolide and yomogiartemin, were isolated and shown to be active
(IC50<10g/ml; similar to 10M) against both gametocytes and intra-erythrocytic
asexual P. falciparum parasites. Interestingly, 1,4-dihydroxybishopsolicepolide was
significantly more potent against late-stage gametocytes than to early-stage
gametocytes and intra-erythrocytic asexual P. falciparum parasites. Additionally,
both isolated compounds were not overly cytotoxic against HepG2 cells in
vitro.ConclusionThis study provides the first instance of isolated compounds from
A. afra against P. falciparum gametocytes as a starting point for further
investigations on more plant species in search of transmission-blocking compounds.
C1 [Moyo, Phanankosi; Niemand, Jandeli; Louw, Abraham I.; Birkholtz, Lyn-Marie]
Univ Pretoria, Inst Sustainable Malaria Control, Fac Nat & Agr Sci, Malaria
Parasite Mol Lab,Dept Biochem Genet & Mic, Private Bag x20, ZA-0028 Hatfield, South
Africa.
[Kunyane, Phaladi; Selepe, Mamoalosi A.; Maharaj, Vinesh J.] Univ Pretoria, Inst
Sustainable Malaria Control, Fac Nat & Agr Sci, Dept Chem, Private Bag x20, ZA-0028
Hatfield, South Africa.
[Eloff, Jacobus N.] Univ Pretoria, Dept Paraclin Sci, Phytomed Programme, Fac
Vet Sci, Private Bag x04, ZA-0110 Pretoria, South Africa.
RP Birkholtz, LM (reprint author), Univ Pretoria, Inst Sustainable Malaria Control,
Fac Nat & Agr Sci, Malaria Parasite Mol Lab,Dept Biochem Genet & Mic, Private Bag
x20, ZA-0028 Hatfield, South Africa.
EM lbirkholtz@up.ac.za
RI Birkholtz, Lyn-Marie/E-2939-2010
OI Birkholtz, Lyn-Marie/0000-0001-5888-2905
FU South African Medical Research Council (SAMRC) Strategic Health
Initiatives Partnerships (MRC-SHIP); South African Research Chairs
Initiative of the Department of Science and Technology [UID84627]; NRF
[98988]
FX This work was supported financially by the South African Medical
Research Council (SAMRC) Strategic Health Initiatives Partnerships
(MRC-SHIP) and the South African Research Chairs Initiative of the
Department of Science and Technology, administered through the South
African National Research Foundation (NRF) to LB (UID84627). VJM is
supported by a grant from the NRF (Grant Number 98988).
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Wubshet SG, 2015, J NAT PROD, V78, P2657, DOI 10.1021/acs.jnatprod.5b00603
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NR 58
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD MAR 8
PY 2019
VL 18
AR 65
DI 10.1186/s12936-019-2694-1
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA HO2TD
UT WOS:000460768200003
PM 30849984
OA DOAJ Gold
DA 2019-04-06
ER

PT J
AU Geldor, T
Huys, I
Van Dyck, W
AF Geldor, Tine
Huys, Isabelle
Van Dyck, Walter
TI Real-World Evidence Gathering in Oncology: The Need for a Biomedical Big
Data Insight-Providing Federated Network
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE real-world data; real-world evidence; oncology; data exploring;
federated network; common data model
AB Moving toward new adaptive pathways for the development and access to innovative
medicines implies that real-world data (RWD) collected throughout the medicinal
product life cycle is becoming increasingly important. Big data analytics on RWD
can obtain new and powerful insights into medicines' effectiveness. However, the
healthcare ecosystem still faces many sector-specific challenges that hamper the
use of big data analytics delivering real world evidence (RWE). We distinguish
between exploratory (ExTE) and hypotheses-evaluating (HETE) studies testing
treatment effectiveness in the real world. From our experience and in the context
of the four V's of data management, we show that to get meaningful results data
Variety and Veracity are needed regardless of the type of study conducted. More so,
for ExTE studies high data Volume is needed while for HETE studies high Velocity
becomes essential. Next, we highlight what are needed within the biomedical big
data ecosystem, being: (a) international data reusability; (b) real-time RWD
processing information systems; and (c) longitudinal RWD. Finally, in an effort to
manage the four V's whilst respecting patient privacy laws we argue for the
development of an underlying federated RWD infrastructure on a common data model,
capable of bringing the centrally-conducted big data analysis to the de-centrally
kept biomedical data.
C1 [Geldor, Tine; Van Dyck, Walter] Vlerick Business Sch, Healthcare Management
Ctr, Ghent, Belgium.
[Geldor, Tine; Huys, Isabelle; Van Dyck, Walter] Katholieke Univ Leuven, Res Ctr
Pharmaceut Care & Pharmacoecon, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium.
RP Geldor, T (reprint author), Vlerick Business Sch, Healthcare Management Ctr,
Ghent, Belgium.; Geldor, T (reprint author), Katholieke Univ Leuven, Res Ctr
Pharmaceut Care & Pharmacoecon, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium.
EM tine.geldof@vierick.com
FU Vlerick Business School
FX Financial support for this study was provided entirely by a grant from
the Vlerick Business School. The funding agreement ensured the authors'
independence in designing the study, interpreting its results, and
publishing the report.
CR Ardeshirdavani A, 2014, GENOME MED, V6, DOI 10.1186/s13073-014-0071-9
Berger ML, 2017, VALUE HEALTH, V20, P1003, DOI 10.1016/j.jval.2017.08.3019
Eichler HG, 2015, CLIN PHARMACOL THER, V97, P234, DOI 10.1002/cpt.59
European Medicines Agency, 2016, EMA2763762016
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Hripcsak G, 2015, STUD HEALTH TECHNOL, V216, P574, DOI 10.3233/978-1-61499-564-
7-574
Hughes N, 2018, EUR ODHSI S
Khozin S, 2017, NAT REV DRUG DISCOV, V16, P306, DOI 10.1038/nrd.2017.26
Laney D, 2001, META GROUP RES NOTE, V6, P70
 Makady A, 2017, VALUE HEALTH, V20, P858, DOI 10.1016/j.jval.2017.03.008
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NR 16
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 8
PY 2019
VL 6
AR 43
DI 10.3389/fmed.2019.00043
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA HO5EP
UT WOS:000460946100001
PM 30906740
OA DOAJ Gold
DA 2019-04-06
ER

PT J
AU Rowland, CM
Shiffman, D
Caulfield, M
Garcia, V
Melander, O
Hastie, T
AF Rowland, Charles M.
Shiffman, Dov
Caulfield, Michael
Garcia, Veronica
Melander, Olle
Hastie, Trevor
TI Association of cardiovascular events and lipoprotein particle size:
Development of a risk score based on functional data analysis
SO PLOS ONE
LA English
DT Article
ID LOW-DENSITY LIPOPROTEINS; PREDICTION; DISEASE; IDENTIFICATION;
CHOLESTEROL; PREVENTION; SUBCLASSES; LDL
AB Background
Functional data is data represented by functions (curves or surfaces of a low-
dimensional index). Functional data often arise when measurements are collected
over time or across locations. In the field of medicine, plasma lipoprotein
particles can be quantified according to particle diameter by ion mobility.
Goal
 We wanted to evaluate the utility of functional analysis for assessing the
association of plasma lipoprotein size distribution with cardiovascular disease
after adjustment for established risk factors including standard lipids.
Methods
We developed a model to predict risk of cardiovascular disease among
participants in a case-cohort study of the Malmo Prevention Project. We used a
linear model with 311 coefficients, corresponding to measures of lipoprotein mass
at each of 311 diameters, and assumed these coefficients varied smoothly along the
diameter index. The smooth function was represented as an expansion of natural
cubic splines where the smoothness parameter was chosen by assessment of a series
of nested splines. Cox proportional hazards models of time to a first
cardiovascular disease event were used to estimate the smooth coefficient function
among a training set consisting of one half of the participants. The resulting
model was used to calculate a functional risk score for the remaining half of the
participants (test set) and its association with events was assessed in Cox models
that adjusted for traditional cardiovascular risk factors.
Results
In the test set, participants with a functional risk score in the highest
quartile were found to be at increased risk of cardiovascular events compared with
the lowest quartile (Hazard ratio = 1.34; 95% Confidence Interval: 1.05 to 1.70)
after adjustment for established risk factors.
Conclusion
In an independent test set of Malmo Prevention Project participants, the
functional risk score was found to be associated with cardiovascular events after
adjustment for traditional risk factors including standard lipids.
C1 [Rowland, Charles M.; Shiffman, Dov; Caulfield, Michael; Garcia, Veronica] Quest
Diagnost, San Juan Capistrano, CA 92675 USA.
[Melander, Olle] Lund Univ, Dept Clin Sci, Malmo, Sweden.
[Hastie, Trevor] Stanford Univ, Dept Stat, Stanford, CA 94305 USA.
RP Rowland, CM (reprint author), Quest Diagnost, San Juan Capistrano, CA 92675 USA.
EM Charles.M.Rowland@QuestDiagnostics.com
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10.1161/CIRCULATIONAHA.108.809582
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10.1161/01.CIR.0000075572.40158.77
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NR 21
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 7
PY 2019
VL 14
IS 3
AR e0213172
DI 10.1371/journal.pone.0213172
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA HO1AY
UT WOS:000460638800042
PM 30845215
OA DOAJ Gold
DA 2019-04-06
ER

PT J
AU Bruggmann, D
Herpe, A
Quarcoo, D
Schoffel, N
Wanke, EM
Ohlendorf, D
Klingelhofer, D
Groneberg, DA
Mache, S
AF Brueggmann, Doerthe
Herpe, Anja
Quarcoo, David
Schoeffel, Norman
Wanke, Eileen M.
Ohlendorf, Daniela
Klingelhoefer, Doris
Groneberg, David A.
Mache, Stefanie
TI Descriptive review of junior OB/GYN physicians' work task financial
compensation in German hospitals
SO JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
LA English
DT Review
DE Task analysis; Job situation; Compensation; Gynecology - obstetrics
ID HEALTH-CARE WORKERS; JOB-SATISFACTION; YOUNG PHYSICIANS; GYNECOLOGIC
ONCOLOGISTS; REAL-TIME; TUBERCULOSIS; STRESS; OBSTETRICIANS;
CONSEQUENCES; INFECTION
AB Beginning in the first decade of the 21st centruy, there was a growing disregard
for the benefits of the German medical system concerning the junior
obstetricians/gynecologists (OB/GYN) job situation. As in other fields of medicine,
numerous colleagues left Germany to work in other countries such as the United
Kingdom, Noway, Sweden, or Switzerland. According to studies, financial factors
represent one of the reasons for the discontent. We here present a practical
descriptive approach to assess/review the actual compensation of single work tasks
of OB/GYNs on the basis of previously published, existing data. Using the workflow
data from the Medical work Assessment in German hospitals (MAGRO) platform of
twenty junior OB/GYNs with an average workday of 9:24:35h (SD=01:05:07h), a large
scale data analysis of 2,325,556 different time points was performed to calculate
the financial valuation of single work tasks. In order to assess the evolution over
the past years, different modern and historic (e.g. AiP) pay scales were used and
analysed in relation to the actual work on a weekly, monthly and per annum basis.
Our review shows that there has been a dramatic increase in the financial reward of
the practical work tasks of junior OB/GYN physicians in German hospitals in
comparison to the situation of the early 2000s years. In this respect, it can not
be further argued that the German system has large disadvantages concerning the
payment of junior doctors in comparison to other European countries.
C1 [Brueggmann, Doerthe] Goethe Univ Frankfurt, Dept Gynecol & Obtest, Theodor
Stern Kai 7, D-60590 Frankfurt, Germany.
[Brueggmann, Doerthe; Herpe, Anja; Quarcoo, David; Schoeffel, Norman; Wanke,
Eileen M.; Ohlendorf, Daniela; Klingelhoefer, Doris; Groneberg, David A.] Goethe
Univ Frankfurt, Inst Occupat Med Social Med & Environm Med, Div Social Med, Theodor
Stern Kai 7, D-60590 Frankfurt, Germany.
[Mache, Stefanie] Charite Univ Med Berlin, Dept Med Psychosomat, Luisenstr 13a,
D-10117 Berlin, Germany.
[Mache, Stefanie] Free Univ, Luisenstr 13a, D-10117 Berlin, Germany.
[Mache, Stefanie] Humboldt Univ, Luisenstr 13a, D-10117 Berlin, Germany.
RP Klingelhofer, D (reprint author), Goethe Univ Frankfurt, Inst Occupat Med Social
Med & Environm Med, Div Social Med, Theodor Stern Kai 7, D-60590 Frankfurt,
Germany.
EM klingelhoefer@med.uni-frankfurt.de
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10.1016/j.ajog.2005.08.002
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Buddeberg-Fischer B, 2005, SWISS MED WKLY, V135, P19
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0
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NR 47
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6673
J9 J OCCUP MED TOXICOL
JI J. Occup. Med. Toxicol.
PD MAR 7
PY 2019
VL 14
AR 6
DI 10.1186/s12995-019-0227-z
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA HO2ON
UT WOS:000460754700001
PM 30899318
OA DOAJ Gold
DA 2019-04-06
ER

EF